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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Endotoxins: Structure, Function and Recognition (Paperback, 2010 ed.)
Loot Price: R5,896
Discovery Miles 58 960
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Endotoxins: Structure, Function and Recognition (Paperback, 2010 ed.)
Series: Subcellular Biochemistry, 53
Expected to ship within 10 - 15 working days
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Total price: R5,916
Discovery Miles: 59 160
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Endotoxins are potentially toxic compounds produced by
Gram-negative bacteria including some pathogens. Unlike exotoxins,
which are secreted in soluble form by live bacteria, endotoxins are
comprised of structural components of bacteria. Endotoxins can
cause a whole-body inflammatory state, sepsis, leading to low blood
pressure, multiple organ dysfunction syndrome and death. This book
brings together contributions from researchers in the forefront of
these subjects. It is divided into two sections. The first deals
with how endotoxins are synthesized and end up on the bacterial
surface. The second discussed how endotoxins activate TLR4 and, in
turn, how TLR4 generates the molecular signals leading to
infectious and inflammatory diseases. The way endotoxins interact
with the host cells is fundamental to understanding the mechanism
of sepsis, and recent research on these aspects of endotoxins has
served to illuminate previously undescribed functions of the innate
immune system. This volume presents a description of endotoxins
according to their genetic constitution, structure, function and
mode of interaction with host cells.
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