This detailed book explores the utilization and delivery of stem cells for therapeutic purposes in patients in the clinic and the tightly controlled Good Manufacturing Practices (GMP) that make these powerful techniques possible. Fully updated and expanded from the first edition, this collection features a new set of protocols to arm stem cell biologists with protocols that are currently being used in a number of well-established facilities around the world. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up to date, Stem Cells and Good Manufacturing Practices: Methods, Protocols, and Regulations, Second Edition serves as an ideal guide for researchers aiming to drive continued improvements to GMP and accelerate new stem cell treatments for patients in need.

Obesity is considered a serious and complex condition. All obese people have previously been overweight and its conditions represent an intriguing area of research both from a clinical and speculative point of view. This book is aimed at raising awareness on individuals who are overweight, a crucial point in order to prevent obesity progression and it is addressed to therapists who are willing to better understand the condition.

The role of adenosine and adenosine receptors in normal cell physiology and in diseases has been an area of active research over the last several decades. The field has advanced from the use of limited tools to examine receptor signaling and function to the use of various molecular and receptor knockout techniques to examine the details of the expression and functions and regulation of these receptors. This book highlights important milestones in adenosine receptor research and reviews recent findings from experts in different research areas. Several research areas, ranging from cardiovascular, cancer, and central nervous system research are discussed. Several of the chapters describe how understanding the basic cellular mechanisms regulated by adenosine could lead to the development of important therapeutics. The editors, Vickram Ramkumar and Roberto Paes-de-Carvalho, have published extensively on adenosine receptors for more than two decades and are still active in this field of research. It is our hope that this book provides an excellent synopsis of the current status of adenosine receptor research which would be valuable for researchers in the field and as a reference source for clinicians and others interested in this area.

Art Therapy is increasingly recognised as an important contributor to psychotherapy and dynamic counselling and is widening its sphere of practice and application. Art Therapists are working not just within traditional psychiatric services but within the fields of social and community care and in specialist areas such as prisons. Increasingly, art therapists are dealing with specific problems ranging from child abuse to eating disorders, often as members of multidisciplinary teams or special units. This new collection represents some of the best and most interesting examples of the widening application of art therapy. The contributors - all experienced art therapists - cover such topics as family trauma, work with children with learning difficulties and with autism, with criminal offenders, anorexics, the sexually abused with people who stammer. The new developments represented in this book have implications not just for the profession of art therapy but also for methods of practice. They point up the challenge of new methodologies which focus on process rather than on the finished image. They remind practitioners how stylistic and aesthetic elements, as well as content, can provide therapeutic insights. Providing a rich diversity of approach, this collection will be required reading for all students and practitioners requiring the broadest and most up-to-date statement of the current status of art therapy.

Physical inactivity has been recognised as one of the common modifiable risk factors for non-communicable diseases such as heart disease, stroke, cancer, chronic respiratory diseases and diabetes. Increased level of physical activity is very effective for health maintenance. In this book, experts from all over the world present evidence for therapeutic physical activities illustrated by different cases. Physical activity can serve as both a preventive measure and a rehabilitation tool. The contents of this book cover the benefits of physical activity from young children with cerebral palsy to older adults with Parkinson's disease. Some chapters focus on specific illness, such as asthma; others study more popular problems like lower back pain. Furthermore, fall risks increase with age. It is a growing problem among the elders, their family, the community, the governments, and the world at large. There is a chapter in this book discussing this issue specifically. Individuals with one of the impairments touched upon in this book, as well as their families, doctors and other health workers can benefit from its contents. The topics of this book include kidney disease, coronary or peripheral artery disease, asthma, vestibular impairments, obstructive sleep apnea, cancer, lower back pain, Alzheimer's disease, dementia, Parkinson's disease, risk of falls, autism spectrum disorder, and cerebral palsy. Students and researchers can use this book as reference when they investigate the effects of physical activity as a preventive measure or therapeutic modality for other populations.

Targeted cancer therapies have revolutionised the therapeutic management of many neoplasms, modifying patients' prognosis and overall survival. These drugs block the cancer's growth and spread by interfering with specific molecules which play a crucial role in the proliferation, differentiation and survival of cancer cells. Targeted therapies act selectively on specific molecular targets related to cancers, whereas most of the conventional chemotherapies act on all rapidly dividing normal and neoplastic cells. Moreover, targeted therapies are often cytostatic and non-cytotoxic as standard chemotherapies. Taken together, these aspects appear important in reducing systemic toxicity and ensuring an improved safety profile. The inhibition of epidermal growth factor receptor (EGFR), vascular growth factor (VEGF) and BRAF represents major achievements in research and development of solid tumour's epithelial therapy. This class of biologics is currently widely used in the treatment of metastatic and unresponsive neoplasms of the colon, pancreas, lung, (NSCLC), breast, head and neck and melanoma. This book aims to emphasize skin toxicity associated with EGFR-, VEGF- and BRAF- inhibitors, focusing particularly on their clinical presentation, histopathological findings, and specific therapeutic options.

