This book brings the animal into the scholarly discussion of animal-assisted therapy and other interventions. Challenging the current reliance on outcome studies, the author offers a new way of thinking empirically about animal-assisted interventions-analysis of human-animal interaction as a critical component. Through empirical demonstrations from laboratory and applied settings, the book encourages practitioners and scholars to undergo a deeper examination of the basic interactions that occur between clients or patients and therapy animals. Dr. Fournier provides new ideas on measurement, experimentation, and interpretation of human-animal interaction, aimed at identifying the role of the animal in interventions for human health and well-being.

Obesity has reached epidemic proportions in countries like the United States. This book provides a comprehensive summary of obesity in America and around the world, discussing the causes and proposing ways to help stem the tide and to help those who are overweight. A highly useful and accessible resource for high school to undergraduate students as well as post-graduate level readers with an interest in health and nutrition, this updated second edition of Obesity: A Reference Handbook offers up-to-date answers to essential questions about obesity and connected societal and health care-related issues. A single-volume, go-to resource, this book addresses difficult questions such as whether obesity is a disease or a moral failing; what factors contribute to obesity; what the economic impacts of obesity are on the health care industry; if and how poverty is a contributor to obesity; how our society encourages obesity; and how changes can be made to improve our society's eating habits as a whole. It presents citations from individuals and peer-reviewed journals and review articles, providing a balance of information sourced from both professionals and informed lay commentators. Also included are dozens of biographies of individuals who have been important in studying, preventing, managing, or increasing awareness about obesity, such as Jared Fogle, longtime Subway sandwiches spokesperson; Kelly Brownell, who coined the phrase "toxic environment" to describe unhealthy food and exercise patterns; researcher Ethan Allen Sims, who examined the relationship between obesity and diabetes; and Oprah Winfrey, well-known celebrity who stated that if there were a pill to lose weight or a magic diet, she would have it. Provides clear, easy-to-understand, and useful information for general readers who want to learn more about the history and current events concerning obesity Includes a Perspectives chapter that enables readers to hear voices from a range of individuals who are concerned with obesity, such as medical professionals and fat acceptance activists Presents real-world strategies and solutions that readers can apply-and benefit from-in their own lives Includes excerpts of key documents from the National Institutes of Health; the National Heart, Lung, and Blood Institute; and the U.S. Surgeon General that inform how we as a society view, prevent, and treat obesity

The Overweight Mind and Body is a self-help guide to understanding the psychological issues that lead to overeating and weight gain. The book enables the reader to discover the psychological drives that lead to unwanted weight and to find ways of meeting those drives other than with food. It introduces a simple, user-friendly theory of Transactional Analysis to promote weight-related self-awareness. The author includes exercises that empower readers to uncover their own stories. She understands that, for many, carrying extra weight is emotionally and physically painful and so gently encourages readers to explore at their own level. She uses case studies to demonstrate the many unconscious influences on one's eating and how, when people discover and resolve these influences, they no longer need extra food. Reading them shows that "you are not alone". This book will also be of interest to, and a useful guide for, practitioners in the caring professions who work with clients struggling with eating and overweight.

What State Do You Live In explains the events that take place in your body if you lose control over your weight. Tens of millions of adult Americanssuffer from weight related chronic disease states including pre-diabetes, high blood pressure, abnormal blood cholesterol, the metabolic syndrome, andtype II diabetes. If you are overweight and suffer from high blood glucose, you're suffering from insulin resistance and need to read this story.

What State Do You Live In begins with you in the normal state, when insulin is in complete control over blood glucose and blood fat levels. Itprogresses into the insulin resistant state which describes in detail the events that stem from weight related insulin resistance including elevatedtriglycerides, high blood pressure, unhealthy cholesterol, the metabolic syndrome, and type II diabetes.

What State Do You live In is different from other books. It provides you with realistic expectations. It does not suggest pills, supplements, or anyother form of synthetic nutrition as a means to reverse faulty nutrition. It does offer you more than a single solution to begin reversing the insulinresistant state, including the lower carbohydrate approach to improve high blood glucose.

What State Do You Live In provides you with five different levels of food strategies to put you back in control of your blood glucose. Don't ignorehigh blood glucose, if left untreated, the consequences are life threatening.

