In this thesis two variants of the fast variable elimination method are developed. They are intuitive, simple to implement and give results which are in very good agreement with those found from numerical simulations. The relative simplicity of the techniques makes them ideal for applying to problems featuring demographic stochasticity, for experts and non-experts alike. Within the context of mathematical modelling, fast variable elimination is one of the central tools with which one can simplify a multivariate problem. When used in the context of of deterministic systems, the theory is quite standard, but when stochastic effects are present, it becomes less straightforward to apply. While the introductory and background chapters form an excellent primer to the theory of stochastic population dynamics, the techniques developed can be applied to systems exhibiting a separation of timescales in a variety of fields including population genetics, ecology and epidemiology.

The Applied Mathematics, Modelling, and Computational Science (AMMCS) conference aims to promote interdisciplinary research and collaboration. The contributions in this volume cover the latest research in mathematical and computational sciences, modeling, and simulation as well as their applications in natural and social sciences, engineering and technology, industry, and finance. The 2013 conference, the second in a series of AMMCS meetings, was held August 26—30 and organized in cooperation with AIMS and SIAM, with support from the Fields Institute in Toronto, and Wilfrid Laurier University. There were many young scientists at AMMCS-2013, both as presenters and as organizers. This proceedings contains refereed papers contributed by the participants of the AMMCS-2013 after the conference. This volume is suitable for researchers and graduate students, mathematicians and engineers, industrialists, and anyone who would like to delve into the interdisciplinary research of applied and computational mathematics and its areas of applications.

This book gives an overview of affine diffusions, from Ornstein-Uhlenbeck processes to Wishart processes and it considers some related diffusions such as Wright-Fisher processes. It focuses on different simulation schemes for these processes, especially second-order schemes for the weak error. It also presents some models, mostly in the field of finance, where these methods are relevant and provides some numerical experiments. The book explains the mathematical background to understand affine diffusions and analyze the accuracy of the schemes.  

This book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universität Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.

The subject of the book is the mathematical theory of the discontinuous Galerkin method (DGM), which is a relatively new technique for the numerical solution of partial differential equations. The book is concerned with the DGM developed for elliptic and parabolic equations and its applications to the numerical simulation of compressible flow. It deals with the theoretical as well as practical aspects of the DGM and treats the basic concepts and ideas of the DGM, as well as the latest significant findings and achievements in this area. The main benefit for readers and the book’s uniqueness lie in the fact that it is sufficiently detailed, extensive and mathematically precise, while at the same time providing a comprehensible guide through a wide spectrum of discontinuous Galerkin techniques and a survey of the latest efficient, accurate and robust discontinuous Galerkin schemes for the solution of compressible flow.

This volume provides updated, in-depth material on the application of intelligent optimization in biology and medicine. The aim of the book is to present solutions to the challenges and problems facing biology and medicine applications. This Volume comprises of 13 chapters, including an overview chapter, providing an up-to-date and state-of-the research on the application of intelligent optimization for bioinformatics applications, DNA based Steganography, a modified Particle Swarm Optimization Algorithm for Solving Capacitated Maximal Covering Location Problem in Healthcare Systems, Optimization Methods for Medical Image Super Resolution Reconstruction and breast cancer classification. Moreover, some chapters that describe several bio-inspired approaches in MEDLINE Text Mining, DNA-Binding Proteins and Classes, Optimized Tumor Breast Cancer Classification using Combining Random Subspace and Static Classifiers Selection Paradigms, and Dental Image Registration. The book will be a useful compendium for a broad range of readers—from students of undergraduate to postgraduate levels and also for researchers, professionals, etc.—who wish to enrich their knowledge on Intelligent Optimization in Biology and Medicine and applications with one single book.  

This book discusses geometric and mathematical models that can be used to study fluid and structural mechanics in the cardiovascular system. Where traditional research methodologies in the human cardiovascular system are challenging due to its invasive nature, several recent advances in medical imaging and computational fluid and solid mechanics modelling now provide new and exciting research opportunities. This emerging field of study is multi-disciplinary, involving numerical methods, computational science, fluid and structural mechanics, and biomedical engineering. Certainly any new student or researcher in this field may feel overwhelmed by the wide range of disciplines that need to be understood. This unique book is one of the first to bring together knowledge from multiple disciplines, providing a starting point to each of the individual disciplines involved, attempting to ease the steep learning curve. This book presents elementary knowledge on the physiology of the cardiovascular system; basic knowledge and techniques on reconstructing geometric models from medical imaging; mathematics that describe fluid and structural mechanics, and corresponding numerical/computational methods to solve its equations and problems. Many practical examples and case studies are presented to reinforce best practice guidelines for setting high quality computational models and simulations. These examples contain a large number of images for visualization, to explain cardiovascular physiological functions and disease. The reader is then exposed to some of the latest research activities through a summary of breakthrough research models, findings, and techniques. The book’s approach is aimed at students and researchers entering this field from engineering, applied mathematics, biotechnology or medicine, wishing to engage in this emerging and exciting field of computational hemodynamics modelling.

