This handbook presents the key properties of silicon carbide (SiC), the power semiconductor for the 21st century. It describes related technologies, reports the rapid developments and achievements in recent years, and discusses the remaining challenging issues in the field. The book consists of 15 chapters, beginning with a chapter by Professor W. J. Choyke, the leading authority in the field, and is divided into four sections. The topics include presolar SiC history, vapor-liquid-solid growth, spectroscopic investigations of 3C-SiC/Si, developments and challenges in the 21st century; CVD principles and techniques, homoepitaxy of 4H-SiC, cubic SiC grown on 4H-SiC, SiC thermal oxidation processes and MOS interface, raman scattering, NIR luminescent studies, Mueller matrix ellipsometry, raman microscopy and imaging, 4H-SiC UV photodiodes, radiation detectors, and short wavelength and synchrotron X-ray diffraction. This comprehensive work provides a strong contribution to the engineering, materials, and basic science knowledge of the 21st century, and will be of interest to material growers, designers, engineers, scientists, postgraduate students, and entrepreneurs.

This book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy. ​

Welfare states face profound challenges. Widening economic and social inequalities have been intensified by austerity politics, sharpened by the rise in ethno-nationalism and exposed by the COVID-19 pandemic. At the same time, recent decades have seen a resurgence of social justice activism at both the local and the transnational level. Yet the transformative power of feminist, anti-racist and postcolonial/decolonial thinking has become relatively marginal to core social policy theory, while other critical approaches - around disability, sexuality, migration, age and the environment - have found recognition only selectively. This book provides a much needed new analysis of this complex landscape, drawing together critical approaches in social policy with intersectionality and political economy. Fiona Williams contextualizes contemporary social policies not only in the global crisis of finance capitalism but also in the interconnected global crises of care, ecology and racialized borders. These shape and are shaped at national scale by the intersecting dynamics of family, nation, work and nature. Through critical assessment of these realities, the book probes the ethical, prefigurative and transformative possibilities for a future welfare commons. This significant intervention will animate social policy thinking, teaching and research. It will be essential reading for anyone wanting to understand the complexities of social policy for the years ahead.

The discovery of novel drugs that fill unmet medical needs is important for the health and well-being of people everywhere. However, the general public knows too little about the pathways through which basic research discoveries are translated into products that protect or restore human health. In the second edition of Hallelujah Moments, Eugene H. Cordes reveals the processes and pitfalls on the route from the laboratory bench to the bedside. These are adventure stories in which wit and grit created several of the most important drugs in human medicine. This new edition adds four new tales of drug discovery: for therapy of cancer, hepatitis C, HIV/AIDS, and for weight control. The stories emphasize the integration of basic research in academe and applied research in the pharmaceutical industry and introduce the key scientists. In each case, success resulted from imagination, risk-taking, problem solving, and perseverance. Cordes shares his firsthand knowledge of the drug-discovery world, having spent a long and distinguished career in both academic and industrial settings. The eleven drug discovery tales take the reader from concept to clinic for some of the most important drugs in human health including the statins, ACE inhibitors, antibiotics, avermectins, Januvia, and Taxol. These stories offer exciting insights into the fascinating world of drug discovery.

Thousands of inorganic and organic chemicals and their metabolites enter the biosphere daily as a direct result of human activities. Many of these chemicals have serious consequences on sensitive species of natural resources, crops, livestock, and public health. The most hazardous of these were identified by a panel of environmental specialists from the U.S. Fish and Wildlife Service; these chemicals are the focus of this encyclopedia.
For each priority group of chemicals, information is presented on sources, uses, physical and chemical properties, tissue concentrations in field collections and their significance, lethal and sublethal effects under controlled conditions. This includes effects on survival, growth, reproduction, metabolism, carcinogenicity, teratogenicity, and mutagenicity - and proposed regulatory criteria for the protection of sensitive natural resources, crops, livestock, and human health. Taxonomic groups of natural resources covered include terrestrial and aquatic plants and invertebrates, fishes, amphibians, reptiles, birds, and mammals.
* The only product that centers on the most hazardous environmental chemicals to sensitive natural resources
* The only single volume compendium on the subject, allowing ease in consulting
* Written by a noted national and international authority on chemical risk assessment to living organisms

