Gastroesophageal reflux disease (GERD) is one of the most common disorders with an increasing prevalence and incidence in the last two decades. This book, edited by two experienced surgeons and a clinical psychologist in cooperation with numerous worldwide leading experts, presents clinically relevant information for gastroenterologists, internists, surgeons, residents and also nurses, who frequently care for GERD patients. Focusing on different treatment concepts - medical, endoscopic as well as surgical - the chapters include the basics of symptomatology and epidemiology, pathophysiology, GERD among different age groups, complications and its treatment, hiatal hernia or H. pylori and GERD, NERD and functional heartburn, diagnostic procedures and also presurgical examination. In addition, the patient's perspectives of disease, diagnostics and treatment are included, the same as economic aspects of GERD, and the impact of disease on quality of life or patient-reported outcomes after treatment.

Movement disorders affect a growing patient population, but providing comprehensive care is extremely difficult. Several of these conditions are progressive and incurable; the basal ganglia has a complex role in movement control, with many potential malfunctions. This book focuses on rehabilitation approaches that have been developed and utilized internationally in an attempt to minimize impairment and maximize participation amongst these patients. Each chapter is written by movement disorder experts, rehabilitation specialists and health care professionals, giving a broad overview of current interventions and emphasizing the need for interdisciplinary management, focussing on deliverable outcomes. Common conditions such as Parkinson's disease, cerebral palsy, dystonia and Huntington's disease are comprehensively covered. This book gives neurologists, geriatricians and rehabilitation specialists an up-to-date, theoretically-based approach to managing movement disorders related to basal ganglia malfunction. Also valuable for physiotherapists, occupational therapists, speech pathologists, nurses and social workers seeking to develop and plan appropriate interventions.

As a result of the rapidly growing rate of obesity worldwide, clinicians are struggling to provide the best strategies for treating obese patients with concomitant pulmonary conditions. Obesity does not simply change the epidemiology of pulmonary disease; obesity has a profound impact on the pathophysiology of common pulmonary diseases. Obesity affects the severity of asthma, response to treatment, and is likely a major modifier of the phenotype of asthma. Obesity also appears to affect response to pathogens, and as such has a major influence on response to pneumonia, and has a significant impact on outcomes pertaining to acute lung injury in the intensive care unit. Obesity and Lung Disease: A Guide to Management is the first text in the field to cover the full range of issues related to managing obese patients with pulmonary problems. All the relevant conditions, in the context of obesity, are covered, including airway inflammation, sleep apnea, asthma, pulmonary hypertension, obesity hypoventilation, as well as others. Written by an international group of experts, this important new volume is an invaluable resource for all clinicians and scientists concerned with the challenging problems surrounding obesity and lung diseases.

This volume thoroughly examines breast cancer stem cells (BCSCs), from basic definitions to techniques for identifying, isolating, culturing, and targeting BCSCs for therapy; there is additional focus on pre-clinical and clinical results. The text begins with a discussion of breast cancer, focusing especially on the limitations of current therapies in its treatment. The subsequent chapters introduce and compare stem cells and cancer stem cells, describe properties and isolation techniques of BCSCs, and examine BCSC-targeting approaches. The text concludes with a discussion of controversy surrounding the BCSC hypothesis and of future research directions. Breast Cancer Stem Cells & Therapy Resistance, part of the SpringerBriefs in Stem Cells series, provides a succinct yet comprehensive overview of BCSCs for advanced students, graduate students and researchers as well as those working with breast cancer or stem cells in a clinical setting.

"The Successful Occupational Therapy Fieldwork Student" is a stimulating new book that paves the way to the profession of occupational therapy. This book fulfills the needs of all OT and OTA students throughout their entire education by fully preparing them for their fieldwork assignments. This is an imperative learning tool for all students since all curricula include Level I and II fieldwork requirements, ranging from the associate's level to a master's program.

This complete fieldwork book contains a wide array of topics that guide the reader from the initial planning steps to the completion of successful fieldwork, including how to design fieldwork as a supervisor. It provides students with the opportunity to not only assess various situations, but also utilize their knowledge to demonstrate clinical reasoning. A multitude of activities are included from the first page to the last, designed to groom students for their fieldwork.

