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Books > Medicine > Complementary medicine
While biotechnological advances, genomics and high throughput
screenings or combinatorial and asymmetric syntheses are opening
new opportunities in drug discovery, the industry is facing serious
innovation deficit. The total number of new molecules registered
per year has dropped in contrast to expected increase. Post
marketing failures of blockbuster drugs have become major concerns
of industries. On the other side, globally there is a major shift
to sue of traditional medicine involving complementary and
alternative therapies. Ethnopharmacology and traditional medicines
have contributed in past significantly in the process of natural
product drug discovery. There are two clear tracks where
ethnopharmacology has potential to contribute in future drug
research. First, as a discovery engine to provide new targets,
leads, and second, use of quality assured and standardized
traditional medicines. In this scenario, it is important to
understand the mechanisms of drug discovery and pharmaceutical
development with a focus on herbal drugs and neutraceutical. This
book provides historical perspective, future prospects and
significance of ethnopharmacology in drug research. It also
provides important steps in botanical drug discovery and
development including bioprospecting, quality control,
standardization, pharmaceutics, stability, pharmacokinetics, and
bioavailability with examples from ethnopharmacology and herbal
medicine. One of the important feature of this book is to give an
excellent insight to Good Laboratory and Good Clinical Practices
along with very useful summary steps involved in filing IND or NDA
of botanical products. The book also gives Regulators' perspective
of validating claims and how ethnopharmacological or traditional
medicines need different approach.
Phytochemical Profiling of Commercially Important South African
Plants comprises a carefully selected group of plant species that
are of interest to researchers and industry partners who would like
to investigate the commercialization of plant species. The book
presents 25 botanicals selected based on commercial relevance. For
each of the species, the following topics are covered: botanical
description and distribution, phytochemistry (including chemical
structures), HPTLC fingerprint analysis, UPLC analysis, and GC
analysis (the latter only in the case of essential oil-bearing
species). Using standard methodology, high-level chromatographic
fingerprints have been developed for better understanding.
Different methods are succinctly summarized allowing for the rapid
identification of botanical raw materials and formulated consumer
products. This book will be extremely valuable to researchers in
the field who wish to rapidly identify the constituents and for
those who want to prepare formulations of plant material for
commercial applications. This work will also be a valuable resource
in the field of pharmacognosy.
Fighting Multidrug Resistance with Herbal Extracts, Essential
Oils and their Components offers scientists a single source aimed
at fighting specific multidrug-resistant (MDR) microorganisms such
as bacteria, protozoans, viruses and fungi using natural products.
This essential reference discusses herbal extracts and essential
oils used or under investigation to treat MDR infections, as well
as those containing antimicrobial activity that could be of
potential interest in future studies against MDR microorganisms.
The need to combat multidrug-resistant microorganisms is an urgent
one and this book provides important coverage of mechanism of
action, the advantages and disadvantages of using herbal extracts,
essential oils and their components and more to aid researchers in
effective antimicrobial drug discovery
Addresses the need to develop safe and effective approaches to
coping with resistance to all classes of antimicrobial drugs
Provides readers with current evidence-based content aimed at using
herbal extracts and essential oils in antimicrobial drug
development Includes chapters devoted to the activity of herbal
products against herpes, AIDS, tuberculosis, drug-resistant cancer
cells and more "
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