Explores the potential of new types of anion-binding catalysts to solve challenging synthetic problems Anion-Binding Catalysis introduces readers to the use of anion-binding processes in catalytic chemical activation, exploring how this approach can contribute to the future design of novel synthetic transformations. Featuring contributions by world-renowned scientists in the field, this authoritative volume describes the structure, properties, and catalytic applications of anions as well as synthetic applications and practical analytical methods. In-depth chapters are organized by type of catalyst rather than reaction type, providing readers with an accessible overview of the existing classes of effective catalysts. The authors discuss the use of halogens as counteranions, the combination of (thio)urea and squaramide-based anion-binding with other types of organocatalysis, anion-binding catalysis by pnictogen and tetrel bonding, nucleophilic co-catalysis, anion-binding catalysis by pnictogen and tetrel bonding, and more. Helping readers appreciate and evaluate the potential of anion-binding catalysis, this timely book: Illustrates the historical development, activation mode, and importance of anion-binding in chemical catalysis Explains the analytic methods used to determine the anion-binding affinity of the catalysts Describes catalytic and synthetic applications of common NH- and OH-based hydrogen-donor catalysts as well as C-H triazole/triazolium catalysts Covers amino-catalysis involving enamine, dienamine, or iminium activation approaches Discusses new trends in the field of anion-binding catalysis, such as the combination of anion-binding with other types of catalysis Presenting the current state of the field as well as the synthetic potential of anion-binding catalysis in future, Anion-Binding Catalysis is essential reading for researchers in both academia and industry involved in organic synthesis, homogeneous catalysis, and pharmaceutical chemistry.

This detailed volume explores techniques in clinical proteomics, an emerging discipline aimed at deciphering the molecular mechanisms underlying the progression of diseases and at identifying new biomarkers and therapeutic targets to expand the physicians' toolbox for precision medicine-based patient care. From sample processing to multi-omics approaches, the book provides straight-forward protocols on a wide array of vital areas of study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Proteomics: Methods and Protocols serves as an ideal guide for researchers working to expand upon the knowledge base needed to push forward toward a more personalized version of medicine.

Remediation of wastewater is important to ensure that pollutants generated in industry do not effect our environment negatively. Traditional wastewater remediation is not a sustainable process, however by using biological means the sustainability can be improved. This book explores how bioremediation biotechnology is used to remove pollutants in wastewater. Both conventional methods bioremediation technologies are discussed.

College and university faculty find themselves tasked with teaching in the face of ever-changing trends in higher education and constant shifts in the student population. Educators must balance student engagement and retention with their learning and satisfaction in a never-ending cycle of changes in technology, the economy, and the political climate. Even when certain pedagogies or classroom techniques are shown to be beneficial in one discipline, individual faculty may find it challenging to apply them in their own classrooms. This is certainly true in chemistry. Many faculty in chemistry today struggle to embrace research-based educational practices, even those coming out of our own discipline. Graduate programs in chemical education, recent reports on discipline-based education research (1), and an increase in the scholarship of teaching and learning in chemistry indicate a desire among many faculty to change-to reach students in new and exciting ways or to change curricula to better meet students' needs. Faculty are looking for things that work-techniques used by chemists, for chemists. This volume contributes to this on-going conversation. The scholarship presented within this volume is organized in three sections. The first explores innovations found to enhance the learning of typical students as well as those who may be under-prepared. Authors describe their experiences using the flipped classroom and institutional readiness models. The second section provides examples of how technology may be utilized in the chemistry classroom-from e-textbook usage to a computational chemistry program to concrete suggestions for teaching chemistry online. The final section addresses broader issues in chemistry. One chapter demonstrates how to incorporate High-Impact Educational Practices (2) into courses for chemistry majors and nonmajors. A final chapter describes how colleges can adopt the Green Chemistry Commitment. Additionally, contextual information for pedagogical change may be found in the Introduction as well as helpful tips for adopting new approaches.

