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Books > Science & Mathematics > Biology, life sciences > Biochemistry

Fluorescent Proteins II - Application of Fluorescent Protein Technology (Hardcover, 2012): Gregor Jung Fluorescent Proteins II - Application of Fluorescent Protein Technology (Hardcover, 2012)
Gregor Jung
R5,172 Discovery Miles 51 720 Ships in 18 - 22 working days

Fluorescent proteins are intimately connected to research in the life sciences. Tagging of gene products with fluorescent proteins has revolutionized all areas of biosciences, ranging from fundamental biochemistry to clinical oncology, to environmental research. The discovery of the Green Fluorescent Protein, its first, seminal application and the ingenious development of a broad palette of fluorescence proteins of other colours, was consequently recognised with the Nobel Prize for Chemistry in 2008.

"Fluorescent Proteins II" highlights the physicochemical and biophysical aspects of fluorescent protein technology beyond imaging. It is tailored to meet the needs of physicists, chemists and biologists who are interested in the fundamental properties of fluorescent proteins, while also focussing on specific applications. The implementations described are cutting-edge studies and exemplify how the physical and chemical properties of fluorescent proteins can stimulate novel findings in life sciences.

Programmed Cell Death Part A, Volume 442 (Hardcover): Roya Khosravi-Far, Zahra Zakeri, Richard A. Lockshin, Mauro Piacentini Programmed Cell Death Part A, Volume 442 (Hardcover)
Roya Khosravi-Far, Zahra Zakeri, Richard A. Lockshin, Mauro Piacentini
R4,236 Discovery Miles 42 360 Ships in 10 - 15 working days

The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death.
* This volume provides the necessary, trusted methods to carry out this research on the latest techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies.
* Presents key methods on studying tumors and how these cancer cells evade cell death.
* Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over.

Molecular Biology of Protein Folding, Part B, Volume 84 (Hardcover): P.Michael Conn Molecular Biology of Protein Folding, Part B, Volume 84 (Hardcover)
P.Michael Conn
R4,111 Discovery Miles 41 110 Ships in 10 - 15 working days

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.
*Follow the new editor-in-chief, P. Michael Conn, as he introduces this second thematic volume in the series an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding
*Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer s and diabetes
*Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science"

Molecular Plant Taxonomy - Methods and Protocols (Hardcover, 2014 ed.): Pascale Besse Molecular Plant Taxonomy - Methods and Protocols (Hardcover, 2014 ed.)
Pascale Besse
R4,106 Discovery Miles 41 060 Ships in 18 - 22 working days

Plant taxonomy is an ancient discipline facing new challenges with the current availability of a vast array of molecular approaches which allow reliable genealogy-based classifications. Although the primary focus of plant taxonomy is on the delimitation of species, molecular approaches also provide a better understanding of evolutionary processes, a particularly important issue for some taxonomic complex groups."Molecular Plant Taxonomy: Methods and Protocols"describes laboratory protocols based on the use of nucleic acids and chromosomes for plant taxonomy, as well as guidelines for phylogenetic analysis of molecular data. Experts in the field also contribute review and application chapters that will encourage the reader to develop an integrative taxonomy approach, combining nucleic acid and cytogenetic data together with other crucial information (taxonomy, morphology, anatomy, ecology, reproductive biology, biogeography, paleobotany), which will help not only to best circumvent species delimitation but also to resolve the evolutionary processes in play.Written in the successful"Methods in Molecular Biology"series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, "Molecular Plant Taxonomy: Methods and Protocols"seeks to provide conceptual as well as technical guidelines to plant taxonomists and geneticists."

Small GTPases in Disease, Part A, Volume 438 (Hardcover): W.E. Balch, Channing J. Der, Alan Hall Small GTPases in Disease, Part A, Volume 438 (Hardcover)
W.E. Balch, Channing J. Der, Alan Hall
R4,222 Discovery Miles 42 220 Ships in 10 - 15 working days

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.

Methods in Enzymology is now available online at ScienceDirect - full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit:
http: //www.info.sciencedirect.com/bookseries/
This volume is the first of two planned volumes on the topic of small GTPases and their role in disease.

