Five Stars. "Best book available if you want to learn about molecular techniques applied to clinical pathology." - Ruben A., Amazon Reviewer Five Stars. "Easy read. helped me to pass ASCP molecular bio certification exam." - Amazon Reviewer The only book you need to become certified. "Excellent book, full of details and clinical information. In addition, it describes very complexed concepts in a very easy way to understand including comprehensive diagrams." - Ruben G., Amazon Reviewer MB(ASCP) must read. "This is a must read for those laboratory professionals trying to advance their knowledge in molecular diagnostics especially for those people taking the MB(ASCP) exam. Sure it helped me pass the exam." - JR, Amazon Reviewer Meet the challenges of this rapidly expanding field: Molecular diagnostics continues to grow in importance in the clinical laboratory. This respected text will prepare your students with a grounding in the fundamental principles of molecular biology. current methods, and their clinical applications. With a focus on the application of molecular concepts to diagnostic purposes, the text explains and illustrate the use and interpretation of molecular-based assays in patient care. Now with an expanded discussion of nucleic acid sequencing, with added emphasis on next generation sequencing (NGS), and updated coverage of proteomics and mass spectrometry applications, your students will have the most current information available today.

There is a widespread view that modern medicine is primarily a scientific enterprise and that the decisions of clinicians follow from evidence-based science. In terms of this view the need for clinical judgement is minimal. The aims of this book are to make a case for the centrality and irreplaceability of clinical judgement, to identify the elements of good clinical judgement, and to suggest how these might be developed by using the humanities in medical undergraduate and postgraduate education. The authors argue that good clinical judgement requires both technical evidence and a humane attitude. But technical evidence is not always quantifiable or even scientific; it can be like that of the detective or the literary scholar. A humane attitude involves ethical sensitivity, but also a broad educated perspective which can be derived from the arts. The authors illustrate their argument by examining decisions made by doctors in clinical situations, in public health, and (in a chapter contributed by a hospital consultant) in resource management. About the authors: Robert S. Downie is Professor of Moral Philosophy at Glasgow University since 1969. He is a member of the BMA Ethics Committee and co-editor of the Journal of Medical Ethics. He has published extensively in the field of medical ethics. Jane MacNaughton has recently taken the position of Director of Centre for Arts, Humanities, Health and Medicine at the University of Durham. Previously she was Clinical Lecturer in General Practice at Glasgow University and a part-time GP.

This is the second edition of a full colour reference atlas published first to excellent reviews in 1994. Every renal unit needs to have a reference text of this kind and urine microscopy is an important diagnostic aid in nephrology. After the 'Historical Introduction' by J Stewart Cameron, chapter 1 descibes the methods used to prepare and analyse the urine samples. Chapter 2, which is the most important section of the book, describes with the help of 249 illustrations (over 200 in full colour) the elements of the urinary sediment. Chapter 3 deals with the urinary sediment of the normal subject, while chapter 4 deals with the urinary changes which are observed in the main diseases of the kidney and urinary tract. Chapter 5 describes the changes of the urinary sediment caused by drugs. Chapter 6 is about the interpretation of the urinary findings shown in the previous chapters. Chapter 7 covers the new systems to analyse the urinary sediments. An appendix shows how to adjust the microscope to analyse the urine specimens. The primary audience is practising nephrologists and nephrologists in training, and also those in internal medicine rotating through the renal unit who perform routinely the analysis of the urinary sediment. Clinical pathologists would also find this an attractive and useful book. The illustrations are outstanding and additional clinical information has been added in this new edition. From review from the Lancet of the first edition in comparison with a competing title: 'Every nephrologist knows and teaches that urine microscopy is an important diagnostic aid. What has been urgently needed is a colour guide to the subject.....I preferred the pictures in the European book. They were of high quality, not repetitive and with clear legends...if I wanted to teach myself.. then the European book was well ahead. The latter is also accompanied by an elegant introductory essay by JS Cameron on the history of urine analysis. Every renal unit needs at least one of these books.' The Lancet

Magnetic Resonance Procedures: Health Effects and Safety is the first authoritative text on MR procedures and its associated health and safety concerns written by noted radiologists, physicists, and scientists with expertise in the field. It contains both theoretical and practical information.

This timely text discusses emergent issues related to MR imaging and concerns such as shielding, the safe use of contrast agents, and management of patients with claustrophobia, anxiety, and emotional stress. It also contains a sample pre-MR screening form; comprehensive safety information for over 700 implants, devices, and materials; a list of medical devices and products for interventional MR procedures; and a summary of peer-reviewed MR safety studies.

