DNA replication is arguably the most crucial process at work in
living cells. It is the mechanism by which organisms pass their
genetic information from one generation to the next and life on
Earth would be unthinkable without it. Despite the discovery of DNA
structure in the 1950s, the mechanism of its replication remains
rather elusive. This work makes important contributions to this
line of research. In particular, it addresses two key questions in
the area of DNA replication: which evolutionary forces drive the
positioning of replication origins in the chromosome and how is the
spatial organization of replication factories achieved inside the
nucleus of a cell?. A cross-disciplinary approach uniting physics
and biology is at the heart of this research. Along with
experimental support, statistical physics theory produces optimal
origin positions and provides a model for replication fork assembly
in yeast. Advances made here can potentially further our
understanding of disease mechanisms such as the
abnormal replication in cancer.
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