Muscle testing - A Concise Manual, provides a reference for understanding how structure relates to function, and how by knowing function we can learn structural configurations. The book summarises the key anatomical facts and figures, give methods for muscle testing by several techniques, and provides clinically useful information to supplement the tests.

Maha Nasrallah-Babenko presents a culturally sensitive and uniquely accessible guide that equips clinicians, student sex therapists, and female clients with the tools to confidently treat genito-pelvic pain and penetration disorders (GPPPD). Addressing the issue from an integrated approach, the book provides evidence-based information and sensate, solo and partner practical exercises derived from the author's experience to help clinicians support women in redefining their relationship with sex, their bodies, and their partners. With a special focus on those from conservative and religious backgrounds, this beautifully illustrated text emphasizes the psychological, emotional, and relational factors that may increase shame and fear surrounding sex. The book defines GPPPD before outlining the author's ABCs approach, awareness, body, control, and safety, where she examines topics such as sexual abuse, how to communicate with you partner, sexual beliefs and messages, the importance of arousal, vulnerability and assertiveness, and shifting the significance of penetration for an enjoyable sex life. This book is essential reading for training and established sex therapists, family therapists, and couple therapists looking to support those struggling with sexual intimacy, as well as the couples seeking their help.

The World Health Organization estimates that there are 2.1 billion individuals with obesity globally. Nearly three quarters of adults in the United States are overweight or obese. The average individual with obesity cuts ten years off their life expectancy, yet less than 40% of physicians routinely counsel individuals concerning the adverse health consequences of obesity. Obesity Prevention and Treatment: A Practical Guide equips healthcare practitioners to include effective weight management counselling in the daily practice of medicine. Written by lifestyle medicine pioneer and cardiologist, Dr. James Rippe and obesity expert Dr. John Foreyt, this book provides evidence-based discussions of obesity and its metabolic consequences. A volume in the Lifestyle Medicine Series, it provides evidence-based information about the prevention and treatment of obesity through lifestyle measures, such as regular physical activity and sound nutrition, as well as the use of new medications or bariatric surgery available to assist in weight management. Provides a framework and practical strategies to assist practitioners in safe and effective treatments of obesity. Contains information explaining the relationship between obesity and increased risk of heart disease, diabetes, cancer, osteoarthritis, and other chronic conditions. Chapters begin with bulleted key points and conclude with a list of Clinical Applications. Written for practitioners at all levels, this user-friendly, evidence-based book on obesity prevention and treatment will be valuable to practitioners in general medicine or subspecialty practices.

Nutrition in the Prevention and Treatment of Abdominal Obesity, Second Edition focuses on the important role that exercise, dietary changes and foods play in promoting and reducing visceral fat. Nutritionists, dieticians and healthcare providers seeking to address the abdominal obesity epidemic will find this book to be a valuable resource in their long-term goal of preventing chronic diseases, especially heart, vascular and diabetic diseases. Chapters define a range of dietary approaches to reduce risk for the associated chronic diseases. In addition, discussions of the importance of dietary approaches to reduce abdominal obesity, along with clinical approaches, are discussed, including costs and risks.

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

Childhood obesity has reached epidemic proportions in the United States and continues to increase in prevalence in almost all countries in which it has been studied, including developed and developing countries around the globe. The causes of obesity are complex and multi-factorial. Childhood obesity becomes a life-long problem in most cases and is associated with long term chronic disease risk for a variety of diseases including type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, as well as psychosocial as issues and obesity seems to affect almost every organ system in the body. In recent years there has been tremendous progress in the understanding of this problem and in strategies for prevention and treatment in the pediatric years. Childhood Obesity: Causes, Consequences, and Intervention Approaches presents current reviews on the complex problem of obesity from the multi-level causes throughout early life before adulthood and the implications for this for long-term disease risk. It reviews numerous types of strategies that have been used to address this issue from conventional clinical management to global policy strategies attempting to modify the global landscape of food, nutrition, and physical activity. Each chapter is written by a global authority in his or her respective field with a focus on reviewing the current status and recent developments. The book features information on contributing factors to obesity, including developmental origins, social/family, birth cohort studies, influence of ethnicity, and global perspectives. It takes a life-course approach to the subject matter and includes exhaustive treatment of contributing factors to childhood obesity, such as assessment, environmental factors, nutrition and dietary factors, host factors, interventions and treatment, consequences, and further action for future prevention. This broad range of topics relevant to the rapidly changing field of childhood obesity is suitable for students, health care professionals, physicians, and researchers.

