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Antituberculosis Drugs (Paperback, Softcover reprint of the original 1st ed. 1988)
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Antituberculosis Drugs (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Handbook of Experimental Pharmacology, 84
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This volume deals specifically with those antituberculosis drugs
which passed the preclinical phase and have been or are used in the
treatment of tuberculosis and other mycobacterial diseases (except
leprosy) in at least some parts of the world. Despite this
restriction, there are 14 such drugs, and as a result this volume
has reached rather large proportions. To prevent it from becoming
even larger and more unwidely, most derivatives of
antituberculotics have been omitted, especially where it is claimed
that they provide only better bioavailibility or tolerability. Only
in the chapter on the chemotherapy of diseases due to so-called
atypical mycobacteria is the clinical use of the drugs described to
a certain extent. In addition to antituberculotics, also discussed
are antimicrobials which have been found to be effective against
these mycobacteria. The sequence in which the drugs are described
is historical, reflecting not the time of discovery but rather the
first clinical application. This order was selected for reasons
which are now no longer relevant. In this volume less emphasis is
placed on detection, biological or synthetic production of
antituberculotics, and structure-activity relationships. In
contrast, emphasis is put on the degree, type, and mechanism of
antimyco bacterial activity, pharmacokinetics, and
biotransformation in animals and man, on experimental
pharmacodynamics, and on the toxicity of antituberculotics used
therapeutically.
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