Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals (Paperback, 1st ed. 2022)

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

General

Imprint:	Springer Verlag, Singapore
Country of origin:	Singapore
Series:	Springer Theses
Release date:	2023
First published:	2022
Authors:	Yunjiao Zhang
Dimensions:	235 x 155mm (L x W)
Format:	Paperback
Pages:	156
Edition:	1st ed. 2022
ISBN-13:	978-981-16-8168-4
Categories:	Books > Professional & Technical > Technology: general issues > Nanotechnology Books > Professional & Technical > Biochemical engineering > General Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Promotions
LSN:	981-16-8168-6
Barcode:	9789811681684

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