"The Successful Occupational Therapy Fieldwork Student" is the ultimate resource for OT/OTA students and the clinicians who educate them, providing a wealth of information while allowing for clinical reasoning to occur. This one-of-a-kind book contains unique features that will prove beneficial to students at varying degrees of education.
Features:

• Each chapter includes activities and assignments for students to complete as they prepare for fieldwork.
• The text is filled with real-life fieldwork student cases.
• The text teaches how to prevent problems that can occur, as well as how to fix them when they do.

In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.

This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.

A dramatic and worldwide increase is occurring in the prevalence of overweight and obesity in women of childbearing age. Obese women carry a significant excess risk of a variety of serious complications during pregnancy, and in addition, maternal obesity predisposes to obesity in the offspring. This book provides a timely update on the latest knowledge on maternal obesity and pregnancy. A very wide range of issues are covered, including macrosomia and associated shoulder dystocia; the risk of miscarriage, malformations, and complications of pregnancy; the impact of hyperglycemia; clinical management; consequences for anesthesia and ultrasound; impacts on breastfeeding, fertility, and childhood obesity; and pregnancy following gastric surgery. All of the authors are recognized experts in their fields, and the book has been designed to meet the practical needs of obstetricians, gynecologists, internists, and general practitioners.

Long-term oxygen therapy (LTOT) usually represents the final step in the management of severe chronic respiratory diseases: a large proportion of patients suffering from these conditions is involved and the corresponding impact for the Health Institutions and the Society is dramatically increasing. Although LTOT is well known and widely used since long ago in most modern countries, it still represents a challenging topic due to the huge amount of variables which can affect both its efficacy and effectiveness. Unfortunately, patients, doctors, care-givers, together with health institutions and political decision makers frequently have different visions on LTOT, thus highly contributing to obtain uneven results and changing outcomes. The focus of this volume is on new insights and novel perspectives of LTOT. Starting from consolidated experiences, it's aim is also to emphasize the strategic value of developing technologies and innovative organizational models uniquely to find out even more opportunities and advantages for the management of chronic respiratory patients needing long-term oxygen treatment.

This 1983 book reports the proceedings of the eleventh European symposium on clinical pharmacy which was held in Brussels in October 1982. The theme of the symposium was the concept of the therapeutic team and the relative contributions and responsibilities of pharmacists, nurses and physicians to the planning and implementation of drug treatment regimens. The first section of the volume provides an introduction to the concept of the therapeutic team and reflects the views several medical professionals. The later sections cover the practice of the therapeutic team in parenteral nutrition, oncology, dermatology, epilepsy, internal medicine, nuclear medicine and drug selection. Not only did this book review achievements and experiences in clinical pharmacy, but it also looked towards the future of clinical pharmacy development in Europe. It will still be of significant interest to clinical pharmacy specialists today.

This thoroughly revised edition of the authoritative reference Fascial Release for Structural Balance includes all of the most current research on the role of fascia and myofascia in the body, and how treatment affects it. James Earls and Thomas Myers have taken advantage of more sophisticated testing to explore in greater detail the relationship between anatomical structure and function, making this updated edition an even more essential guide. Fascia, the soft tissue surrounding muscles, bones, and organs, plays a crucial role in supporting the body. By learning to intelligently manipulate it, a bodyworker or therapist can help with many chronic conditions that their clients suffer from, providing immediate pain relief as well as reducing the strains that may contribute to the patient's ongoing aches and pains and leading to rapid, effective, and lasting pain relief. The authors argue that approaching the fascia requires "a different eye, a different touch, and tissue-specific techniques." Offering a detailed introduction to structural anatomy and fascial release therapy, including postural analysis, complete technique descriptions, and the art of proper assessment of a patient through "bodyreading," the book features 150 color photographs that clearly demonstrate each technique. Earls and Myers, both respected bodywork professionals, provide any bodywork practitioner using manual therapy-including physiotherapists, osteopaths, chiropractors, myofascial and trigger point therapists, and massage therapists-the information they need to deliver effective treatments and create long-lasting, systemic change in clients' shape and structure.

The aim of this book is to provide clear and concise information about the safe prescribing of insulin both subcutaneously and intravenously. It provides information on the different types of insulin, the delivery devices, side effects of insulin and, most importantly, on rational dose adjustment.