Corticosteroids (CS) are naturally occurring biomolecules produced in the adrenal cortex and have a multitude of roles which includes carbohydrate, protein and fat metabolism, inflammation and regulation of water, electrolyte etc. Based on their functions, steroids are classified as glucocorticoids and/or mineralocorticoids, and only the former have anti-inflammatory properties which have been chemically modified to produce potent anti-inflammatory drugs which also retain the metabolic and bone effects of the primary chemical. This book provides new research which includes the role of corticosteroids in diseases such as chronic obstructive pulmonary disease, adenoids, chronic subdural hematoma, osteonecrosis, and autoimmune diseases.

This text can be used in all clinical skills courses and practica across the human services. It is designed to teach students the fundamental interviewing tools (e.g., empathy, reflection, summarizing, etc.) that comprise professional clinical contact. After orienting students to their responsibilities as new practitioners, the author presents, in clear and concise language, essential clinical communication tools in a unified format. Each section presents: (1) the name of the tool, (2) rationale for use, (3) exemplary dialogue between therapist and client demonstrating actual usage/s of the tool, (4) tutorial commentary embedded in the dialogue example, (5) dialogue debriefing, and (6) suggestions for variations.

This clinician manual presents the Accept Yourself! Program, which is derived from empirically supported interventions (including Acceptance and Commitment Therapy and Health At Every Size) that have a demonstrated ability to enhance women's mental and physical health. This book offers a clear, research-based, and forgiving explanation for clients' failure to lose weight, helpful guidance for clinicians who are frustrated with poor client weight loss outcomes, as well as a liberating invitation to clients to give up this struggle and find another way to achieve their dreams and goals.

Obesity is an increasing problem on a global scale, and strategies for its prevention involve experts from many disciplines including nutritionists, physicians, policy-makers and public health professionals. This book covers the latest advances in obesity development, management and prevention with specific focus on dietary interventions. Part one covers the development of obesity and key drivers for its continuation and increase. Part two looks at the role of specific dietary components in obesity management, and part three discusses the role of behavioural factors such as eating patterns in managing and preventing obesity. Part four focuses on structured dietary interventions for obesity treatment, and part five looks at public interventions and consumer issues.

Through a biophysical approach, Electromagnetic Fields in Biology and Medicine provides state-of-the-art knowledge on both the biological and therapeutic effects of Electromagnetic Fields (EMFs). The reader is guided through explanations of general problems related to the benefits and hazards of EMFs, step-by-step engineering processes, and basic results obtained from laboratory and clinical trials. Basic biological mechanisms reviewed by several authors lead to an understanding of the effects of EMFs on microcirculation as well as on immune and anti-inflammatory responses. Based upon investigational mechanisms for achieving potential health benefits, various EMF medical applications used around the world are presented. These include the frequent use of EMFs in wound healing and cartilage/bone repair as well as use of EMFs in pain control and inhibition of cancer growth. Final chapters cover the potential of using the novel biophysical methods of electroporation and nanoelectroporation in electrochemotherapy, gene therapy, and nonthermal ablation. Also covered is the treatment of tendon injuries in animals and humans. This book is an invaluable tool for scientists, clinicians, and medical and engineering students.

The Most Comprehensive, State-of-the-Art Book on Using Gene and Cell Therapy in Clinical Medicine Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. The fourth edition of this bestseller continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors' research efforts as well as current technologies, disease targets, and clinical applications. Divided into four sections, the book covers: Delivery systems and therapeutic strategies Other therapeutic strategies, including technologies that knock down gene expression Gene expression, regulation, and detection Gene and cell therapies, disease targets, clinical trials, and regulatory issues Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to state-of-the-art technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.