Nitric Oxide, Part F, Volume 440 (Hardcover): Enrique Cadenas, Lester Packer Nitric Oxide, Part F, Volume 440 (Hardcover)
Enrique Cadenas, Lester Packer
R4,221 Discovery Miles 42 210 Ships in 10 - 15 working days

The discovery that nitrogen monoxide or nitric oxide (NO)is a biologically produced free radical has revolutionized our thinking about physiological and pathological processes. This discovery has ignited enormous interest in the scientific community. When generated at low levels, NO is a signaling molecule, but at high concentration, NO is a cytotoxic molecule. The physiological and pathological processes of NO production and metabolism and its targets, currently areas of intensive research, have important pharmacologic implications for health and disease.

Globins and Other Nitric Oxide-Reactive Proteins, Part B, Volume 437 (Hardcover): Robert K. Poole Globins and Other Nitric Oxide-Reactive Proteins, Part B, Volume 437 (Hardcover)
Robert K. Poole
R4,242 Discovery Miles 42 420 Ships in 10 - 15 working days

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today truly an essential publication for researchers in all fields of life sciences.

Methods in Enzymology is now available online at ScienceDirect full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit:
http: //www.info.sciencedirect.com/bookseries/
This volume is the second of two planned volumes on the topic of globin and other nitric oxide-reactive proteins.

Ribosome Display and Related Technologies - Methods and Protocols (Hardcover, 2012): Julie A. Douthwaite, Ronald H. Jackson Ribosome Display and Related Technologies - Methods and Protocols (Hardcover, 2012)
Julie A. Douthwaite, Ronald H. Jackson
R4,114 Discovery Miles 41 140 Ships in 18 - 22 working days

Display technologies have become a very powerful way of generating therapeutic lead molecules and specific reagents for increasing our understanding of biology; however, despite being first described shortly after phage display, the use of ribosome display and related methods have been much less widespread. Since this is in part due to the complexity of the methods, "Ribosome Display and Related Technologies: Methods and Protocols" seeks to extend their use by collecting expert contributions describing these detailed protocols. The protocols described range from well-established methods that have been used for a decade to generate high affinity antibodies, which are already in the clinic, to methods that are in their early stages of application such as display of peptides incorporating non-canonical amino acids. Written in the highly successful "Methods in Molecular Biology " series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Invaluable and easy to use, "Ribosome Display and Related Technologies: Methods and Protocols" will be of great benefit to those with general molecular biology or protein engineering experience who wish to select peptides or proteins by display, those with phage display experience who would benefit from the application of ribosome display, as well as those with some ribosome display experience who would like to expand the range of applications to which they are applying the technology."

Medicinal Organometallic Chemistry (Hardcover, 2010 ed.): Gerard Jaouen, Nils Metzler-Nolte Medicinal Organometallic Chemistry (Hardcover, 2010 ed.)
Gerard Jaouen, Nils Metzler-Nolte
R7,677 Discovery Miles 76 770 Ships in 18 - 22 working days

Contents: Gerard Jaouen, Nils Metzler-Nolte : Introduction ; Stephane GIBAUD and Gerard JAOUEN: Arsenic - based drugs: from Fowler's solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessieres, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes - Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide - an essential signaling molecule.

Activity-Based Protein Profiling (Hardcover, 2012 ed.): Stephan A. Sieber Activity-Based Protein Profiling (Hardcover, 2012 ed.)
Stephan A. Sieber
R5,141 Discovery Miles 51 410 Ships in 18 - 22 working days

ABPP Methodology: Introduction and Overview, by Matthew B. Nodwell und Stephan A. Sieber Activity-Based Protein Profiling for Natural Product Target Discovery, by Joanna Krysiak und Rolf Breinbauer Photoaffinity Labeling in Activity-Based Protein Profiling, by Paul P. Geurink, Laurette M. Prely, Gijs A. van der Marel, Rainer Bischoff und Herman S. Overkleeft Application of Activity-Based Protein Profiling to the Study of Microbial Pathogenesis, by William P. Heal und Edward W. Tate Functional Analysis of Protein Targets by Metabolomic Approaches, by Yun-Gon Kim und Alan Saghatelian

Molecular Modeling of Proteins (Hardcover, 2nd ed. 2015): Andreas Kukol Molecular Modeling of Proteins (Hardcover, 2nd ed. 2015)
Andreas Kukol
R4,823 Discovery Miles 48 230 Ships in 18 - 22 working days

