Written specifically for urological trainees by a distinguished team of contributors, this third edition of The Scientific Basis of Urology provides the reader with a thorough coverage of urology. Every area, function, illness and treatment of the urinary tract, along with specific discussions of the relevant anatomy and physiology, is included in clearly written text, abundantly illustrated with full color photographs and diagrams. Each chapter takes the basic principles of its topic area and expands upon them to ensure maximum understanding.

Entirely new chapters in the Third Edition:

• Genetic and Biological Alterations in Cancer
• The Scientific Basis of Male Hypogonadism
• Minimally Invasive Technologies in the Treatment of Renal and Prostate Cancer
• Preoperative Assessment

This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.

This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

Here's a user-friendly, readable introduction to the study of electrocardiography. It guides you in capturing and interpreting ECGs, with an eye towards clinical correlation for easy application to your practice. New in this edition are increased content on pediatric ECGs, implantable cardiodefibrillators, and pacemakers. Comprehensively and expertly describes how to capture and interpret all normal and abnormal ECG findings in adults and children. Features the expertise of internationally recognized authorities on electrocardiography, for advanced assistance in mastering the subtle but critical nuances of this complex diagnostic modality. Features new chapters on pediatric electrocardiography that explore rhythm problems associated with pediatric obesity, heart failure, and athletic activity. Presents a new chapter on recording and interpreting heart rhythms in patients with pacemakers. Includes new material on interpreting ECG findings associated with implantable cardioverter-defibrillators. Provides fully updated coverage on the increased importance of ECGs in stress testing.

Objective Structured Clinical Examinations (OSCEs) are commonly encountered at all levels of medical school including the final MBBS examination. OSCEs also play an important role at postgraduate level and are used to assess competency in the Foundation Years. One of the fundamental requirements of passing the OSCE is an understanding of the standard which is expected and an appreciation of how to demonstrate this. This book discusses 170 commonly encountered OSCE scenarios, with a step-by-step approach to maximise your chances of success in the examination. The scenarios are presented with sufficient background information to enable candidates to tackle variations. This comprehensive book, covering both surgery and medicine, overcomes any problems of a tick-box approach and insufficient detail faced by some alternative texts. The clear, straight-forward style and logical layout make this book perfect preparation for OSCE examinations.

There are numerous advantages to using Bayesian methods in diagnostic medicine, which is why they are employed more and more today in clinical studies. Exploring Bayesian statistics at an introductory level, Bayesian Biostatistics and Diagnostic Medicine illustrates how to apply these methods to solve important problems in medicine and biology. After focusing on the wide range of areas where diagnostic medicine is used, the book introduces Bayesian statistics and the estimation of accuracy by sensitivity, specificity, and positive and negative predictive values for ordinal and continuous diagnostic measurements. The author then discusses patient covariate information and the statistical methods for estimating the agreement among observers. The book also explains the protocol review process for cancer clinical trials, how tumor responses are categorized, how to use WHO and RECIST criteria, and how Bayesian sequential methods are employed to monitor trials and estimate sample sizes. With many tables and figures, this book enables readers to conduct a Bayesian analysis for a large variety of interesting and practical biomedical problems.

Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.

This atlas is an invaluable aid for pathologists and trainees who have worked with conventional smear cytology but need to familiarize themselves with the appearance seen in liquid-based cytology, which has largely replaced conventional smears for cervical screening. It includes state of the art information on normal Pap smears, normal glandular constituents, smear patterns, and inflammation, reactive changes, and repair; it also covers pathological changes, such as typical and atypical squamous cell abnormalities, high-grade intraepithelial lesions, and glandular cell abnormalities. It will be a useful guide for practitioners who need a quick reference on cytological specimens.

The only text to focus specifically on advanced health assessment/management of women This authoritative text for busy clinicians, advanced practice students, and faculty delivers essential content focused on improving the quality of healthcare provided to women/persons with a vagina across the lifespan. Brimming with new and updated content, the fifth edition reflects the most current evidence-based clinical practice guidelines available. It includes 14 new chapters written by experts in their field and the addition of disease management content, especially medications. Chapters are enhanced with management/pharmacology summary charts and case studies with discussion questions. The use of two colors improves readability, and amplified Instructor Resources include key statistics/epidemiology, learning objectives, suggested student activities and self-assessment questions, and UAB videos. Using a clear, concise outline format, this user-friendly text delivers quick, comprehensive information regarding the health assessment and management of women/persons with a vagina. It defines the role, skills, and scope of practice of different health providers and illuminates a variety of assessment skills, techniques, and procedures used by advanced practice clinicians in everyday practice. Sample assessment forms are integrated throughout along with numerous educational handouts for patients. Discussion of techniques includes a comprehensive list of requisite equipment and information on patient prep and recommended follow-up. Boxes, tables, and figures throughout reinforce key information. Purchase includes access to eBook for use on most mobile devices or computers. New to the Fifth Edition: Fourteen new chapters Telehealth in women's health Vaginal health and vaginal microscopy Mental health screening Preconception care Complementary and alternative medical therapies Adolescent health Lactation assessment and management Female veterans Male sexual and reproductive health Amenorrhea PMS/PMDD Sexual health and related problems Human trafficking The contraceptive consult Expanded breast health including breastfeeding Transgender care Updates on screening instruments Best-practice apps Case studies Management/treatment summaries Enhanced instructor package including key statistics/epidemiology, learning objectives, student activities, and self-assessment questions Two-color printing to improve readability Step-by-step videos of five office gynecology simulations from UAB Key Features: Delivered in outline, bulleted format for speedy reference Reflects the most current evidence-based clinical practice guidelines Offers easy-to-follow, step-by-step coverage of procedures Addresses treatment/management of multiple conditions Includes detailed illustrations

