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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 8Human Diseases (Hardcover)
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging - Volume 8Human Diseases (Hardcover)
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Understanding the importance and necessity of the role of autophagy
in health and disease is vital for the studies of cancer, aging,
neurodegeneration, immunology, and infectious diseases.
Comprehensive and forward-thinking, these books offer a valuable
guide to both cellular processes while inciting researchers to
explore their potentially important connections. Volume 8 Autophagy
and Human Diseases, concentrates on the role of Autophagy in human
diseases, including tumorigenesis. The diseases discussed include
melanoma, liver cancer, pancreatic cancer, and neurodegenerative
disorders. Loss of autophagy in the central nervous system causes
neurodegeneration (Alzheimers disease, Huntington's disease,
Parkin's disease, and Amyotrophic Lateral Sclerosis). Melanoma is
one of the most serious diseases in humans. Autophagy plays a key
role in the anticancer response to Chemotherapy. However, autophagy
can increase or decrease the effectiveness of chemotherapy. The
reasons for these contradictory effects are explained. Autophagy
also plays a role in idiopathic inflammatory diseases, infection,
and immunity. An explanation is given how autophagy is closely
linked to control of innate and adaptive immune responses in host
defense in part by regulating cytokine production. The role of
autophagy in cutaneous malignant melanoma is discussed in detail
and expression of Beclin 1 and LC3 autophagic genes in melanoma is
included to explain the molecular mechanisms underlying this very
serious disease, which tends to metastasize to the brain. The
effect of the treatment of this disease using Terfenadine through
the induction of autophagy and apoptosis is also included.
Autophagy and apoptosis are two main mechanisms involved in
programmed cell death. Considering that autophagy is associated
with numerous biological processes including cellular development
and differentiation, cancer (both antitumor and protumor
functions), immunity, infectious diseases, inflammation,
maintenance of homeostasis, response to cellular stress, and
degenerative diseases such as Alzheimer's, Parkinson's,
Huntington's, amyotrophic lateral sclerosis, and prion diseases,
there is a great need to understanding its role. Cell homeostasis
is achieved by balancing biosynthesis and cellular turnover. In
spite of the increasing importance of autophagy in various
pathophysiological situations (conditions) mentioned above, this
process remains underestimated and overlooked. As a consequence,
its role in the initiation, stability, maintenance, and progression
of these and other diseases (e.g., autoimmune disease) remains
poorly understood. Volumes in the Series Volume 1: Molecular
Mechanisms. Elucidates autophagy's association with numerous
biological processes, including cellular development and
differentiation, cancer, immunity, infectious diseases,
inflammation, maintenance of homeostasis, response to cellular
stress, and degenerative diseases such as Alzheimer's, Parkinson's,
Huntington's, amyotrophic lateral sclerosis, and prion diseases.
Volume 2: Role in General Diseases. Describes the various aspects
of the complex process of autophagy in a myriad of devastating
human diseases, expanding from a discussion of essential autophagic
functions into the role of autophagy in proteins, pathogens,
immunity, and general diseases. Volume 3: Role in Specific
Diseases. Explores the role of autophagy in specific diseases and
developments, including: Crohn's Disease, Gaucher Disease,
Huntington's Disease, HCV infection, osteoarthritis, and liver
injury, with a full section devoted to in-depth exploration of
autophagy in tumor development and cancer, as well as the
relationship between autophagy and apoptosis. Volume 4: Mitophagy.
Presents detailed information on the role of mitophagy, the
selective autophagy of mitochondria, in health and disease, by
delivering an in-depth treatment of the molecular mechanisms
involved in mitophagy initiation and execution, as well as the role
of mitophagy in Parkinson Disease, cardiac aging, and skeletal
muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively
describes the role of autophagy in human diseases, delivering
coverage of the antitumor and protumor roles of autophagy; the
therapeutic inhibition of autophagy in cancer; and the duality of
autophagy's effects in various cardiovascular, metabolic, and
neurodegenerative disorders. Volume 6: Regulation of Autophagy and
Selective Autophagy. Provides coverage of the mechanisms of
regulation of autophagy; intracellular pathogen use of the
autophagy mechanism; the role of autophagy in host immunity; and
selective autophagy. Volume 7: Role of Autophagy in Therapeutic
Applications. Provides coverage of the latest developments in
autophagosome biogenesis and regulation; the role of autophagy in
protein quality control; the role of autophagy in apoptosis;
autophagy in the cardiovascular system; and the relationships
between autophagy and lifestyle. Volume 8: Autophagy and Human
Diseases. Reviews recent advancements in the molecular mechanisms
underlying a large number of genetic and epigenetic diseases and
abnormalities, and introduces new, more effective therapeutic
strategies, in the development of targeted drugs and programmed
cell death, providing information that will aid on preventing
detrimental inflammation. Volume 9: Human Diseases and
Autophagosome. Emphasizes the role of Autophagy in necrosis and
inflammation, explaining in detail the molecular mechanism(s)
underlying the formation of autophagosomes, including the
progression of Omegasomes to autophagosomes.
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