Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

Based on the success of the best-selling "Comfort Food Diet Cookbook and the Comfort Food Diet Family Classics Collection," Taste of Home is excited to bring you the brand-new time-saving edition, "The Comfort Food Diet, New Quick and Easy Favorites "

Inside you'll find 380 mouthwatering recipes that will satisfy your cravings in a healthy way. You can induldge in hearty casseroles, creamy pastas, crunchy snacks -even rich tasting desserts--and still lose weight And you can cut back on the time you spend in the kitchen, since more than a third of the recipes are quick and easy to prepare.

The diet is simple. Inside you'll discover a 6-week meal plan that counts up the calories for you. Each day you'll find breakfast, lunch, and dinner menus that keep your weight-loss goals in focus. The plan even includes snacks and desserts. Each recipe features prep and cook times so you can make dishes that fit your family's schedule. The slow-cooker and 20-minute or less prep chapters will save you time in the kitchen while the 8-ingredients or less chapter will save you time at the store.

Also included are motivational "before and after" weight loss stories and tips from followers of the diet on how they get the most from the program, their weight-loss strategies and advice.

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

There have been many books written on the subject of obesity, but most have approached the topic from the standpoint of the nutritionist, concluding from the somewhat fallacious evidence of changes in body mass that exercise has little place in the prevention or the treatment of obesity. This new volume, written by an exercise physiologist, approaches the topic through a thoughtful lens, suggesting that regular physical activity plays an important role in preventing the development of obesity, is a valuable adjunct therapy in the treatment of the established condition, and makes a solid contribution to the maintenance of weight loss once target weights have been achieved. In addition to detailing evidence that supports such a conclusion, the text offers a unique perspective on obesity over the ages. It evaluates methods of determining body fat content that are appropriate to field and epidemiological studies, and it looks at the timing and aetiology of the recent obesity epidemic. It also considers the diseases associated with obesity and the resultant medical costs, attempting to disentangle the respective contributions of a sedentary lifestyle and the resultant accumulation of fat to the observed patterns of ill-health. Other sections of the text suggest that adipose tissue has important functions beyond the passive storage of energy, and looks critically at the excuse of "bad genes" that some people plead to explain their excessive body weight. Obesity: A Kinesiologist's Perspective should thus provide helpful information and be a key resource for students and researchers alike in bariatrics, kinesiology and nutrition as well as the related disciplines.

First published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

The United States, we are told, is facing an obesity epidemic-a "battle of the bulge" of not just national, but global proportions-that requires drastic and immediate action. Experts in the media, medical science, and government alike are scrambling to find answers. What or who is responsible for this fat crisis, and what can we do to stop it? Abigail Saguy argues that these fraught and frantic debates obscure a more important question: How has fatness come to be understood as a public health crisis at all? Why, she asks, has the view of "fat" as a problem-a symptom of immorality, a medical pathology, a public health epidemic-come to dominate more positive framings of weight-as consistent with health, beauty, or a legitimate rights claim-in public discourse? Why are heavy individuals singled out for blame? And what are the consequences of understanding weight in these ways? What's Wrong with Fat? presents each of the various ways in which fat is understood in America today, examining the implications of understanding fatness as a health risk, disease, and epidemic, and revealing why we've come to understand the issue in these terms, despite considerable scientific uncertainty and debate. Saguy shows how debates over the relationship between body size and health risk take place within a larger, though often invisible, contest over whether we should understand fatness as obesity at all. Moreover, she reveals that public discussions of the "obesity crisis" do more harm than good, leading to bullying, weight-based discrimination, and misdiagnoses. Showing that the medical framing of fat is literally making us sick, What's Wrong with Fat? provides a crucial corrective to our society's misplaced obsession with weight.

Learn How to Fix A Broken Relationship#1 Bestseller in Marriage & Family, Family Relationships, and Divorce Create lasting harmony, healthy communication, and everlasting love with Jonathan Robinson's powerful couple communication book. Develop effective communication skills for a lasting relationship. The original Communication Miracles for Couples by bestselling author, psychotherapist, and one of Oprah's favorite relationship experts Jonathan Robinson has helped hundreds of thousands of couples repair their relationships with over 200,000 copies sold. Now updated, you can learn how to fix a broken relationship or simply strengthen your relationship using proven marriage therapy tools and techniques. Become one of those couples that work-period. This couple communication book is for couples who want to learn new skills and build a solid foundation for working through conflicts and moving forward in ways that strengthen their bonds. Learn how to enhance your relationship by learning to communicate with less blame and more understanding. Inside, you'll find: Insightful tips to repair your marriage Couples communication skills to help you stop arguing, feel loved, and repair broken trust in your relationship The best at-home book for couples therapy, written by a trusted psychotherapist Readers of couple communication books like Relationship Goals, Alpha Female Bible, or More Love Less Conflict will love Communication Miracles for Couples.

