Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field. A better understanding of receptor intra-and interspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses. The development of new histaminergic ligands is an ongoing process that constantly provide new preclinical tools. The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.

Both volumes of this dictionary consists of some 63,000 and over 100,000 translations from all the main areas of chemistry and chemical technology including: Analytical Chemistry, Biochemistry, Biotechnology, Chromatography, Colour, Inorganic Chemistry, Laboratory techniques, Metallurgy & Treatment, Organic chemistry, Physical chemistry, Plastics, Process engineering, Spectroscopy and Industrial Chemistry.

Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a 'must' for researchers and students wishing to stay up-to-date on current developments in computational chemistry.
* Broad coverage of computational chemistry and up-to-date information
* The topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings
* Each chapter reviews the most recent literature on a specific topic of interest to computational chemists

This series provides chemical physics with a forum for critical, authoritative evaluations of advances in every are of the discipline. Volume 92 continues to report recent advances with a significant, up-to-date selection of papers by internationally recognized researchers.

Reviews of Environmental Contamination and Toxicology provides detailed review articles concerned with aspects of chemical contaminants, including pesticides, in the total environment with toxicological considerations and consequences.

This updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers' interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nucleic Acid Aptamers: Selection, Characterization, and Application, Second Edition serves as an ideal guide for researchers aiming to further our understanding of aptamer biology and more.

Offering all aspects of humidity measurement and instrumentation, this work includes rudiments and theory, common applications, advantages and limitations of frequently-used sensors and techniques, and guidelines for installation, maintenance and calibration. The disk is intended for easy conversions of humidity parameters and units.

The physical and chemical properties and processes of clouds are of great interest from a variety of perspectives, such as acid deposition, oxidant chemistry, and radiative transfer in the atmosphere. The Kleiner Feldberg Cloud Experiment was conducted in October--November 1990 at the field observatory of Kleiner Feldberg near Frankfurt, Germany, in the Taunus Highlands. The experiment was planned and organized within the EUROTRAC sub- project GCE (Ground-Based Cloud Experiment). The general aim of this project is to experimentally investigate physical and chemical processes occurring in ground-based clouds, to provide the basic information needed to understand the incorporation and transformation of trace atmospheric constituents within the multiphase cloud system. This book reports the results of the Kleiner Feldberg Cloud Experiment, addressing the main scientific questions related to the properties of clouds and the processes taking place in the cloud multiphase system. How are the different atmospheric trace species partitioned between gas phase, interstitial aerosols, cloud droplets? What kind of physical and chemical processes cause changes in the phase partitioning of trace species within clouds? Which interactions can be found between the microphysical and dynamical processes in clouds and the chemical composition of cloud droplets? Is the chemical composition of cloud droplets size-dependent, as can be expected by the different scavenging processes? Which influence do chemical reactions have on cloud water chemical composition? Does the gas/liquid partitioning in cloud obey Henry's law? How important is the deposition of atmospheric trace substances due to cloud dropletinterception with the Earth's surface? Are the sampling techniques for aerosols and cloud droplets reliable with respect to their chemical composition? This book provides updated information on cloud research to scientists involved in other fields of atmospheric sciences and also useful reference material for graduate students enrolled in atmospheric chemistry programmes.

Biomaterials are advanced materials that garner interdisciplinary research. Wastewater pollution causes many adverse effects on human health and the environment. In order to rectify this, biomaterials and other nanomaterials have been utilized as photocatalysts against environmental waste. In this book, biomaterials are highlighted as a promising material for waste management, as biomaterials are cost-effective, eco-friendly and closer to nature.

Production from tropical agricultural systems will need to increase to satisfy the rising food demand of an increasing population coupled with changes in consumption patterns. At the same time, the agricultural sector is a significant source of greenhouse gases (GHG) in many developing countries, which can be attributed mainly to land-use change and methane emissions from rice and livestock. But how can we reconcile less GHG emissions from tropical agricultural systems while increasing productivity?

Due to the interactive nature of these issues, this book is compiled of articles on natural resource management, as well as the socio-economic aspects of GHG mitigation. The scope of mitigation options in tropical agriculture is discussed for three different activities: (a) agroforestry; (b) rice-based production systems; (c) pasture/animal husbandry.

Agronomic solutions alone will not be sufficient, as the institutional and economic frameworks within which farmers operate dictate whether a recommended agronomic management practice is acceptable. The prevention of deforestation, and the re-forestation of degraded land, could become key elements to national climate protection programs of some developing countries. Alternative management practices in rice-based and pasture systems may offer win-win options to reduce emissions and improve resource-use efficiencies.

This book is tailored designed for both researchers as well as academics teaching or introducing Advanced Manufacturing course to their classrooms. It presents the current state of research in this field of research and major challenges identified so far, for the integration of additive manufacturing into chemical processes. Unique capability of transforming materials into functional devices with specific geometry using the emerging additive manufacturing technologies has stimulated significant interest in biology, engineering and materials science, to provide custom-made designs for tailored applications. However, the applications of this emerging technology in the field of chemical sciences and engineering have started very recently. Therefore, the major focus of this book is to introduce the basic principles of additive manufacturing practices as well as advent into conventional chemical processes and various unit operations. The potential advantage of introducing these additive manufacturing technologies has the potential to scale down large scale chemical processes into small scale, which offers several advantages including lower foot print, waste reduction and efficient heat integration as well as distributed chemical manufacturing.

