Molecular Diagnostics covers current molecular biological techniques used to identify the underlying molecular defects in inherited disease. Although an increasing number of laboratories, both academic and private are moving in that direction, there are only a few books in the existing literature, and they deal only partly with diagnosis at the molecular level. Each chapter includes the principle and a brief description of the technique, followed by exmples from the authors' own epertise. Contributors are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage.
* Examines widely used molecular biology techniques to screen for genetic defects causing inherited disorders
* Includes state-of-the-art techniques for the detection of the underlying genetic heterogeneity leading to inherited disorders
* Identification of genetically modified organisms (GMO's)
* Forensic analysis and every-day issues in a diagnostic laboratory
* Discusses ethics, genetic counselling and quality management

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.

The definitive resource to the signs, symptoms, and patterns of medical diseases that CAN present as psychological problems This invaluable reference enables clinicians, as well as patients and their families, to become more familiar with these medical conditions and how they may masquerade as mental disorders.Part One of this book is organized so that it corresponds to the sections of the Standard Mental Status Exam. It is composed of clinical presentation descriptions that direct the reader to the medical diseases described inPart Two that may be contributing to the patient's discomfort. Without medical jargon, Barbara Schildkrout lucidly explains how patients with each medical condition may end up seeking help from a mental health professional. The conditions explored in this book include: * Alzheimer's disease * Brain tumors * Carbon monoxide poisoning * Diseases of the thyroid * Endocrine disorders * Hepatic encephalopathy * HIV/AIDS * Hyperventilation syndrome * Hypoglycemia * Limbic encephalitis * Lyme disease * Syphilis * Thiamine deficiency * Traumatic brain injury The book also describes a proven process for working with patients during and after the referral process, and integrating medical findings into ongoing therapeutic work. All mental health professionals need access to this information, and Masquerading Symptoms puts it all in a single, easily navigated reference. BARBARA SCHILDKROUT, MD,is an Assistant Clinical Professor of Psychiatry at Harvard Medical School. She has taught for many years at the Beth Israel Deaconess Medical Center. She has a Subspecialty Board Certification through the United Council for Neurological Subspecialties in behavioral neurology and neuropsychiatry and has maintained a private clinical practice in the Boston area for over 25 years.

This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.

This title includes a Book & DVD. About The DVD: The best-selling book "Arterial Blood Gas Analysis Made Easy" discussion and excerpts are now also available in a DVD movie format. Watch this 55 minute presentation by Dr Anup, MD and learn complex topics like ABG Report, Sa02, Pulse Oximetry, Pa02, PACO2, PaCO2, Fi02, Sp02, A-a Gradient, Ca02, pH, BE and much more. Understand these parameters and common pitfalls while interpreting them. The presentation narrative uses very simple, easy-to-understand language. The viewer will find that the difficult to understand topic of ABGs becomes interesting and easy. This DVD is a must for any new resident in Internal Medicine, Casualty and intensive care units (ICU) and will further facilitate and expedite learning of the blood gas report analysis. Approximate running time: 55 minutes. About The Book: Learn basics about how to read a blood gas report. What are the principle components, how they are derived and what is their significance? This includes pH, PaCO2, PCO2, PaO2, PAO2, FiO2, CaO2, A-a gradient, SaO2, HCO3, Pulse oximetry, Carbon-monoxide poisoning, Hyperbaric Chamber. This is section I of the book. Section II of the book is a work book approach where the doctor learns to interpret blood gases from the given report (emphasis is not to use the graph) in a step by step manner. One learns to interpret simple and mixed disorders including Respiratory Acidosis, Metabolic Acidosis, Anion gap and Non Anion Gap Acidosis, Respiratory Alkalosis, Metabolic Alkalosis, Chloride Responsive and Non-Responsive Alkalosis, Mixed Disorders and common mistakes made while interpreting a blood gas report and how to avoid them. Each disorder is separately explained. Section III further challenges the resident with over 200 exercises on blood gases. Section IV is the summary of the book.