"Molecular Modeling of Proteins, Second Edition" provides a theoretical background of various methods available and enables non-specialists to apply methods to their problems by including updated chapters and new material not covered in the first edition. This detailed volume opens by featuring classical and advanced simulation methods as well as methods to set-up complex systems such as lipid membranes and membrane proteins and continues with chapters devoted to the simulation and analysis of conformational changes of proteins, computational methods for protein structure prediction, usage of experimental data in combination with computational techniques, as well as protein-ligand interactions, which are relevant in the drug design process. Written for the highly successful "Methods in Molecular Biology" series, chapters include thorough introductions, step-by-step instructions and notes on troubleshooting and avoiding common pitfalls.

Update-to-date and authoritative, "Molecular Modeling of Proteins, Second Edition" aims to aid researchers in the physical, chemical and biosciences interested in utilizing this powerful technology.

Early Adventures in Biochemistry, Volume 1 (Hardcover, Revised ed.): L. a. Stocken, M. G. Ord Early Adventures in Biochemistry, Volume 1 (Hardcover, Revised ed.)
L. a. Stocken, M. G. Ord
R2,732 Discovery Miles 27 320 Ships in 10 - 15 working days

The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.

Integrated Study of Protein Kinases (Hardcover): Michelle McGuire Integrated Study of Protein Kinases (Hardcover)
Michelle McGuire
R2,308 R2,111 Discovery Miles 21 110 Save R197 (9%) Ships in 18 - 22 working days
Insect Immunology (Hardcover): Nancy E. Beckage Insect Immunology (Hardcover)
Nancy E. Beckage
R1,976 Discovery Miles 19 760 Ships in 10 - 15 working days

Given the critical importance of insect immunology in insect vector-parasite interactions and vector control, biological control of agricultural insect pests, and other key areas of entomological research and practice, a new comprehensive work summarizing recent breakthroughs in this rapidly expanding field is sorely needed. This work will constitute the first book-length publication on the topic of insect immunology since 1991, complimenting earlier works by offering a fresh perspective on current research. Interactions of host immune systems with both parasites and pathogens will be presented as well as the genomics and proteomics approaches which have been lacking in other publication.
* Encompasses the most important topics of insect immunology including mechanisms, genes, proteins, evolution and phylogeny
* Provides comprehensive coverage of topics important to medical researchers including Drosophila as a model for studying cellular and humoral immune mechanisms, biochemical mediators of immunity, and insect blood cells and their functions
* Most up-to-date information published with contributions from international leaders in the field

Biology of Inositols and Phosphoinositides (Hardcover, 2006 ed.): A. Lahiri Majumder, B.B. Biswas Biology of Inositols and Phosphoinositides (Hardcover, 2006 ed.)
A. Lahiri Majumder, B.B. Biswas
R5,338 Discovery Miles 53 380 Ships in 18 - 22 working days

From being to becoming important, myo-inositol and its derivatives including phosphoinositides and phosphoinositols involved in diversi?ed functions in wide varieties of cells overcoming its insigni?cant role had to wait more than a century. Myo-inositol, infact, is the oldest known inositol and it was isolated from muscle as early as 1850 and phytin (Inositol hexakis phosphate) from plants by Pfeffer in 1872. Since then, interest in inositols and their derivatives varied as the methodology of isolation and puri?cation of the stereoisomers of inositol and their derivatives advanced. Phosphoinositides were ?rst isolated from brain in 1949 by Folch and their structure was established in 1961 by Ballou and his coworkers. After the compilation of scattered publications on cyclitols by Posternak (1965), proceedings of the conference on cyclitols and phosphoinositides under the supervision of Hoffmann-Ostenhof, were p- lished in 1969. Similar proceedings of the second conference on the same s- ject edited by Wells and Eisenberg Jr was published in 1978. In that meeting at the concluding session Hawthorne remarked "persued deeply enough p- haps even myoinositol could be mirror to the whole universe." This is now infact the scenario on the research on inositol and their phosphoderivatives. Finally a comprehensive information covering the aspects of chemistry, b- chemistry and physiology of inositols and their phosphoderivatives in a book entitled Inositol Phosphates written by Cosgrove (1980) was available.