This textbook provides broad coverage of energy supply and use. It discusses how energy is produced, transformed, delivered to end users, and consumed. The author discusses all of this at an undergraduate level, accessible to students of varying backgrounds. High-level and human-scale perspectives are included. As a high-level example, the book discusses the shares of global primary energy that are provided by oil, gas, coal, hydroelectricity, and renewables, as well as trends in energy consumption and supply over time. Human-scale examples will resonate with readers' every day experiences. The link between economic development and energy consumption is presented, which facilitates understanding of how global energy consumption growth is inevitable as economic development occurs. Coverage includes separate chapters on the oil, natural gas, coal, and electricity sectors. Each of these provides high-level descriptions of the technology involved in the production of that type of energy as well as the processing and transportation that occurs to bring the energy to end users. The book discusses the technological implications of energy transitions such as increased use of renewables or changes in the use of nuclear energy using Germany and Japan as examples. It closes with a discussion of future energy use.

Advances in Clinical Chemistry, Volume 78, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

Green Chemistry and Biodiversity: Principles, Techniques, and Correlations reports on new approaches to designing chemicals and chemical transformations that are beneficial for human health and the environment, a continuing emerging important field of study. This volume provides a collection of innovative research on the development of alternative sustainable technologies, taking a broad view of the subject and integrating a wide variety of approaches. With a focus on the interdisciplinary applications of green chemistry and biodiversity, this volume will be a rich resource for scientists and researchers in many subfields of chemistry and chemical engineering.

Project managers in drug development are the driving force behind the coordination of efforts. This book provides a practical reference for project managers in the pharmaceutical and biotech drug development industry, with the goal of assisting in creating an efficient and effective team structure and environment. The text details the role of project managers at each stage of drug development, the key interfaces that the PM will need to work closely with, and essential tools of the trade including frequently used techniques and methodologies. This book is useful for both entry-level and advanced-level PMs, as well as non-project managers from other functions. Features Includes authors' recent experience with improved tactics and technologies/software at various stages of drug development. Provides the most up-to-date and best practices, techniques, and methodologies in project management. Details the role of the PM at each stage of drug development, including working with the key interfaces throughout the process. Diverse audience including nonproject managers in clinical development, clinical operations, regulatory affairs, medical affairs, clinical pharmacology, and biostatistics. Provides templates and timelines for critical paths from development to commercialization and has potential as a textbook on relevant courses.

The world wide web has been in existence for just over twenty-five years, but already its potential for impacting education appears to be infinite. Online platforms provide increasingly sophisticated tools for the mass dissemination of knowledge and sharing of ideas. These platforms can currently be accessed by the more than half of the people on Earth who have access to the internet in 2017, and the infrastructure for the internet continues to expand rapidly into developing global locations. Today, online learning is an important current topic for contemporary educators in diverse fields. The chapters in this book address these topics specifically for the field of chemistry, giving overviews of existing work as well as "snapshot in time" examples of the work being conducted in this area. The purpose of the book is to examine the relevant successes, challenges, research findings, and practical examples in online approaches to chemistry education.

