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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Monoclonal Antibodies to Receptors - Probes for Receptor Structure and Funtcion (Paperback, Softcover reprint of the original 1st ed. 1984)
Loot Price: R5,441
Discovery Miles 54 410
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Monoclonal Antibodies to Receptors - Probes for Receptor Structure and Funtcion (Paperback, Softcover reprint of the original 1st ed. 1984)
Series: Series B, 17
Expected to ship within 10 - 15 working days
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Total price: R5,461
Discovery Miles: 54 610
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Receptor specific antibodies are excellent probes for a wide range
of biological investigations on receptor structure and function.
The hybridoma technology (Kohler and Milstein, 1975) has inevitably
had a major impact on this field with most of the better known
receptors now identified with monoclonal antibodies. This volume of
the Receptors and Recognition series provides reviews of recent
developments in this field and emphasizes in particular the new
opportunities afforded by the judicious application of monoclonal
reagents. It is assumed that most readers will be familiar with the
now fairly routine methods of cell fusion, hybridoma cloning and
selection for producing monoclonal antibodies and so few details of
the basic technical procedures are described. Several good reviews
on this topic are however available (see Galfre and Milstein, 1981;
Goding, 1980; Yelton and Scharf, 1981; McMichael and Fabre, 1982).
By no means all vertebrate receptor species are discussed here;
omissions include antibodies to low density lipoprotein receptors
(Beisiegel et al. , 1981; Kita et al. , 1981), prolactin and growth
hormone receptors (Friesen etal. , 1982; Simpson et al. , 1983) and
the hepatocyte asialoglycoprotein receptor (Schwartz et al. , 1981;
Harford et al. , 1982). Nevertheless the coverage is comprehensive
and critical and the individual chapters provided illustrate
vividly the rapid progress being made.
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