This book provides an integrated account of the phenomenon of acidity set against the background of the acidic substances which are of major significance in the chemical industry and commerce.

This book emphasizes various challenges and opportunities in biopolymers and identifying their potential applications in various fields including food, pharmaceuticals, cosmetics, and electronics. It offers an overview of the environmental-related issues, regulatory and legislative issues, green extraction technologies, and sustainability challenges. It will be interesting and valuable for researchers working in the related field.

This book presents experimental as well as simulation methodologies for analysis and development of nanostructures for introducing the desirable effects through modifications in the basic structure of select nanomaterials. The initial chapters in this book focus on exploring the basic aspects of nanomaterials, e.g., distinguishing features, synthesis, processing, characterization, simulation and application dimensions, or nanostructures that enable novel/enhanced properties or functions. The chapters also cover the size-dependent electronic, optical, and magnetic properties of nanomaterials in exposing the specific properties essential for applications in nanophotonics, nanoplasmonics, nanosystems (e.g., biological, medical, chemical, catalytic, energy, and environmental applications), and nanodevices (e.g., electronic, photonic, magnetic, imaging, diagnostic, and sensor applications). This book is a useful resource for students, researchers, and technologists in gathering recent knowledge on novel nanostructures and their use in different application areas.

This detailed volume explores newly-developed methods in PIWI-interacting RNAs (piRNAs) research, methods currently applied to other ncRNAs involved in nuclear regulation which can be used to study piRNAs, and piRNA methods applied in non-classical organisms. It also includes several bioinformatic and biophysical methods related to piRNA studies, consistent with the increasing importance of high-throughput sequencing and computational methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, piRNA: Methods and Protocols serves as an ideal guide for researchers seeking to elucidate the numerous mysteries of this area of multicellular biology.

Chemistry has a human face and the aim of this resource is to present chemists as real people and not stereotypical 'mad scientists' whose lives are completely dominated by science. It includes carefully chosen examples of chemists through the ages and reflects on the difficulties they overcame. Today we live in a world where scientists are accepted regardless of race or gender, however some examples show that this has not always been the case. Chemists in a Social and Historical Context focuses on strategies for teaching about people in chemistry and is an introduction to some chemists who played a role in the development of major ideas in the subject. This resource includes a range of activities designed to look at different aspects of teaching about people in chemistry and the chemical sciences to 11-19 year old students. It contains teachers' notes, background information, photocopiable student worksheets and answers.

This book presents an authoritative account of the potential of advanced composites such as composites, biocomposites, composites geopolymer, hybrid composites and hybrid biocomposites in aerospace application. It documents how in recent years, composite materials have grown in strength, stature, and significance to become a key material of enhanced scientific interest and resultant research into understanding their behavior for selection and safe use in a wide spectrum of technology-related applications. This collection highlights how their unique combination of superior properties such as low density, high strength, high elastic modulus, high hardness, high temperature capability, and excellent chemical and environmental stability are optimized in technologies within these field.

Food authentication is an issue that has become increasingly important over recent years due in part to the legislative trend away from compositional legislation to label declaration. In the US and Europe working groups have been established to bring scientists, industry and the government together to exchange information about food authenticity. This book surveys the range of analytical methods applied to investigate and confirm authenticity or adulteration. Food manufacturers need to ensure that their products meet the demands of legislation in the countries where they are sold, where as governments need to ensure that tested and valid methods are available to meet the needs of industry and to protect the public from misleading or fradulent labelling. The book assesses the applicability of various methods according to the needs of these different groups. The text should be of interest to analytical chemists, quality assurance personnel, and enforcement officers in local and national governments.

This book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods for modeling the mechanical, physical, and biological properties of biomaterials. The book gathers the proceedings of the 3rd International Conference on Bio and Nanomaterials, held on September 29-October 3, 2019, on an MSC cruise ship navigating the Mediterranean Sea. It particularly highlights Horizon 2020 projects, covering topics such as novel synthetic strategies for nanomaterials, the implementation of bio- and smart materials for pharmacological and medical purposes, as well as environmental applications. Intended for a broad audience of academics and professionals, it offers a comprehensive and timely snapshot of the field of biomaterials. In addition to a set of innovative theories together with the necessary practical tools for their implementation, it also addresses the current challenges in the field, fostering new discussions and possible future collaborations between diverse groups.