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology

Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, "Medicinal Chemistry of Nucleic Acids" presents a thorough overview of nucleic acid chemistry--a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids--such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs--to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes:

In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry

A close look at a large range of current topics on nucleic acid chemistry and biology

Essential information on the use of nucleic acid drugs to treat diseases like cancer

A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area

Thorough in its approach and promising in its message, "Medicinal Chemistry of Nucleic Acids" probes the new domains of pharmaceutical research--and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

This is a timely and informative updated edition for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, this updated title is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current treatment issues and strategies for both adults and children. While several of the chapters are no longer relevant from the first edition, other topics have emerged as interesting and current. This edition will keep the two-section format of Physiology and Pathophysiology and Clinical Management, but it increases the first section to 10 chapters and reduces the second section to 12 chapters. The plan is to keep this edition in the range of about 350 to 400, maximum, printed pages. The volume is again divided into two parts. Part 1 covers new discoveries in the physiological control of body weight, as well as the pathophysiology of obesity. Expert authors discuss pathways that control food intake, energy expenditure and peripheral nutrient metabolism, including a look at the emerging evidence of the role of adipose tissue as an endocrine organ. Part 2 covers all the key issues central to clinical management, including recent developments in the epidemiology of obesity, assessment of the obese patient, behavioral strategies in weight management, dietary modification as a weight management strategy, physical activity as a weight management strategy, weight loss drugs, surgical approaches to obesity and other important clinical topics. An essential, practical text that sorts, synthesizes and interprets the latest information on obesity-related topics, this second edition will be an essential resource for clinical endocrinologists and other health care providers across a broad spectrum of specialties.

This book presents a comparison analysis of two cancer treatment therapies: carbon ion therapy and protontherapy. It is divided in 5 sections. The first ones gives the reader a brief history of Radiotherapy and types of radiation. In the second section, the techniques and equipments, including new ones in development such as Cyclinac , Laser and DWA, are described. The third section describes biophysical (such as stopping power and LET) and biological (such as RBE and OER) properties, the fundamental experiments and clinical area. The fourth section presents models and the fifth section compares both techniques, showing advantages and disadvantages of each, and their similarities.

In this issue of Physical Medicine and Rehabilitation Clinics, guest editor Dr. Thomas (Quin) Throckmorton brings his considerable expertise to Shoulder Rehabilitation. Top experts in the field cover key topics such as shoulder impingement syndrome; non-operative treatment of rotator cuff tears; post-operative rehabilitation following rotator cuff repair; non-operative treatment of the biceps-labral complex; post-operative rehabilitation after SLAP repair; and more. Contains 12 relevant, practice-oriented topics including post-operative rehabilitation after surgery for shoulder instability; scapular dyskinesis; adhesive capsulitis; post-operative rehabilitation after shoulder arthroplasty; muscular re-training and rehabilitation after tendon transfer surgery in the shoulder; and more. Provides in-depth clinical reviews on shoulder rehabilitation, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

There have been many books written on the subject of obesity, but most have approached the topic from the standpoint of the nutritionist, concluding from the somewhat fallacious evidence of changes in body mass that exercise has little place in the prevention or the treatment of obesity. This new volume, written by an exercise physiologist, approaches the topic through a thoughtful lens, suggesting that regular physical activity plays an important role in preventing the development of obesity, is a valuable adjunct therapy in the treatment of the established condition, and makes a solid contribution to the maintenance of weight loss once target weights have been achieved. In addition to detailing evidence that supports such a conclusion, the text offers a unique perspective on obesity over the ages. It evaluates methods of determining body fat content that are appropriate to field and epidemiological studies, and it looks at the timing and aetiology of the recent obesity epidemic. It also considers the diseases associated with obesity and the resultant medical costs, attempting to disentangle the respective contributions of a sedentary lifestyle and the resultant accumulation of fat to the observed patterns of ill-health. Other sections of the text suggest that adipose tissue has important functions beyond the passive storage of energy, and looks critically at the excuse of "bad genes" that some people plead to explain their excessive body weight. Obesity: A Kinesiologist's Perspective should thus provide helpful information and be a key resource for students and researchers alike in bariatrics, kinesiology and nutrition as well as the related disciplines.

