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Books > Science & Mathematics > Biology, life sciences > Biochemistry

Therapy of Viral Infections (Hardcover, 2015 ed.): Wibke E Diederich, Holger Steuber Therapy of Viral Infections (Hardcover, 2015 ed.)
Wibke E Diederich, Holger Steuber
R6,431 Discovery Miles 64 310 Ships in 10 - 15 working days

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Subtelomeres (Hardcover, 2014 ed.): Edward J. Louis, Marion M Becker Subtelomeres (Hardcover, 2014 ed.)
Edward J. Louis, Marion M Becker
R4,972 Discovery Miles 49 720 Ships in 12 - 19 working days

New genes and diversity leading to adaptation and evolution are generated in special areas of genomes. One such area in all eukaryotic genomes and in those prokaryotes with linear chromosomes is the region near the ends of the chromosomes. These telomere-associated sequences or subtelomeres, have different properties than the rest of the genome and are one of the most exciting frontiers left in genomics.

This book provides a broad introduction to the field of subtelomeres with detailed information from various fields and systems, covering yeasts and fungi, pathogens and parasites, plants, insects, humans and primates and bacteria with linear chromosomes. Advances in the field as well as continuing challenges are discussed throughout. The mosaic nature of this collection and the everchanging perspectives reflect the nature of subtelomeres themselves.

Unlike the core of most genomes, which are conserved and stable over time, subtelomeres are dynamic and polymorphic, so much so that generally no two individuals look alike in these regions. The dynamic nature of the region and the ability to change the copy number, generate diversity and try novel combinations make it the evolutionary tinker s toolbox. In many organisms the genes found in the region are involved in dealing with the environment. In yeasts, different gene families involved in sugar metabolism as well as clumping together are found in subtelomeres and differences in the region may be the reason why some strains are good for baking, others for brewing and why some are pathogenic. In fungal plant and animal pathogens, many of the genes involved in virulence are found here. In humans and primates there are a number of gene families that vary between ends, for example the diverse olfactory receptor genes. Even in bacterial linear chromosomes the region contains genes involved in adapting to their environments. Perhaps the ultimate use of these regions is in parasites where they rapidly adapt and escape from host immune systems through dynamic changes to the proteins exposed to the host s defenses. Such dynamic, polymorphic structures are also found in plants and insects though it is not always clear what the function might be; in some cases they take on the role of end maintenance. The dynamic, polymorphic nature of subtelomeres, where many ends share segmental duplications, is an exciting area for study but also presents a difficult challenge from the technical perspective."

Fluorescent Proteins, Volume 85 (Hardcover, 2nd edition): Kevin F. Sullivan Fluorescent Proteins, Volume 85 (Hardcover, 2nd edition)
Kevin F. Sullivan
R4,426 Discovery Miles 44 260 Ships in 12 - 19 working days

This new edition of "Fluorescent Proteins" presents current applications of autofluorescent proteins in cell and molecular biology authored by researchers from many of the key laboratories in the field. Starting from a current review of the broad palette of fluorescent proteins available, several chapters focus on key autofluorescent protein variants, including spectral variants, photodynamic variants as well as chimeric FP approaches. Molecular applications are addressed in chapters that detail work with single molecules, approaches to generating protein fusions and biosensors as well as analysis of protein-protein interactions in vivo by FRET, fluorescence polarization and fluorescence cross correlation techniques. A number of approaches to in vivo dynamics are presented, including FRAP, photoactivation, and 4-dimensional microscopy. Behavior of spindle components, membrane proteins, mRNA trafficking as well as analysis of cell types in tissues and in development are detailed and provide models for a wide variety of experimental approaches. In addition, several chapters deal directly with the computational issues involved in processing multidimensional image data and using fluorescent imaging to probe cellular behavior with quantitative modeling. This volume brings together the latest perspective and techniques on fluorescent proteins and will be an invaluable reference in a wide range of laboratories.

