A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

This is the premiere clinical textbook on neonatal ultrasound diagnosis. Profusely illustrated, including Doppler sonographs in color, it contains eleven original new chapters by prominent clinician-teachers from America s foremost medical schools and teaching hospitals. The entire text focuses on definitive, clinically relevant, how-to information on normal neonatal head ultrasound, congenital malformations of the brain, sonography in periventricular leukomalacia and intraventricular hemorrhage, ultrasound of the neonatal gastrointestinal tract, sonographic evaluation of the neonatal biliary system, the neonatal adrenal gland, kidney abnormalities including embryogenesis and imaging appearance, neonatal hydronephrosis, sonography of the neonatal ovary, developmental displacement of the neonatal hip, and sonography of the neonatal spinal canal.

This popular reference facilitates diagnostic and therapeutic decision making for a wide range of common and often complex problems faced in outpatient and inpatient medicine. Comprehensive algorithmic decision trees guide you through more than 245 disorders organized by sign, symptom, problem, or laboratory abnormality. The brief text accompanying each algorithm explains the key steps of the decision making process, giving you the clear, clinical guidelines you need to successfully manage even your toughest cases. An algorithmic format makes it easy to apply the practical, decision-making approaches used by seasoned clinicians in daily practice. Comprehensive coverage of general and internal medicine helps you successfully diagnose and manage a full range of diseases and disorders related to women's health, emergency medicine, urology, behavioral medicine, pharmacology, and much more. A Table of Contents arranged by organ system helps you to quickly and easily zero in on the information you need. More than a dozen new topics focus on the key diseases and disorders encountered in daily practice. Fully updated decision trees guide you through the latest diagnostic and management guidelines.

The only text to focus specifically on advanced health assessment/management of women This authoritative text for busy clinicians, advanced practice students, and faculty delivers essential content focused on improving the quality of healthcare provided to women/persons with a vagina across the lifespan. Brimming with new and updated content, the fifth edition reflects the most current evidence-based clinical practice guidelines available. It includes 14 new chapters written by experts in their field and the addition of disease management content, especially medications. Chapters are enhanced with management/pharmacology summary charts and case studies with discussion questions. The use of two colors improves readability, and amplified Instructor Resources include key statistics/epidemiology, learning objectives, suggested student activities and self-assessment questions, and UAB videos. Using a clear, concise outline format, this user-friendly text delivers quick, comprehensive information regarding the health assessment and management of women/persons with a vagina. It defines the role, skills, and scope of practice of different health providers and illuminates a variety of assessment skills, techniques, and procedures used by advanced practice clinicians in everyday practice. Sample assessment forms are integrated throughout along with numerous educational handouts for patients. Discussion of techniques includes a comprehensive list of requisite equipment and information on patient prep and recommended follow-up. Boxes, tables, and figures throughout reinforce key information. Purchase includes access to eBook for use on most mobile devices or computers. New to the Fifth Edition: Fourteen new chapters Telehealth in women's health Vaginal health and vaginal microscopy Mental health screening Preconception care Complementary and alternative medical therapies Adolescent health Lactation assessment and management Female veterans Male sexual and reproductive health Amenorrhea PMS/PMDD Sexual health and related problems Human trafficking The contraceptive consult Expanded breast health including breastfeeding Transgender care Updates on screening instruments Best-practice apps Case studies Management/treatment summaries Enhanced instructor package including key statistics/epidemiology, learning objectives, student activities, and self-assessment questions Two-color printing to improve readability Step-by-step videos of five office gynecology simulations from UAB Key Features: Delivered in outline, bulleted format for speedy reference Reflects the most current evidence-based clinical practice guidelines Offers easy-to-follow, step-by-step coverage of procedures Addresses treatment/management of multiple conditions Includes detailed illustrations