In the wake of recent government demands for increased patient safety in hospitals, along with the rapidly expanding use of MRI, this book is particularly important. It is the definitive resource for information on the safety aspects of magnetic resonance procedures.

Fully revised for its third edition, the Oxford Handbook of Clinical Diagnosis provides a concise and practical summary of the reasoning processes behind clear and confident diagnosis. The handbook is set out systematically with symptoms and signs through each specialty, and includes a detailed description of the basis of logical evidence-based differential diagnosis. This new edition has been updated with more straightforward diagrams as well as brand new images to help aid understanding. Including rarer diagnoses alongside common conditions, and vital information about longer-term management alongside the initial treatments, this handbook will ensure your excellence and confidence no matter what signs and symptoms your patient presents with. Providing practical help when dealing with problems outside your area of expertise or with unforeseen situations, you can be sure that this handbook will be the reader's perfect companion to sharp and self-assured diagnoses throughout their medical career.

Medical practice in the modern age requires familiarity with clinical guidelines and standards, which are often published separately in long and discursive documents. This new addition to the Oxford Medical Publications summarises the key clinical practice guidelines which all final year medical students and Foundation Year 1 and 2 doctors should know when managing common conditions. Logically organised by medical specialty, the reader can quickly familiarise themselves with the key principles of diagnosis and management at the appropriate level for beginning a new rotation on the wards. Each guideline summary is tailored to the education level expected of doctors in their first two years of training, with clear instructions for when a more senior colleague should be called upon to help. Written by a team of junior doctors under the supervision of senior clinicians, this is the first resource to distil a range of guidelines from different locations (such as NICE, SIGN, and more) into an easily digestible format. Practical and user-friendly, with tables, diagrams, flowcharts, and algorithms to convey the key points quickly and easily, Oxford Clinical Guidelines is the new invaluable resource for every final year medical student and doctor at the beginning of their training.

Immunohistochemistry and immunocytochemistry are invaluable tools for the visualization of tissue and cellular antigens in diagnostic and biological research environments. The need to obtain accurate, reliable and reproducible results is paramount. It is with this fundamental aim in mind that we have compiled Immunohistochemistry: Essential Methods. We have achieved this by examining each aspect of immunochemistry in turn, with each chapter including detailed information regarding the subject matter in question. Each chapter is written by an expert in their field and includes protocols that are typically used in their own research. Subjects covered are, amongst others, antibodies and their production; selection of reporter labels; immunochemical staining methods and experimental design (both using single and multiple reporter labels); quality assurance; automated immunochemistry; confocal microscopy and electron microscopy. In addition, benefits and limitations of each approach are discussed within the chapters.

The last ten years have seen an increase in travel to tropical countries and, as a consequence, infections such as malaria and schistosomiasis are more common. It is therefore essential that physicians, microbiologists, and scientists are familiar with the diagnosis of these parasitic diseases. There is a growing recognition of the importance of "temperate" parasites, and this has been emphasized by the HIV epidemic.
This book is a practical manual for use in both routine diagnostic microbiology laboratories and more specialists laboratories diagnosing human parasites. All of the major groups of parasites are dealt with in individual chapters which include detailed protocols and recommendation for the diagnosis of infections caused by those parasites, together with color and black and white illustrations. The authors provide information and practical guidance appropriate for both the developed and developing world. This informative new book will be of great use to clinical pathologists, laboratory technicians, and students and researchers in tropical medicine.

Differential Diagnosis of Autism Spectrum Disorder provides a framework for clinical considerations and best practices related to diagnosing children with autism spectrum disorder (ASD) versus commonly co-occurring conditions. Differential diagnosis is a complex process, and it is common for clinicians to observe symptom overlap between conditions. In this comprehensive text, the authors focus on the similarities and differences between ASD and a second diagnosis. Leading experts provide practical guidance in the diagnostic process for ASD versus a second condition, such as anxiety or attention deficit/hyperactivity disorder. Each chapter includes clinical case studies to provide real-world examples of how clinicians make diagnostic decisions. Ample illustrations and 'decision trees' provide a visual representation of clinical decision-making.