The authorized companion to the #1 New York Times bestseller Grain Brain, with more than 150 life-changing gluten-free recipes for complete health and vitality.
Dr. David Perlmutter's groundbreaking bestseller "Grain Brain" revolutionized the way we think about our health, exposing the devastating effects of wheat, sugar, and carbs on the brain and empowering us with new knowledge: By eating the right foods, you can profoundly affect how your brain will be working next year, in five years, and for the rest of your life.
"The Grain Brain Cookbook" equips you to do just that, presenting more than 150 delectable recipes to keep your brain vibrant and your body fit, all while dramatically reducing your risk for - and treating - Alzheimer's, depression, ADHD, and epilepsy, as well as relieving more common, everyday conditions like chronic headaches, insomnia, anxiety, and "senior moments" of forgetfulness. The meals in this book are wholesome, easy to prepare, and best of all, delicious to eat, making your transition to a gluten-free life seamless, satisfying, and stress-free in the kitchen. Enjoy a terrific selection of options for every meal, including Eggs Benedict with Zucchini Pancakes for breakfast, Spicy Chicken Burgers with Guacamole for lunch, Gruyere-Glazed Pork Chops and Cauliflower "Couscous" for dinner, Curried Almonds and Kale Chips for snacks, Coconut-Cashew Bars for dessert, and many more.
What you eat is the most important decision you make every day in terms of your health, and once you've tasted how good the "Grain Brain" diet can be, you'll want to keep making the right choices day after day. "The Grain Brain Cookbook" gives you all the tools you need to shift your body away from dependence on carbs, cut gluten from your diet, eliminate sugar cravings for good, embrace healthy fats, and establish a new mealtime repertoire for long-term, vibrant living.

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: Genetic approaches for personal oncologyTargeting epigenetic dysregulation and protein interaction networksVaccines and antibodies in cancer immunotherapyTumor heterogeneity and chemotherapy resistanceTumor associated macrophages in anticancer treatment

Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences

Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviewsseries, which features reviews published in "Cell Press" primary research and "Trends" reviews journals.
Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics
Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy
Features reviews on basic science advances translated into drug discovery and therapeutic approaches
Includes articles originally published in "Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine," and "Trends in Pharmacological Sciences""

Seeing older age as a time of loss and helplessness too often prevents therapists from providing treatments that can be of enormous benefit to older people.

Ken Laidlaw, Larry Thompson, Leah Dick-Siskin and Dolores Gallagher-Thompson draw upon their collective wealth of clinical experience to provide a comprehensive and practical guide to the applications of CBT to older adults.

Special features include:

• A new CBT model, effectively adapted from Beck's basic CBT model, for use with older adults.

• Numerous clinical examples of the usefulness of CBT to treat depression, anxiety, caregiver distress and sleep disturbances.

• Recommendations for treating depression co-morbid with common medical problems including stroke, Parkinson's disease, the dementias and arthritis.

• Specific recommendations for 'troubleshooting' frequent dilemmas, such as managing suicidality.

• Appendices containing blank examples of forms used within the text, and recommended self-help books and websites for further consultation.

Cognitive Behaviour Therapy with Older People is essential reading for all clinical psychologists, psychiatrists and related health professionals who work with older people.

First published in 1943, "Vitamins and Hormones" is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, "Vitamins and Hormones" continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on obesity.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans.
Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant potential as new anti-obesity drugs.

Chapters are written by leading experts.

In a world where charlatans promise to fix the alarming obesity epidemic with a silver-bullet diet or trendy new exercise program, Robyn Toomath, a physician and realist, steps out of the fray to deliver some tough news: it's really hard to lose weight. Dispelling common myths and telling provocative truths about weight gain-and loss- The Obesity Epidemic is an engaging investigation into the complicated factors that lead to obesity. While genes certainly play a part, Toomath argues, more people are fat than ever before because most of us consume significantly more calories than we did 30 years ago. But why? The answer, she asserts, is the commodification of food created by junk food advertising coupled with urbanization, globalization, and trade agreements. And while government, advertisers, gyms, and the weight loss industry keep pushing solutions that science shows do not work-from extreme exercise regimens and fad dieting to prohibitively expensive surgeries, pills, and misguided education campaigns-Toomath outlines what just might make a difference in terms of helping people truly control their weight. Drawing on the latest research and her twenty years of working with overweight patients, Dr. Toomath argues that even strongly determined people who are offered appealing incentives typically cannot lose weight permanently. Instead of demonizing people by treating weight as an issue of personal or even moral responsibility, Dr. Toomath makes it clear that nothing will change until we make it easy, not all but impossible, for people to eat healthily. Raising important questions about obesity, Toomath sidesteps the standard sound bites and puts an end to the myth of personal responsibility for body size by focusing on the environment all around us.