Volume 66 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Volume65 in the internationally acclaimed "Advances in Clinical Chemistry" contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists.The serialprovides the latest and most up-to-date technologies related to the field of Clinical Chemistry andis the benchmark for novel analytical approaches in the clinical laboratory.
Expertise of international contributorsLatest cutting-edge technologiesComprehensive in scope"

Immunoassay techniques have become essential in various fields of pure and applied research. This volume of the well known "Laboratory Techniques" series will be of assistance to those who have plans or are making efforts to develop ultrasensitive enzyme immunoassays for antigens and antibodies.
The volume describes factors limiting the sensitivity of noncompetitive solid phase enzyme immunoassays, methods to overcome difficulties limiting sensitivities, methods to perform ultrasensitive enzyme immunoassays as rapidly as possible, and protocols of enzyme labeling and enzyme assays as well as ultrasensitive enzyme immunoassays.
"Ultrasensitive and Rapid Enzyme Immunoassay, " with its clear presentation and up-to-date information, will be essential to scientists in pharmaceutical companies and in applied research.

There is currently no detailed and comprehensive source of direct information from Chinese sources on the full scope of Traditional Chinese medicine diagnosis. This meticulous translation offers, for the first time in English, an authoritative and detailedcompilation of the principles and practice of TCM diagnostic methods and approaches. This translation has been carefully prepared and polished by translators in both China and the west, and has been edited thoroughly to maximize its accessibility by Western practitioners.Provides a single source for the widest variety of applied approaches and methods to come out in one volume on the topic of diagnosis Covers commonly seen clinical symptoms in separate chapters, detailing possible approaches to diagnosis and lines of exploration

This comprehensive text explains the diagnostic and optometric management procedures involved in the care of patients with binocular vision anomalies. It is a clinically oriented text that can be used by the student as well as the clinician. It provides thorough descriptions of the many binocular vision anomalies, describes the necessary testing procedures to correctly diagnose each disorder, and suggests the most appropriate management. Featuring many illustrations, photos and case studies, particularly on strabismus and incomitant deviations, it presents an orderly practical approach to diagnosis, differential diagnosis and treatment decision making. * Every topic area in binocular vision anomalies is included, from heterophoria and accommodative disorders to severe strabismic disorders. * Discusses not only the most common forms of treatment for a particular anomaly, but also discusses less known but deserving treatment alternatives, providing the reader with an understanding of the full range of treatment possibilities. * In each chapter, an anomaly is identified, then classified according to its significant symptoms and clinical findings. Once a diagnosis is certain, the appropriate forms of treatment are discussed. * Editors Rutstein and Daum are well known and respected in their field. They are scientists who have lectured extensively, have written many articles and have a wealth of clinical experience. * Organized to take the reader from the base to the tip of the "pyramid" of binocular vision. Sensory anomalies are discussed first, integrative anomalies next, and motor anomalies last. * An invaluable reference for both optometrists and ophthalmologists. * Features many references and case studies. * Contains approximately 309 illustrations and photographs, providing the reader with a clear, visual guide to the disorders and their management. * Features clinical pearls succinct bits of "clinical wisdom" that are boxed within the text for easy reference. * Outlines appear at the beginning of each chapter, giving the reader a quick overview of chapter content. * Glossary appears at the end of the book, defining key words that appear in the text.

Oxford Cases in Medicine and Surgery, second edition, teaches students a hypothesis-driven, logical step-by-step approach to diagnosis when faced with each of 29 common patient presentations. This approach mirrors that used by successful clinicians on the wards, challenging students with questions at each stage of a case (history-taking, examination, investigation, management). In tackling these questions, students understand how to critically analyse information and learn to integrate their existing knowledge to a real-life scenario from start to finish. Each chapter focuses on a common presenting symptom (e.g. chest pain). By starting with a symptom, mirroring real life settings, students learn to draw on their knowledge of different physiological systems - for example, cardiology, respiratory, gastroenterology - at the same time. All the major presenting symptoms in general medicine and surgery (mapped to UK medical school curricula) are covered, together with a broad range of pathologies. This book is an essential resource for all medicine students, and provides a modern, well-rounded introduction to life on the wards. Ideal for those starting out in clinical medicine and an ideal refresher for those revising for OSCEs and finals.

