Neurofibromatosis Type 1 - Molecular and Cellular Biology (Paperback, Softcover reprint of the original 1st ed. 2012)

Neurofibromatosis type 1 (NF1), caused by mutational inactivation of the NF1 tumour suppressor gene, is one of the most common dominantly inherited human disorders, affecting 1 in 3000 individuals worldwide. This book presents in concise fashion, but as comprehensively as possible, our current state of knowledge on the molecular genetics, molecular biology and cellular biology of this tumour predisposition syndrome. Written by internationally recognized experts in the field, the 44 chapters that constitute this edited volume provide the reader with a broad overview of the clinical features of the disease, the structure and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the structure and function of its protein product (neurofibromin), NF1 modifying loci, the molecular pathology of NF1-associated tumours, animal models of the disease, psycho-social aspects and future prospects for therapeutic treatment.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Release date:	August 2016
First published:	2012
Editors:	Meena Upadhyaya • David N. Cooper
Dimensions:	235 x 155 x 47mm (L x W x T)
Format:	Paperback
Pages:	717
Edition:	Softcover reprint of the original 1st ed. 2012
ISBN-13:	978-3-662-50717-9
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-662-50717-X
Barcode:	9783662507179

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