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Developmental Biology of Peripheral Lymphoid Organs (Paperback, 2011 ed.)
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Developmental Biology of Peripheral Lymphoid Organs (Paperback, 2011 ed.)
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The human immune system is a complex network of tissues and organs
dispersed throughout the body. Immunology, as one of the most
rapidly evolving fields in biomedical research, has to date covered
the essential cellular and molecular events necessary for immune
responses to occur. However, it has paid relatively little
attention to important developmental processes underlying the
formation of the tissues themselves that carry out immune responses
in humans and other mammalians. In contrast to the thymus and bone
marrow that are the sole tissues for generating mature leukocytes
for antigen recognition and handling in humans and most mammalian
species, the peripheral lymphoid tissues where adaptive immune
responses are focused display broad tissue distribution and possess
diverse architectural characteristics. These organs develop prior
to the individual's exposure to external antigens, and despite
their similar functions, their varied appearances indicate a
substantial complexity of tissue ontogeny. This volume presents a
comprehensive overview of the developmental features of the major
peripheral lymphoid organs, thus examining the connection between
immunological functionality and structural characteristics
utilizing a developmental approach, for an audience ranging from
undergraduate students to senior researchers in immunology,
histology and clinical medicine.
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