Selected as a Doody's Core Title for 2022! Concise, portable, and user-friendly, The Washington Manual (R) Rheumatology Subspecialty Consult, Third Edition, provides essential information on inpatient and outpatient management of rheumatologic diseases and disorders. This edition offers state-of-the-art content on how to perform the musculoskeletal exam and arthrocentesis, what laboratory testing may prove useful, and which medications are appropriate, including dosages and recommended monitoring. Ideal for residents, fellows, and practicing physicians who need quick access to current scientific and clinical information in rheumatology, the manual is also useful as a first-line resource for internists and other primary care providers. Thoroughly revised content from cover to cover, including new chapters on current topics such as mosquito-transmitted viral arthritis and arthralgias, IgG4-related disease, interstitial lung disease, and cutting-edge technologies in rheumatology. Text covers all aspects of rheumatology, including hereditary periodic fever syndromes, recently approved drugs and biologic agents used in the treatment of rheumatic disease, and much more. Utilizes a highly templated, bulleted format ensuring that you can find what you need quickly and easily. Content is written by residents, fellows, and clinical faculty of the distinguished Washington University School of Medicine in St. Louis. Enrich Your Ebook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech. The Washington Manual (R) is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University.

'...approaches the consultation intuitively ... The book oozes with patience for the patient and for the reader. What better prescription for the clinic could the practitioner need?' Glycosmedia (of the Fifth Edition) '... this is a book worth having available at the point of care for health professionals, including doctors, nurses, undergraduates and postgraduates, to help them make sense of common symptoms. With the help of the authors' opinions in combination with our own experience we should then be able to make better clinical decisions.' Sultan Qaboos University Medical Journal (of the Fourth Edition) Across its six editions, Symptom Sorter has excelled in redressing the balance between symptoms and diagnoses to become the essential handbook to accompany the consultation in primary care. Presenting a multitude of symptoms commonly encountered in primary care, these are meticulously explored using the red flags, top tips and ready reckoner format for sorting symptoms that have made previous editions so popular and respected. This revised and updated sixth edition includes several new chapters and features expanded coverage of paediatric symptoms. Key features: * Fully updated, with 'investigations' sections amended in line with latest guidelines and significant revisions throughout * Brand new chapters on acute abdominal pain in childhood, hand and wrist swellings, diarrhoea in children, loin pain, rectal bleeding in children, vomiting in babies, skinfold rash and dysuria * Consistent and logical presentation enables speedy access * Replicates accurately the experience in the consultation or clinic An invaluable reference for all general practitioners, especially GP trainers and registrars, this new edition of Symptom Sorter is also highly recommended for advanced nurse practitioners, A&E nurses and pharmacists requiring a concise, easy-to-use guide. The authors: Keith Hopcroft is a GP in Basildon, Essex, UK, an associate trainer, an editorial adviser to Pulse, and a medical writer and columnist. Vincent Forte is a former GP based in Norfolk, UK

Because principles of nursing process are the building blocks for all care models, the nursing process is the first model nurses need to learn to "think like a nurse." This trusted resource provides the practical guidance needed to understand and apply each phase of the nursing process, with an increased emphasis on developing both critical thinking and clinical reasoning skills. With an easy-to-follow and engaging writing style, the author provides strategies, tools, and abundant examples to help nurses develop the skills they need to thrive in today's complex health care setting.

In order to accurately describe and diagnose psychiatric illness, practitioners require in-depth knowledge of the signs and symptoms of behavioral disorders. Descriptive Psychopathology provides a broad review of the psychopathology of psychiatric illness, beyond the limitations of the DSM and ICD criteria. Beginning with a discussion of the background to psychiatric classification, the authors explore the problems and limitations of current diagnostic systems. The following chapters then present the principles of psychiatric examination and diagnosis, described with accompanying patient vignettes and summary tables, and related to different diagnostic concerns. A thought-provoking conclusion proposes a restructuring of psychiatric classification based on the psychopathology literature and its validating data. Written for psychiatry and neurology residents, clinical psychologists, behavioral neurologists, clinical psychology students and psychiatric nurse practitioners, it is invaluable to anyone who accepts the responsibility for the care of patients with behavioral syndromes.

What are the ethical issues raised by the increasing use of big data and artificial intelligence in health care? How should physicians respond when they have a conscientious objection to an intervention requested by a patient? How should health care organizations respond to physician requests? How can physicians best help patients make informed decisions about end-of-life and life-sustaining care? How should interns and residents respond to ethical dilemmas created by duty hours restrictions? Resolving Ethical Dilemmas: A Guide for Clinicians helps residents, students, and practitioners work through these and many more common and challenging ethical questions that affect patient care. The 6th Edition reflects important changes in medicine and healthcare policy and provides additional clarity to complex concepts. Offering practical, real-world advice, it helps you think through and resolve difficult cases, prompting thoughtful, well-reasoned answers to the question of "What do I do in this situation?" Begins with a concise discussion of clinical ethics that provides background information essential to understanding key ethical issues. Explores a wide range of real-world ethical dilemmas, each accompanied by expert guidance on salient issues and how to approach them. Provides new insights on cases related to oncology, palliative care, family medicine, clinical practice guidelines, genetic testing, the electronic health record, opioid prescriptions, evidence-based medicine, ambulatory care, quality improvement, and advance care planning. Helps you work thorough challenges such as how to handle changes arising from the Affordable Care Act, how to manage treatment when it no longer works for the patient, and much more. Uses a highly visual, two-color design to facilitate retention of material. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.