Cycloadditions are a very important class of reactions, which can be 1 used to obtain compounds of various ring sizes * Although these ,2 react? been largf: nvnntigated expnnivnntntit consi:fn ee f, :~oversy still fgeir mechanism, A reaction gene' ves the formaci new (J bonds between the reactants at the expense of n bonds. For such processes it is possible to postulate three different mechanisms: i) a synchron.ous concerted approach involving a cyclic transition state (TS) new bonds formed extent: ii)a neynchronous co:,:':" m:"chanism in whict fWO disticc to changes in e:f,me occurring the reactants and the single TS and the others mainly between the TS and products. iii) a two-step process, which occurs in two kinetically distinct steps via a ghnntical intermedintn Renect! gene computed the petential enerse or the ies of prototype tion reaction:f 4a i) the [2+2] cycloadditions H2C=CH2 + H C=CH , H C=O + H C=O,':b 2 2 2 2 H2 = 2 + O=O:4c C CH ii) the 1,3 dipolar cycloaddition HCNO + HC=CH, HCNO + H2C=CH2, H2CNHO 4d + H2C=CHd' 4e iii) cgdoaddition H C=CH * 2 2 have been potential enenpd th (STO-3G)5 ab-ini techniques f:ntcnged (4-31G)6 basis sets. All critical points have been fully optimized 7 using MC-SCF gradient techniques and characterized by diagonalizing 35 the related Hessian matrices computed using finite differences.

This is a completely revised and updated edition of the comprehensive and widely used survey of cereal technology. The first section describes the botany, classification, structure, composition, nutritional importantance and uses of wheat, corn, oats, rye, sorghum, rice and barley, as well as six other grains. The book also details the latest methods of producing, cleaning, and storing these grains. The second section of the book offers current information on the technological and engineering principles of feed milling, flour milling, baking, malting, brewing, manufacturing breakfast cereals, snack food production, wet milling (starch and oil production from grains), rice processing, and other upgrading procedures applied to cereal grains. This section also explains the value and utilization of by-products and examines many rarely discussed processing methods. In addition, the book provides reviews of current knowledge on the dietary importance of cereal proteins, lipids, fibre, vitamins, minerals, and anti-nutrient factors, as well as the effects of processing methods on these materials. This book should be of interest to those involved in agriculture, meat production and food science/technology.

A definitive, single source of information on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.
This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and Aromatic Compounds
* Reactive Vapors in the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and Related Compounds
* Pesticides and Persistent Organic Pollutants
* Dioxin and Related Compounds
* Metals and Inorganic Compounds
* Drugs
* Antineoplastic Agents
* Perinatal Transfer
* Mixtures
* Dermal Exposure Models
In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.

This book, as the fourth volume, continues on ultra-high temperature materials with melting (sublimation or decomposition) points around or over 2500 DegreesC. In this quality the book has over-branched cross-links with the sections and tables of the previous Volumes I-III. Similarly to Volumes I-III, the book includes a thorough treatment of the physical and chemical properties of ultra-high temperature materials, namely such as W semi- and monocarbides, and continues the description of refractory carbides, which was begun from Volume II of the series. The book will be of interest to researchers, engineers, postgraduate, graduate and undergraduate students alike. The readers are provided with the full qualitative and quantitative assessment, which is based on the latest updates in the field of fundamental physics and chemistry, nanotechnology, materials science, design and engineering.

The spectacular culinary creations of modern cuisine are the stuff of countless articles and Instagram feeds. But to a scientist they are also perfect pedagogical explorations into the basic scientific principles of cooking. In Science and Cooking, Harvard professors Michael Brenner, Pia Soerensen and David Weitz bring the classroom to your kitchen to teach the physics and chemistry underlying every recipe. Science and Cooking answers questions such as why we knead bread, what determines the temperature at which we cook a steak or the how much time our chocolate chip cookies should spend in the oven, through fascinating lessons ranging from the role of pressure and boiling points in pecan praline to that of microbes in your coffee. With beautiful full-colour illustrations and recipes, hands-on experiments, and engaging introductions from world-renowned chefs Ferran Adria and Jose Andres, Science and Cooking will change the way readers approach both subjects-in their kitchens and beyond.

Mass Transport in Magmatic Systems describes the properties and processes of these natural occurrences, including a description and discussions of how properties can be used for quantitative description of mass and energy transport on, and in, Earth and terrestrial planets. As the experimentally obtained chemical and physical properties of magma is scattered across literature, this book provides a comprehensive volume on the topic. Moreover, links between properties and processes are rarely appreciated. This makes it challenging for a non-experimentalist to access, evaluate, and apply such data.

