Multiple sclerosis (MS) is a progressive neurological disease that affects millions of people worldwide. Currently, the causes of MS are still unclear and the cure remains symptomatic, while the effectiveness of treatment varies widely among individuals. The clinical features and neurological defects derived from this progressive neurological disease are diverse since MS may affect the human central nervous system (CNS)) at all levels from the brain to the end of the spinal cord. Immunopathogenesis of MS involves many steps, including activation of peripheral leucocytes against putative CNS antigens, activated leucocytes with inflamed cerebral endothelial cells, the migration of activated lymphocytes and macrophages through the endothelium to the CNS environment, and further propagation of a massive immune response within the CNS. Such large-scale immune activation leads to loss of the myelin-oligodendrocyte complex. Various types of immune cells and mediators of the immune-inflammatory response actively contribute to MS pathogenesis. Genetic factors are also thought to play a central role in the development of most forms of MS. Axonal degeneration and neuronal loss are the core components of irreversible and permanent CNS atrophy and disability in MS. This book provides a comprehensive overview of the current MS situation as researchers try to understand the process and develop treatments that can slow or stop the disease, possibly repair the damage, alleviate specified symptoms, and improve the abilities of MS patients to function in everyday life. Various biological holistic approaches have been shown to slow disease progression in some patients, and the recovery rate of cellular mechanisms in the brain and spinal cord has been accelerated, increasing the possibility of achieving complete balance of the disease state. The panel reviews the background, focusing on novel strategies that are most likely to understand the biological mechanisms of recovery and translate findings into alternative comprehensive approach to the MS management. The modality of such complementary therapies adds a new dimension, geared to further improvement in the management and sustain the acquired long-term results of MS. This book will be necessary to researchers, research funders, healthcare advocates of MS research and treatment, and interested patients and their families.

The only text to focus specifically on advanced health assessment/management of women This authoritative text for busy clinicians, advanced practice students, and faculty delivers essential content focused on improving the quality of healthcare provided to women/persons with a vagina across the lifespan. Brimming with new and updated content, the fifth edition reflects the most current evidence-based clinical practice guidelines available. It includes 14 new chapters written by experts in their field and the addition of disease management content, especially medications. Chapters are enhanced with management/pharmacology summary charts and case studies with discussion questions. The use of two colors improves readability, and amplified Instructor Resources include key statistics/epidemiology, learning objectives, suggested student activities and self-assessment questions, and UAB videos. Using a clear, concise outline format, this user-friendly text delivers quick, comprehensive information regarding the health assessment and management of women/persons with a vagina. It defines the role, skills, and scope of practice of different health providers and illuminates a variety of assessment skills, techniques, and procedures used by advanced practice clinicians in everyday practice. Sample assessment forms are integrated throughout along with numerous educational handouts for patients. Discussion of techniques includes a comprehensive list of requisite equipment and information on patient prep and recommended follow-up. Boxes, tables, and figures throughout reinforce key information. Purchase includes access to eBook for use on most mobile devices or computers. New to the Fifth Edition: Fourteen new chapters Telehealth in women's health Vaginal health and vaginal microscopy Mental health screening Preconception care Complementary and alternative medical therapies Adolescent health Lactation assessment and management Female veterans Male sexual and reproductive health Amenorrhea PMS/PMDD Sexual health and related problems Human trafficking The contraceptive consult Expanded breast health including breastfeeding Transgender care Updates on screening instruments Best-practice apps Case studies Management/treatment summaries Enhanced instructor package including key statistics/epidemiology, learning objectives, student activities, and self-assessment questions Two-color printing to improve readability Step-by-step videos of five office gynecology simulations from UAB Key Features: Delivered in outline, bulleted format for speedy reference Reflects the most current evidence-based clinical practice guidelines Offers easy-to-follow, step-by-step coverage of procedures Addresses treatment/management of multiple conditions Includes detailed illustrations

