This textbook contains the essential knowledge in modeling, simulation, analysis, and applications in dealing with biological cellular control systems. In particular, the book shows how to use the law of mass balance and the law of mass action to derive an enzyme kinetic model - the Michaelis-Menten function or the Hill function, how to use a current-voltage relation, Nernst potential equilibrium equation, and Hodgkin and Huxley's models to model an ionic channel or pump, and how to use the law of mass balance to integrate these enzyme or channel models into a complete feedback control system. The book also illustrates how to use data to estimate parameters in a model, how to use MATLAB to solve a model numerically, how to do computer simulations, and how to provide model predictions. Furthermore, the book demonstrates how to conduct a stability and sensitivity analysis on a model.

Descriptor linear systems theory is an important part in the general field of control systems theory, and has attracted much attention in the last two decades. In spite of the fact that descriptor linear systems theory has been a topic very rich in content, there have been only a few books on this topic. This book provides a systematic introduction to the theory of continuous-time descriptor linear systems and aims to provide a relatively systematic introduction to the basic results in descriptor linear systems theory. The clear representation of materials and a large number of examples make this book easy to understand by a large audience. General readers will find in this book a comprehensive introduction to the theory of descriptive linear systems. Researchers will find a comprehensive description of the most recent results in this theory and students will find a good introduction to some important problems in linear systems theory.

This book is devoted to the multiplicative differential calculus. Its seven pedagogically organized chapters summarize the most recent contributions in this area, concluding with a section of practical problems to be assigned or for self-study. Two operations, differentiation and integration, are basic in calculus and analysis. In fact, they are the infinitesimal versions of the subtraction and addition operations on numbers, respectively. From 1967 till 1970, Michael Grossman and Robert Katz gave definitions of a new kind of derivative and integral, moving the roles of subtraction and addition to division and multiplication, and thus established a new calculus, called multiplicative calculus. It is also called an alternative or non-Newtonian calculus. Multiplicative calculus can especially be useful as a mathematical tool for economics, finance, biology, and engineering. Multiplicative Differential Calculus is written to be of interest to a wide audience of specialists such as mathematicians, physicists, engineers, and biologists. It is primarily a textbook at the senior undergraduate and beginning graduate level and may be used for a course on differential calculus. It is also for students studying engineering and science. Authors Svetlin G. Georgiev is a mathematician who has worked in various areas of the study. He currently focuses on harmonic analysis, functional analysis, partial differential equations, ordinary differential equations, Clifford and quaternion analysis, integral equations, and dynamic calculus on time scales. He is also the author of Dynamic Geometry of Time Scales (CRC Press). He is a co-author of Conformable Dynamic Equations on Time Scales, with Douglas R. Anderson (CRC Press). Khaled Zennir earned his PhD in mathematics from Sidi Bel Abbes University, Algeria. He earned his highest diploma in Habilitation in Mathematics from Constantine University, Algeria. He is currently Assistant Professor at Qassim University in the Kingdom of Saudi Arabia. His research interests lie in the subjects of nonlinear hyperbolic partial differential equations: global existence, blowup, and long-time behavior. The authors have also published: Multiple Fixed-Point Theorems and Applications in the Theory of ODEs, FDEs and PDE; Boundary Value Problems on Time Scales, Volume 1 and Volume II, all with CRC Press.

A substantial number of problems in physics, chemical physics, and biology, are modeled through reaction-diffusion equations to describe temperature distribution or chemical substance concentration. For problems arising from ecology, sociology, or population dynamics, they describe the density of some populations or species. In this book the state variable is a concentration, or a density according to the cases. The reaction function may be complex and include time delays terms that model various situations involving maturation periods, resource regeneration times, or incubation periods. The dynamics may occur in heterogeneous media and may depend upon a small or large parameter, as well as the reaction term. From a purely formal perspective, these parameters are indexed by n. Therefore, reaction-diffusion equations give rise to sequences of Cauchy problems.The first part of the book is devoted to the convergence of these sequences in a sense made precise in the book. The second part is dedicated to the specific case when the reaction-diffusion problems depend on a small parameter intended to tend towards 0. This parameter accounts for the size of small spatial and randomly distributed heterogeneities. The convergence results obtained in the first part, with additionally some probabilistic tools, are applied to this specific situation. The limit problems are illustrated through biological invasion, food-limited or prey-predator models where the interplay between environment heterogeneities in the individual evolution of propagation species plays an essential role. They provide a description in terms of deterministic and homogeneous reaction-diffusion equations, for which numerical schemes are possible.