The Most Comprehensive, State-of-the-Art Book on Using Gene and Cell Therapy in Clinical Medicine Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. The fourth edition of this bestseller continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors' research efforts as well as current technologies, disease targets, and clinical applications. Divided into four sections, the book covers: Delivery systems and therapeutic strategies Other therapeutic strategies, including technologies that knock down gene expression Gene expression, regulation, and detection Gene and cell therapies, disease targets, clinical trials, and regulatory issues Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to state-of-the-art technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.

There is an urgent need to better understand the causes and consequences of obesity, and to learn what works to prevent or reduce obesity. This volume accurately and conveniently summarizes the findings and insights of obesity-related research from the full range of social sciences including anthropology, economics, government, psychology, and sociology. It is an excellent resource for researchers in these areas, both bringing them up to date on the relevant research in their own discipline and allowing them to quickly and easily understand the cutting-edge research being produced in other disciplines. The Oxford Handbook of the Social Science of Obesity is a critical reference for obesity researchers and is also valuable for public health officials, policymakers, nutritionists, and medical practitioners. The first section of the book explains how each social science discipline models human behavior (in particular, diet and physical activity), and summarizes the major research literatures on obesity in that discipline. The second section provides important practical information for researchers, including a guide to publicly available social science data on obesity and an overview of the challenges to causal inference in obesity research. The third part of the book synthesizes social science research on specific causes and correlates of obesity, such as food advertising, food prices, and peers. The fourth section summarizes social science research on the consequences of obesity, such as lower wages, job absenteeism, and discrimination. The fifth and final section reviews the social science literature on obesity treatment and prevention, such as food taxes, school-based interventions, and medical treatments such as anti-obesity drugs and bariatric surgery.

Obesity During Pregnancy in Clinical Practice highlights the medical evidence on obesity in the postpartum and interconception period, arming clinicians with the knowledge necessary to communicate with their patients on the effect of these changes on diabetes, cardio vascular disease and certain cancers. Obesity During Pregnancy in Clinical Practice provides concise and understandable summaries of the evidence-based, theory-driven lifestyle interventions that have been shown to be effective for weight loss and modifying the risk of developing diabetes and obesity.

Regulating Obesity?: Government, Society, and Questions of Health explores the effectiveness of legal interventions aimed at promoting healthier lifestyles. In it, W.A. Bogart suggests that the government's emphasis on encouraging weight loss and preventing excess gain have largely failed to resolve obesity and have instead fueled prejudice against fat people. He suggests that a major challenge lies in shifting norms away from stigmatization of the obese and towards more nutritious and healthy lifestyle habits in addition to the acceptance of bodies in all shapes and sizes. Part of this challenge lies in the complex effects of law and its relationship with norms, including the unintended consequences of regulation. Regulating Obesity? begins by arguing for the protection of the overweight and obese from discrimination through human rights laws. It then examines three other areas of interventions-marketing, fiscal policy, and physical activity-and how these interventions operate within the context of "health equity." Professor Bogart evaluates the effectiveness of legal regulation in addressing obesity and concludes that a healthier population is more important than a thinner population. Regulating Obesity? is the first book to engage in the comprehensive evaluation of this role for law and the implications of society's fascination with regulating consumption.

Starting out in practice can be difficult and confusing. This guide for newly qualified occupational therapists provides an authoritative overview of what to expect in your role and work settings, and is full of practical guidance on how to make a good start to a successful practice. With chapters by experienced practitioners in the field, it offers insights into work in paediatrics, mental health, learning disability and the acute hospital setting. Vital information is also included on difficult aspects of practice such as legislation and data protection. It signposts sources for support and resources for furthering techniques in individual areas of work. Most importantly, the book offers tips for managing a busy workload, while building the positive relationships and resilience needed for a successful career in the occupational therapy.

This book explores the pathophysiology, clinical assessment and management of the obese patient in the context of serious chronic disease, as well as the political and environmental aspects, including prevention. The book's approach of arriving at an exploration of these issues through the vehicle of assessing the controversies is unique and interesting, attempting to debunk the myths and explore the genuine science whilst demonstrating areas where healthy debate is rife.