Over the last century the ECG has been used by clinicians to make major clinical decisions with regard to electric pacing, the use of thrombolytic drugs in acute myocardial infarction and the timing of surgery. In conjunction with a chest X-ray and the echocardiogram it is a fundamental part of the initial investigation of a patient with suspected heart disease. These electrical squiggles have always been difficult for students to understand. In part the problem has been that the formatting of the ECG has only become standard in the last two decades. Some important books have not provided the full twelve-lead ECG. On occasion the interpretation of the ECG has been related to complex explanations of the shapes of the electrical signals. For the practising physician much of the interpretation is a matter of pattern recognition.

Diagnosing Dental and Orofacial Pain: A Clinical Manual approaches a complex topic in a uniquely practical way. This text offers valuable advice on ways to observe and communicate effectively with patients in pain, how to analyze a patients pain descriptions, and how to provide a proper diagnosis of orofacial pain problems that can arise from a myriad of sources anywhere from teeth, joint and muscle pain, and paranasal sinuses to cluster headaches, neuralgias, neuropathic pain and viral infections. * Helps the student and practitioner understand the diagnostic process by addressing the exact questions that need to be asked and then analyzing verbal and non-verbal responses to these * Edited by experts with decades of clinical and teaching experience, and with contributions from international specialists * Companion website provides additional learning materials including videos, case studies and further practical tips for examination and diagnosis * Includes numerous color photographs and illustrations throughout to enhance text clarity

*The bestselling reference and text, updated throughout for DSM-5--from the author of DSM-5 Made Easy. *Provides a complete course in how to derive an accurate diagnosis, using an active-learning approach. *A virtual roadmap: diagrams, figures, and tables highlight key elements of the process. *Diagnostic strategies are brought to life in over 100 case examples. *Broad audience: used by psychiatrists, psychologists, social workers, nurses, counselors, graduate students, and residents.

The diagnosis and management of ADHD co-occurring with other disorders such as anxiety, depression and personality disorders remain major challenges for clinicians treating all age groups. This book guides clinicians through each step in the diagnosis and management of the comorbidities of adult ADHD on the basis of essential case studies describing psychiatric disorders that frequently occur with ADHD. Each case includes a diagnosis section and management section and is accompanied by questions and answers concerning the most important aspects in diagnosing and managing both ADHD and the comorbid disorders. Drawn from actual clinical encounters, the case studies also feature ample current and valid references.

Epidemiology, the so-called "science of public health," has undergone a boom in the last decade as public interest and engagement in population health has skyrocketed. While this boom has done much to spark advances in the technology of epidemiology, it has also made it harder for those who want to use epidemiology to guide policy and clinical practice to fully appreciate the meaning of the research findings. Interpreting Epidemiologic Evidence offers those who have had an introductory course in epidemiology the knowledge they need to make clear connections from research findings to practical applications. Written in clear and lively prose, it empowers students at all levels to evaluate a study's design, implementation, and ultimate findings, giving the guidance needed to apply the information appropriately. Liberal use of practical examples serves both to illustrate core concepts and to motivate readers to think critically about the causal connections that population health studies aim to explore. Completely revised and updated, this new edition of Interpreting Epidemiologic Evidence is an invaluable core text for both epidemiologists in training and practitioners across other disciplines with even an introductory knowledge of epidemiology.

This book aims to provide condensed and crystallised knowledge, providing the rationale for investigations and interventions. Emergency medicine is a specialty where time and knowledge are critical factors in deciding appropriate management which could otherwise result in loss of life or limb. The challenge often is to have lucid management plans, whilst standing at the bedside of the patient. In order to address this challenge, a manuscript is needed which aims to enhance the clinical skills of the emergency physician. The objective of this book is to compile a road map for practitioners of emergency medicine, which would guide them through algorithm-based pathways. This format is distinctive by nature for its concise presentation, which facilitates easy reading and early application. Written by global experts, this book aims to be a truly international representation of emergency physicians who have come together to deliver contemporary concepts in emergency patient care.