This book closes a current gap by providing the scientific basis for consumer exposure assessment in the context of regulatory risk assessment. Risk is defined as the likelihood of an event occurring and the severity of its effects. The margin between the dose that leads to toxic effects and the actual dose of a chemical is identified by estimating population exposure. The objective of this book is to provide an introduction into the scientific principles of consumer exposure assessment, and to describe the methods used to estimate doses of chemicals, the statistics applied and computer tools needed. This is presented through the backgrounds of the special fields in exposure analysis, such as exposure via food and by the use of consumer products, toys, clothing and other items. As a general concept, human exposure is also understood to include exposure via the environment and from the work setting. In this context, the specific features of consumer exposure are pointed out and put into the context of regulation, in particular food safety, chemicals safety (REACh) and consumer product safety. The book is structured into three parts: The first part deals with the general concepts of consumer exposure as part of the overall risk analysis framework of risk characterization, risk assessment and risk communication. It describes the three basic features of exposure assessment (i) the exposure scenario (ii) the exposure model and (iii) the exposure parameters, addressing external and internal exposure. Also, the statistical presentation of data to characterize populations, in connection with variability, uncertainty and quality of information and the presentation of exposure evaluation results is described. The second part deals with the specific issues of exposure assessment, exposure via food consumption, exposure from use of consumer products, household products, toys, cosmetic products, textiles, pesticides and others. This part also covers methods for acquisition of data for exposure estimations, including the relevant information from regulations needed to perform an accurate exposure assessment. The third part portrays a prospect for further needs in the development and improvement of consumer exposure assessment, as well as international activities and descriptions of the work of institutions that are involved in exposure assessment on the regulatory and scientific level. And conversely, it creates the rationale for the exposure assessment details necessary to satisfy regulatory needs such as derivation of upper limits and risk management issues.

This book highlights the present scenario of energy demand and power generation technologies in tropical countries. The tropics are well known to receive direct sunlight. Furthermore, different than four-season countries, tropical countries have a continuous summer-like season, and therefore, they are rich in clean energy sources, like solar and biomass. Home to 40% of the world's population, the demand for energy in these countries keeps increasing. With the present serious global concern on the environment, the choice of power generation is no doubt the cleanest possible resources. This book delves into the opportunity that various tropical countries have in pursuing environmentally friendly power generation systems.

This book treats the theoretical fundamentals of adsorption technology for water treatment from a practical perspective. It presents all the basics needed for experimental adsorption studies as well as for process modeling and adsorber design. According to the increasing importance of micropollutants in the water cycle, particular attention is paid to their competitive adsorption in the presence of background organic matter. The current edition considers recent developments in adsorption theory and practice.

This book presents detailed and reliable ecotoxicological results from both laboratory and field experiments, performed for a comprehensive range of chemicals to Photobacterium Phosphoreum. It provides a considered estimate of the potential impact of such chemicals on the environment.

Collates the most relevant and up to date information on renewable energy systems in a user friendly format for undergraduate and high school students Focused on power production technologies from renewable energy sources. An introduction to how sources of renewable energy work; their advantages and drawbacks. Timely text with the need for fast adoption of renewable energy technologies around the world. Diverse audience including students with some scientific background such as final year in high school wanting to know more about combatting climate change.

Explores the utilization of marine surfactants for biological and biomedical applications Provides depth knowledge on marine surfactant preparations Discusses the development of personal care or cosmeceutical products using marine surfactants Examines various marine derived surfactants for treatment of cancer related diseases Reviews marine surfactants for environmental applications

This book presents comprehensively the science and technology behind the formulation of disperse systems like emulsions, suspensions, foams and others. Starting with a general introduction, the book covers a broad range of topics like the role of different classes of surfactants, stability of disperse systems, formulation of different dispersions, evaluation of formulations and many more. Many examples are included, too. Written by the experienced author and editor Tharwart Tadros, this book is indispensable for every scientist working in the field.

This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Providing complete, step-by-step coverage of the 2008 Edexcel GCE Chemistry specification, this is the official Student Book for the concept-led approach to the specification. Written by experienced examiners, it offers students motivating and relevant content to improve exam performance and ensure students fulfil their full potential. *Allows for regular testing and exam preparation with real Edexcel past questions, provided in the 'Examzone' sections. *Supports independent learning through a range of additional resources provided on the ActiveBook CD-ROM, included FREE in the back of each book. *Helps students build a wide range of skills, including data analysis, critical evaluation of information, communication and collaborative work. *Gives students an in-depth, scientific understanding of the principles covered in each topic, including How Science Works. *Helps students easily see how content from the specification is covered through topic overview maps. *Written by highly respected and experienced authors.