This book disseminates information on paper-based diagnostics devices and describes novel paper materials, fabrication techniques, and Basic Paper-based microfluidics/electronics theory. The section on sample preparation, paper-based electronics/sensors for developing paper-based point-of-care (POC) systems also contains detailed descriptions. In the application sections this book covers sensing technique for DNA/RNA, bacteria/virus and integration of lateral flow assay. The book provides deep understanding and knowledge of paper-based diagnostic device development in terms of concept, materials, fabrication and applications.

A physician with thirty-five years of experience treating people with brain injuries shares the latest research on concussions and best practices for care. The explosion of attention to sports concussions has many of us thinking about the addled brains of our football and hockey heroes. But concussions happen to everyone, not just elite athletes. Children fall from high chairs, drivers and cyclists get into accidents, and workers encounter unexpected obstacles on the job. Concussions are prevalent, occurring even during everyday activities. In fact, in less time than it takes to read this sentence, three Americans will experience a concussion. The global statistics are no less staggering. Shaken Brain offers expert advice and urgently needed answers. Elizabeth Sandel, MD, is a board-certified physician who has spent more than three decades treating patients with traumatic brain injuries, training clinicians, and conducting research. Here she explains the scientific evidence for what happens to the brain and body after a concussion. And she shares stories from a diverse group of patients, educating readers on prevention, diagnosis, and treatment. Few people understand that what they do in the aftermath of their injury will make a dramatic difference to their future well-being; patient experiences testify to the best practices for concussion sufferers and their caregivers. Dr. Sandel also shows how to evaluate risks before participating in activities and how to use proven safety strategies to mitigate these risks. Today concussions aren't just injuries-they're big news. And, like anything in the news, they're the subject of much misinformation. Shaken Brain is the resource patients and their families, friends, and caregivers need to understand how concussions occur, what to expect from healthcare providers, and what the long-term consequences may be.

The analysis of blood, bone marrow and tissue fluid specimens requires a multi-faceted approach with the integration of scientific data from a number of disciplines. No single discipline can operate in isolation or errors will occur. Flow cytometry is in a privileged position in that it can provide rapid analysis of specimens and it is often the first definitive investigation to produce results and help formulate a working diagnosis. This companion text to Practical Flow Cytometry in Haematology Diagnosis contains 100 worked examples drawn from real clinical cases presenting to the authors institution. Cases are illustrated with peripheral blood and bone marrow cytology, tissue pathology and cytogenetic and molecular data, which are integrated to generate, where appropriate, a diagnosis based on the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The spectrum of clinical cases includes adult and paediatric patients, and both neoplastic and reactive disorders. The cases appear in no particular order to challenge the reader to make their own diagnosis. The reader will review May Grunwald Giemsa (MGG)-stained films of peripheral blood and bone marrow aspirates presented alongside flow cytometric data and haematoxylin and eosin (H&E)-stained bone marrow and other tissue biopsy sections. Immunohistochemistry is used to further clarify the tissue lineage and cell differentiation. Cytogenetic studies using metaphase preparations are used to identify translocations and chromosome gains and losses whilst interphase fluorescence in situ hybridisation (FISH) studies and polymerase chain reaction (PCR) are used to identify gene fusions, gene rearrangements and deletions. Each case concludes with a discussion of the features that are important to making a diagnosis. The cases are also listed according to disease classification in the appendix so that the text can also be used as a reference. Practical Flow Cytometry in Haematology: 100 Worked Examples: * Provides a practical, example-based resource for flow cytometry * Demonstrates how flow cytometry results should be interpreted and applied to optimize patient care * Includes both malignant and benign conditions * Can be used in conjunction with Practical Flow Cytometry in Haematology Diagnosis, by the same author team (ISBN 9780470671207) Practical Flow Cytometry in Haematology: 100 Worked Examples is ideal for practicing haematologists and histopathologists with an interest in haematopathology, but particularly directed at trainee haematologists and scientists preparing for FRCPath and related examinations.

