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Articular Cartilage Tissue Engineering (Paperback)
Loot Price: R1,042
Discovery Miles 10 420
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Articular Cartilage Tissue Engineering (Paperback)
Series: Synthesis Lectures on Tissue Engineering
Expected to ship within 10 - 15 working days
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Cartilage injuries in children and adolescents are increasingly
observed, with roughly 20% of knee injuries in adolescents
requiring surgery. In the US alone, costs of osteoarthritis (OA)
are in excess of $65 billion per year (both medical costs and lost
wages). Comorbidities are common with OA and are also costly to
manage. Articular cartilage's low friction and high capacity to
bear load makes it critical in the movement of one bone against
another, and its lack of a sustained natural healing response has
necessitated a plethora of therapies. Tissue engineering is an
emerging technology at the threshold of translation to clinical
use. Replacement cartilage can be constructed in the laboratory to
recapitulate the functional requirements of native tissues. This
book outlines the biomechanical and biochemical characteristics of
articular cartilage in both normal and pathological states, through
development and aging. It also provides a historical perspective of
past and current cartilage treatments and previous tissue
engineering efforts. Methods and standards for evaluating the
function of engineered tissues are discussed, and current cartilage
products are presented with an analysis on the United States Food
and Drug Administration regulatory pathways that products must
follow to market. This book was written to serve as a reference for
researchers seeking to learn about articular cartilage, for
undergraduate and graduate level courses, and as a compendium of
articular cartilage tissue engineering design criteria. Table of
Contents: Hyaline Articular Cartilage / Cartilage Aging and
Pathology / In Vitro / Bioreactors / Future Directions
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