Protein Homeostasis in Drug Discovery Comprehensive resource on all aspects of protein homeostasis, covering both historical perspectives and emerging technologies that are revolutionizing the field Protein Homeostasis in Drug Discovery highlights drug discovery and development efforts targeting protein homeostasis and considers the emerging appreciation that a protein's activity may not be the only factor to consider when developing therapeutic agents. The chapters cover various aspects of protein homeostasis such as cellular localization, abundance, interactions, and more. Moreover, the text contains up-to-date information regarding targeted protein degradation, an emerging drug discovery modality. Readers interested in targeting different regulatory events that control protein homeostasis or modulating protein abundance will find this book an excellent resource. Furthermore, those interested in the link between biological function and regulating protein levels in living organisms, especially in the context of drug discovery, will learn from numerous examples discussed in this book. In Protein Homeostasis in Drug Discovery, readers can expect to find information on: Protein folding, quality control, pharmacology, and drug targeting processes Recent advances in our understanding of protein homeostasis, covering emerging technologies and opportunities for therapeutic intervention Targeted protein degradation (TPD) and strategies such as PROTACs and molecular glues, including a chapter on TPD as an antiviral drug discovery strategy Drug discovery and development efforts aimed at correcting, stabilizing, and rescuing proteins, with examples included Advantages and key shortcomings of both phenotypic and target-based traditional drug discovery methods Collectively, Protein Homeostasis in Drug Discovery offers the reader an opportunity to learn more about the importance of considering and targeting protein homeostasis. The text is a must-read resource for academics, professionals in the pharmaceutical industry, and advanced students in various science-related fields.

Project managers in drug development are the driving force behind the coordination of efforts. This book provides a practical reference for project managers in the pharmaceutical and biotech drug development industry, with the goal of assisting in creating an efficient and effective team structure and environment. The text details the role of project managers at each stage of drug development, the key interfaces that the PM will need to work closely with, and essential tools of the trade including frequently used techniques and methodologies. This book is useful for both entry-level and advanced-level PMs, as well as non-project managers from other functions. Features Includes authors' recent experience with improved tactics and technologies/software at various stages of drug development. Provides the most up-to-date and best practices, techniques, and methodologies in project management. Details the role of the PM at each stage of drug development, including working with the key interfaces throughout the process. Diverse audience including nonproject managers in clinical development, clinical operations, regulatory affairs, medical affairs, clinical pharmacology, and biostatistics. Provides templates and timelines for critical paths from development to commercialization and has potential as a textbook on relevant courses.

The chemistry, physics, and applications of liquid crystals "beyond" LCDs

Liquid Crystals (LCs) combine order and mobility on a molecular and supramolecular level. But while these remarkable states of matter are most commonly associated with visual display technologies, they have important applications for a variety of other fields as well. "Liquid Crystals Beyond Displays: Chemistry, Physics, and Applications" considers these, bringing together cutting-edge research from some of the most promising areas of LC science.

Featuring contributions from respected researchers from around the globe, this edited volume emphasizes the chemistry, physics, and applications of LCs in areas such as photovoltaics, light-emitting diodes, filed-effect transistors, lasers, molecular motors, nanophotonics and biosensors. Specific chapters look at magnetic LCs, lyotropic chromonic LCs, LC-based chemical sensors, LCs in metamaterials, and much more.

Introducing readers to the fundamentals of LC science through the use of illustrative examples, "Liquid Crystals Beyond Displays" covers not only the most recent research in the myriad areas in which LCs are being utilized, but also looks ahead, addressing potential future developments. Designed for physicists, chemists, engineers, and biologists working in academia or industry, as well as graduate students specializing in LC technology, this is the first book to consider LC applications across a wide range of fields.

This book demonstrates the basic and fundamental aspects of nanotechnology and potential application as a photocatalysis in multiple application especially in environment and energy harvesting. This book also contains methods of preparation and characterization of unique nanostructured photocatalysts, and details about their catalytic action. The book consists of seven chapters, including the principles and fundamentals of heterogeneous photocatalysis; the mechanisms and dynamics of surface photocatalysis; research on pure and composites based materials with unique nanostructures; the latest developments and advances in exploiting photocatalyst alternatives to WO3; and photocatalytic materials for applications other than the traditional degradation of pollutants, such as carbon dioxide reduction, water oxidation, a complete spectrum of selective organic transformations and water splitting by photocatalytic reduction. This book will appeal to a wide readership of the academic and industrial researchers and it can also be used in the classroom for undergraduate and graduate students focusing on heterogeneous photocatalysis, sustainable chemistry, energy conversion and storage, nanotechnology, chemical engineering, environmental protection, optoelectronics, sensors, and surface and interface science.

