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Cyclin Dependent Kinase (CDK) Inhibitors (Paperback, Softcover reprint of the original 1st ed. 1998)
Loot Price: R3,488
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Cyclin Dependent Kinase (CDK) Inhibitors (Paperback, Softcover reprint of the original 1st ed. 1998)
Series: Current Topics in Microbiology and Immunology, 227
Expected to ship within 10 - 15 working days
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More than 10 years ago, the discovery of cyclin-dependent ki nases
(Cdks) ushered in a new era in the understanding of cell
proliferation and its control. Not only were both of the known cell
cycle transitions, from G 1 to S phase and G2 to M phase, found to
be dependent on these protein kinases, but the reg ulatory
assumption intrinsic to cyclin-dependent kinases, a stable inactive
catalytic subunit (the Cdk) and an unstable requisite positive
regulatory activating subunit (the cyclin), led to a simple model
for cell cycle control. Modulation of cyclin accumulation, and
thereby Cdk activation, was proposed to be the overarching
principle governing the passage through cell cycle phases. An other
reality to emerge from the discovery of Cdks was the ex ceptional
degree of evolutionary conservation maintained in the machinery and
organization of proliferation control. Not only were Cdks shown to
be structurally conserved between yeast and man, but mammalian Cdks
could substitute functionally for the endogenous enzymes in a yeast
cell. The problem of cell cycle control was thought to have been
virtually solved. The ensuing years have provided a much more
complex view of cell cycle control and the role and regulation of
Cdks. The uncritical enthusiasm with which many of the ideas were
em braced has required tempering. For example, although Cdks appear
to be highly conserved phylogenetically, cyclins are much less so.
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