Combining the fundamental coverage of a traditional nursing assessment text with a modern, student-friendly presentation and an enhanced emphasis on clinical judgment, Nursing Health Assessment: A Clinical Judgment Approach, 4th Edition, helps students easily develop the understanding, critical thinking, and decision-making skills to excel in any clinical setting. A consistent, two-column format presents normal and abnormal findings and guides students progressively through realistic clinical case scenarios, instilling the nursing knowledge to observe and assess situations, prioritize patient concerns, and generate the best possible solutions. Case-based Next Generation NCLEX (R) (NGN) style questions throughout the text (and answers with rationales in an appendix) align with the NCSBN Clinical Judgment Model (NCJMM) to prepare students for success on the Next Generation NCLEX (R) and to help them confidently deliver safe patient care in any clinical setting. New and Updated Features for the 4th Edition NEW! 180 case-based Next Generation NCLEX (R) (NGN) style questions (and answers with rationales) boost students' exam readiness and test-taking confidence. NEW! NCSBN Clinical Judgment Measurement Model (NCJMM) cues, hypotheses, and evaluation components incorporated into case studies throughout the text strengthen students' critical thinking and decision-making capabilities. UPDATED! New and revised content familiarizes students with social determinants of health, incorporates unbiased language, and reflects current infection and source control measures. UPDATED! Diagnoses incorporate International Classification for Nursing Practice [INCP] language to clarify challenging terminology.

This unique workbook can be used as a stand-alone text or supplemental text for any course designed to enhance the work of radiologic technology students. It will also serve the needs of graduate radiographers as well as the physician in learning specific areas of the Fluoroscopic Image Intensifier such as:

A physician with thirty-five years of experience treating people with brain injuries shares the latest research on concussions and best practices for care. The explosion of attention to sports concussions has many of us thinking about the addled brains of our football and hockey heroes. But concussions happen to everyone, not just elite athletes. Children fall from high chairs, drivers and cyclists get into accidents, and workers encounter unexpected obstacles on the job. Concussions are prevalent, occurring even during everyday activities. In fact, in less time than it takes to read this sentence, three Americans will experience a concussion. The global statistics are no less staggering. Shaken Brain offers expert advice and urgently needed answers. Elizabeth Sandel, MD, is a board-certified physician who has spent more than three decades treating patients with traumatic brain injuries, training clinicians, and conducting research. Here she explains the scientific evidence for what happens to the brain and body after a concussion. And she shares stories from a diverse group of patients, educating readers on prevention, diagnosis, and treatment. Few people understand that what they do in the aftermath of their injury will make a dramatic difference to their future well-being; patient experiences testify to the best practices for concussion sufferers and their caregivers. Dr. Sandel also shows how to evaluate risks before participating in activities and how to use proven safety strategies to mitigate these risks. Today concussions aren't just injuries-they're big news. And, like anything in the news, they're the subject of much misinformation. Shaken Brain is the resource patients and their families, friends, and caregivers need to understand how concussions occur, what to expect from healthcare providers, and what the long-term consequences may be.

BORB provides a set of standardised procedures for assessing neuropsychological disorders of visual object recognition, based on tests developed in the cognitive neuropsychological literature. The tests are introduced in terms of cognitive neuropsychological analyses of object recognition, and guidance is given concerning test use and interpretation.
The tests assess low-level aspects of visual perception (using same-different matching of basic perceptual features, such as orientation, length, position and object size), intermediate visual processes (e.g., matching objects different in viewpoint), access to stored perceptual knowledge about objects (object decision), access to semantic knowledge (function and associative matches) and access to names from object (picture naming). BORB will serve as an invaluable companion test battery to the PALPA test of language ability.

MicroRNA research and development is the billion-dollar baby and most lucrative option for drug discovery in gene therapy industries worldwide. Personalized microRNA treatments are in many cases the only remedy for viral diseases that have no cure in conventional drugs and offer to bring us closer than ever to "personalized medicine." They also counteract cancer and other infectious and neuro-diseases. Early diagnosis, prognosis, staging, and sub-classification of various cancers can easily be facilitated by microRNA-based biomarkers. MicroRNA surveys recent advances in RNA and RNA-protein components that highlight RNA delivery, its stability, and applications of RNA-based drugs for the modulation of gene/protein expression and gene editing. The book not only focuses on the modern medicines of microRNA-based early diagnostic and therapy development, but also works as a hidden treasure for drug discovery of multiple rare diseases worldwide. It offers indispensable learning materials for academic researchers, graduate, and medical students, and offers a powerful practical guide for RNA-Pharma and gene therapy industries.