A mononeuropathy has to be recognised through physical examination before it can be explained and treated. This practical book provides valuable guidance on examination of peripheral nerves, and then looks at possible causes, prognosis and treatment. Mononeuropathies of the arm, leg and trunk are covered, and causes of mononeuropathies other than focal lesions are included. The easy to follow text is well illustrated with over 90 line diagrams.practical book in the style of Aids to the Examination of the Peripheral Nervous system Each chapter includes anatomy, lesions, causes, and treatmentEach chapter is illustrated by clear line diagrams will be of immediate practical help to office neurologists, and all those undertaking physical examination of patientsof interest to a broad group of physicians, neurologists, orthopaedic surgeons, hand surgeons, and neurosurgeons

This work presents an unflinching look inside the detective story that marks nearly every illness - the diagnosis - revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying.

In order to accurately describe and diagnose psychiatric illness, practitioners require in-depth knowledge of the signs and symptoms of behavioral disorders. Descriptive Psychopathology provides a broad review of the psychopathology of psychiatric illness, beyond the limitations of the DSM and ICD criteria. Beginning with a discussion of the background to psychiatric classification, the authors explore the problems and limitations of current diagnostic systems. The following chapters then present the principles of psychiatric examination and diagnosis, described with accompanying patient vignettes and summary tables, and related to different diagnostic concerns. A thought-provoking conclusion proposes a restructuring of psychiatric classification based on the psychopathology literature and its validating data. Written for psychiatry and neurology residents, clinical psychologists, behavioral neurologists, clinical psychology students and psychiatric nurse practitioners, it is invaluable to anyone who accepts the responsibility for the care of patients with behavioral syndromes.

This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The "Evidence Base of Clinical Diagnosis" has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data.

With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.

"Limb X-Ray Interpretation" provides a comprehensive guide to limb X-ray trauma diagnosis. The content is separated into two distinct parts; part I addresses the technical and professional issues in trauma radiography, from the initial request for an examination to the final image, including the normal and abnormal appearance of bone on radiographs and the classifications of fractures. Part II is subdivided into distinct anatomical regions by chapter describing a systematic approach to the interpretation of X-ray images.

Each chapter follows a similar format with core anatomy linked to the normal radiographic anatomy, using over 570 X-ray images and line drawings. The common and less common fractures, together with specific radiological signs of abnormalities, mechanism of injury and subsequent treatments are presented.

This book is of of great value to Emergency Nurse Practitioners, Accident and Emergency staff, radiographers, junior doctors, medical students, and physiotherapists.

"Sound Diagnosis" to the rescue - a little prompt at the bedside, when you need sound guidance to see through a hazy clinical picture and make sense of a problem in the most lucid and confident way. How will you benefit from this diagnosticum? As your bedside companion it will: shed bright light on unclarified diagnostic pictures; encourage use of a systematic method of diagnosis; structure and simplify diagnosis; help you define a problem; make you notice and respond to diagnostic key pointers; direct your energies to the core of the problem; give your knowledge an opportunity to surface; make you more aware and open to reading signs of disease; serve as a ward-round guide; keep you fresh and motivated with each case; and, tie up the loose ends, enabling you to complete a diagnosis.

This groundbreaking book explains prognosis from the perspective of doctors, examining why physicians are reluctant to predict the future, how doctors use prognosis, the symbolism it contains, and the emotional difficulties it involves. Drawing on his experiences as a doctor and sociologist, Nicholas Christakis interviewed scores of physicians and searched dozens of medical textbooks and medical school curricula for discussions of prognosis in an attempt to get to the core of this nebulous medical issue that, despite its importance, is only partially understood and rarely discussed.
"Highly recommended for everyone from patients wrestling with their personal prognosis to any medical practitioner touched by this bioethical dilemma."--"Library Journal, " starred review
" T]he first full general discussion of prognosis ever written. . . . A] manifesto for a form of prognosis that's equal parts prediction-an assessment of likely outcomes based on statistical averages-and prophecy, an intuition of what lies ahead."--Jeff Sharlet, "Chicago Reader"
" S]ophisticated, extraordinarily well supported, and compelling. . . . Christakis] argues forcefully that the profession must take responsibility for the current widespread avoidance of prognosis and change the present culture. This prophet is one whose advice we would do well to heed."--James Tulsky, M.D., "New England Journal of Medicine"

