Fatty liver disease including nonalcoholic steatohepatitis (NASH)
involves the ac- mulation of triglycerides in hepatocytes with
necrosis,in?ammation,and often ?b- sis with progression to
cirrhosis. The two-hit model summarizes the important early
metabolic events leading to hepatocellular necrosis in NASH. In
these proceedings, we present various new ?ndings and a review of
NASH. The liver has an important role in nutritional homeostasis,
and liver diseases lead to abnormalities in nutrient metabolism and
to subsequent malnutrition,especially in patients with liver cirr-
sis. Protein-energy malnutrition (PEM) is a common ?nding in
cirrhotic patients; it may be present in 20% of patients with
well-compensated disease and in more than 60% of patients with
severe liver insuf?ciency. Therefore,special attention is required
in the management of those patients; proper nutritional assessment
and support for cirrhotic patients is essential. This volume also
includes new ?ndings on the nut- tional aspects of the treatment of
liver cirrhosis, which we hope will contribute to a better
understanding of NASH and nutritional treatment. We thank Otsuka
Pharmaceutical Co. Ltd. for their continuing support. Organizing
Committee of the Yamaguchi Symposium on Liver Disease Kiwamu
Okita,M. D. ,Yamaguchi University,Ube Masamichi Kojiro,M. D.
,Kurume University,Kurume Masao Omata,M. D. ,The University of
Tokyo,Tokyo Norio Hayashi,M. D. ,Osaka University,Osaka Takeshi
Okanoue,M. D. ,Kyoto Prefectural University of Medicine,Kyoto
Secretary General Isao Sakaida,M. D. ,Yamaguchi University,Ube V
Table of Contents Preface ...V List of Participants ...IX
Nonalcoholic Fatty Liver (NAFL): Overview S. H. Caldwell,A.
Al-Osaimi,C. Chang,C. Davis,E. E.
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