In the last few years the major effect that RNAi has had in
invertebrate systems is beginning to take hold in mammalian systems
through both single gene knockdown experiments and genome-scale
screens. In the next decade, there will no doubt be both notable
successes and failures as we attempt to apply this genetic tool to
various biological problems. Through the introduction of RNAi,
mammalian systems have finally gained admittance to the pantheon of
model genetic systems.
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