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn s disease, diabetes, multiple sclerosis, critical limb ischemia and many others.

MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies "in vitro. "In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable "in vitro "expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress.

The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Noncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) - what they are, their burden, their determinants and how they can be prevented and controlled. Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world's biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action. Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.

Nutritional Pathophysiology of Obesity and Its Comorbidities: A Case-Study Approach challenges students and practitioners to understand the role of nutrients within the pathophysiology and development of disease, specifically those diseases which develop as a result of obesity. Through a case-based approach, the author presents complex clinical scenarios that require multiple treatment strategies, including targeted diet modification as an adjuvant to medical therapy. The book is divided into 9 modules and 5 appendices each of which covers aspects of obesity and its comorbidities. Within each module, a case is detailed with relevant history, laboratory and physical data, and follow-up information. Each case is followed by a resource section which delineates current understanding of the pathophysiology of the condition, as well as the actions of nutrients and food components shown to modify these processes. A "further readings" section cites current supporting clinical and basic literature as well as published guidelines.

The 27th volume of the Evidence-based Clinical Chinese Medicine series examines the management of people who are overweight and obese with Chinese medicine using a 'whole evidence' approach. Overweight and obesity are recognised as leading health concerns worldwide. They have significant impacts on quality of life and mortality and are associated with many complications and chronic illnesses, including diabetes mellitus, cardiovascular disease, hypertension, stroke and some cancers. Conventional medicine understanding of weight gain, including common causes, diagnosis and treatment are included, along with the Chinese medicine conceptualisation of overweight and obesity.Evidence from clinical studies is reviewed using internationally accepted scientific methods. Systematic reviews describe the treatments used in clinical studies, and analyse the effectiveness of Chinese herbal medicines, acupuncture and related therapies, other Chinese medicine therapies, and combinations of Chinese medicine therapies. Experimental studies that describe the potential mechanisms of action of key herbs are summarised. The final chapter synthesises the current evidence and offers suggestions for contemporary clinical practice and future research.This book is a handy desktop reference for both clinicians and students of Chinese and integrative medicine. It provides a comprehensive synthesis of both traditional and contemporary knowledge that can inform clinical decision-making.

Physiotherapy for the Hip Joint offers consolidated, current coverage of recent advances on various musculoskeletal hip conditions related to physiotherapy. Drs. Patitapaban Mohanty and Monalisa Pattnaik provide thorough, focused information on coxa valga, coxa vara, anteversion, retroversion, pelvic tilt, osteoarthritis, rheumatoid arthritis, and more. Physical medicine and rehabilitation specialists, physiotherapists, and orthopaedic surgeons will find this unique, concise title to be useful in everyday practice settings. Includes introductory chapters covering anatomy and biomechanics. Offers comprehensive coverage of hip conditions from trauma to deformities to post-surgical rehabilitation. Discusses clinical reasoning for posterior hip pain, piriformis syndrome, sacroiliac joint dysfunction, lumbar radiculopathy and meralgia paresthetica. Consolidates today's available information on this timely topic into a single, convenient resource.

The book describes how to use breathing as a medium for self-regulation and self-reflection and how balanced breathing thus helps to promote mental and physical health and alleviate symptoms resulting from imbalanced breathing. The authors describe applications of psychophysical breathing therapy in many areas of life, developed by both themselves and other professionals trained by them. The approach of the book is based on the interactional aspects between mind and body. A person's breathing style influences their relation both to themselves and to others - and vice versa, and thus mental and also physical health. A comprehensive theoretical description of the psychophysical regulation of breathing and the consequences of imbalanced breathing is complemented by material derived from the authors' extensive clinical experience. Psychological orientations used by the writers include object relations theories, and psychodynamic, cognitive, brief and group therapy theories. As a new aspect the writers introduce how breathing patterns are learnt in early interaction. The writers also acknowledge how physical factors affect and interact with psychological factors in producing imbalanced breathing.

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.