The focus of this book is the large-scale statistical behavior of solutions of divergence-form elliptic equations with random coefficients, which is closely related to the long-time asymptotics of reversible diffusions in random media and other basic models of statistical physics. Of particular interest is the quantification of the rate at which solutions converge to those of the limiting, homogenized equation in the regime of large scale separation, and the description of their fluctuations around this limit. This self-contained presentation gives a complete account of the essential ideas and fundamental results of this new theory of quantitative stochastic homogenization, including the latest research on the topic, and is supplemented with many new results. The book serves as an introduction to the subject for advanced graduate students and researchers working in partial differential equations, statistical physics, probability and related fields, as well as a comprehensive reference for experts in homogenization. Being the first text concerned primarily with stochastic (as opposed to periodic) homogenization and which focuses on quantitative results, its perspective and approach are entirely different from other books in the literature.

A timely, accessible introduction to the mathematics of chaos

The past three decades have seen dramatic developments in the theory of dynamical systems, particularly regarding the exploration of chaotic behavior. Complex patterns of even simple processes arising in biology, chemistry, physics, engineering, economics, and a host of other disciplines have been investigated, explained, and utilized.

Introduction to Discrete Dynamical Systems and Chaos makes these exciting and important ideas accessible to students and scientists by assuming, as a background, only the standard undergraduate training in calculus and linear algebra. Chaos is introduced at the outset and is then incorporated as an integral part of the theory of discrete dynamical systems in one or more dimensions. Both phase space and parameter space analysis are developed with ample exercises, more than 100 figures, and important practical examples such as the dynamics of atmospheric changes and neural networks.

An appendix provides readers with clear guidelines on how to use Mathematica to explore discrete dynamical systems numerically. Selected programs can also be downloaded from a Wiley ftp site (address in preface). Another appendix lists possible projects that can be assigned for classroom investigation. Based on the author’s 1993 book, but boasting at least 60% new, revised, and updated material, the present Introduction to Discrete Dynamical Systems and Chaos is a unique and extremely useful resource for all scientists interested in this active and intensely studied field.

This is the first book to systematically present control theory for stochastic distributed parameter systems, a comparatively new branch of mathematical control theory. The new phenomena and difficulties arising in the study of controllability and optimal control problems for this type of system are explained in detail. Interestingly enough, one has to develop new mathematical tools to solve some problems in this field, such as the global Carleman estimate for stochastic partial differential equations and the stochastic transposition method for backward stochastic evolution equations. In a certain sense, the stochastic distributed parameter control system is the most general control system in the context of classical physics. Accordingly, studying this field may also yield valuable insights into quantum control systems. A basic grasp of functional analysis, partial differential equations, and control theory for deterministic systems is the only prerequisite for reading this book.

The heart of the book is the development of a short-time asymptotic expansion for the heat kernel. This is explained in detail and explicit examples of some advanced calculations are given. In addition some advanced methods and extensions, including path integrals, jump diffusion and others are presented. The book consists of four parts: Analysis, Geometry, Perturbations and Applications. The first part shortly reviews of some background material and gives an introduction to PDEs. The second part is devoted to a short introduction to various aspects of differential geometry that will be needed later. The third part and heart of the book presents a systematic development of effective methods for various approximation schemes for parabolic differential equations. The last part is devoted to applications in financial mathematics, in particular, stochastic differential equations. Although this book is intended for advanced undergraduate or beginning graduate students in, it should also provide a useful reference for professional physicists, applied mathematicians as well as quantitative analysts with an interest in PDEs.