Diagnostic Pathology: Hospital Autopsy, a volume in the highly regarded Diagnostic Pathology series, is the first reference to present autopsy pathology in the way in which it is practiced clinically. The unique approach in presenting classic autopsy techniques also emphasizes the role of molecular studies and other laboratory and ancillary tests (cytology, radiographic analysis) not commonly thought of during autopsy practice. The practices covered will help maximize diagnostic information from each and every autopsy. Complete coverage of every aspect of autopsy practice-including clinical presentation with chart review, technical and diagnostic aspects of autopsy performance, and reporting-makes this an invaluable guide for the resident in training and practicing pathologist. Cases presented as seen in clinical practice, from clinical chart review through autopsy performance and important reporting criteria Topical chapters are organized more broadly while disease-specific chapters are similar to other surgical pathology chapters in the Diagnostic Pathology series Detailed dissection descriptions in the organ system chapters provide step-by-step guidance with even the most difficult technical aspects of autopsy performance Approximately 1,500 high-quality, carefully annotated color images provide important clinical and diagnostic information Chapters covering every system and expanded sections with key clinical information help the pathologist perform the most comprehensive evaluations Case presentation highlights important aspects of reporting that impact clinicians as well as next of kin Expert Consult eBook version included, which allows you to search all of the text, figures, and references from the book on a variety of devices

The past few years have witnessed rapid progress in the characterization of mechanisms that underlie the generation and processing of inter- and intracellular signals. While there have been significant corollary advances in the area of signaling in disease processes, there is as yet no single resource that connects these advances with an understanding of disease processes and applications for novel therapeutics. Collecting chapters from the leading experts in their respective fields, editors Toren Finkel and Silvio Gutkind deliver a much-needed introduction to signaling and a fruitful discussion of promising directions for future research.

Signal Transduction and Human Disease capitalizes on the current emphasis on translational research and biological relevance in biotechnology and, conversely, the importance of molecular approaches for clinical research. Each chapter conveys the sense of a disease process, what it affects, how it presents, how common it is, and what the treatments are. Clinical descriptions are not exhaustive but rather serve as an outline regarding the disease’s manifestations and current treatment options. Following this introduction, the authors present an in-depth discussion of one or two signal transduction pathways or biological processes relevant to the disease. The editors divide their study into five sections:

• Cardio-Pulmonary Disease
• Oncology
• Endocrinology
• Infectious Disease
• Allergy/Rheumatology
• Neurology/Psychiatry

Biochemists, molecular and cell biologists, immunologists, pharmacologists, and clinical researchers, as well as graduate students in a variety of scientific disciplines, will find Signal Transduction and Human Disease to be an invaluable addition to the literature.

Carpenito's best-selling, Handbook of Nursing Diagnosis, now in an impressive sixteenth edition, is the ideal quick reference for nursing diagnosis information. This handbook offers practical guidance on nursing diagnoses and associated care. The quick-reference type scope of content, makes it easy for students to use while in clinical, in the classroom or simulation lab. From goals to specific interventions, Handbook of Nursing Diagnosis focuses on nursing. It provides a condensed, organized outline of clinical nursing practice designed to communicate creative clinical nursing. It is not meant to replace nursing textbooks, but rather to provide nurses who work in a variety of settings with the information they need without requiring a time-consuming review of the literature. It will assist students in transferring their theoretical knowledge to clinical practice. This is a must-have reference that nursing students will use throughout their curriculum and into their professional career.