Multiscale Modeling of Developmental Systems, Volume 81 (Hardcover, 81st edition): Gerald P. Schatten Multiscale Modeling of Developmental Systems, Volume 81 (Hardcover, 81st edition)
Gerald P. Schatten; Volume editing by Santiago Schnell, Philip Maini, Stuart A. Newman, Timothy Newman
R4,839 Discovery Miles 48 390 Ships in 12 - 19 working days

Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.
This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists - especially graduate students and post-docs, from both biological and quantitative backgrounds.
* Articles written by leading exponents in the field
* Provides techniques to address multiscale modelling
* Coverage includes a wide spectrum of modeling approaches
* Includes descriptions of the most recent advances in the field

Mitochondrial Biology and Experimental Therapeutics (Hardcover, 1st ed. 2018): Paulo J. Oliveira Mitochondrial Biology and Experimental Therapeutics (Hardcover, 1st ed. 2018)
Paulo J. Oliveira
R7,206 Discovery Miles 72 060 Ships in 10 - 15 working days

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Biophysical Tools for Biologists, Volume 84 - In Vitro Techniques (Hardcover, 84th edition): John J. Correia, H. William... Biophysical Tools for Biologists, Volume 84 - In Vitro Techniques (Hardcover, 84th edition)
John J. Correia, H. William Detrich III
R4,469 Discovery Miles 44 690 Ships in 12 - 19 working days

Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques "in vitro" and their applications to cellular biology. The volume covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval.
* Describes techniques in the context of important biological problems
* Delineates critical steps and potential pitfalls for each method
* Includes full-color plates to illustrate techniques

Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology (Hardcover, 1st ed. 2020): John Torday, William Miller Jr Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology (Hardcover, 1st ed. 2020)
John Torday, William Miller Jr
R5,098 Discovery Miles 50 980 Ships in 10 - 15 working days

There has been no mechanistic explanation for evolutionary change consistent with phylogeny in the 150 years since the publication of 'Origins'. As a result, progress in the field of evolutionary biology has stagnated, relying on descriptive observations and genetic associations rather testable scientific measures. This book illuminates the need for a larger evolutionary-based platform for biology. Like physics and chemistry, biology needs a central theory in order to frame the questions that arise, the way hypotheses are tested, and how to interpret the data in the context of a continuum.The reduction of biology to its self-referential, self-organized properties provides the opportunity to recognize the continuum from the Singularity/Big Bang to Consciousness based on cell-cell communication for homeostasis.

Development of Metallothionein-based Assays for the Measurement of Zinc Status in Humans (Hardcover): Vicki Sullivan Development of Metallothionein-based Assays for the Measurement of Zinc Status in Humans (Hardcover)
Vicki Sullivan
R2,220 Discovery Miles 22 200 Ships in 10 - 15 working days
Class 1 Oxidoreductases - EC 1 (Hardcover, 2nd ed. 2009): Antje Chang Class 1 Oxidoreductases - EC 1 (Hardcover, 2nd ed. 2009)
Antje Chang; Edited by Dietmar Schomburg, Ida Schomburg
R8,472 Discovery Miles 84 720 Ships in 10 - 15 working days

The objective of the "Springer Handbook of Enzymes" is to provide in concise form data on enzymes sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. The volumes are arranged according to enzyme classes. Considerable progress has been made in enzymology since the publication of the first edition (published as "Enzyme Handbook"): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: "application" and "engineering" (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition consists of 39 volumes plus synonym index. All newly classified enzymes are treated in the supplement volumes. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences, as well as for medicinal applications.

The supplement volumes contain all newly classified enzymes - about 100-150 per year.

Evidence Based Validation of Traditional Medicines - A comprehensive Approach (Hardcover, 1st ed. 2021): Subhash C. Mandal,... Evidence Based Validation of Traditional Medicines - A comprehensive Approach (Hardcover, 1st ed. 2021)
Subhash C. Mandal, Raja Chakraborty, Saikat Sen
R5,859 Discovery Miles 58 590 Ships in 10 - 15 working days

The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine.

Chemokines - Chemokines and Their Receptors in Drug Discovery (Hardcover, 2015 ed.): Nuska Tschammer Chemokines - Chemokines and Their Receptors in Drug Discovery (Hardcover, 2015 ed.)
Nuska Tschammer
R6,489 Discovery Miles 64 890 Ships in 10 - 15 working days

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Advances in Carbohydrate Chemistry and Biochemistry, Volume 61 (Hardcover, 63rd edition): Derek Horton Advances in Carbohydrate Chemistry and Biochemistry, Volume 61 (Hardcover, 63rd edition)
Derek Horton
R5,786 Discovery Miles 57 860 Ships in 12 - 19 working days

Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

Translation Initiation: Reconstituted Systems and Biophysical Methods, Volume 430 (Hardcover, 430th edition): Jon Lorsch Translation Initiation: Reconstituted Systems and Biophysical Methods, Volume 430 (Hardcover, 430th edition)
Jon Lorsch
R5,164 Discovery Miles 51 640 Ships in 12 - 19 working days

For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.