Includes PDE Modeler interface including example solutions of the two- and three dimensional PDEs * Presents methodology for all the types of Partial Differential Equations, representative of any engineering problem * Describes the ODE solver for the IVP and BVP problems by the practical examples from mechanics and thermodynamic properties of materials * Covers the basics of MATLAB (R) to solve both ordinary and partial differential equations * Reviews spatially one dimensional PDE solver with actual engineering examples

This book focuses on developments in complex dynamical systems and geometric function theory over the past decade, showing strong links with other areas of mathematics and the natural sciences. Traditional methods and approaches surface in physics and in the life and engineering sciences with increasing frequency - the Schramm-Loewner evolution, Laplacian growth, and quadratic differentials are just a few typical examples. This book provides a representative overview of these processes and collects open problems in the various areas, while at the same time showing where and how each particular topic evolves. This volume is dedicated to the memory of Alexander Vasiliev.

Features Introduces, defines, and illustrates the concept of "dynamic consistency" as the foundation of modeling Can be used as the basis of an upper-level undergraduate course on general procedures for mathematical modeling using differential equations Discusses the issue of dimensional analysis and continually demonstrates its value for both the construction and analysis of mathematical modeling.

This book is written for students and researchers who are fond of mathematics and the natural sciences. It consists of two parts. Part I presents the theory of analysis in which the mathematical theory is described not as an accomplished palace, but as a building under construction. It uncovers how a theory has been or is being constructed. In Part II, the theory of differential equations is applied to interesting practical problems, such as pursuit-line and tractrix, attack on an object from an airplane, an insect crawling along a stretching rubber rod, the SIR model of a virus infection, string vibration, circular membrane vibration, as well as the wind ripple, sand dune and wave phenomena on a highway. Furthermore, the problems of a one-dimensional lattice vibration, the keyboard percussion vibration and the eigenvalue problems in quantum mechanics, such as the Aharonov-Bohm effect, are also investigated in detail.

A comprehensive description of the current theoretical and numerical aspects of inverse problems in partial differential equations. Applications include recovery of inclusions from anomalies of their gravity fields, reconstruction of the interior of the human body from exterior electrical, ultrasonic, and magnetic measurement. By presenting the data in a readable and informative manner, the book introduces both scientific and engineering researchers as well as graduate students to the significant work done in this area in recent years, relating it to broader themes in mathematical analysis.

This is a volume originating from the Conference on Partial Differential Equations and Applications, which was held in Moscow in November 2018 in memory of professor Boris Sternin and attracted more than a hundred participants from eighteen countries. The conference was mainly dedicated to partial differential equations on manifolds and their applications in mathematical physics, geometry, topology, and complex analysis. The volume contains selected contributions by leading experts in these fields and presents the current state of the art in several areas of PDE. It will be of interest to researchers and graduate students specializing in partial differential equations, mathematical physics, topology, geometry, and their applications. The readers will benefit from the interplay between these various areas of mathematics.

The book contains a selection of high quality papers, chosen among the best presentations during the International Conference on Spectral and High-Order Methods (2012), and provides an overview of the depth and breath of the activities within this important research area. The carefully reviewed selection of the papers will provide the reader with a snapshot of state-of-the-art and help initiate new research directions through the extensive bibliography.

This book gathers nineteen papers presented at the first NLAGA-BIRS Symposium, which was held at the Cheikh Anta Diop University in Dakar, Senegal, on June 24-28, 2019. The four-day symposium brought together African experts on nonlinear analysis and geometry and their applications, as well as their international partners, to present and discuss mathematical results in various areas. The main goal of the NLAGA project is to advance and consolidate the development of these mathematical fields in West and Central Africa with a focus on solving real-world problems such as coastal erosion, pollution, and urban network and population dynamics problems. The book addresses a range of topics related to partial differential equations, geometrical analysis of optimal shapes, geometric structures, optimization and optimal transportation, control theory, and mathematical modeling.