Part of the highly regarded Diagnostic Pathology series, this updated volume covers more than 180 of the most common pediatric pathology diagnoses using a highly visual, quick-reference format. Thorough updates include the most recent clinical, pathological, histological, and molecular knowledge in the field, highlighted by more than 2,400 outstanding images. A comprehensive, practice-oriented approach makes this reference ideal for pathologists, residents, or fellows. Essential knowledge in all areas of pediatric pathology, including the most important benign and malignant diagnoses for every major organ system Unmatched visual coverage, with carefully annotated clinical images, gross pathology, histology, and special and immunohistochemical stains that provide clinically and diagnostically important information on typical and variant disease features Layout designed to help you identify crucial elements of each diagnosis along with associated differential diagnoses and pitfalls, to more quickly resolve problems during routine signout of cases Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index Thoroughly updated content throughout, reflecting new nomenclature; molecular findings, classifications, and reclassifications such as "integrated diagnosis" in the CNS chapters; CNS tumors and entity designations based on molecular findings; reclassifications of soft tissue lesions and new molecular findings recently described in undifferentiated round cell sarcoma/Ewing-like sarcomas and DICER-1 sarcoma; updates to all hematologic diagnoses to reflect the new 2016 WHO classification; and more histologic images and updated references New coverage of vascular lesions using the International Society for the Study of Vascular Anomalies (ISSVA) classification Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This title contains 2 DVDs. DVD 1 - "Essentials of ABG": Understand in simple language various parameters of the blood gas report including the Sa02, Pa02, PB, Pi02, Fi02, PaCO2, A-a D02, pH and much more. Understand how and why normal and abnormal values are achieved and what their clinical signifi-cance is. This DVD is at least equivalent to 10 hours of reading. DVD 2 - "Details of ABG": It explains step by step as to how to interpret the blood gas report without using a paper, pen or calculator; It discusses simple and then mixed acid base disorders. Common conditions like metabolic acidosis, metabolic alkalosis, Respiratory Acidosis are explained in more details. This DVD is equivalent to at least 20 hours of reading and trains the reader for a life time in less than an hour.

Renowned for its holistic perspective and "see and do" approach, Nurses' Handbook of Health Assessment, 10th Edition delivers streamlined, step-by-step guidance at every phase of nursing assessment to help students ensure accurate and effective assessments across all patient populations. This full-color handbook - updated to reflect the latest clinical insights in Health Assessment for Nursing, 7th Edition - details everything students need to interview clients and conduct thorough physical assessments with ease, including up-to-date assessment guidelines, full-color anatomy and physiology illustrations, images of normal and abnormal findings, and more - all in a convenient format ideal for today's on-the-go learning. Ensure mastery of essential nursing skills and equip students for success throughout the nursing education continuum with the complete Health Assessment in Nursing, 7th Edition solution (available for separate purchase): Health Assessment in Nursing, 7th Edition Lippincott (R) CoursePoint+ for Health Assessment in Nursing, 7th Edition Nurses' Handbook of Health Assessment, 10th Edition vSim (R) for Nursing / Health Assessment Lippincott (R) DocuCare

Renowned for its holistic perspective and "see and do" approach, Nurses' Handbook of Health Assessment, 10th Edition delivers streamlined, step-by-step guidance at every phase of nursing assessment to help students ensure accurate and effective assessments across all patient populations. This full-color handbook - updated to reflect the latest clinical insights in Health Assessment for Nursing, 7th Edition - details everything students need to interview clients and conduct thorough physical assessments with ease, including up-to-date assessment guidelines, full-color anatomy and physiology illustrations, images of normal and abnormal findings, and more - all in a convenient format ideal for today's on-the-go learning.

Reviews of the First Edition . . .

"This is the first major manual on Bender Gestalt testing in over 30 years, and includes detailed administration and scoring instructions, and data on validity and reliability." —Epilepsia.

"This book will provide both psychologists and psychiatrists [with] a comprehensive yet easy-to-use manual for screening brain dysfunction." —Contemporary Psychiatry.

