The nuclear factor erythroid 2-related factor 2 (Nrf2) was
described as a master regulator of the cellular antioxidant
response. Moreover, many critical biological functions linked to
cell viability, metabolism, autophagy, inflammation, immunity, and
differentiation have been attributed to Nrf2, which regulates over
600 genes. It is well known that oxidative stress, which Nrf2 can
ameliorate, plays a key role in many pathologic processes such as
aging, obesity, diabetes, cancer, and neurodegenerative diseases.
Flavonoids, on the other hand, through their ability to activate
and upregulate Nrf2, can have anti-oxidative, anti-inflammatory,
anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an
essential ingredient in nutraceuticals, functional foods, and
pharmaceuticals. The present book Flavonoids and Anti-Aging: The
Role of Transcription Factor Nuclear Erythroid 2-Related Factor2
focuses on the interaction between Nrf2 and flavonoids and their
applications in various conditions such as aging, osteoporosis,
cardiovascular diseases, and neurodegenerative disease and many
other areas. Key Features: Focuses on the mechanisms and use of
flavonoids in activating Nrf2 as an anti-aging and "WELLNESS"
molecule Provides a specific approach to flavonoid activation of
Nrf2 and its implications in aging and various disease conditions
and its applications as nutraceuticals Presents flavonoid-based
functional foods Discusses the flavonoid nutraceuticals market and
future trends Written by experts in the field, this book provides a
unique approach to understanding the flavonoid activation of the
transcription factor Nrf2, which is responsible for many different
disease conditions due to increased reactive oxidative species in
the body caused by some physiological triggers.
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