Introduction to nanofluids--their properties, synthesis, characterization, and applications
Nanofluids are attracting a great deal of interest with their enormous potential to provide enhanced performance properties, particularly with respect to heat transfer. In response, this text takes you on a complete journey into the science and technology of nanofluids. The authors cover both the chemical and physical methods for synthesizing nanofluids, explaining the techniques for creating a stable suspension of nanoparticles. You get an overview of the existing models and experimental techniques used in studying nanofluids, alongside discussions of the challenges and problems associated with some of these models.
Next, the authors set forth and explain the heat transfer applications of nanofluids, including microelectronics, fuel cells, and hybrid-powered engines. You also get an introduction to possible future applications in large-scale cooling and biomedicine.
This book is the work of leading pioneers in the field, one of whom holds the first U.S. patent for nanofluids. They have combined their own first-hand knowledge with a thorough review of theliterature. Among the key topics are:
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Synthesis of nanofluids, including dispersion techniques and characterization methods
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Thermal conductivity and thermo-physical properties
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Theoretical models and experimental techniques
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Heat transfer applications in microelectronics, fuel cells, and vehicle engines

This text is written for researchers in any branch of science and technology, without any prerequisite.It therefore includes some basic information describing conduction, convection, and boiling of nanofluids for those readers who may not have adequate background in these areas. Regardless of your background, you'll learn to develop nanofluids not only as coolants, but also for a host ofnew applications on the horizon.

Natural Products Chemistry: Biomedical and Pharmaceutical Phytochemistry focuses on the development of biochemical, biomedical and their applications. It highlights the importance of accomplishing an integration of engineering with biology and medicine to understand and manage the scientific, industrial, and clinical aspects. It also explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. The biological background provided enables readers to comprehend the major problems in biochemical engineering and formulate effective solutions. This title also expands upon current concepts with the latest research and applications, providing both the breadth and depth researchers need. The book also introduces the topic of natural products chemistry with an overview of key concepts. This book is aimed at professionals from industry, academicians engaged in chemical science or natural product chemistry research, and graduate-level students.

This volume offers environmentally friendly technical solutions that can be implemented to solve problems throughout the value chain of the fossil fuel industry. This new book presents an up-to date view of hydrocarbon microbiology and biotechnology, presented by experts around the world with interest in how our expanding understanding of hydrocarbonoclast ecology and physiology can translate to better tools for bioremediation, oil recovery, bio-upgrading of unconventional crudes, the development of biorefining technologies, and the production of hydrogen and electricity from hydrocarbon wastes. The common theme across the chapters in this book is an interest in how developing hydrocarbon biotechnologies may reduce our impact on the global environment. Written by eminent scientists from both academia and industry, the book starts with a historical perspective on hydrocarbon chemistry and formation, petroleum microbiology, and biotechnology. This is followed by a review of recent research developments in bioremediation and other biotechnologies for hydrocarbons, the principal constituents of petroleum and natural gas.

Advanced Porous Biomaterials for Drug Delivery Applications probes cutting-edge progress in the application of advanced porous biomaterials in drug delivery fields. These biomaterials offer promise in improving upon the design, cost, and creation of potent novel drug delivery systems. The book focuses on two categories: nature engineered and synthetic advanced porous biomaterials, with a wide range of low-cost porous biomaterial-based systems that have been used for the delivery of diverse drugs through in vitro/in vivo approaches. Details how advanced porous biomaterial-assisted systems improve essential properties in drug delivery applications Explains how advanced porous biomaterials systems are being used and explored to improve overall performances of drug delivery systems in mitigating a variety of diseases Emphasizes major applications in drug delivery such as controlled release, cancer therapy, and targeted delivery, and with focus on oral, topical, and transdermal applications Focuses on both naturally available and synthetic low-cost advanced porous biomaterials and their role in enhancing important parameters in drug delivery applications Accessible to readers with bio and non-bio backgrounds This book is an ideal reference for academics, researchers, and industry professionals in the interdisciplinary fields of biomedicine and biomedical engineering, pharmaceuticals, materials science, and chemistry.