In the five years since the publication of the first edition, there have been significant changes in clinical HIV care. The growth of aids in the developing world is continuing at an alarming rate, the introduction of highly-active antiretroviral therapy has presented new complications, and the increased longevity of HIV-infected patients has changed the issues involved in long-term HIV care. The second edition has been completely revised with new clinical information, drug interactions, antiretroviral therapy, and more. The succinct explanations combined with the copious illustrations make this the essential tool for the care and management of HIV patients.

Cutting-edge information on databases for research and clinical practice in neuropathy! Quantitative Electroencephalographic Analysis (QEEG) Databases for Neurotherapy: Description, Validation, and Application examines the strengths and limitations of QEEG databases as a tool for the diagnosis of neurological and psychiatric disorders. This book is written by experts who have had considerable experience in either the development of databases or in working with them. This text can improve your ability to fine-tune existing protocols and develop new ones leading to better treatment, better long-term outcome, and fewer training sessions. Quantitative Electroencephalographic Analysis (QEEG) Databases for Neurotherapy can help you differentiate cognitive states, clinical disorders, and EEG changes throughout the lifespan of a patient. This book also reveals the latest technological developments and methodological practices, and comparisons are made between EEG databases to help you determine what is best for your needs. Several controversies involving quantitative EEGs are discussed, including ethical concerns and early criticisms against the use of these methods for diagnostic purposes. This book addresses important topics such as: the development of methodology for estimating the deviance from the database norms to determine abnormal brain functioning the most widely used QEEG databasestheir construction and application as well as a comparison and contrast of their features the creation of a universal set of standards for determining which database is suitable for a researcher's or practitioner's needs the use of quantitative EEG and normative databases for clinical purposesethical concerns, advantages and limitations, and the proposal for a new clinical approach for neurotherapy the comparison of QEEG reference databases in analysis and in the evaluation of Adult Attention Deficit Hyperactivity Disorder Quantitative Electroencephalographic Analysis (QEEG) Databases for Neurotherapy is supplemented with case studies, tables, figures, and graphs to support the experts' most recent findings. Furthermore, several chapters contain topographic maps to show the effects of these databases in clinical practice. This volume will be helpful to both novice and advanced neurotherapists in professions such as medicine, psychiatry, psychology, social work, nursing, and biofeedback.

" Clinical interviewing with adults is both an art and a science. This handbook will appeal to a wide range of clinical researchers, therapists, interns, and graduate students new to the complexities of the clinical interview and diagnostic process. The comprehensive range of topics and coverage that includes case illustrations with dialogue and differential diagnosis and co morbidity will be highly attractive features to researchers, professional therapists, and graduate students. The Hersen and Thomas team is highly qualified to succeed in this ambitious set of three projects. " Carolyn Brodbeck, "Chapman University"The Handbook of Clinical Interviewing with Adults is one of three interrelated handbooks on the topic of interviewing for specific populations. It presents a combination of theory and practice plus concern with diagnostic entities for readers who work, or one day will work, with adults in clinical settings.The volume begins with general issues (structured versus unstructured interview strategies, mental status examinations, selection of treatment targets and referrals, writing up the intake interview, etc.), moves to a section on major disorders most relevant to adult clients (depression, bipolar disorder, agoraphobia, posttraumatic stress disorder, eating disorders, alcohol and drug abuse, sexual dysfunction, etc.), and concludes with a chapter on special populations and issues (neurologically impaired patients, older adults, behavioral health consultation, etc.)."

This acclaimed text has comprehensive coverage of pathologies affecting the toes and finger nails. This latest edition contains new material on podiatry and investigation techniques including histopathology, ultrasonography and MRI, and dermatoscopy making this an invaluable diagnosis aid for dermatologists and podiatrists.