Volume 66 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Volume65 in the internationally acclaimed "Advances in Clinical Chemistry" contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists.The serialprovides the latest and most up-to-date technologies related to the field of Clinical Chemistry andis the benchmark for novel analytical approaches in the clinical laboratory.
Expertise of international contributorsLatest cutting-edge technologiesComprehensive in scope"

This book is a comprehensive reference on both the structure and content of the clinical interview and its authors present the strategies and fundamental knowledge required to conduct the clinical interview with different kinds of patients and for specific psychopathologies. It provides a thorough overview on clinical and diagnostic interviewing with state-of-the-art presentations of significant theoretical orientations (psychoanalytic, behavioral, humanistic/existential, and family systems) as well as information on frequently encountered psychopathologies. The book stresses the idea that the clinical interview is controlled by the therapist and develops in a phase-sequenced progression along predictable lines. Clinical interviews flow from a theoretical stance on the part of the clinician, are usually semi-structured to the extent that areas are probed consistent with official diagnostic criteria and with know aspects of suspected psychopathologies, including co-morbidities, and include an understanding of the patient's personality and possible personality disorders that may complicate treatment of Axis I disorders or which may be the focus of treatment itself. This book elucidates this process and may serves as a primary source for practitioners who want to know more about the process of clinical interviewing as well as a useful text for those students who are in the process of learning clinical interviewing.

First Aid™ remains the most trusted name in USMLE® review—just ask any medical student!   First Aid Clinical Algorithms for the USMLE Step 2 CK was designed to help you develop and refine your clinical thinking skills—preparing you for success in your clerkship and on the Step 2 CK exam. This new addition to the First Aid™ series uses an algorithmic approach that allows you to methodically walk through the diagnostic decision making process. The content is organized by symptom to reflect how information will be presented in an actual clinical setting. Clinical vignettes focusing on specific illnesses are followed by step-by-step flowcharts outlining the diagnosis and treatment of the illness and its relevant differential diagnoses.  •  Unique algorithmic approach  •  Clinical vignettes accompany decision-making algorithms  •  Flowcharts outline the diagnosis and treatment process  

Over the past 20 years, diagnostic tests for pediatric pulmonologists have revolutionized care of children afflicted with respiratory disorders. These tests have been used to not only help in diagnosis, but also in the management and treatment of these children. Bronchoscopic, imaging and physiologic advances have improved clinical care of these children and have been used as outcome measures in research trials. Diagnostic Tests in Pediatric Pulmonology: Applications and Interpretation describes the various diagnostic modalities (especially the newer ones) that are available for the evaluation of pediatric respiratory disorders. It also provides an understanding of the advantages and limitations of each test so that the clinician may choose the most appropriate ones. An internationally renowned group of authors describe how best to interpret the key findings in a variety of tests as well as the possible pitfalls in incorrect interpretation. This volume focuses on the main diagnostic modalities used in the evaluation of pediatric patients with respiratory disorders and presents up-to-date information on the advantages and limitations of each test for a variety of conditions encountered in the practice of pediatric pulmonology. Clinical utility of these tests is also highlighted. This valuable resource is well suited to practicing clinicians, including pediatric pulmonologists, pediatricians and primary care practitioners, as well as trainees, respiratory therapists and clinical researchers.

Handbook for Clinical Trials of Imaging and Image-Guided Interventions is the first single-source, multi-disciplinary reference, based on the didactic sessions presented at the annual Clinical Trials Methodology Workshop for radiologists, radiation oncologists and imaging scientists (sponsored by the Radiological Society of North America (RSNA)). It focuses on educating radiologists, radiation oncologists and those involved in imaging research with how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. The internationally renowned contributors take a broad approach, starting with principles of technology assessment, and then move into specific topics covering the clinical trials of therapy and clinical research in imaging guided interventions including radiotherapy. They discuss the use of imaging as a predictor of therapeutic response, screening trial design, and the practicalities of how to run an efficient clinical trial and good working practices. Later chapters provide a comprehensive array of quantitative methods including: an introduction to statistical considerations in study design, biostatistical analysis methods and their role in clinical imaging research, methods for quantitative imaging biomarker studies, and an introduction to cost effectiveness analysis. Handbook for Clinical Trials of Imaging and Image-Guided Interventions will educate and prepare radiologists at all levels and in all capacities in planning and conducting clinical imaging trials.

