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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Tumor Ablation - Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions (Hardcover, 2013 ed.)
Loot Price: R4,006
Discovery Miles 40 060
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Tumor Ablation - Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions (Hardcover, 2013 ed.)
Series: The Tumor Microenvironment, 5
Expected to ship within 10 - 15 working days
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The growing knowledge on tumor-immune response interactions and on
the tumor microenvironment did not translate so far into better
control of cancer by anti-tumor vaccination. The percentage of
patients who benefited from vaccination strategies is still too
small to justify their general use. It is the aim of this book to
present an alternative to the conventional approach of developing
injected tumor vaccines to activate anti-tumor immunity, which will
fight cancer. It is argued that in situ tumor ablation
(destruction) that involves tumor antigen release; cross
presentation and the release of danger associated molecular
patterns (DAMPs) can make the tumor its own cellular vaccine. Tumor
ablation methods using chemicals, radiation, photodynamic therapy,
cryoablation, high-temperature, radiofrequency, high intensity
focused ultrasound, and electric-based ablation have been developed
for focal tumors. In this book experts will deal with two main
topics: I. What are the principles of the various ablation
modalities, and II. How each method affects the tumor cells and
their microenvironment, and how these effects are responsible for
the induction of specific anti-tumor immunity. The aims of this
book are thus: 1. Familiarize the readers with various methods of
in situ tumor ablation. 2. Review the literature and stimulate
comparisons on the efficacy of different ablation methods for the
treatment of tumors of different histotypes. 3. Review the
literature on the effects of various ablation methods on systemic
and local anti tumor immunity and on other manifestations of the
interactions of tumors with their microenvironment. 4. Stimulate
comparative studies on the immunostimulatory effects of different
ablation modalities.
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