Information is vital for healthcare professionals striving to keep their practice current and based on the best available evidence. The Internet is playing an increasingly crucial role in life long learning of health professionals and is becoming the most practical way to access publications on clinical guidelines systematic reviews and for updating users about the key aspects of health policy. This book covers the diversity and variable value of material available on the Internet and takes a fresh approach to coping with information overload. It illustrates how simple techniques such as making and using smart maps concept maps and mind maps can help clinicians keep up-to-date and how these methods can be applied to particular areas of healthcare. It provides numerous case studies in key areas including mental health child health primary care and care of the elderly. Mapping Health on the Internet is essential reading for all healthcare professionals and will assist in their learning and continuing professional development.

The analysis of blood, bone marrow and tissue fluid specimens requires a multi-faceted approach with the integration of scientific data from a number of disciplines. No single discipline can operate in isolation or errors will occur. Flow cytometry is in a privileged position in that it can provide rapid analysis of specimens and it is often the first definitive investigation to produce results and help formulate a working diagnosis. This companion text to Practical Flow Cytometry in Haematology Diagnosis contains 100 worked examples drawn from real clinical cases presenting to the authors institution. Cases are illustrated with peripheral blood and bone marrow cytology, tissue pathology and cytogenetic and molecular data, which are integrated to generate, where appropriate, a diagnosis based on the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The spectrum of clinical cases includes adult and paediatric patients, and both neoplastic and reactive disorders. The cases appear in no particular order to challenge the reader to make their own diagnosis. The reader will review May Grunwald Giemsa (MGG)-stained films of peripheral blood and bone marrow aspirates presented alongside flow cytometric data and haematoxylin and eosin (H&E)-stained bone marrow and other tissue biopsy sections. Immunohistochemistry is used to further clarify the tissue lineage and cell differentiation. Cytogenetic studies using metaphase preparations are used to identify translocations and chromosome gains and losses whilst interphase fluorescence in situ hybridisation (FISH) studies and polymerase chain reaction (PCR) are used to identify gene fusions, gene rearrangements and deletions. Each case concludes with a discussion of the features that are important to making a diagnosis. The cases are also listed according to disease classification in the appendix so that the text can also be used as a reference. Practical Flow Cytometry in Haematology: 100 Worked Examples: * Provides a practical, example-based resource for flow cytometry * Demonstrates how flow cytometry results should be interpreted and applied to optimize patient care * Includes both malignant and benign conditions * Can be used in conjunction with Practical Flow Cytometry in Haematology Diagnosis, by the same author team (ISBN 9780470671207) Practical Flow Cytometry in Haematology: 100 Worked Examples is ideal for practicing haematologists and histopathologists with an interest in haematopathology, but particularly directed at trainee haematologists and scientists preparing for FRCPath and related examinations.

MicroRNA research and development is the billion-dollar baby and most lucrative option for drug discovery in gene therapy industries worldwide. Personalized microRNA treatments are in many cases the only remedy for viral diseases that have no cure in conventional drugs and offer to bring us closer than ever to "personalized medicine." They also counteract cancer and other infectious and neuro-diseases. Early diagnosis, prognosis, staging, and sub-classification of various cancers can easily be facilitated by microRNA-based biomarkers. MicroRNA surveys recent advances in RNA and RNA-protein components that highlight RNA delivery, its stability, and applications of RNA-based drugs for the modulation of gene/protein expression and gene editing. The book not only focuses on the modern medicines of microRNA-based early diagnostic and therapy development, but also works as a hidden treasure for drug discovery of multiple rare diseases worldwide. It offers indispensable learning materials for academic researchers, graduate, and medical students, and offers a powerful practical guide for RNA-Pharma and gene therapy industries.

Demonstrating the role of nuclear medicine as a complementary technique to mammography and other imaging modalities for the diagnosis of breast cancer, Radionuclide Imaging of the Breast provides a comprehensive overview of scintimammography-an accurate, safe, and noninvasive imaging method for the evaluation of breast lesions and malignancies. Reveals the encouraging results of multicenter clinical trials in the U.S. and Canada using 99mTc sestamibi breast imaging for the diagnosis of primary breast carcinoma! Addressing nonsurgical sampling of nonpalpable breast lesions as an effective means of providing diagnostic and prognostic information, Radionuclide Imaging of the Breast -discusses increasing the diagnostic value of mammography and its widespread use -examines the reliability of FDG-PET and FDG-SPECT in detecting lymph node involvement and distant metastases -reviews breast cancer imaging with monoclonal antibodies, including murine and bioengineered antibodies -compares the benefits and limitations of Thallium-20l to 99mTc-sestamibi breast imaging in evaluating suspected malignancy -assesses the clinical impact of scintimammography as an adjunctive test to mammography to improve the dependability of diagnoses -considers the possibility of replacing axillary lymph node dissection in patients with small breast cancers with the sentinel node approach -clarifies the importance of surgery in the multimodality treatment of breast cancer -elucidates pathologic difficulties for breast cancer diagnosis -and more! Radionuclide Imaging of the Breast serves as an essential reference for nuclear medicine physicians, radiologists, breast surgeons, medical and surgical oncologists, gynecologists, pathologists, internists, and primary care physicians.