Clear, step-by-step guidelines show how to perform Physical Therapy procedures! Joint Mobilization/Manipulation: Extremity and Spinal Techniques, 3rd Edition is your go-to resource for evidence-based Interventions treating conditions of the spine and extremities. New full-color photos and illustrations show detail with added realism, and 192 online videos demonstrate the major techniques described in the book. Written by rehabilitation and movement sciences educator Susan Edmond, this text provides current, complete information ranging from the principles of examination and evaluation to making effective manual therapy interventions. Illustrated descriptions of joint mobilizations make procedures easy to understand and then perform. Unique focus on spine and extremities provides an all-in-one resource for essential information. Contraindications, precautions, and indications are included for each joint mobilization to reinforce clinical decision-making. Clearly labeled photos show the direction of force for each therapy technique. Evidence-based information at the beginning of each chapter provides the latest research and rationales for specific procedures. Cervical Spine chapter includes mobilization techniques such as Paris cervical gliding, Grade V (thrust), and muscle energy. Guidelines to the examination of joint play of the spine include current, evidence-based research. Coverage of osteokinematic and arthrokinematic motion, and degrees of freedom, provides perspective on the body planes. 23 NEW videos demonstrate each step of manual therapy techniques. NEW full-color photos and illustrations show techniques with a higher degree of clarity and realism. NEW mobilization and manipulation techniques include step-by-step videos for each. UPDATED research makes this book the most current, evidence-based text available on manual therapy of the spine and extremities.

Cardiopulmonary Physical Therapy: Management and Case Studies, Second Edition is a unique and succinct textbook for the classroom that blends clinical notes on assessment and management together with case-based instructional approaches to cardiopulmonary care for acute and ambulatory care patients. This one-of-a-kind text describes current approaches that cover traditional physical therapist management strategies and includes evidence-based chapters on early mobilisation and exercise training on a wide range of cardiopulmonary patient groups. The updated Second Edition presents twenty-four cases that were designed to complement each chapter topic and represent the most common pulmonary, cardiac, and neurological conditions that are typically managed in cardiopulmonary care. These cases have been carefully selected and developed over several years to illustrate a spectrum of clinical issues essential for the preparation of the entry-level therapist. The very interactive nature of the case history approach is engaging and provides the opportunity to work through many of the steps of the clinical decision-making process. Cardiopulmonary Physical Therapy: Management and Case Studies, Second Edition also includes answer guides for the questions posed in the assessment and management chapters, as well as for the twenty-four cases. New in the Second Edition: Twenty-four carefully selected evidence-based cases designed to go "hand-in-hand" with chapter topics An international perspective that is relevant to physical therapy practice in several countriesDetailed chapter on non-invasive ventilation and mechanical ventilationSeveral chapters describe early mobilisation and exercise training for a range of cardiopulmonary patient groups including those admitted to an intensive care unitFaculty will benefit from the "Talk Me Through" PowerPoint slides, which provide a great opportunity for independent learning and complement classroom teaching The two-fold evidence and case-based learning approach used by Dr. W. Darlene Reid, Frank Chung, and Dr. Kylie Hill allows for a more engaging experience. The inclusion of interactive materials will allow students to learn and develop skills to prepare themselves for their professional transition while clinicians can use the text as a reference tool.

Improvisation plays a key role in the toolbox of the music therapist. Tony Wigram's practical and comprehensive guide and online content will prove indispensable to students, teachers, therapists and musicians as a book of musical techniques and therapeutic methods. Beginning with an overview of developing, teaching and analysing the skills of improvisation, Wigram describes techniques ranging from warming up to mirroring, rhythmic grounding, containing and holding. With specific sections on piano improvisation, chordal and 2-, 3- and 4- note improvisation are covered, in addition to advanced skills such as frameworking and transitions. Wigram also includes techniques for thematic improvisation, group improvisation and outlines methods for analysing and reporting improvisational processes. Notated examples allow readers to try out techniques and progress as they read, with audio examples on the accompanying online content adding another dimension to the structure and guidance provided for all levels of music student and therapist.

Childhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, Pathogenesis, and Treatment addresses the controversy with a range of features that make it a unique resource for those who care for obese children and their families. Written from a perspective that is international in scope, the distinguished authors re-assess the roles of genetic and environmental factors in the pathogenesis of childhood obesity and critically review new studies of the effects of lifestyle, pharmacologic, and surgical interventions. The evidence-based approach of Pediatric Obesity: Etiology, Pathogenesis, and Treatment provides a comprehensive and invaluable guide for all healthcare providers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.

With the advent of the worldwide obesity epidemic, a concurrent rise has occurred in the prevalence of type 2 diabetes mellitus and metabolic syndrome. Type 2 diabetes mellitus is affecting younger individuals-the disease is no longer exclusive to adulthood. Diabetic micro- and macrovascular complications are also occurring at an earlier age, leading to increasing demands and costs on the healthcare system. In addition, the morbidity, disability and premature death caused by diabetic complications create a huge burden to families, employers and society at large. Thankfully, there has been a tremendous growth in new therapeutic classes of medications to help manage type 2 diabetes mellitus. These agents target many of the pathophysiologic defects of the disease with fewer side effects than the older agents. Newer insulin formulations have more predictable kinetics so patients can achieve better glycemic control with less risk of hypoglycemia and weight gain. Insulin delivery devices have also improved to include higher quality insulin pens, finer and shorter pen needles, and more technologically advanced insulin pumps. As part of the Oxford American Endocrinology Library series, this handbook reviews the epidemiology and pathophysiology of obesity and type 2 diabetes mellitus. The content covers micro- and macrovascular diabetic complications, the array of glucose regulating therapies, treatment algorithms targeting the pathophysiologic defects of type 2 diabetes mellitus as well as strategies for macrovascular risk reduction via therapeutic lifestyle change (diet, exercise, smoking cessation), pharmacotherapeutic treatment of dyslipidemia and hypertension, bariatric surgery and subcutaneous insulin infusion therapy, among other topics. Because of the concise yet comprehensive nature of the handbook, this volume is an excellent point-of-care reference for the clinician who regulary treats obese and diabetic patients.

Regain Be Gone is the only resource readers need to help them keep weight regain at bay after bariatric surgery. With 20 years of training in the field of bariatrics, trusted dietitian Sameera Khan shares strategies toward a balanced, stress-free weight-loss journey so that readers can feel confident, powerful, and successful. Weight regain is a manageable setback that can be reversed with a little effort and guidance. The longer one ignores it, the harder it is to regain lost ground, so act now. Regain Be Gone is the only resource people need to help them keep weight regain at bay after bariatric surgery.

Effectively earn a high score on the new 2020 NBRC credentialing examination with Respiratory Care Exam Review, 5th Edition. This new edition contains everything you need to review and prepare for the Therapist Multiple-Choice Examination and the advanced Clinical Simulations Exam that closely aligns with the NBRC's new testing format. It includes over 800 questions (both multiple choice and open ended) within the text and online. Also on the accompanying Evolve website is both the Therapist Multiple-Choice Exam and twenty clinical simulations to provide additional practice and familiarize you with the computerized exam format. 2020 NBRC Detailed Content Outline and examination matrix are reflected in the updated text so you know exactly what to expect on the exams. Comprehensive, yet concise approach utilizes a simple, straightforward outline format that is easy to follow. Pre-tests of several multiple-choice questions are formatted like those found on the NBRC TMC and begin each chapter. Open-ended post-chapter study questions help reinforce information. Practice exam mirroring the new TMC is included at the back of the book with the answer key and rationales on Evolve. Clinical Simulations on Evolve reflect the new quantity of simulations (20) and the newly revised length of these sims on the actual 2020 Clinical Simulation Exam (CSE). Practice Exams on Evolve are available in both study (untimed) and exam (timed) modes to provide an additional opportunity to practice and experience the actual NBRC testing environment in a computerized format. NEW! Thoroughly updated content incorporates the new 2020 NBRC Exam Content Outline. NEW! Extensively updated questions have been added throughout the text and online resources. NEW! Chapter-specific revisions include updates in the following areas: oxygen delivery devices endotracheal tube maintenance (cuff pressure, minimal leak, and occlusive volume techniques) bronchscopy (bronchoscopy) CPR procedures hyperinflation devices new drugs pulmonary rehabilitation FeNO