In the past three decades, bifurcation theory has matured into a well-established and vibrant branch of mathematics. This book gives a unified presentation in an abstract setting of the main theorems in bifurcation theory, as well as more recent and lesser known results. It covers both the local and global theory of one-parameter bifurcations for operators acting in infinite-dimensional Banach spaces, and shows how to apply the theory to problems involving partial differential equations. In addition to existence, qualitative properties such as stability and nodal structure of bifurcating solutions are treated in depth. This volume will serve as an important reference for mathematicians, physicists, and theoretically-inclined engineers working in bifurcation theory and its applications to partial differential equations.

The second edition is substantially and formally revised and new material is added. Among this is bifurcation with a two-dimensional kernel with applications, the buckling of the Euler rod, the appearance of Taylor vortices, the singular limit process of the Cahn-Hilliard model, and an application of this method to more complicated nonconvex variational problems.

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This book, which is a continuation of Almost Automorphic Type and Almost Periodic Type Functions in Abstract Spaces, presents recent trends and developments upon fractional, first, and second order semilinear difference and differential equations, including degenerate ones. Various stability, uniqueness, and existence results are established using various tools from nonlinear functional analysis and operator theory (such as semigroup methods). Various applications to partial differential equations and the dynamic of populations are amply discussed. This self-contained volume is primarily intended for advanced undergraduate and graduate students, post-graduates and researchers, but may also be of interest to non-mathematicians such as physicists and theoretically oriented engineers. It can also be used as a graduate text on evolution equations and difference equations and their applications to partial differential equations and practical problems arising in population dynamics. For completeness, detailed preliminary background on Banach and Hilbert spaces, operator theory, semigroups of operators, and almost periodic functions and their spectral theory are included as well.

In this book we analyze relaxation oscillations in models of lasers with nonlinear elements controlling light dynamics. The models are based on rate equations taking into account periodic modulation of parameters, optoelectronic delayed feedback, mutual coupling between lasers, intermodal interaction and other factors. With the aim to study relaxation oscillations we present the special asymptotic method of integration for ordinary differential equations and differential-difference equations. As a result, they are reduced to discrete maps. Analyzing the maps we describe analytically such nonlinear phenomena in lasers as multistability of large-amplitude relaxation cycles, bifurcations of cycles, controlled switching of regimes, phase synchronization in an ensemble of coupled systems and others. The book can be fruitful for students and technicians in nonlinear laser dynamics and in differential equations.

The trajectory of fractional calculus has undergone several periods of intensive development, both in pure and applied sciences. During the last few decades fractional calculus has also been associated with the power law effects and its various applications. It is a natural to ask if fractional calculus, as a nonlocal calculus, can produce new results within the well-established field of Lie symmetries and their applications. In Lie Symmetry Analysis of Fractional Differential Equations the authors try to answer this vital question by analyzing different aspects of fractional Lie symmetries and related conservation laws. Finding the exact solutions of a given fractional partial differential equation is not an easy task, but is one that the authors seek to grapple with here. The book also includes generalization of Lie symmetries for fractional integro differential equations. Features Provides a solid basis for understanding fractional calculus, before going on to explore in detail Lie Symmetries and their applications Useful for PhD and postdoc graduates, as well as for all mathematicians and applied researchers who use the powerful concept of Lie symmetries Filled with various examples to aid understanding of the topics

The subject of the book is the mathematical theory of the discontinuous Galerkin method (DGM), which is a relatively new technique for the numerical solution of partial differential equations. The book is concerned with the DGM developed for elliptic and parabolic equations and its applications to the numerical simulation of compressible flow. It deals with the theoretical as well as practical aspects of the DGM and treats the basic concepts and ideas of the DGM, as well as the latest significant findings and achievements in this area. The main benefit for readers and the book's uniqueness lie in the fact that it is sufficiently detailed, extensive and mathematically precise, while at the same time providing a comprehensible guide through a wide spectrum of discontinuous Galerkin techniques and a survey of the latest efficient, accurate and robust discontinuous Galerkin schemes for the solution of compressible flow.