Medical Geochemistry - Geological Materials and Health (Hardcover, 2013 ed.): Paolo Censi, Thomas Darrah, Yigal Erel Medical Geochemistry - Geological Materials and Health (Hardcover, 2013 ed.)
Paolo Censi, Thomas Darrah, Yigal Erel
R4,126 R3,325 Discovery Miles 33 250 Save R801 (19%) Ships in 10 - 15 working days

This book includes a collection of chapters illustrating the application of geochemical methods to investigate the interactions between geological materials and fluids with humans. Examples include the incorporation and human health effects of inhaling lithogenic materials, the reactivity of biological fluids with geological materials, and the impact on nascent biomineral formation. Biomineralization is investigated in terms of mineralogy, morphology, bone chemistry, and pathological significance with a focus on the health impacts of "foreign" geological/environmental trace element incorporation. One of the contribution is devoted to particulate matter, the presence of metals and metalloids in the environment, and the possibility of using human hair as a biomarker between environmental/geological exposure and human bioincorporation. Other chapters focus on the last advances on the analytical methods and instrumentational approaches to investigating the chemistry of biological fluids and tissues.

Endosomes and Lysosomes: A Dynamic Relationship, Volume 1 (Hardcover): B. Storrie, R.F. Murphy Endosomes and Lysosomes: A Dynamic Relationship, Volume 1 (Hardcover)
B. Storrie, R.F. Murphy
R2,735 Discovery Miles 27 350 Ships in 10 - 15 working days

The intent in initiating this volume was to bring together a series of essays which would define our present understanding of the endosome and lysosome and their interrelationship. The editors deliberately encouraged the contributors to be speculative; to strive to put order to the "real" world of incomplete and sometimes conflicting data. Seeing science from the laboratory bench can often be like viewing an impressionistic painting from up close; a series of paint dabs with no apparent order. The contributors to this volume were asked to step back and leave the reader with a sense of the whole as well as the detail. To the extent that this has happened, the credit should go to the individual authors.
Our understanding of endosomes and lysosomes has undergone a molecular revolution over the last decade. Hence, we now know much about the molecular features required for internalization of an endocytic receptor, or the function of mannose 6-phosphate receptors in the transport of lysosomal enzymes. We can trace and follow the flow of molecules. In this volume current molecular knowledge concerning the function and relationship of endosomes and lysosomes is presented. Because of this vast increase in knowledge of molecules, we have realized that endosomes in particular are very ephemeral organelles. In fact, endosomes may well not be discrete entities but rather continuously changing and evolving in their molecular composition. The dynamic nature of the relationship between endosomes and lysosomes is the unifying focus of the genetic, biochemical, microscopic, and molecular biological approaches described in the chapters which follow.

Proteostasis - Methods and Protocols (Hardcover, 1st ed. 2016): Rune Matthiesen Proteostasis - Methods and Protocols (Hardcover, 1st ed. 2016)
Rune Matthiesen
R4,203 Discovery Miles 42 030 Ships in 18 - 22 working days

This volume highlights the role of proteostasis in human health and associated disease model systems, reflecting its rising importance which has led to the development of new technologies to obtain insight into underling protein mechanistic events. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Proteostasis: Methods and Protocols aims to become a reference book on proteostasis in human health.

Ribonucleases (Hardcover, 2011): Allen W. Nicholson Ribonucleases (Hardcover, 2011)
Allen W. Nicholson
R5,205 Discovery Miles 52 050 Ships in 18 - 22 working days

Ribonucleases are a ubiquitous and functionally diverse group of enzymes that have a common ability to cleave RNA. Either through scission of internal phosphodiesters, or removal of nucleotides from RNA 5' or 3' ends, ribonucleases perform essential roles in gene expression and regulation, genome replication and maintenance, host defense, stress response, and viral strategies of infection. Ribonucleases have also served as highly informative models to understand virtually every aspect of biomolecular structure and function. The fifteen chapters in this volume are written by recognized researchers in the field, and provide in-depth analyses of the major ribonuclease families. Particular focus is given to the relation of ribonuclease structure and mechanism to biological function, as well as ribonuclease dysfunction in certain disease states. Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability. This volume should serve as an essential reference for a broad range of researchers and educators with interests in RNA metabolism, enzymology, and gene regulation.