This is a comprehensive, large-format review text with complete answers for the American national examination of the Registry of Diagnostic Medical Sonographers (RDMS). It contains 600 questions divided evenly between sections on physics, the abdomen and small parts, and obstetrics and gynecology. The authors combine many years of experience teaching diagnostic ultrasound and provide illustrative scans and drawings for added comprehension.

A physician with thirty-five years of experience treating people with brain injuries shares the latest research on concussions and best practices for care. The explosion of attention to sports concussions has many of us thinking about the addled brains of our football and hockey heroes. But concussions happen to everyone, not just elite athletes. Children fall from high chairs, drivers and cyclists get into accidents, and workers encounter unexpected obstacles on the job. Concussions are prevalent, occurring even during everyday activities. In fact, in less time than it takes to read this sentence, three Americans will experience a concussion. The global statistics are no less staggering. Shaken Brain offers expert advice and urgently needed answers. Elizabeth Sandel, MD, is a board-certified physician who has spent more than three decades treating patients with traumatic brain injuries, training clinicians, and conducting research. Here she explains the scientific evidence for what happens to the brain and body after a concussion. And she shares stories from a diverse group of patients, educating readers on prevention, diagnosis, and treatment. Few people understand that what they do in the aftermath of their injury will make a dramatic difference to their future well-being; patient experiences testify to the best practices for concussion sufferers and their caregivers. Dr. Sandel also shows how to evaluate risks before participating in activities and how to use proven safety strategies to mitigate these risks. Today concussions aren't just injuries-they're big news. And, like anything in the news, they're the subject of much misinformation. Shaken Brain is the resource patients and their families, friends, and caregivers need to understand how concussions occur, what to expect from healthcare providers, and what the long-term consequences may be.

This unique workbook can be used as a stand-alone text or supplemental text for any course designed to enhance the work of radiologic technology students. It will also serve the needs of graduate radiographers as well as the physician in learning specific areas of the Fluoroscopic Image Intensifier such as:

This is a complete, medically reliable dictionary of congenital malformations and disorders. As the authors explain, "Down syndrome is the only common congenital disorder; the other defects and disorders are rare or very rare, some having been reported fewer than 20 times worldwide." This dictionary covers them all. Examples: Aagenaes syndrome is due to congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant-cell hepatitis with fibrosis of the portal tracts. Acrocallosal syndrome is characterized by total or partial absence of the corpus callosum, craniofacial dysmorphism, polydactyly, and severe mental retardation. Other features can be retinal pigmentation anomalies, optic atrophy, strabismus, nystagmus, cleft lip and palate, cardiovascular anomalies, hernia, abnormal nipples, and fits. Acrodysostosis is characterized by prenatal growth deficiency, brachycephaly, deformities of the humerus, radius and ulna, short and broad hands, hypoplastic maxilla, and mental retardation.

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.

BORB provides a set of standardised procedures for assessing neuropsychological disorders of visual object recognition, based on tests developed in the cognitive neuropsychological literature. The tests are introduced in terms of cognitive neuropsychological analyses of object recognition, and guidance is given concerning test use and interpretation.
The tests assess low-level aspects of visual perception (using same-different matching of basic perceptual features, such as orientation, length, position and object size), intermediate visual processes (e.g., matching objects different in viewpoint), access to stored perceptual knowledge about objects (object decision), access to semantic knowledge (function and associative matches) and access to names from object (picture naming). BORB will serve as an invaluable companion test battery to the PALPA test of language ability.

Not sure how to interpret the wealth of data in front of you?

Do you lack confidence in applying the results of investigations to your clinical decision making?

Then this pocket-sized, quick reference guide to data interpretation may be just right for you.

"The Hands-on Guide to Data Interpretation" is the perfect companion for students, doctors, nurses and other health care professionals who need a reference guide on the ward or when preparing for exams. It focuses on the most common investigations and tests encountered in clinical practice, providing concise summaries of how to confidently interpret investigative findings and, most importantly, how to apply this to clinical decision making.

The benefits of this book include: An overview of the normal ranges of test results, followed by a consideration of the differential diagnoses suggested by variance from these valuesArranged by system to allow quick access to the key investigations encountered in different specialtiesA summary 'patient data' chapter to bring the different specialties together, providing an overview to completing investigation documentation and chartsSummary table and bullet point format, with a full index, to aid rapid retrieval of informationEach chapter reviewed by a specialist to ensure an accurate, practical approach to data interpretation

Take the stress out of data interpretation with "The Hands-on Guide"

Volume 66 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.