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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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RNP Particles, Splicing and Autoimmune Diseases (Paperback, 1998 ed.)
Loot Price: R1,289
Discovery Miles 12 890
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RNP Particles, Splicing and Autoimmune Diseases (Paperback, 1998 ed.)
Series: Springer Lab Manuals
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The first insights into the site and mechanisms of RNA process- ing
to functional mRNA in eukaryotic cells came from the group of
Georgiev (Lukanidin et al. 1972) who demonstrated the association
of rapidly labelled, heterogeneous nuclear RNA (hnRNA) with a
limited number of specific proteins in the cell nucleus. These
"informofers", i. e. packaged precursors of mRNA (pre-mRNA or
hnRNA), are in a form presumably amenable to the action of
nucleases. With the availability of better analytical techniques,
the considerable heterogeneity of hnRNA associated proteins was
revealed (Niessing and Sekeris 1970), suggesting a role that was
more composite, rather than solely structural, for these proteins.
Later studies investigated the RNA binding behavior of these
proteins (Schenkel et al. 1988, 1989; Wilk et al. 1983). For a long
time, the small nuclear RNAs, well characterized with respect to
primary structure (reviewed by Reddy and Busch 1983), were naively
ignored regarding their function. Several events then set the stage
for a detailed study of the intricate mechanisms of the splicing
process and other steps involved in hnRNA processing: (1) The
demonstration of a second class of nuclear ribonucleoproteins
(RNPs), composed of small nuclear RNAs (snRNAs) and another
characteristic group ofheterogene- ous proteins (Lerner et al.
1980; Guialis et al. 1983); (2) the detec- tion of the association
of snRNPs with hnRNPs by virtue of base pairing between hnRNA and
snRNA (Flytzanis et al.
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