The second edition of this volume provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Difference Gel Electrophoresis: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients' quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients' quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.

For the millions who remain curious about the world around them, but gained little from science at school, this book offers a way forward. Based on live discussions with adults from all walks of life, each chapter begins with an everyday experience, like swallowing a pill or watching a bee on a flower. The main scientific ideas underlying each topic are then explored, so that understanding of a set of fundamental concepts builds up gradually throughout the book. In contrast to more traditional approaches to science learning, topics range freely across the subject areas. The story of Covid, for example includes aspects of biology, chemistry, mathematics and social behaviour. Plain English is used throughout and mathematical expressions are avoided. Key points are illustrated with clear diagrams and photographs. By drawing on questions and perspectives of ordinary people, the book offers an introduction to basic ideas in science as a whole, rather than any one particular subject. For the adult wishing to make good a gap in their understanding it provides a starting point for entering the rich world of popular science.

Advances in Clinical Chemistry, Volume 84, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark for novel analytical approaches in the clinical laboratory.

This book presents an in depth study of different aspects of pesticide use in food production. The text covers the sources of pesticide residues in foods, relevant health and environmental concerns, degradation of pesticides after their use, and available laws and regulations to regulate pesticide use. In addition, different pesticide management techniques, such as: reduction of pesticide residues in grains and foods, alternatives to conventional pesticides, and prospects of organic farming are also covered. Pesticide Residue in Foods: Sources, Management, and Control aims to raise awareness of the proper use of these chemicals in order to lower residue in foods and reduce risk for consumers.

This book presents the pioneering role of the women chemists at the London School of Medicine for Women (LSMW). The account is placed within the framework of the long-forgotten background to the founding of this unique Institution, and the individuals whose lives came together to make it happen: Sophia Jex-Blake; Elizabeth Garrett Anderson; Edith Pechey; and Isabel Thorne. The London School of Medicine for Women (LSMW) was the first School in Britain to enable women to gain medical qualifications. Though its pioneering medical role is beginning to be recognized, the Chemistry Department at the School has been totally overlooked. All first-year students at the LSMW had to spend a significant portion of their time taking theoretical and practical chemistry, taught by dedicated women chemistry instructors. In this book, particular attention is given to each of these exceptionally-talented women chemists who found a haven at, and devoted their lives to, the LSMW. This book also covers the enthusiasm of the women medical students which becomes evident through the chemistry prose and poetry which they wrote. This book will appeal to a wide readership interested in the early role of women in science, and it is particularly relevant to those interested in the lives and contributions of pioneering women chemists.

Provides a comprehensive review of challenges and opportunities as related to the applications of big data, AI, and machine learning in the entire spectrum of drug R&D Discusses regulatory developments in leveraging big data and advanced analytics in drug review and approval Offers a balanced approach to data science organization build Presents real-world examples of AI-powered solutions to a host of issues in the lifecycle of drug development Affords sufficient context for each problem and provides detailed description of solutions suitable for practitioners with limited data science expertise

Application as well as detection of different chemicals plays an important role in the progress of modern science and technology. The beauty of various characteristics of materials and the inherent logic behind their working mechanisms can be wisely utilized for sensing different chemicals. The mechanisms as well as performances of different materials viz. carbon nanotube, graphene, metal oxides, biomaterials, luminescent metal-organic frameworks, hydrogels, textiles, quantum dots, ligands, crown ethers etc. for identification of different chemicals has been discussed here. This book would be a valuable reference to select suitable materials for possible use in chemical sensors.

Develop and learn to apply your knowledge, progressing from basic concepts to more complicated Chemistry, with worked examples, practical activities and mathematical support in this updated, all-in-one textbook for Years 1 and 2. Written for the AQA A-level Chemistry specification, this revised textbook will: - Provide support for all 12 required practicals with activities that introduce practical work and other experimental investigations in Chemistry. - Offer detailed examples to help you get to grips with difficult concepts such as physical chemistry calculations. - Helps to improve mathematical skills with support throughout, examples of method and a dedicated 'Maths for chemistry' chapter. - Allow you to easily measure progression with differentiated end-of-topic questions and 'Test yourself' questions. - Develop understanding with free online access to 'Test yourself' answers, 'Practice' question answers and extended glossaries*.