The focus of this volume is research carried out as part of the program Mathematics of Planet Earth, which provides a platform to showcase the essential role of mathematics in addressing planetary problems and creating a context for mathematicians and applied scientists to foster mathematical and interdisciplinary developments that will be necessary to tackle a myriad of issues and meet future global challenges. Earth is a planet with dynamic processes in its mantle, oceans and atmosphere creating climate, causing natural disasters and influencing fundamental aspects of life and life-supporting systems. In addition to these natural processes, human activity has increased to the point where it influences the global climate, impacts the ability of the planet to feed itself and threatens the stability of these systems. Issues such as climate change, sustainability, man-made disasters, control of diseases and epidemics, management of resources, risk analysis and global integration have come to the fore. Written by specialists in several fields of mathematics and applied sciences, this book presents the proceedings of the International Conference and Advanced School Planet Earth, Mathematics of Energy and Climate Change held in Lisbon, Portugal, in March 2013, which was organized by the International Center of Mathematics (CIM) as a partner institution of the international program Mathematics of Planet Earth 2013. The book presents the state of the art in advanced research and ultimate techniques in modeling natural, economical and social phenomena. It constitutes a tool and a framework for researchers and graduate students, both in mathematics and applied sciences.

The chapters which appear in this volume are selected studies presented at the First International Conference on Engineering and Applied Sciences Optimization (OPT-i), Kos, Greece, 4-6 June 2014 and works written by friends, former colleagues and students of the late Professor M. G. Karlaftis; all in the area of optimization that he loved and published so much in himself. The subject areas represented here range from structural optimization, logistics, transportation, traffic and telecommunication networks to operational research, metaheuristics, multidisciplinary and multiphysics design optimization, etc. This volume is dedicated to the life and the memory of Professor Matthew G. Karlaftis, who passed away a few hours before he was to give the opening speech at OPT-i. All contributions reflect the warmth and genuine friendship which he enjoyed from his associates and show how much his scientific contribution has been appreciated. He will be greatly missed and it is hoped that this volume will be received as a suitable memorial to his life and achievements.

This book deals with dynamics of pre-stressed or pre-strained bi-material elastic systems consisting of stack of pre-stressed layers, stack of pre-stressed layers and pre-stressed half space (or half plane), stack of pre-stressed layers as well as absolute rigid foundation, pre-stressed compound solid and hollow cylinders and pre-stressed sandwich hollow cylinders. The problems considered in the book relate to the dynamics of a moving and oscillating moving load, forced vibration caused by linearly located or point located time-harmonic forces acting to the foregoing systems. Moreover, a considerable part of the book relate to the problems regarding the near surface, torsional and axisymmetric longitudinal waves propagation and dispersion in the noted above bi-material elastic systems. The book carries out the investigations within the framework of the piecewise homogeneous body model with the use of the Three-Dimensional Linearized Theory of Elastic Waves in Initially Stressed Bodies.

This volume studies electron resonant tunneling in two- and three-dimensional quantum waveguides of variable cross-sections in the time-independent approach. Mathematical models are suggested for the resonant tunneling and develop asymptotic and numerical approaches for investigating the models. Also, schemes are presented for several electronics devices based on the phenomenon of resonant tunneling. Devices based on the phenomenon of electron resonant tunneling are widely used in electronics. Efforts are directed towards refining properties of resonance structures. There are prospects for building new nano size electronics elements based on quantum dot systems. However, the role of resonance structure can also be given to a quantum wire of variable cross-section. Instead of an "electrode - quantum dot - electrode" system, one can use a quantum wire with two narrows. A waveguide narrow is an effective potential barrier for longitudinal electron motion along a waveguide. The part of the waveguide between two narrows becomes a "resonator" , where electron resonant tunneling can occur. This phenomenon consists in the fact that, for an electron with energy E, the probability T(E) to pass from one part of the waveguide to the other part through the resonator has a sharp peak at E = Eres, where Eres denotes a "resonant" energy. Such quantum resonators can find applications as elements of nano electronics devices and provide some advantages in regard to operation properties and production technology. The book is addressed to mathematicians, physicists, and engineers interested in waveguide theory and its applications in electronics.

