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Current Topics in Microbiology and Immunology (Paperback, Softcover reprint of the original 1st ed. 1979)
Loot Price: R2,929
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Current Topics in Microbiology and Immunology (Paperback, Softcover reprint of the original 1st ed. 1979)
Series: Current Topics in Microbiology and Immunology, 86
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1.1 Classification of Togaviruses The family, Togaviridae, is
composed of the alphaviruses, the flaviviruses, rubella (a
rubivirus), and the pestiviruses (Fenner, 1976). Of these four
genera, two (the alpha- and flaviviruses) are transmitted by
blood-sucking arthropods, specif ically mosquitoes and ticks. Among
the togaviruses, extensive studies of defective interfering (DI)
particles have so far been carried out only with Sindbis virus (SV)
and Semliki Forest virus (SFV), both members of the alphavirus
genus. Since these viruses are so similar, in most cases it will be
assumed that what is true of one is also true of the other. 1.2
Definition of Defective Interfering (DI) Particles Defective
interfering viral particles, as defined by Huang (1973), have the
follow ing properties: (1) they are deletion mutants and therefore
lack large amounts of the genetic material present in the standard
virus; (2) they contain the same viral structural proteins as
standard virus; (3) they are unable to replicate alone; however,
they are replicated in cells co-infected with standard virions; and
(4) at the same time as they require standard virus to replicate,
they inhibit the replication of standard virus and hence are
interfering."
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