This book collects research works of data-driven medical diagnosis done via Artificial Intelligence based solutions, such as Machine Learning, Deep Learning and Intelligent Optimization. Physical devices powered with Artificial Intelligence are gaining importance in diagnosis and healthcare. Medical data from different sources can also be analyzed via Artificial Intelligence techniques for more effective results.

Following the familiar, easy-to-use at a Glance format, OSCEs at a Glance 2nd Edition is both a revision guide and a comprehensive introduction to objective structured clinical examinations for medical students. Fully revised to suit the current curriculum, and written with student feedback and experiences in mind, this full-colour textbook contains brand new and comprehensively indexed chapters which include 32 new OSCE stations, covering distinct areas of specialisation as well as broader practical and communication skills covered in the exams. This new edition of OSCEs at a Glance is also supported by a companion website at www.ataglanceseries.com/osces containing downloadable OSCE checklists - perfect for testing knowledge in the run-up to exams. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.

'Medical technology is beneficial for well researched dangerous diseases. However, most symptoms that people bring to their primary care physician have no single clearly identifiable cause: investigations and drugs do more harm than good - and also waste resources - ' - Wilfrid Treasure Diagnosis and Risk Management in Primary Care teaches that adopting an evidence-based approach to primary care improves patient care and treatment outcomes. It demonstrates that brief clinical assessments, repeated if necessary, allow effective diagnosis while avoiding the costs and complications associated with more advanced testing. Adopting a fresh approach, this book sets consultation skills alongside evidence-based information by both itemising the specific techniques and facts that are needed in the consulting room, and providing detailed information on odds and likelihood ratios to quantify risk and deal with uncertainty. This book provides food for thought, and helps doctors develop communication skills that support their personal styles of consulting, encouraging a more traditional, intuitive treatment. It provides a map of the consultation and a compass to navigate through symptoms, signs and evidence - listening to their patients with one ear and, with the other, to the reflective inner voice of reason. General Practitioner Specialist Trainees and their teachers will find much of interest, as will established General Practitioners with an interest in maintaining traditional models of care. Undergraduate medical students and candidates for the MRCGP will find this an ideal reader for the clinical skills assessment. 'What a breath of fresh air to find an author capable of putting the patient back at the centre of the consultation and who is able to entertain at the same time as he informs and to stimulate critical reflection while nudging us in the direction of a rigorous approach to diagnosis, and the assessment and communication of risk.' From the foreword by Roger Jones

Diagnosis is central to medical practice, medical knowledge and research, medicalization dynamics, and health and illness experience. Embedded in social relations, diagnoses reflect and shape social dynamics and cultural concerns. Diagnoses are integral to resource allocation, form the basis for identities, and may become a focal point of turf battles and contested authority. Some diagnoses are willingly embraced, whereas others are strenuously resisted. Some diagnoses come and go as fashions; others persist. A sociological approach to diagnosis therefore occupies a complex intersection of diverse subfields including medical sociology, sociology of knowledge, mental health, deviance, social control, sociology of science, social movements, the body, sexualities, gender, and health and illness. This volume explores the breadth of diagnosis and diagnoses through empirical reports, conceptual work, and theoretical statements from diverse perspectives. Reflecting the multi-faceted nature of the emerging field, the book is arranged in five sections: Frameworks, Context, Contestation, Identity, and Social Control. Sociology of Diagnosis thus provides both a starting point for discussion and means with which to organize the nascent conceptual landscape.

Rapid advancement of telecommunications and information technology has created the potential for high-quality expert healthcare to be delivered when and where it is needed. This text charts the development of the telemedicine industry, defines its current scope and reveals the potential of new methodologies.