The book provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. The book focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides. The book starts with an introductory overview of bioanalysis showcasing the integral role it plays in understanding the drug disposition (pharmacokinetics/pharmacodynamics and immunogenicity) and the progression of bioanalytical strategy as the drug progresses through discovery and development stages of the program, taking into consideration the continually evolving regulatory landscape. The book further diversifies into individual biopharmaceutical modalities - monoclonal antibodies, antibody-drug conjugates, bispecifics, Fc-fusion proteins, gene therapies, cell therapies, peptides and oligonucleotides. The individual chapters focus on modality-specific bioanalytical assay strategies, critical reagents, assay formats, analytical platforms, associated bioanalytical challenges and mitigation strategies, industry best practices, and the latest understanding of regulatory guidance as applicable to the fast-growing biopharmaceutical landscape.

The book provides a comprehensive detailed summary of current status on skin microbiome research in health and disease as well as key regulatory and legal aspects. In the past decade, interest and technology have greatly advanced to unravel the nature and effect of skin microbiome on our health. Diseases such as atopic dermatitis and acne are at the forefront of this research, but also other conditions such as skin cancer are under investigation. In addition, mapping of the skin microbiome has gone from basic to more detailed with attempts to correlate it to various ages, ethnicities and genders. In parallel to mapping it, a great deal of research is dedicated to understanding its functionality and communication (and hence effect) on human cells. The Skin Microbiome Handbook is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome and oral-skin interaction; skin microbiome observational research; skin microbiome in disequilibrium and disease; skin's innate immunity; testing and study design; regulatory and legal aspects for skin microbiome related products. The 18 chapters of the book are written by carefully selected leaders in the academia and industry exhibiting extensive experience and understanding in the areas of interest.

This book provides an integrated account of the phenomenon of acidity set against the background of the acidic substances which are of major significance in the chemical industry and commerce.

This book is for undergraduate and diploma chemistry students who are about to begin their project work. Student projects are now an essential part of most undergraduate and diploma chemistry courses in the UK, and are an important component of the later years of chemistry degree courses in Australia, South Africa and New Zealand The book covers all aspects of project work, from choosing a suitable topic and supervisor to communicating research results effectively. There is advice on the best way to use libraries and on how to gather relevant references. Students are taught how to work safely and effectively, and to present their results in report, seminar or conference poster form. Additionally, the author offers guidance on engaging a keyboard operator, on how to prepare artwork and visual aids, and coaching tips on effective communication. The work is a distillation of the author's many years of experience of guiding students of all abilities to success in their project work This book should be of interest to second and third year undergraduates and diploma students in chemistry.

Key Features: Provides botanical descriptions, distribution and pharmacological investigations of notable medicinal and herbal plants used to prevent or treat diabetes. Discusses phytochemical and polyherbal formulations for the management of diabetes and other related complications. Contains reports on antidiabetic plants and their potential uses in drug discovery based on their bioactive molecules.

Originally, scientists believed that molecules were three-dimensional; however, studies have proven that geometric dimensions are continuous. Therefore, molecules are able to have higher dimensions which influences how they interact with other molecules leading to advances in various fields including nanomedicine, nanotoxicology and quantum biology. Chemical Compound Structures and the Higher Dimension of Molecules: Emerging Research and Opportunities is a pivotal reference work studying the relationship between chemical compounds and dimensional space. Featuring comprehensive coverage across a range of related topics, such as convex polytypes, Euler-Poincare equations, intermolecular interactions, and the Schrodiner equation, this book is an ideal reference source for academicians, researchers, and advance-level students seeking innovative research on molecule dimensions and interactions.

Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine "Nanorobotics and nanodiagnostics" can be defined as a new generation of biohybrid and nanorobotics that translate fundamental biological principles into engineering design rules, or integrative living components into synthetic structures to create biorobots and nanodiagnotics that perform like natural systems. Nanorobots or nanobots are structured of a nanoscale made of individual assemblies. They can be termed as intelligent systems manufactured with self-assembly strategies by chemical, physical and biological approaches. The nanorobot can determine the structure and enhance the adaptability to the environment in interdisciplinary tasks. "Nanorobotics and nanodiagnostics" is a new generation of biohybrid that translates fundamental biological principles into engineering design rules to create biorobots that perform like natural systems. These biorobotics and diagnostics can now perform various missions to be accomplished certain tasks in the research areas such as integrative biology and biomedicine. "Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine" sheds light on a comprehensive overview of the multidisciplinary areas that explore nanotherapeutics and nanorobotic manipulation in biology and medicine. It provides up-to-date knowledge of the promising fields of integrative biology and biomedicine for nano-assisted biorobotics and diagnostics to detect and treat diseases that will enable new scientific discoveries.