PREFACE IN the present volume, dealing with the Chemical Technology of the Textile Fibres except as concerns the dye-stuffs, which will be treated in a separate work, the author has been obliged to con- dense the available matter as much as possible, in order to preserve the form of a text-book. Nevertheless, it seemed necessary, in certain cases, in the interests of the book, to give definite data and an exact description of individual processes. In such instances the details have been gathered exclusively either from the authors personal experience or from reliable sources. The most important part of the book is the chapter treating of dyeing, whilst, on the other hand, the subject of printing had to be dealt with in a more general fashion, the materials being less suitable for treatment in text-book style. The author thinks it desirable to point out that in the present work an attempt has been made to completely separate the chemical and mechanical technology of the subject, a standpoint he considers justified by the extensive area occupied by each of these branches. Hence only a few sketches of apparatus have been given and the methods of dressing the finished goods have been described very briefly, since they almost entirely belong to the domain of mechanical technology. The author is indebted to Prof. J. Zipser for the whole of the sketches given, and to Mr. C. Schimke, teacher of dyeing at the Koyal State Trade School, Bielitz, for much assistance in the production of the book. GEOEG VON GEOEGIEVICS Artificial Fibres . Mineral, , . Vegetable Cellulose..... Cotton . . . . Bombax Cotton .... Vegetable Silk .... ..... Flax .- . . ..... Hemp Jute Ramie, Rhea, China Grass, NettleFibre . TABLE OF CONTENTS CHAPTER L THE TEXTILE FIBRES Distinguishing Tests for the Various Fibres Animal Fibres .... Silk . . Animal Hairs . Sheeps Wool . Goat Wool and Camel Wool Artificial Wool Wool Substitutes Conditioning CHAPTER II. WASHING, BLEACHING, CARBONISING Washing and ..... Bleaching Definition Bleaching Agents ... Cotton-Bleaching . . ...... . . . PAGE iii 1 2 2 3 8 12 12 12 16 17 19 20 2-2 23 34 35 45 46 19 50 53 viii CONTENTS Linen-Bleaching . . . Ramie-Bleaching... Hemp-Bleaching... Jute-Bleaching . 76 Scouring and Bleaching Silk 77 Washing and Bleaching Wool ... 80 Blueing or White 86 Dyeing... Carbonising .... 87 CHAPTER III. MORDANTS AND MORDANTING Mordants..... 95 Mordanting Wool . ... 96 Mordanting Silk . . . . . . .98 Mordanting Cotton ....... 99 Alumina Mordants . . . . . . .102 Mordants........ Iron Mordants . . . . . . .,106 ........ Chrome 108 Tin Mordants 112 Copper and other Mordants . . . . . ...... .114 The Fixing Agents Acid Mordants 115 Tannic Acids ... . Oleic Acids . . . PAGE . . . . .116 - . . . . .122 CHAPTER IV. DYEING 1. Theory of Colour Combination of Colours Dyeing to Pattern . . 125 2. Theory of Dyeing . . . . . . 130 3. Classification of Dye-Stuffs Methods of Dyeing . . . ., 138 Application of Acid Dye-Stuffs . . . . Application of Basic v . Dye-Stuffs ., . . .- 143 Application of Direct or Substantive Cotton Dyes...... . Dyes . . 146 Application of the Mordant 154 Dyeing with Cochineal . . . . . .160 Dyeing with Catechu....... 178 Black and Blue Dyeings with Logwood on Wool . . . 163 Turkey-Red Dyeing . .. . -. . .172 Black-Dyeing Cotton with Logwood..... 180 ...

To optimize separations, membranes are imprinted with various molecules. The theory and mechanism of the separation as well as strategies for imprinting are explained in this book. Different molecules and applications are summarized such as imprinting of proteins, ions and cyclodextrins as well as sensor based imprinted membranes and drug delivery in context of molecular imprinting.

Facilitates good understanding of concepts of emerging 2D materials and its applications Covers details of highly sensitive sensors using 2D materials for environmental monitoring Outlines the role of 2D materials in improvement of energy harvesting and storage Details application in biosensing and healthcare for the realization of next-generation biotechnologies for personalized health monitoring and so forth Provides exclusive coverage of inorganic 2D MXenes compounds

Provide knowledge on multiple related fields in application of nanomaterials. Provide most updated literature. Prove readers to understand applications in closely related fields. Consists of examples and illustrations so that readers can absorb the content very fast.