Develop and assess your students' knowledge and skills throughout A level with worked examples, practical assessment guidance and differentiated end of topic questions in this updated, all-in-one textbook for Years 1 and 2. Combining everything your students need to know for the Pearson Edexcel A level Chemistry specification, this revised textbook will: - Identify the level of your students' understanding with diagnostic questions and a summary of prior knowledge at the start of the Student Book. - Provide support for all 16 required practicals with various activities and questions, along with a 'Practical' chapter covering procedural understanding and key ideas related to measurement. - Improve mathematical skills with plenty of worked examples, including notes on methods to help explain the strategies for solving each type of problem. - Offer plenty of practice with 'Test yourself' questions to help students assess their understanding and measure progress. - Encourage further reading and study with short passages of extension material. - Develop understanding with free online access to 'Test yourself' answers and an extended glossary.

This book presents the proceedings of the International Conference on Health, Safety, Fire, Environment, and Allied Sciences. It highlights latest developments in the field of science and technology aimed at improving health and safety in the workplace. The volume comprises content from leading scientists, engineers, and policy makers discussing issues relating to industrial safety, fire hazards and their management in industry, forests and other settings. Also dealt with are issues of occupational health in engineering, process and agricultural industry and protection against incidents of arson and terror attacks. The contents of this volume will be of interest to researchers, practitioners, and policy makers alike.

This book familiarizes personnel serving as Emergency Managers, Safety Officers, Assistant Safety Officers, and in other safety-relevant Incident Command System (ICS) roles with physical and psychosocial hazards and stressors that may impact the health and safety of workers and responders in an All-Hazards Response, and ways to minimize exposure. This book provides knowledge on regulations and worker safety practices to the Safety Officer with an emergency responder background, and provides the tools for the Safety Officer with an industrial hygiene or safety professional background that help them be successful in this role. In order to work together effectively, it is important that anyone responding to an emergency be familiar with all standards and protocols.

"This fantastic CGP Student Book comprehensively covers both years of AQA A-Level Chemistry. It's bursting with in-depth, accessible notes explaining every course topic, plus all of the Required Practicals. Everything's supported by clear diagrams, photographs, tips and worked examples. Throughout the book there are lots of practice questions and exam-style questions (with answers at the back). There's detailed guidance on Maths Skills and Practical Skills, as well as indispensable advice for success in the final exams. We've even thrown in a free Online Edition of the whole book - just use the code printed inside the book to access it on your PC, Mac or tablet. If you'd prefer Year 1 (9781782943211) & Year 2 (9781782943266) in separate books, CGP has them too! And for more detailed coverage of the mathematical elements of A-Level Chemistry, try our Essential Maths Skills book (978182944720)! "

In this first volume, various materials such as chitosan, lignin-based biomaterials, cellulosic based bio materials, carbon materials, Polysaccharide-composites materials, Aromatic-Based Synthetic Macromolecules, Agricultural wastes, etc for treating textile waste water are highlighted. One of the major pollutants in the textile and fashion industry is (textile) waste water. Textile wastewater can lead to serious environmental issues if discharged without proper and sufficient treatment. The materials employed along with the technologies available to trate waste water are the key. There are a lot of advancements in terms materials, technologies employed for textile waste water treatment. Sustainable bio-nano materials and macro molecules play a major role in the efficient treatment of textile waster.

This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening (HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as to graduate students and scholars who are interested in this rapidly improving technology.

This book provides an indispensable reference guide to the sustainable control and treatment of biomass residues from a wide variety of agroindustrial sources, e.g. sugarcane, livestock, pulp & paper, food wastes, among others. Pursuing a structured and clear approach, the book opens with a general introduction to biomass, sustainability and environmental chemistry aspects, and on how the use of biomass as a renewable material ties into the UN's Sustainable Development Goals. The book subsequently presents analytical methods applied to different biomass types and their residues and reviews monitoring and treatment strategies in order to avoid pollution of the same. The book closes by describing the value chains, bioeconomy and circular economy for globally relevant agroindustrial biomass. The book is intended for researchers in academia and industry alike and shows how, in addition to sustainability criteria and life cycle assessments, integrating environmental chemistry aspects can contribute to a holistic approach, and unlock the economic potential of biomass in the age of circular economy and sustainable development.