With the advent of the Safe Drinking Water Act Amendments of 1986, many water utilities are reexamining their water treatment practices. Upcoming new regulations on disinfection and on disinfection by-products, in particular, are the primary driving forces for the big interest in ozone. It appears that ozone, with its strong disinfection capabilities, and apparently lower levels of disinfection by-products (compared to other disinfectants), may be the oxidant/disinfectant of choice. Many utilities currently using chlorine for oxidation may need to switch due to chlorine by-product concerns. Utilities using chloramines may need to use ozone to meet CT requirements.
This book, prepared by 35 international experts, includes current technology on the design, operation, and control of the ozone process within a drinking water plant. It combines almost 100 years of European ozone design and operating experience with North American design/operations experience and the North American regulatory and utility operational environment. Topics covered include ozone chemistry, toxicology, design consideration, engineering aspects, design of retrofit systems, and the operation and economics of ozone technology. The book contains a "how to" section on ozone treatability studies, which explains what information can be learned using treatability studies, at what scale (bench, pilot, or demonstration plant), and how this information can be used to design full-scale systems. It also includes valuable tips regarding important operating practices, as well as guidance on retrofits and the unique issues involved with retrofitting the ozone process.
With ozone being one of the hottest areas of interest in drinking water, this book will prove essential to all water utilities, design engineers, regulators, and plant managers and supervisors.

This book explores the most important processing steps of proteomics data analysis and presents practical guidelines, as well as software tools, that are both user-friendly and state-of-the-art in chemo- and biostatistics. Beginning with methods to control the false discovery rate (FDR), the volume continues with chapters devoted to software suites for constructing quantitation data tables, missing value related issues, differential analysis software, and more. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice that leads to successful results. Authoritative and practical, Statistical Analysis of Proteomic Data: Methods and Tools serves as an ideal guide for proteomics researchers looking to extract the best of their data with state-of-the art tools while also deepening their understanding of data analysis.

This book presents recent developments and future scopes of glassy systems, such as their electrical and optical properties, use as electrodes, photonics devices, battery applications and others, which are of great interest for material scientists and professionals. Each chapter is designed to increase coherence, containing examples and question sets as exercises for in-depth understanding of the text. It provides a valuable resource for researchers, professionals and students in the area of material research especially on Li-doped glasses.

This volume provides a practical guide providing step-by-step methods and protocols on vaccine development and production. Divided into three volumes, Volume 3: Resources for Vaccine Development guides readers through chapters on vaccine adjuvants, vaccine vectors, production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation, and intellectual property. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 3: Resources for Vaccine Development aims to be a useful practical guide to researchers to help further their study in this field.

This book provides practical guidelines to chemical engineers, plant managers, maintenance engineers, and senior managements in modern chemical processing facilities. It provides guidelines to the readers for operational competencies such as hazard identification (HAZID), hazard operability studies (HAZOP), avoiding mistakes in plant facilities to ensure safety, compliance with various statutory rules and regulations; and management of human resources through improved working conditions, provision of safety equipment etc. It further presents technical information on pressure vessels, design of piping and selection of pumping systems, materials for construction and lining of process units operating at high temperature and corrosive conditions, and criteria for selection of different methods for heating of process units. In addition to its application to existing operations, the book includes information on expansion, diversification, and modernization of facilities and guidelines for revival of old and idle plants. Finally, the authors discuss various safety issues, controlling cost of production, and sustainability topics such as planning and implementing co-generation of steam and power, environmental pollution control for chemical plants and safe disposal of hazardous wastes.

• Describes the endemic plants used in traditional medicine • Includes the chemical and bioactive compounds from desertic medicinal plants • Addresses the analytic techniques to determine chemical and bioactive compounds • Represents an effort to keep the ethnobiological knowledge of communities

Rabies is one of the oldest known pathogens, is incurable, and has the highest fatality rate of all infectious diseases. The Americas is the only region with bat rabies virus, including vampire bat rabies. The region is rich in cultural references and notable for many discoveries in the field, including the current vaccine potency test, diagnostic assay, conception of oral vaccines for wildlife, the first human survivor and the first successful canine rabies program executed at a broad level. Rabies remains the most important viral zoonosis, with tens of thousands of human fatalities and tens of millions of exposures annually, which can be used to model for other pathogens, such as COVID-19. There is an international effort to eliminate human rabies caused by dogs over the next decade, and the Americas represent the primary region with the greatest proof-of-concept evidence to accomplish this goal.  This two-volume set addresses the medical history and modern results of rabies in countries throughout the Americas, including the implications of and on cultural, economic, sociological, and research developments in the region. Volume I presents an overview of concepts critical to the study of rabies in the region, including evolutionary aspects, reservoir ecology and control, elimination efforts, vaccine development, and disease hallmarks and progression. It also analyzes the long-term cultural, social, and economic impacts of the disease in the Americas. 

Volumes 21 to 29 in a 29-volume set which contain all Charles Darwin's published works. Darwin was one of the most influential figures of the 19th century whose work remains a central subject of study in the history of ideas, the history of science, zoology, botany, geology and evolution.