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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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PARP Inhibitors for Cancer Therapy (Paperback, Softcover reprint of the original 1st ed. 2015)
Loot Price: R4,585
Discovery Miles 45 850
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PARP Inhibitors for Cancer Therapy (Paperback, Softcover reprint of the original 1st ed. 2015)
Series: Cancer Drug Discovery and Development
Expected to ship within 10 - 15 working days
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PARP Inhibitors for Cancer Therapy provides a comprehensive
overview of the role of PARP in cancer therapy. The volume covers
the history of the discovery of PARP (poly ADP ribose polymerase)
and its role in DNA repair. In addition, a description of discovery
of the PARP family, and other DNA maintenance-associated PARPs will
also be discussed. The volume also features a section on accessible
chemistry behind the development of inhibitors. PARP inhibitors are
a group of pharmacological inhibitors that are a particularly good
target for cancer therapy. PARP plays a pivotal role in DNA repair
and may contribute to the therapeutic resistance to DNA damaging
agents used to treat cancer. Researchers have learned a tremendous
amount about the biology of PARP and how tumour-specific defects in
DNA repair can be exploited by PARPi. The "synthetic lethality" of
PARPi is an exciting concept for cancer therapy and has led to a
heightened activity in this area.
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