This book presents different experimental results as evidence of the good results obtained compared with respect to conventional approaches and literature references based on fuzzy logic. Nowadays, the evolution of intelligence systems for decision making has been reached considerable levels of success, as these systems are getting more intelligent and can be of great help to experts in decision making. One of the more important realms in decision making is the area of medical diagnosis, and many kinds of intelligence systems provide the expert good assistance to perform diagnosis; some of these methods are, for example, artificial neural networks (can be very powerful to find tendencies), support vector machines, that avoid overfitting problems, and statistical approaches (e.g., Bayesian). However, the present research is focused on one of the most relevant kinds of intelligent systems, which are the fuzzy systems. The main objective of the present work is the generation of fuzzy diagnosis systems that offer competitive classifiers to be applied in diagnosis systems. To generate these systems, we have proposed a methodology for the automatic design of classifiers and is focused in the Generalized Type-2 Fuzzy Logic, because the uncertainty handling can provide us with the robustness necessary to be competitive with other kinds of methods. In addition, different alternatives to the uncertainty modeling, rules-selection, and optimization have been explored. Besides, different experimental results are presented as evidence of the good results obtained when compared with respect to conventional approaches and literature references based on Fuzzy Logic.

In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.

Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000.

For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human.

In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures.

He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome.

These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

This volume presents several machine intelligence technologies, developed over recent decades, and illustrates how they can be combined in application. One application, the detection of dementia from patterns in speech, is used throughout to illustrate these combinations. This application is a classic stationary pattern detection task, so readers may easily see how these combinations can be applied to other similar tasks. The expositions of the methods are supported by the basic theory they rest upon, and their application is clearly illustrated. The book's goal is to allow readers to select one or more of these methods to quickly apply to their own tasks. Includes a variety of machine intelligent technologies and illustrates how they can work together Shows evolutionary feature subset selection combined with support vector machines and multiple classifiers combined Includes a running case study on intelligent processing relating to Alzheimer's / dementia detection, in addition to several applications of the machine hybrid algorithms

Modern practical medicine requires high tech in diagnostics and therapy and in consequence in education. All disciplines use computers to handle large data bases allowing individual therapy, to interpret large data bases in form of neuronal signals, help visualization of organs during surgery. This book contains chapters on personalised therapy, advanced diagnostics in neurology, modern techniques like robotic surgery (da Vinci robots), 3D-printing and 3D-bioprinting, augmented reality applied in medical diagnostics and therapy. It is impossible without fast large scale data mining in both: clinical data interpretation as well as in hospital organization including hybrid surgery rooms and personal data flow. The book is based on a course for medical students organized in the editor's department. Every year, around 300 international undergraduate medical students take the course.

Volatile biomarkers play a significant signalling role in communication between biological cells living as individual entities or as mini-societies that sense, respond and adapt to changes in their environment. In this process, volatile biomarkers can leak into the blood, from which they can be secreted into most body fluids (blood, breath, skin, urine, saliva, feces, etc.), from which sensing devices can capture and interpret their chemical fingerprint to reflect any association with health disorders in a fast, easy, and minimally non-invasive manner. This book introduces the concept of biomarkers within the body in terms of basic and translational sciences. It starts with a comprehensive review of the expression and mechanistic pathways involving volatile biomarkers at single cell and (micro)organism levels, cell-to-cell and cell-to-organism communications, and their secretion into body fluids. It discusses several ways for discovering and detecting the secreted biomarkers using mass spectrometry and other spectroscopic techniques. This is followed by an appraisal and translation of the accumulating knowledge from the laboratory to the Point-of-Care phase, using selective sensors as well as desktop and wearable artificial sensing devices, e.g., electronic noses and electronic skins, in conjugation with AI-assisted data processing and healthcare decision-making in diagnostics. The book offers an outlook into the challenges in the continuing development of volatile biomarkers and their wider availability to healthcare, which can be substantially improved. It should appeal to research groups in universities, start-up and large-scale industries associated in all aspects of biomedicine.

The revised, updated Fifth Edition of this pocket book is a handy reference to consult when making bedside interpretations of clinical data. Remarkably complete for its small size, the book lists nearly 200 symptoms, physical signs, laboratory test results, and radiologic findings and their differential diagnoses.

This edition has a new, more user-friendly two-color design, tabs indicating sections, and shortened lists of the most common diagnoses. An expanded section on HIV infection covers new manifestations, including immune reconstitution syndrome. The infectious disease chapter has been revised to reflect its increasing importance in clinical medicine, the emergence of multi-drug resistant bacteria, and the threat of bioterrorism.