Translation Initiation: Extract Systems and Molecular Genetics, Volume 429 (Hardcover, 429th edition): Jon Lorsch Translation Initiation: Extract Systems and Molecular Genetics, Volume 429 (Hardcover, 429th edition)
Jon Lorsch
R5,168 Discovery Miles 51 680 Ships in 12 - 19 working days

For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the first of three on the topic of Translation Initiation includes articles written by leaders in the field.

Evolutionary Bioinformatics (Hardcover, 3rd ed. 2016): Donald R. Forsdyke Evolutionary Bioinformatics (Hardcover, 3rd ed. 2016)
Donald R. Forsdyke
R7,626 Discovery Miles 76 260 Ships in 12 - 19 working days

Now in its third edition and supplemented with more online material, this book aims to make the "new" information-based (rather than gene-based) bioinformatics intelligible both to the "bio" people and the "info" people. Books on bioinformatics have traditionally served gene-hunters, and biologists who wish to construct family trees showing tidy lines of descent. While dealing extensively with the exciting topics of gene discovery and database-searching, such books have hardly considered genomes as information channels through which multiple forms and levels of information have passed through the generations. This "new bioinformatics" contrasts with the "old" gene-based bioinformatics that so preoccupies previous texts. Forms of information that we are familiar with (mental, textual) are related to forms with which we are less familiar (hereditary). The book extends a line of evolutionary thought that leads from the nineteenth century (Darwin, Butler, Romanes, Bateson), through the twentieth (Goldschmidt, White), and into the twenty first (the final works of the late Stephen Jay Gould). Long an area of controversy, diverging views may now be reconciled.

Translation Initiation: Cell Biology, High-throughput and Chemical-based Approaches, Volume 431 (Hardcover, 431st edition): Jon... Translation Initiation: Cell Biology, High-throughput and Chemical-based Approaches, Volume 431 (Hardcover, 431st edition)
Jon Lorsch
R5,165 Discovery Miles 51 650 Ships in 12 - 19 working days

For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the third of three on the topic of Translation Initiation includes articles written by leaders in the field.

Fundamentals of Animal Nutrition (Hardcover, 1st ed. 2021): Subodh Kumar Saha, Nityanand Pathak Fundamentals of Animal Nutrition (Hardcover, 1st ed. 2021)
Subodh Kumar Saha, Nityanand Pathak
R4,588 Discovery Miles 45 880 Ships in 12 - 19 working days

The book provides comprehensive information about the different aspects of veterinary nutrition in tropical countries.The introductory chapter discuss the importance of nutrition, feeds and feeding of balanced and optimum feeds specifically required for the sustenance of life. The second chapter, discusses briefly the history of research in animal nutrition.The book further talks about the relationship between the environment and nutrition in animals; the chemical composition of plants and animals; and the various sources of feed for animals. It provides details on the different phases of life cycle in animals, and the effect of nutrition on the performance. Various Nutrients and its importance in livestock nutritionand production has been illustrated in details. Various nutrients such as water, carbohydrate, protein, fats, vitamins, minerals etc are individually dealt in a separate chapter. The digestive system,digestion and metabolism of carbohydrates, protein and fats in ruminant and non ruminant livestock have been illustrated. A dedicated chapter fully describes the activity of enzymes which are directly involved in nutrition. Also this book deals with the harmful components of animal feed which are found mainly in the unconventional feeds. The books also provide chapters like partitioning of feed& energy and also the therapeutic and clinical nutrition which are very importantfor the under graduate & post graduate students and researchers of animal nutrition and livestock production and management. This book is useful for researchers, undergraduate and post graduate students studying veterinary sciences, animal husbandry, zoology and biochemistry.

Phospholipases in Health and Disease (Hardcover, 2014 ed.): Paramjit S. Tappia, Naranjan S. Dhalla Phospholipases in Health and Disease (Hardcover, 2014 ed.)
Paramjit S. Tappia, Naranjan S. Dhalla
R6,227 Discovery Miles 62 270 Ships in 12 - 19 working days

Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.

