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Books > Social sciences > Psychology > Physiological & neuro-psychology
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Neurophenotypes - Advancing Psychiatry and Neuropsychology in the "OMICS" Era (Paperback, Softcover reprint of the original 1st ed. 2016)
Loot Price: R3,278
Discovery Miles 32 780
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Neurophenotypes - Advancing Psychiatry and Neuropsychology in the "OMICS" Era (Paperback, Softcover reprint of the original 1st ed. 2016)
Series: Innovations in Cognitive Neuroscience
Expected to ship within 10 - 15 working days
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The interest in 'biomarkers' seen across a spectrum of biomedical
disciplines reflects the rise of molecular biology and genetics. A
host of 'omics' disciplines in addition to genomics, marked by
multidimensional data and complex analyses, and enabled by
bioinformatics, have pushed the trajectory of biomarker development
even further. They have also made more tractable the complex
mappings of genotypes to phenotypes - genome-to-phenome mapping -
to which the concept of a biomarker is central. Genomic
investigations of the brain are beginning to reveal spectacular
associations between genes and neural systems. Neural and cognitive
phenomics are considered a necessary complement to genomics of the
brain. Other major omics developments such as connectomics, the
comprehensive mapping of neurons and neural networks, are heralding
brain maps of unprecedented detail. Such developments are defining
a new era of brain science. And in this new research environment,
neural systems and cognitive operations are pressed for new kinds
of definitions - that facilitate brain-behavioral alignment in an
omics operating environment. This volume explores the topic of
markers framed around the constructs of cognitive and neural
systems. 'Neurophenotype' is a term adopted to describe a neural or
cognitive marker that can be scientifically described within an
associative framework - and while the genome-to-phenome framework
is the most recognized of these, epigenetics and non-gene-regulated
neural dynamics also suggest other frameworks. In either case, the
term neurophenotype defines operational constructs of
brain-behavioral domains that serve the integration of these
domains with neuroscientific and omics models of the brain. The
topic is critically important to psychiatry and neuropsychology:
Neurophenotypes offer a 'format' and a 'language' by which
psychiatry and neuropsychology can be in step with the brain
sciences. They also bring a new challenge to the clinical
neurosciences in terms of construct validation and refinement.
Topics covered in the volume include: Brain and cognition in the
omics era Phenomics, connectomics, and Research Domain Criteria
Circuit-based neurophenotypes, and complications posed by non-gene
regulated factors The legacy of the endophenotype concept - its
utility and limitations Various potential neurophenotypes of
relevance to clinical neuroscience, including Response Inhibition,
Fear Conditioning and Extinction, Error Processing, Reward
Dependence and Reward Deficiency, Face Perception, and Language
Phenotypes Dynamic (electrophysiological) and computational
neurophenotypes The challenge of a cultural shift for psychiatry
and neuropsychology The volume may be especially relevant to
researchers and clinical practitioners in psychiatry and
neuropsychology and to cognitive neuroscientists interested in the
intersection of neuroscience with genomics, phenomics and other
omics disciplines.
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