"Dr. Lacks should be complimented for her treatment of the use of the BGT in screening for organic brain dysfunction." —Book Reviews in Neurosciences.

Utilized for over 60 years by clinicians worldwide, the Bender Gestalt Test (BGT) today continues to be a widely used assessment tool to measure the cognitive domain of visuoconstructive abilities and to screen for brain dysfunction. Much of the BGT's popularity rests on its brevity, simplicity, and proven effectiveness with individuals from age 4 to 100. The test is often employed in inpatient psychiatric settings because of its ability to discriminate between brain impairment and serious mental disorders like schizophrenia. More recently, the BGT has also been used to identify older adults at high risk for cognitive decline.

This Second Edition is fully revised and includes an up-to-date review of the relevant scientific literature on the test's reliability, validity, and diagnostic accuracy. The book also contains additional normative data, a discussion of malingering, and almost all new examples and practice case materials. Five new chapters address issues in neuropsychological screening, eight steps to interpretation of test results, and use of the Bender Gestalt Test with children, adolescents, and older adults.

The book serves as a comprehensive manual for the administration, scoring, and interpretation of the Bender Gestalt Test. The diagnostic significance of general and specific behavioral observations is stressed and a format for recording them is included. For scoring, there are descriptions and multiple examples within the author's adaptation of the 12 errors of the Hutt and Briskin scoring system. The reader can use the 12 varied clinical case examples with explication of the scoring and 10 additional practice cases to gain rapid scoring facility and accuracy. Norms are provided for adult non-patients and psychiatric inpatients, nonpatient and demented older adults, and adolescents.

Designed for practical use and adhering to APA standards for test manuals, Bender Gestalt Screening for Brain Dysfunction is a comprehensive and easy-to-use manual that will enable psychology clinicians, psychometricians, and graduate students to increase their level of diagnostic accuracy in screening for brain damage.

Written entirely by surgical endoscopists, Principles of Flexible Endoscopy for Surgeons presents a comprehensive overview of past, present, and future flexible gastrointestinal endoscopic techniques, with a focus on educating surgeons who may or may not already have the skills to perform flexible endoscopy. In addition to the endoscopic management of surgical issues, the volume describes the role of surgery in the management of endoscopic complications. Basic as well as advanced flexible endoscopic techniques are presented in both a didactic and visual mode, with representative endoscopic images and video clips. Recent endoscopic advancements which are not routinely a core component of surgical training programs are also covered in detail. Extensively illustrated with endoscopic images and accompanied by a DVD, Principles of Flexible Endoscopy for Surgeons is a valuable resource for surgeons on all facets of flexible endoscopy.

This text will be of enormous value to anyone involved in the monitoring and investigation of adverse medical events occurring during the clinical trials, or during the post marketing period of a drug. The book reviews the biochemical and physiological abnormalities in each of the bodys organ systems and helps the investigator decide if the problem is of drug-induced origin. Most of the information is presented as a series of observations with accompanying questions which should be addressed in order to make an accurate diagnosis. Easy-to-read with useful flow charts for the management of adverse drug events and examples of specific report forms, this text will be of interest to all those involved in drug monitoring in clinical medicine, pharmaceutical companies, contract research organisations or regulatory authorities.

