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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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Preclinical Evaluation of Antimicrobial Nanodrugs (Paperback, 1st ed. 2020)
Loot Price: R3,004
Discovery Miles 30 040
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Preclinical Evaluation of Antimicrobial Nanodrugs (Paperback, 1st ed. 2020)
Series: Nanotechnology in the Life Sciences
Expected to ship within 10 - 15 working days
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Translational medicine addresses the gap between research and the
clinical application of new discoveries. To efficiently deliver new
drugs to care centers, a preclinical evaluation, both in vitro and
in vivo, is required to ensure that the most active and least toxic
compounds are selected as well as to predict clinical outcome.
Antimicrobial nanomedicines have been shown to have higher
specificity in their therapeutic targets and the ability to serve
as adjuvants, increasing the effectiveness of pre-existing immune
compounds. The design and development of new standardized protocols
for evaluating antimicrobial nanomedicines is needed for both the
industry and clinical laboratory. These protocols must aim to
evaluate laboratory activity and present models of
pharmacokinetic-pharmacodynamic and toxicokinetic behavior that
predict absorption and distribution. Likewise, these protocols must
follow a theranostics approach, be able to detect promising
formulations, diagnose the infectious disease, and determine the
correct treatment to implement a personalized therapeutic behavior.
Given the possibilities that nanotechnology offers, not updating to
new screening platforms is inadequate as it prevents the correct
application of discoveries, increasing the effect of the valley of
death between innovations and their use. This book is structured to
discuss the fundamentals taken into account for the design of
robust, reproducible and automatable evaluation platforms. These
vital platforms should enable the discovery of new medicines with
which to face antimicrobial resistance (RAM), one of the great
problems of our time.
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