Since most of the problems arising in science and engineering are nonlinear, they are inherently difficult to solve. Traditional analytical approximations are valid only for weakly nonlinear problems and often fail when used for problems with strong nonlinearity. Nonlinear Flow Phenomena and Homotopy Analysis: Fluid Flow and Heat Transfer presents the current theoretical developments of the analytical method of homotopy analysis. This book not only addresses the theoretical framework for the method, but also gives a number of examples of nonlinear problems that have been solved by means of the homotopy analysis method. The particular focus lies on fluid flow problems governed by nonlinear differential equations. This book is intended for researchers in applied mathematics, physics, mechanics and engineering.

Both Kuppalapalle Vajravelu and Robert A. Van Gorder work at the University of Central Florida, USA."

Differential equations is one of the oldest subjects in modern mathematics. It was not long after Newton and Leibniz invented the calculus that Bernoulli and Euler and others began to consider the heat equation and the wave equation of mathematical physics. Newton himself solved differential equations both in the study of planetary motion and also in his consideration of optics. Today differential equations is the centerpiece of much of engineering, of physics, of significant parts of the life sciences, and in many areas of mathematical modeling. This text describes classical ideas and provides an entree to the newer ones. The author pays careful attention to advanced topics like the Laplace transform, Sturm-Liouville theory, and boundary value problems (on the traditional side) but also pays due homage to nonlinear theory, to modeling, and to computing (on the modern side). This book began as a modernization of George Simmons' classic, Differential Equations with Applications and Historical Notes. Prof. Simmons invited the author to update his book. Now in the third edition, this text has become the author's own and a unique blend of the traditional and the modern. The text describes classical ideas and provides an entree to newer ones. Modeling brings the subject to life and makes the ideas real. Differential equations can model real life questions, and computer calculations and graphics can then provide real life answers. The symbiosis of the synthetic and the calculational provides a rich experience for students, and prepares them for more concrete, applied work in future courses. Additional Features Anatomy of an Application sections. Historical notes continue to be a unique feature of this text. Math Nuggets are brief perspectives on mathematical lives or other features of the discipline that will enhance the reading experience. Problems for Review and Discovery give students some open-ended material for exploration and further learning. They are an important means of extending the reach of the text, and for anticipating future work. This new edition is re-organized to make it more useful and more accessible. The most frequently taught topics are now up front. And the major applications are isolated in their own chapters. This makes this edition the most useable and flexible of any previous editions.

Modelling with Ordinary Differential Equations: A Comprehensive Approach aims to provide a broad and self-contained introduction to the mathematical tools necessary to investigate and apply ODE models. The book starts by establishing the existence of solutions in various settings and analysing their stability properties. The next step is to illustrate modelling issues arising in the calculus of variation and optimal control theory that are of interest in many applications. This discussion is continued with an introduction to inverse problems governed by ODE models and to differential games. The book is completed with an illustration of stochastic differential equations and the development of neural networks to solve ODE systems. Many numerical methods are presented to solve the classes of problems discussed in this book. Features: Provides insight into rigorous mathematical issues concerning various topics, while discussing many different models of interest in different disciplines (biology, chemistry, economics, medicine, physics, social sciences, etc.) Suitable for undergraduate and graduate students and as an introduction for researchers in engineering and the sciences Accompanied by codes which allow the reader to apply the numerical methods discussed in this book in those cases where analytical solutions are not available

The present volume gathers contributions to the conference Microlocal and Time-Frequency Analysis 2018 (MLTFA18), which was held at Torino University from the 2nd to the 6th of July 2018. The event was organized in honor of Professor Luigi Rodino on the occasion of his 70th birthday. The conference's focus and the contents of the papers reflect Luigi's various research interests in the course of his long and extremely prolific career at Torino University.