The global lubricants market exceeds $110 billion, with strong future-estimated annual growth projections. While much has been written about the technical aspects of lubricant development, Lubricant Marketing, Selling, and Key Account Management fills a need for a comprehensive guide on the important commercial aspects of the business, offering unique and valuable insights from a veteran of the industry. It answers questions and offers insights on how to effectively market and sell all types of lubricants, including automotive, industrial, mining, marine, agricultural and aerospace, among others. Covers how and why people and companies buy lubricants. Instructs readers how to research and analyze markets and use the results to plan marketing and sales campaigns and activities. Details how to identify specific target market segments and sell to key lubricant accounts. Discusses how to forecast future demand for lubricants in all types of global markets. This practical book is written for technical and non-technical readers involved in the sale and management of lubricant products and offers hands-on guidance for how to successfully navigate and grow your profitability in this vitally important product sector.

This book advocates the importance and value of errors for the progress of scientific research! Hans Kricheldorf explains that most of the great scientific achievements are based on an iterative process (an 'innate self-healing mechanism'): errors are committed, being checked over and over again, through which finally new findings and knowledge can arise. New ideas are often first confronted with refusal. This is so not only in real life, but also in scientific and medical research. The author outlines in this book how great ideas had to ripen over time before winning recognition and being accepted. The book showcases in an entertaining way, but without schadenfreude, that even some of the most famous discoverers may appear in completely different light, when regarding errors they have committed in their work. This book is divided into two parts. The first part creates a fundament for the discussion and understanding by introducing important concepts, terms and definitions, such as (natural) sciences and scientific research, laws of nature, paradigm shift, and progress (in science). It compares natural sciences with other scientific disciplines, such as historical research or sociology, and examines the question if scientific research can generate knowledge of permanent validity. The second part contains a collection of famous fallacies and errors from medicine, biology, chemistry, physics and geology, and how they were corrected. Readers will be astonished and intrigued what meanders had to be explored in some cases before scientists realized facts, which are today's standard and state-of-the-art of science and technology. This is an entertaining and amusing, but also highly informative book not only for scientists and specialists, but for everybody interested in science, research, their progress, and their history!

Remediation of wastewater is important to ensure that pollutants generated in industry do not effect our environment negatively. Traditional wastewater remediation is not a sustainable process, however by using biological means the sustainability can be improved. This book explores how bioremediation biotechnology is used to remove pollutants in wastewater. Both conventional methods bioremediation technologies are discussed.

This book is part of a two-part volume book that highlights the latest advances in innovative bioceramics applied in the highly interdisciplinary area referred to as "translational medicine". This volume predominantly written by surgeons in the fields of craniomaxillofacial, orthopedics, and spinal surgery, examines the translation of innovative bioceramics and bioceramics-based composite from the laboratory to a personalized surgical environment for the repair of damaged and diseased bone tissues. This book also covers the topic of osteoporosis, a skeletal disorder in which the World Health Organization (WHO) has recognized it as a public health emergency due to the high number of subjects who exhibited the disease and the morbidity and mortality related to fractures. The book caters to biomaterials researchers and medical clinicians who are interested in incorporating innovative bioceramics to the above-mentioned applications.

Environmental Chemistry in the Lab presents a comprehensive approach to modern environmental chemistry laboratory instruction, together with a complete experimental experience. The laboratory experiments have an introduction for the students to read, a pre-lab for them to complete before coming to the lab, a data sheet to complete during the lab, and a post-lab which would give them an opportunity to reinforce their understanding of the experiment completed. Instructor resources include a list of all equipment and supplies needed for 24 students, a lab preparation guide, an answer key to all pre-lab and post-lab questions, sample data for remote learners, and a suggested rubric for grading the labs. Additional features include: * Tested laboratory exercises with instructor resources for environmental science students * Environmental calculations, industrial regulation, and environmental stewardship * Classroom and remote exercises * An excellent, user-friendly, and thought-provoking presentation which will appeal to students with little or no science background * A qualitative approach to the chemistry behind many of our environmental issues today