The increasing global prevalence of obesity and nutrition-based non-communicable disease has many causes, including food availability; social norms as evidenced in local foodways; genetic predisposition; economic circumstance; cultural variation in norms surrounding body composition; and policies affecting production, distribution, and consumption of food locally and globally. The Applied Anthropology of Obesity: Prevention, Intervention, and Identity advances understanding of the many cultural factors underlying increased global obesity prevalence. This collection of chapters showcase the value of anthropology's holistic approach to human interaction by exploring how human identity associated with obesity/overweight is affected by cultural norms, policy decisions, and perceptions of cultural change. They also demonstrate best practices for the application of anthropological skillsets to develop culturally-appropriate nutritional behavior change across multiple levels of analysis, from local programming to policy decisions at local and national levels. In addition to soliciting explanatory models used by respondents in different cultures and situations, anthropologists find themselves on the front lines of public health and policy attempts at affecting behavioral change. As such, this applied-focused volume will be of utility to scholars and practitioners in applied and medical anthropology, as well as to scholars and professionals in public health and other disciplines. The volume's authors are professional and student anthropologists from both public health practice and academia. Chapters are geographically diverse, containing lessons learned from attempts to combat obesity by anthropologically focusing on culture, history, economy, and power relative to obesity causation, prevention, and intervention. The Applied Anthropology of Obesity: Prevention, Intervention, and Identity candidly provides rich information about social identity, obesity, and treatment.

As the role of the physical therapist widens to include more primary care and diagnostic responsibilities, there is a greater need for a single, up-to-date resource that explores professional roles and developments in this changing field. This new book is the definitive reference on this important topic. This concise book provides information on every vital area important to professionalism: documentation, law and ethics, and leadership - all in the context of the five roles of the physical therapist as defined by the APTA's Guide to Physical Therapist Practice, 2nd Edition. Readers will find information on the history of professionalism in physical therapy, the five roles of the physical therapist (Patient/Client Manager, Consultant, Critical Inquirer, Educator, and Administrator), the role of the physical therapist in today's health care system, and professional leadership and development. Case studies, "how to lists" and "tips from the field" encourage critical thinking and provide strategies for various issues. The book also offers tips on preparing a portfolio, determining leadership style, and preparing a professional development plan based on the APTA's five roles. Develops and defines principles and concepts of professionalism to guide physical therapists in times of change Follows the APTA's Guide and includes quotes and information from this document throughout Offers a comprehensive history of physical therapy, with unique information on origins of the profession Offers comprehensive coverage of legal and ethical issues, showing how these issues affect the entire practice of physical therapy Discusses billing and reimbursement practices, with specific information on how to document and bill as an aspect of practice Defines and explains the role of the consultant, both as an autonomous health care provider or as a member of a health care team Features real-life case studies and discussion questions at the end of each chapter to encourage practical application of concepts and test readers' knowledge Provides end-of-chapter "tips" to help readers develop best practices

New methods, new approaches and advanced technologies have started to be used for patients to gain access to less costly and more quality diagnosis and treatment services in a shorter time. This book, which includes new approaches in health sciences, has been written by successful and expert researchers who work in different health disciplines of health sciences.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

This is a short guide on sit-stand working in the office. It reviews the research on sitting and standing at work from the 1950s to present and provides guidance for specialists, therapists, practitioners, and managers. The book is illustrated with many photos and figures, provides guidance for active working at the end of every chapter, and is understandable to the layman as well as the specialist. With the increased emphasis on healthy lifestyles, coupled with the obesity and overweight epidemic, many are claiming that we should spend more time standing at work. Some have even claimed that sitting is the new smoking. Readers of the book will learn and understand what is behind these claims, what stacks-up, what doesn't, and be able to make informed decisions about whether to invest in new facilities, and what to invest. This book is of value to human factors specialists, physical therapists, chiropractors and occupational health practitioners, architects, and facilities managers. Features Explains the origins of sedentary office work Summarizes the health risks of sitting and standing and how to avoid them Reviews new research on active working and practical ways of developing active working habits in the office Discusses the obesogenic workplace, and how to avoid it Includes over 60 key points to help you decide how to be more active at work

Subtle-body practices are found particularly in Indian, Indo-Tibetan and East Asian societies, but have become increasingly familiar in Western societies, especially through the various healing and yogic techniques and exercises associated with them. This book explores subtle-body practices from a variety of perspectives, and includes both studies of these practices in Asian and Western contexts.

