Hormesis - A Revolution in Biology, Toxicology and Medicine (Paperback, 2010 ed.)

The term hormesis is de?ned as "a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive bene?cial effect on the cell or organism" (Calabrese et al., 2007; Mattson, 2008). To survive and reproduce in harsh competitive environments, organisms and their cellular components have, through evolution, developed molecular mec- nisms to respond adaptively to various hazards or "stressors" that they encounter. Examples of such stressors include chemicals ingested in food and water (metals, phytochemicals, etc.), increased energy expenditure (running, ?ghting, cognitive challenges, etc.), and reduced energy availability (food scarcity), among others. In most cases, the response of the cell or organism to the stressor exhibits a biphasic dose response, with bene?cial/adaptive responses at low doses (improved fu- tion, increased resistance to damage and disease) and adverse/destructive effects (dysfunction, molecular damage, or even death) at high doses. The prevalence of the biphasic (hormetic) dose response characteristic of biological systems merits consideration of hormesis as a fundamental principle of biology.

General

Imprint:	HumanaPress
Country of origin:	United States
Release date:	November 2014
First published:	2010
Editors:	Mark P. Mattson • Edward J. Calabrese
Dimensions:	235 x 155 x 12mm (L x W x T)
Format:	Paperback
Pages:	213
Edition:	2010 ed.
ISBN-13:	978-1-62703-851-5
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
LSN:	1-62703-851-5
Barcode:	9781627038515

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