This book describes the mathematical underpinnings of algorithms used for molecular dynamics simulation, including both deterministic and stochastic numerical methods. Molecular dynamics is one of the most versatile and powerful methods of modern computational science and engineering and is used widely in chemistry, physics, materials science and biology. Understanding the foundations of numerical methods means knowing how to select the best one for a given problem (from the wide range of techniques on offer) and how to create new, efficient methods to address particular challenges as they arise in complex applications.  Aimed at a broad audience, this book presents the basic theory of Hamiltonian mechanics and stochastic differential equations, as well as topics including symplectic numerical methods, the handling of constraints and rigid bodies, the efficient treatment of Langevin dynamics, thermostats to control the molecular ensemble, multiple time-stepping, and the dissipative particle dynamics method. 

Presenting techniques, case-studies and methodologies that combine the use of simulation approaches with optimization techniques for facing problems in manufacturing, logistics, or aeronautical problems, this book provides solutions to common industrial problems in several fields, which range from manufacturing to aviation problems, where the common denominator is the combination of simulation’s flexibility with optimization techniques’ robustness. Providing readers with a comprehensive guide to tackle similar issues in industrial environments, this text explores novel ways to face industrial problems through hybrid approaches (simulation-optimization) that benefit from the advantages of both paradigms, in order to give solutions to important problems in service industry, production processes, or supply chains, such as scheduling, routing problems and resource allocations, among others.

This volume deals with topics such as mechanism and machine design, biomechanics and medical engineering, gears, mechanical transmissions, mechatronics, computational and experimental methods, dynamics of mechanisms and machines, micromechanisms and microactuators, and history of mechanisms and transmissions. Following MeTrApp 2011 and 2013, held under the auspices of the IFToMM, these proceedings of the 3rd Conference on Mechanisms, Transmissions and Applications offer a platform for original research presentations for researchers, scientists, industry experts and students in the fields of mechanisms and transmissions with special emphasis on industrial applications in order to stimulate the exchange of new and innovative ideas.

This book describes current practices in science communication, from citizen science to Twitter storms, and celebrates this diversity through case studies and examples. However, the authors also reflect on how scholars and practitioners can gain better insight into science communication through new analytical methods and perspectives. From science PR to the role of embodiment and materiality, some aspects of science communication have been under-studied. How can we better notice these? Science Communication provides a new synthesis for Science Communication Studies. It uses the historical literature of the field, new empirical data, and interdisciplinary thought to argue that the frames which are typically used to think about science communication often omit important features of how it is imagined and practised. It is essential reading for students, scholars, and practitioners of science education, science and technology studies, museum studies, and media and communication studies.

This authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas.

This volume contains thirteen articles on advances in applied mathematics and computing methods for engineering problems. Six papers are on optimization methods and algorithms with emphasis on problems with multiple criteria; four articles are on numerical methods for applied problems modeled with nonlinear PDEs; two contributions are on abstract estimates for error analysis; finally one paper deals with rare events in the context of uncertainty quantification. Applications include aerospace, glaciology and nonlinear elasticity. Herein is a selection of contributions from speakers at two conferences on applied mathematics held in June 2012 at the University of Jyväskylä, Finland. The first conference, “Optimization and PDEs with Industrial Applications� celebrated the seventieth birthday of Professor Jacques Périaux of the University of Jyväskylä and Polytechnic University of Catalonia (Barcelona Tech) and the second conference, “Optimization and PDEs with Applications� celebrated the seventy-fifth birthday of Professor Roland Glowinski of the University of Houston. This work should be of interest to researchers and practitioners as well as advanced students or engineers in computational and applied mathematics or mechanics.

An original mechanical formulation to treat nonlinear orthotropic behavior of composite materials is presented in this book. It also examines different formulations that allow us to evaluate the behavior of composite materials through the composition of its components, obtaining a new composite material. Also two multiple scale homogenization methods are given, one based on the analytical study of the cells (Ad-hoc homogenization) and other one, more general based on the finite element procedure applied on the macro scale (upper-scale) and in the micro scale (sub-scale). A very general formulation to simulate the mechanical behavior for traditional composite structures (plywood, reinforced concrete, masonry, etc.), as well as the new composite materials reinforced with long and short fibers, nanotubes, etc., are also shown in this work. Typical phenomena occurring in composite materials are also described in this work, including fiber-matrix debonding, local buckling of fibers and its coupling with the overall buckling of the structure. Finally, several numerical examples that evaluates the qualities and capabilities of the general model formulated are offered in this book. This book is intended for graduate engineering students who want to expand their knowledge of composite structures behavior.