Nutrition in the Prevention and Treatment of Disease has been proving itself in the classroom for nearly 10 years and is praised as being accessible, applicable and a valuable textbook. It focuses specifically on the relationship between disease and nutrition, an area of ever increasing interest and concern as health care costs and availability continue to be an issue worldwide. Now reaching beyond just the individual healthcare concern, the potential for nutritional interventions to improve health status is also of heightened interest to public health professionals who are faced with an aging, obese, at-risk-of-diabetes population who may or may not have access to insurance. This textbook is the foundation of understanding how nutrition can be used to improve health status.

New to this edition:

100% overall new material. 26 new authors or co-authors and all chapters have been completed updated

4 completely new chapters: "

Surgery for Severe Obesity

Snacking and Energy Balance in Humans

Phytochemicals in the Prevention and Treatment of Obesity and Its Related Cancers

Bioavailability and Metabolism of Bioactive Compounds from Foods "

New section on "Dietary Bioactive Compounds for Health" explores bioactive components present in edible plants of particular interest for the prevention of disease

New to the obesity section is a chapter on the management of patients who have undergone surgical treatment for obesity
Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences librariesIntegration of food issues with nutrition provides a unique perspective to disease prevention/controlMaterial in the book is up-to-date with current researchIndividual sections of the book can be used for mini-courses or in-depth studyDiversity of material makes this text useful for nutritional scientists and also for upper division nutrition course work

Neurological Rehabilitation is the latest volume in the definitive Handbook of Clinical Neurology series. It is the first time that this increasing important subject has been included in the series and this reflects the growing interest and quality of scientific data on topics around neural recovery and the practical applications of new research. The volume will appeal to clinicians from both neurological and rehabilitation backgrounds and contains topics of interest to all members of the multidisciplinary clinical team as well as the neuroscience community. The volume is divided into five key sections. The first is a summary of current research on neural repair, recovery and plasticity. The authors have kept the topics readable for a non-scientific audience and focused on the aspects of basic neuroscience that should be most relevant to clinical practice. The next section covers the basic principles of neurorehabilitation, including excellent chapters on learning and skill acquisition, outcome measurement and functional neuroimaging. The key clinical section comes next and includes updates and reviews on the management of the main neurological disabling physical problems, such as spasticity, pain, sexual functioning and dysphagia. Cognitive, emotional and behavioural problems are just as important and are covered in the next section, with excellent chapters, for example, on memory and management of executive dysfunction. The final part draws the sections on symptom management together by discussing the individual diseases that are most commonly seen in neurorehabilitation and providing an overview of the management of the disability associated with those disorders. The volume is a definitive review of current neurorehabilitation practice and will be valuable to a wide range of clinicians and scientists working in this rapidly developing field.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Heavy Burdens: Stories of Motherhood and Fatness seeks to address the systemic ways in which the moral panic around 'obesity' impacts fat mothers and fat children. Taking a life-course approach, the book begins with analyses of the ways in which fatphobia is enacted on pregnant (or even not-yet-pregnant) women, whose bodies immediately become viewed as objects warranting external control by not only medical professionals, but family members, and even passers-by. The story unfolds as adults recount childhood stories of growing up fat, or growing up in fear of being fat, and how their mothers' relationships with their own bodies and attempted weight-loss experiences shaped how food, exercise, and body management were approached in their homes in sometimes harmful ways. Finally, the book concludes with stories of women who have since become mothers, examining the ways in which having their own children altered their views on their own bodies and their perceptions of their mothers' actions, and working to find fat-friendly futures via their own parenting (or grand-parenting) techniques.

This volume of Methods in Enzymology looks at Gene Transfer Vectors for Clinical Application. The chapters providean invaluable resource for academics, researchers and students alike. With an international board of authors, this volume covers such topics as General principles of retrovirus vector design, Chronic granulomatous disease (CGD), Gene therapy for blindness, and Retrovirus genetic strategy and vector design.
Chapters provide an invaluable resource for academics, researchers and students alikeInternational board of authorsThis volume covers such topics as general principles of retrovirus vector design, chronic granulomatous disease (CGD), gene therapy for blindness, and retrovirus genetic strategy and vector design"

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters providean invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such asPeptides, and Scaffolds
Chapters providean invaluable resource for academics, researchers and students alike Iinternational board of authorsThis volume is split into sections that cover subjects such aspeptides, and scaffolds"

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the "Methods in Enzymology" series comprehensively covers this topic. With an international board of authors, this volume covers subjects such asCrystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems.

This volume in the "Methods in Enzymology" series comprehensively covers the topic of serpins

With an international board of authors, this volume covers subjects such asCrystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems"