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Design of Caspase Inhibitors as Potential Clinical Agents (Paperback)
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Design of Caspase Inhibitors as Potential Clinical Agents (Paperback)
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Presents the Therapeutic Potential for Caspase Inhibitors: Present
and Future Caspases represent one of the most specific protease
families described to date. These extremely important enzymes are
crucial to the destruction of aberrant cells - the body's
self-protection mechanism for warding off the growth of abnormal
cells, many of which can promote cancer. Design of Caspase
Inhibitors as Potential Clinical Agents introduces cutting-edge
evidence regarding caspases' role in pro-inflammatory responses.
New research now shows that the inhibition of caspase function is a
critical component for the treatment of many diseases, including:
Arthritic and neurological disorders Lung disease Hereditary fever
syndromes Inflammatory bowel and skin diseases Sepsis Liver
fibrosis Outlines Efforts to Develop Molecule Inhibitors for
Caspase Activity Transformation Under the editorial guidance of
authoritative inflammatory disease, small molecule discovery, and
apoptosis researchers, the book organizes the wide array of caspase
literature into one convenient resource. It also summarizes the
relative difficulty of transitioning a caspase small molecule
inhibitor from the lab to the clinic and suggests approaches to
circumvent this difficulty. Taking a novel, yet core approach to
disease treatment, this seminal work sets the stage to combat a
slew of debilitating diseases through groundbreaking drug
development.
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