In Silico Chemistry and Biology - Current and Future Prospects (Hardcover): Girish Kumar Gupta, Mohammad Hassan Baig In Silico Chemistry and Biology - Current and Future Prospects (Hardcover)
Girish Kumar Gupta, Mohammad Hassan Baig
R4,013 Discovery Miles 40 130 Ships in 12 - 19 working days

In Silico Chemistry and Biology: Current and Future Prospects provides a compact overview on recent advances in this highly dynamic branch of chemistry. Various methods of protein modelling and computer-assisted drug design are presented, including fragment- and ligand-based approaches. Many successful practical applications of these techniques are demonstrated. The authors also look to the future and describe the main challenges of the field.

Amino Acid Biosynthesis - Pathways, Regulation and Metabolic Engineering (Hardcover, 2007 ed.): Volker F Wendisch Amino Acid Biosynthesis - Pathways, Regulation and Metabolic Engineering (Hardcover, 2007 ed.)
Volker F Wendisch
R5,645 Discovery Miles 56 450 Ships in 10 - 15 working days

Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch.

The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives. Comprehensive reviews are given of recent achievements to enable or improve production of amino acids and dipeptides by fermentation and enzyme catalysis. Here, the particular focus is on metabolic engineering, the rational improvement of metabolic functions using recombinant DNA technology.

The Enzymes, Volume 25 - Molecular Machines Involved in Protein Transport across Cellular Membranes (Hardcover, 25th edition):... The Enzymes, Volume 25 - Molecular Machines Involved in Protein Transport across Cellular Membranes (Hardcover, 25th edition)
Ross Dalbey, Carla Koehler, Fuyuhiko Tamanoi
R3,699 Discovery Miles 36 990 Ships in 12 - 19 working days

This volume of The Enzymes features high-caliber thematic articles on the topic of molecular machines involved in protein transport across cellular membranes. The book consists of five parts which span the range of membranes including bacterial, endoplasmic reticulum, mitochondrial, chloroplast, and peroxismal.

The Chemistry of Benzotriazole Derivatives - A Tribute to Alan Roy Katritzky (Hardcover, 1st ed. 2016): Jean-Christophe M... The Chemistry of Benzotriazole Derivatives - A Tribute to Alan Roy Katritzky (Hardcover, 1st ed. 2016)
Jean-Christophe M Monbaliu
R6,628 Discovery Miles 66 280 Ships in 10 - 15 working days

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

The Cholesterol Wars - The Skeptics vs the Preponderance of Evidence (Hardcover): Daniel Steinberg The Cholesterol Wars - The Skeptics vs the Preponderance of Evidence (Hardcover)
Daniel Steinberg
R1,983 Discovery Miles 19 830 Ships in 12 - 19 working days

Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.
* Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community.
* Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs
* Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis

Water and Biomolecules - Physical Chemistry of Life Phenomena (Hardcover, 2009 ed.): Kunihiro Kuwajima, Yuji Goto, Fumio... Water and Biomolecules - Physical Chemistry of Life Phenomena (Hardcover, 2009 ed.)
Kunihiro Kuwajima, Yuji Goto, Fumio Hirata, Masahide Terazima, Mikio Kataoka
R5,629 Discovery Miles 56 290 Ships in 10 - 15 working days

Life is produced by the interplay of water and biomolecules. This book deals with the physicochemical aspects of such life phenomena produced by water and biomolecules, and addresses topics including "Protein Dynamics and Functions," "Protein and DNA Folding," and "Protein Amyloidosis." All sections have been written by internationally recognized front-line researchers. The idea for this book was born at the 5th International Symposium "Water and Biomolecules," held in Nara city, Japan, in 2008. Written for: Scientists, academic libraries, advanced students

Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases (Hardcover, 2012 ed.):... Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases (Hardcover, 2012 ed.)
Farid Rahimi, Gal Bitan
R5,689 Discovery Miles 56 890 Ships in 10 - 15 working days

Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to mediate various pathogenic mechanisms that lead to cellular dysfunction, cytotoxicity, and cell loss, eventuating in disease-specific degeneration and systemic morbidity. The particular pathologies thus are determined by the afflicted cell types, organs, systems, and the proteins involved. Evidence suggests that the oligomeric species may share structural features and possibly common mechanisms of action. In many cases, the structure function interrelationships amongst the various protein assemblies described in vitro are still elusive. Deciphering these intricate structure function correlations will help understanding a complex array of pathogenic mechanisms, some of which may be common across different diseases albeit affecting different cell types and systems."

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