Pocket Nephrology is a practical, high-yield reference offering current, evidence-based practices and expert guidance from physicians at the world-renowned Columbia University Medical Center. Featuring an easy-to-use loose-leaf format, it can be used as a portable diagnosis and treatment reference, as a quick dosage check, as a review for complex glomerular diseases and acid-base physiology, and for board preparation. Mirrors the thought process of nephrologists in day-to-day practice. Contains the latest clinical guidelines and new therapeutic recommendations. Follows the popular Pocket Notebook format, featuring bulleted lists, tables, diagrams, and algorithms that make essential facts easy to find and retain. Covers all topics encountered in nephrology practice, categorized by subspecialties, making it ideal for trainees in nephrology as well as practicing nephrology consultants with years of experience. Written by current and former faculty members and fellows from Columbia University Medical Center. Enrich Your Ebook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Following the familiar, easy-to-use at a Glance format, OSCEs at a Glance 2nd Edition is both a revision guide and a comprehensive introduction to objective structured clinical examinations for medical students. Fully revised to suit the current curriculum, and written with student feedback and experiences in mind, this full-colour textbook contains brand new and comprehensively indexed chapters which include 32 new OSCE stations, covering distinct areas of specialisation as well as broader practical and communication skills covered in the exams. This new edition of OSCEs at a Glance is also supported by a companion website at www.ataglanceseries.com/osces containing downloadable OSCE checklists - perfect for testing knowledge in the run-up to exams. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.

The diagnosis and monitoring of hematological malignancies is complex and requires a systematic approach. Morphology, cell phenotyping, cytogenetics and molecular genetics are essential, and the results must be integrated. Diagnostic Techniques in Hematological Malignancies details the principles and applications of each of these test types in the diagnosis of hematological malignancies in blood and bone marrow. The first section describes the test modalities - including methodological principles, data interpretation and limitations - and is illustrated by clinical examples. The second section focuses on the clinical entities, detailing the most appropriate tests for diagnosis, staging and monitoring of different hematological malignancies and includes test utilization to identify prognostic markers and potential therapeutic targets. With contributions from multiple international experts, this illustrated book is an essential resource for qualified and trainee hematologists, oncologists, and pathologists. It's a practical and useful guide, providing a rational and structured approach to the laboratory assessment of hematological malignancies.

A classic text, Chamberlain's Symptoms and Signs in Clinical Medicine has been providing students and professionals with a detailed and well-illustrated account of the symptoms and signs of diseases affecting all the body systems since the first edition published in 1936. Now completely rewritten by a new team of authors selected for their experience and reputation in writing quality publications in their specialist fields, the 13th edition brings the title into line with current teaching and practice. One of the key challenges of writing a textbook of diagnostic medicine is to balance the "bottom up" approach of constructing a differential diagnosis from individual clinical findings, and the "top down" approach of learning the key features pertaining to a particular diagnosis. The 13th edition of Chamberlain's Symptoms and Signs in Clinical Medicine integrates both approaches into a coherent working framework that will assist the reader in preparing for academic and professional examinations, and in everyday practice. Presented in full colour and illustrated with relevant images, this book provides a thorough lesson in diagnostic medicine, ensuring the reader is fully prepared to deal with the challenging process of differential diagnosis through a thorough knowledge of the central features of the conditions that they are likely to encounter. Key features: Teaches the reader how to diagnose correctly through assessment of symptoms and signs while simultaneously recalling all key features of a given condition Full colour and generously illustrated Conforms with the core competencies required for the foundation years Includes bullet point lists and tip boxes Chapters conclude with a summary of key points for easy revision Written and edited by a highly experienced team of specialists Companion website

Everything you need to know about the DSM-5 in an organized and concise presentation Providing you with a quick and easy way to get up-to-speed on recent changes to the two main classification systems DSM-5 Essentials highlights these changes in a logical and systematic manner so that you can easily make the transition from DSM-IV to DSM-5. Author Lourie Reichenberg offers health care providers, instructors, clinicians in practice settings, and office staff who do coding for insurance reimbursement the information they need to do their jobs smoothly and efficiently with coverage of: * The twenty classifications of disorders * Emerging measures and models * The future of diagnosis and treatment planning * Matching clients' needs with the best evidence-based treatment * Major changes to the DSM-5 such as the replacement of the multiaxial system, the developmental and lifespan approach, and cultural and gender considerations Arranged in the same sequence as the DSM-5, DSM-5 Essentials covers what has changed from the DSM-IV, what these changes mean for diagnosis, and the implication of these changes on the selection of effective, evidence-based treatment.