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Infection, Immune Homeostasis and Immune Privilege (Paperback, 2012 ed.)
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Infection, Immune Homeostasis and Immune Privilege (Paperback, 2012 ed.)
Series: Birkhauser Advances in Infectious Diseases
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Organs and tissues that can tolerate little or no inflammation have
developed multiple overlapping mechanisms of immune protection in
the absence of inflammation. These areas have been designated
"immune-privileged sites" by Peter Medawar and include the central
nervous system, eye, reproductive tract, testis and possibly the
liver. Mechanisms of immune homeostasis found in less
immune-regulated organs are often evident in the immune privileged
sites and vice versa. It is important that the non-inflammatory
mechanisms that contribute to immune privilege allow host defense
against infectious organisms. This volume highlights the mechanisms
leading to immune privilege in tissues and organs, the deviation of
immune responses and the modification of the behavior of the immune
cells that manage to cross the blood barriers of tissues, in the
context of infection.
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