This detailed volume explores techniques in clinical proteomics, an emerging discipline aimed at deciphering the molecular mechanisms underlying the progression of diseases and at identifying new biomarkers and therapeutic targets to expand the physicians' toolbox for precision medicine-based patient care. From sample processing to multi-omics approaches, the book provides straight-forward protocols on a wide array of vital areas of study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Proteomics: Methods and Protocols serves as an ideal guide for researchers working to expand upon the knowledge base needed to push forward toward a more personalized version of medicine.

This book continues the legacy of a well-established reference within the pharmaceutical industry - providing perspective, covering recent developments in technologies that have enabled the expanded use of biomarkers, and discussing biomarker characterization and validation and applications throughout drug discovery and development. Explains where proper use of biomarkers can substantively impact drug development timelines and costs, enable selection of better compounds and reduce late stage attrition, and facilitate personalized medicine Helps readers get a better understanding of biomarkers and how to use them, for example which are accepted by regulators and which still non-validated and exploratory Updates developments in genomic sequencing, and application of large data sets into pre-clinical and clinical testing; and adds new material on data mining, economics, and decision making, personal genetic tools, and wearable monitoring Includes case studies of biomarkers that have helped and hindered decision making Reviews of the first edition: "If you are interested in biomarkers, and it is difficult to imagine anyone reading this who wouldn't be, then this book is for you." (ISSX) and "...provides a good introduction for those new to the area, and yet it can also serve as a detailed reference manual for those practically involved in biomarker implementation." (ChemMedChem)

This book examines the synthesis of graphene obtained from different natural raw materials and waste products as a low-cost, environmentally friendly alternative that delivers a quality final product. Expert researchers review potential sources of natural raw materials and waste products, methods or characterization, graphene synthesis considerations, and important applications. FEATURES Explores the different approaches to the synthesis of graphene oxide (GO) and reduced graphene oxide (rGO) from natural and industrial carbonaceous wastes Outlines the modification and characterization methods of GO and rGO Addresses the characterization methods of GO and rGO Details applications of GO and rGO created from natural sources Graphene is a multidisciplinary material with applications in almost every sector of science and engineering. Graphene from Natural Sources: Synthesis, Characterization, and Applications is a noteworthy reference for material scientists and engineers in academia and industry interested in reducing costs and employing green synthesis methods in their work.

Include advance knowledge and detailed developments in natural product science Discusses about the most important phytopharmaceuticals used in pharmaceutical industries Explores the analysis and classification of novel plant-based medicinal compounds Includes standardization, quality control, global trade of natural products Gives a deep understanding related to recent advances in the herbal medicines to treat various ailments Discusses about national and WHO regulations and policies related to herbal medicine Covers the complete profile of some important traditional medicinal plants especially their historical background, biology and chemistry

Natural Substances for Cancer Prevention explores in detail how numerous investigations in chemical biology and molecular biology have established strong scientific evidence demonstrating how the properties of naturally occurring bioactive chemicals hamper all stages of cancers (from initiation to metastasis). Accordingly, important goals for cancer prevention are the modification of our dietary habits and an increase in the intake of more anticancer-related natural substances. More significantly, the bioactive chemicals presented in the functional foods should be readily available, inexpensive, non-toxic, and nutritional.

This book reviews work that covers everything from basic chemistry to advanced applications. Chitin and chitosan are used in a plethora of applications from wastewater treatment to prosthetics. After introducing the subject of polysaccharides as a whole, the authors turn to the preparation of chitin and chitosan and the characterization of the latter. The book provides information on chitin chemistry, extraction of chitin, chitosan preparation processes, and the applications of their derivatives in various fields. Among the applications that are included in detail are the adsorption of heavy metals for pollution prevention and clean-up, biosensors, cosmetics, various medical applications from anti-tumor activity to bone tissue engineering, agriculture and food production, and proton exchange membranes for fuel cells. Chitin and Chitosan features: * information on molecular structure, synthesis, properties, and latest research related to chitin and chitosan; * coverage of a wide range of topics from the properties of chitosan to its derivatives and applications; * in-depth information on biomedical applications of chitin and chitosan; and * information that can be applied to other biopolymer processing engineering areas. This book will be of interest to practitioners working in a wide variety of industries for which chitin and chitosan are useful materials, researchers in biosensors and heavy-metal adsorption, and to academic researchers investigating the properties, preparation, and uses of these materials.