This book features 13 papers presented at the Fifth International Symposium on Recurrence Plots, held August 2013 in Chicago, IL. It examines recent applications and developments in recurrence plots and recurrence quantification analysis (RQA) with special emphasis on biological and cognitive systems and the analysis of coupled systems using cross-recurrence methods. Readers will discover new applications and insights into a range of systems provided by recurrence plot analysis and new theoretical and mathematical developments in recurrence plots. Recurrence plot based analysis is a powerful tool that operates on real-world complex systems that are nonlinear, non-stationary, noisy, of any statistical distribution, free of any particular model type and not particularly long. Quantitative analyses promote the detection of system state changes, synchronized dynamical regimes or classification of system states. The book will be of interest to an interdisciplinary audience of recurrence plot users and researchers interested in time series analysis of complex systems in general.

Aliens, flying saucers, ESP, the Bermuda Triangle, antigravity ... are we talking about science fiction or pseudoscience? Sometimes it is difficult to tell the difference. Both pseudoscience and science fiction (SF) are creative endeavours that have little in common with academic science, beyond the superficial trappings of jargon and subject matter. The most obvious difference between the two is that pseudoscience is presented as fact, not fiction. Yet like SF, and unlike real science, pseudoscience is driven by a desire to please an audience - in this case, people who "want to believe". This has led to significant cross-fertilization between the two disciplines. SF authors often draw on "real" pseudoscientific theories to add verisimilitude to their stories, while on other occasions pseudoscience takes its cue from SF - the symbiotic relationship between ufology and Hollywood being a prime example of this. This engagingly written, well researched and richly illustrated text explores a wide range of intriguing similarities and differences between pseudoscience and the fictional science found in SF. Andrew May has a degree in Natural Sciences from Cambridge University and a PhD in astrophysics from Manchester University. After many years in academia and the private sector, he now works as a freelance writer and scientific consultant. He has written pocket biographies of Newton and Einstein, as well as contributing to a number of popular science books. He has a lifelong interest in science fiction, and has had several articles published in Fortean Times magazine

This book covers original research and the latest advances in symbolic, algebraic and geometric computation; computational methods for differential and difference equations, symbolic-numerical computation; mathematics software design and implementation; and scientific and engineering applications based on features, invited talks, special sessions and contributed papers presented at the 9th (in Fukuoka, Japan in 2009) and 10th (in Beijing China in 2012) Asian Symposium on Computer Mathematics (ASCM). Thirty selected and refereed articles in the book present the conference participants’ ideas and views on researching mathematics using computers.

This highly multidisciplinary volume contains contributions from leading researchers in STEAM-H disciplines (Science, Technology, Engineering, Agriculture, Mathematics and Health). The volume explores new frontiers in multidisciplinary research, including: the mathematics of cardiac arrhythmia; brain research on working memory; penalized ordinal regression to classify melanoma skin samples; forecasting of time series data; dynamics of niche models; analysis of chemical moieties as anticancer agents; study of gene locus control regions; qualitative mathematical modelling; convex quadrics and group circle systems; remanufacturing planning and control; complexity reduction of functional differential equations; computation of viscous interfacial motion; and differentiation in human pluripotent stem cells. An extension of a seminar series at Virginia State University, the collection is intended to foster student interest and participation in interdisciplinary research and to stimulate new research. The content will be of interest to a broad spectrum of scientists, mathematicians and research students working in interdisciplinary fields including the biosciences, mathematics, engineering, neurosciences and behavioral sciences.

This book deals with the economic aspects of changing attitudes in arts and sciences. The effects of the public good character of culture, along with the very long production period and lifetime for its products, are emphasized, since both contribute to the failure of normal market solutions. Embodiment of ideas and the consequences of modern reproduction technology for protection of property rights are closely examined. The evolution within arts and sciences, which often seems to return to previously scrapped ideals, is illustrated by detailed case studies, in which the importance of changing tastes, rather than progress proper, is emphasized. The author attempts an understanding for this using Darwinian evolution in combination with modern mathematical complexity theory, expressed in terms accessible to the general reader. The second edition is extended and updated especially as regards the illustration material.

The topics addressed in this book cover the whole range of kinematic analysis, synthesis and design and consider robotic systems possessing serial, parallel and cable driven mechanisms. The robotic systems range from being less than fully mobile to kinematically redundant to over constrained. The fifty-six contributions report the latest results in robot kinematics with emphasis on emerging areas such as design and control of humanoids or humanoid subsystems. The book is of interest to researchers wanting to bring their knowledge up to date regarding modern topics in one of the basic disciplines in robotics, which relates to the essential property of robots, the motion of mechanisms.

The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems.  More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy.  Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology.  Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology.  Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources.  In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function.  As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.