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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Ion Channels - Volume 1 (Paperback, Softcover reprint of the original 1st ed. 1988)
Loot Price: R1,603
Discovery Miles 16 030
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Ion Channels - Volume 1 (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Ion Channels, 1
Expected to ship within 10 - 15 working days
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A wealth of information has been accumulated about the function of
ion channels of excitable cells since the extensive and pioneering
voltage clamp studies by Hodgkin, Huxley, and Katz 36 years ago.
The study of ion chan nels has now reached a stage at which a
quantum jump in progress is antici pated. There are many good
reasons for this. Patch clamp techniques origi nally developed by
Neher and Sakmann 12 years ago have made it possible to study the
function of ion channels in a variety of cells. Membrane ionic
currents can now be recorded practically from many types of cells
using the whole-cell patch clamp technique. The opening and closing
of individual ion channels can be analyzed using the single-channel
patch clamp method. Techniques have also been developed to
incorporate purified ion channels into lipid bilayers to
reconstitute an "excitable membrane. " Advanced tech niques
developed in molecular biology, genetics, and immunology, such as
gene cloning and the use of monoclonal antibodies, are now being
applied to the study of ion channels. A variety of drugs have now
been found or are suspected to interact with ion channels to exert
therapeutic effects. In addition to the classical exam ples, as
represented by local anesthetics, many other drugs, including cal
cium antagonists, psychoactive drugs, cardiac drugs, and
anticonvulsants, shown to alter ion channel function. For certain
pesticides such as have been pyrethroids and DDT, sodium channels
are clearly the major target site.
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