An NRC Handelsblad Book of the Year "Offers rich discussions of olfactory perception, the conscious and subconscious impacts of smell on behavior and emotion." -Science Decades of cognition research have shown that external stimuli "spark" neural patterns in particular regions of the brain. We think of the brain as a space we can map: here it responds to faces, there it perceives a sensation. But the sense of smell-only recently attracting broader attention in neuroscience-doesn't work this way. So what does the nose tell the brain, and how does the brain understand it? A. S. Barwich turned to experts in neuroscience, psychology, chemistry, and perfumery in an effort to understand the mechanics and meaning of odors. She discovered that scents are often fickle, and do not line up with well-defined neural regions. Upending existing theories of perception, Smellosophy offers a new model for understanding how the brain senses and processes odors. "A beguiling analysis of olfactory experience that is fast becoming a core reference work in the field." -Irish Times "Lively, authoritative...Aims to rehabilitate smell's neglected and marginalized status." -Wall Street Journal "This is a special book...It teaches readers a lot about olfaction. It teaches us even more about what philosophy can be." -Times Literary Supplement

This new edition of Essential Chemistry for Safe Aromatherapy provides an accessible account of the key theoretical aspects of chemistry and their application into the safe practice of aromatherapy. For readers with a limited science background, this book offers a clear and concisely written guide to essential information in chemistry. For practitioners, the book applies chemistry to the practical and therapeutic use of essential oils, and leads to a better understanding of composition, properties and technical data related to essential oils. Takes the fear and mystery out of chemistry for aromatherapy students! Presents crucial information in a clear and easily-digestible format, highlighting key points all along Allows professional aromatherapists to practice with greater confidence, safety and skill, and to extend the range of their practice through a clearer understanding of chemical properties of essential oils. Covers the scope of what is taught at major aromatherapy teaching centres, and structures the material to make sure each chapter provides the reader with a rounded understanding of the topic covered. A glossary is included for easy reference. Fully-updated throughout Chapter 5, Analytical Techniques completely brought up to date Chapter 6 Oil Profiles updated to include those used in current training New section entitled 'In perspectives' covers risks and benefits, interpretation of clinical trials and experimental data, use of essential oils in aromatherapy and functional groups in relation to therapeutic properties

Due to the increasing popularity of herbal-based drugs under the pandemic like COVID 19, the worldwide demand for medicinal plants has increased to aid the immune system. Very timely topic for working on or have an interest in the traditional as well as modern research of medicinal plants. The book can be a useful reference for students, pharmacists, pharmacognosists, chemists, phytochemists, and cosmetic chemists by providing information about fundamental chemical principles, modes of action, and product formulation of bioactive natural products for medical applications.

Gene delivery is a transport of genes of therapeutic values into the chromosomes of the cells or tissues which can be targeted to replace the faulty genes. In last two decades lot of research efforts are dedicated to gene delivery for therapeutic applications. Today gene therapy is promising approach in treatment of genetic diseases including mitochondrial related diseases like blindness, muscular dystrophy, cystic fibrosis, and some cancers. Gene Delivery Systems: Nano Delivery Technologies observes the exploration of nanotechnology for gene therapy and gene delivery. Written by prominent authors in the field, this book covers various aspects of gene delivery including challenges in delivering gene therapy, advances in genome editing, RNA-based gene therapy, Green nanoparticles for oligonucleotide delivery. Additional features include" Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing. Includes knowledge of the current application of CRISPR/Cas9 gene-editing technique; an approach that has recently been given the Noble Prize. Examines the development of mRNA vaccines for Covid -19 in challenging pandemic scenario Discusses siRNA, mRNA, and DNA plasmids.

Addresses simple to advance microscopy techniques for the effective analyses of trace evidence Pairs chapters on a particular type of microscopy, explaining it fully, before delving into specific usage for forensic applications Presents theories and as well as the real-world applications outlining current standards and best practices Provides numerous micro-photographs from authors' and editors' collections, including graphical representations and flow charts to clearly illustrate concepts

Explores the utilization of marine surfactants for biological and biomedical applications Provides depth knowledge on marine surfactant preparations Discusses the development of personal care or cosmeceutical products using marine surfactants Examines various marine derived surfactants for treatment of cancer related diseases Reviews marine surfactants for environmental applications