• Explains the main features of telemedicine and telecare
• Reviews the technology needed for telemedicine
• Describes how to develop, deliver and evaluate telemedicine services
• Considers the associated ethical and legal issues
• Includes an in-depth survey of the literature with over 300 references to research articles and hyperlinks to associated websites

The definitive resource to the signs, symptoms, and patterns of medical diseases that CAN present as psychological problems This invaluable reference enables clinicians, as well as patients and their families, to become more familiar with these medical conditions and how they may masquerade as mental disorders.Part One of this book is organized so that it corresponds to the sections of the Standard Mental Status Exam. It is composed of clinical presentation descriptions that direct the reader to the medical diseases described inPart Two that may be contributing to the patient's discomfort. Without medical jargon, Barbara Schildkrout lucidly explains how patients with each medical condition may end up seeking help from a mental health professional. The conditions explored in this book include: * Alzheimer's disease * Brain tumors * Carbon monoxide poisoning * Diseases of the thyroid * Endocrine disorders * Hepatic encephalopathy * HIV/AIDS * Hyperventilation syndrome * Hypoglycemia * Limbic encephalitis * Lyme disease * Syphilis * Thiamine deficiency * Traumatic brain injury The book also describes a proven process for working with patients during and after the referral process, and integrating medical findings into ongoing therapeutic work. All mental health professionals need access to this information, and Masquerading Symptoms puts it all in a single, easily navigated reference. BARBARA SCHILDKROUT, MD,is an Assistant Clinical Professor of Psychiatry at Harvard Medical School. She has taught for many years at the Beth Israel Deaconess Medical Center. She has a Subspecialty Board Certification through the United Council for Neurological Subspecialties in behavioral neurology and neuropsychiatry and has maintained a private clinical practice in the Boston area for over 25 years.

This pioneering book investigates how biographical evidence has been variously used, misused, or not used at all, by clinicians entirely reliant on biographical evidence for the influential posthumous diagnoses they have produced of Winston Churchill as a manic-depressive. Attention is paid, also, to the distinct question of Churchill and "nerves," otherwise known as neurasthenia. This question has a place alongside the manic-depression issue because, by ensuring there is a marked contrast between two lines of biographical inquiry, it facilitates a significant move in the direction of a more rounded, a more securely founded, understanding of how Churchill functioned psychologically, and how he did not. That goal of a more rounded understanding is important, and the contribution Diagnosing Churchill makes towards its achievement is worthwhile, because accuracy in the depiction of key elements in the functioning of a major historical figure, one of the heroes of Western democratic civilization, is enjoined by a principle Churchill expressed thus: "the meanest historian owes something to the truth."

Western medicine treats sick patients like broken machines -- figure out what is physically wrong, fix it, and send the patient on their way. But humans are not machines. When we are ill, we experience our illness: we become scared, distressed, tired, weary. Our illnesses are not just biological conditions, but human ones. It was Arthur Kleinman, a Harvard psychiatrist and anthropologist, who saw this truth when most of his fellow doctors did not. Based on decades of clinical experience studying and treating chronic illness, The Illness Narratives makes a case for interpreting the illness experience of patients as a core feature of doctoring. Before Being Mortal or The Body Keeps the Score, there was The Illness Narratives. It remains today a prescient and passionate case for bridging the gap between patient and practitioner.

A revision and reference text for pre-registration and postgraduate optometrists, covering procedures for investigating heterophoria, heterotropia, vergence and accommodative anomalies. The text covers the diagnosis of disorders of voluntary eye movement, nystagmus and supranuclear defects, paresis and non-paralytic incomitancy. Both motor and sensory anomalies are discussed together with syndromes involving oculomotor anomalies. Clinical management is outlined in protocols in an easily assimilable form. The second edition has additional information for final year undergraduates. Amblyopia treatment has been extended to cover new American optometric methods. Strabismus surgical techniques are now included. There are two new chapters on vision training and case management which will interest optometrists and orthoptists involved in sports vision and in developmental vision therapy. Pre-registration optometrists will find the chapters on routine orthoptic assessment and the PQE examination of particular interest.