Circulating Nucleic Acids in Plasma and Serum - Proceedings of the 6th international conference on circulating nucleic acids in... Circulating Nucleic Acids in Plasma and Serum - Proceedings of the 6th international conference on circulating nucleic acids in plasma and serum held on 9-11 November 2009 in Hong Kong. (Hardcover, 2011 Ed.)
Peter B Gahan
R5,304 Discovery Miles 53 040 Ships in 18 - 22 working days

DNA and RNA fractions have been isolated from the whole blood, serum, plasma, the surface of blood cells, urine, saliva and spinal fluid from both healthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules and their use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis and prognosis.

Reviews of Environmental Contamination and Toxicology Volume 209 (Hardcover, Edition.): David M. Whitacre Reviews of Environmental Contamination and Toxicology Volume 209 (Hardcover, Edition.)
David M. Whitacre
R4,101 Discovery Miles 41 010 Ships in 18 - 22 working days

Presenting a new way to examine water quality criteria, this volume provides concise, critical reviews of timely advances in the field of xenobiotics. The text explores the research findings and procedures of The University of California-Davis Methodology for Deriving Aquatic Life Pesticide Water Quality Criteria.

Translation Initiation: Extract Systems and Molecular Genetics, Volume 429 (Hardcover, 429th edition): Jon Lorsch Translation Initiation: Extract Systems and Molecular Genetics, Volume 429 (Hardcover, 429th edition)
Jon Lorsch
R4,863 Discovery Miles 48 630 Ships in 10 - 15 working days

For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the first of three on the topic of Translation Initiation includes articles written by leaders in the field.

Lipoproteins and Cardiovascular Disease - Methods and Protocols (Hardcover, 2013 ed.): Lita A. Freeman Lipoproteins and Cardiovascular Disease - Methods and Protocols (Hardcover, 2013 ed.)
Lita A. Freeman
R3,900 R3,640 Discovery Miles 36 400 Save R260 (7%) Ships in 10 - 15 working days

The lipid-rich and otherwise challenging nature of many key tissues complicates many aspects of current research, and applications of the unique nature of lipoproteins and their biological effects has engendered unique and vital methodologies. In Lipoproteins and Cardiovascular Disease: Methods and Protocols, experts in the field present a compendium of advanced and classical molecular biology methods targeted towards lipoprotein, atherosclerosis, and vascular biology research, bringing together in a single volume an updated set of protocols and strategies for methods now driving the most recent advances, along with classical methods that are still widely used. Among the many topics covered in this cutting-edge work, the book delves into crucial techniques such as quantitative real-time PCR, microarrays, RT-PCR laser capture microdissection, and tissue-specific gene overexpression, knockout, and knockdown methodologies, including AAV as a liver-directed gene delivery vehicle. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and valuable notes which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Lipoproteins and Cardiovascular Disease: Methods and Protocols serves both novices and experts alike as a complete guide for any researcher with an interest in lipoproteins and their significant biological effects.

Single-Molecule Fluorescence Spectroscopy of the Folding of a Repeat Protein (Hardcover, 1st ed. 2016): Sharon A. Cohen Single-Molecule Fluorescence Spectroscopy of the Folding of a Repeat Protein (Hardcover, 1st ed. 2016)
Sharon A. Cohen
R2,653 Discovery Miles 26 530 Ships in 18 - 22 working days

In this thesis single-molecule fluorescence resonance energy transfer (FRET) spectroscopy was used to study the folding of a protein that belongs to the large and important family of repeat proteins. Cohen shows that the dynamics of the expanded conformations is likely to be very fast, suggesting a spring-like motion of the whole chain. The findings shed new light on the elasticity of structure in repeat proteins, which is related to their function in binding multiple and disparate partners. This concise research summary provides useful insights for students beginning a PhD in this or a related area, and researchers entering this field.

Methods for the Discovery and Characterization of G Protein-Coupled Receptors (Hardcover, 2011): Craig W Stevens Methods for the Discovery and Characterization of G Protein-Coupled Receptors (Hardcover, 2011)
Craig W Stevens
R2,757 Discovery Miles 27 570 Ships in 18 - 22 working days

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In "Methods for the Discovery and Characterization of G Protein-Coupled Receptors," experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader s particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called Future Directions which gives the reader an insight into advances soon to be realized in each area. Written for the popular "Neuromethods" series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, "Methods for the Discovery and Characterization of G Protein-Coupled Receptors" serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.

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