The book discusses how subtle-body practices assume a quasi-material level of human existence that is intermediate between conventional concepts of body and mind. Often, this level is conceived of in terms of an invisible structure of channels, associated with the human body, through which flows of quasi-material substance take place. Contributors look at how subtle-body concepts form the basic explanatory structure for a wide range of practices. These include forms of healing, modes of exercise and martial arts as well as religious practices aimed at the refinement and transformation of the human mindbody complex.

By highlighting how subtle-body practices of many kinds have been introduced into Western societies in recent years, the book explores the possibilities for new models of understanding which these concepts open up. It is a useful contribution to studies on Asian Religion and Philosophy.

Basic and clinical scientists with an interest in how cytokines regulate the production of antibody, and the selective expression of distinct antibody classes in response to microbial and other antigenic challenges, now have a single, comprehensive and timely volume covering this complex field. Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects uniquely focuses on the impact of the cytokine network on the humoral immune response, as well as its implications for the evolving field of cytokine-based medical therapeutics. With introductory chapters on basic B lymphocyte biology, a systematic and detailed review of the major B cell active cytokines, and discussions on cytokine regulation of normal and pathogenic humoral immune states, this highly referenced book will serve as a valuable source of information for both students and seasoned investigators active in multiple branches of basic and clinical immunology.

This reference provides contemporary information on all aspects of Down syndrome, investigating health concerns by age group and by organ system. The text sets out to identify and correct problems before they interrupt developing skills. It includes preventive medical checklists with summaries of appropriate medical intervention; supplies background information about history, genetics and epidemiology; outlines clinical management strategies; establishes guidelines on how to inform parents of the diagnosis and conveys practical suggestions on the handling and care of the infant; and offers a detailed review of the medical literature. Appendices provide information including growth charts and financial checklists.

This book is designed to present a comprehensive, state-of the-art approach to assessing and managing bariatric surgery and psychosocial care. Unlike any other text, this book focuses on developing a biopsychosocial understanding of patients' obesity journey and psychosocial factors contributing to their obesity and its management from an integrated perspective. Psychiatric Care in Severe Obesity takes a 360 approach by covering the disease's prevalence and relationship to psychiatric illness and social factors, including genetics, neurohormonal pathways and development factors for obesity. This book presents evidence and strategies for assessing psychiatric issues in severe obesity and uses common psychiatric presentations to feature the impact on bariatric surgery and key assessment features for weight loss. Concluding chapters focus on evidence-based psychosocial treatments for supporting patients with weight loss and bariatric surgery and includes educational tools and checklists for assessment, treatment, and care. Experts on non-pharmacological interventions such as mindfulness, cognitive-behavioral therapy and nutrition education describe treatment approaches in each modality, concluding with pharmacological approaches for psychiatric conditions and eating pathology. Additional tools in the appendices support clinicians, making this the ultimate guide for managing psychiatric illness in patients suffering from severe obesity. As obesity continues to grow in prevalence as a medically recognized epidemic, Psychiatric Care in Severe Obesity serves a vital resource to medical students, psychiatrists, psychologists, bariatric surgeons, primary care physicians, dietitians, mental health nurses, social workers, and all medical professionals working with severely obese patients.

In the crowded and busy arena of obesity and fat studies, there is a lack of attention to the lived experiences of people, how and why they eat what they do, and how people in cross-cultural settings understand risk, health, and bodies. This volume addresses the lacuna by drawing on ethnographic methods and analytical emic explorations in order to consider the impact of cultural difference, embodiment, and local knowledge on understanding obesity. It is through this reconstruction of how obesity and fatness are studied and understood that a new discussion will be introduced and a new set of analytical explorations about obesity research and the effectiveness of obesity interventions will be established.

This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.

Global Perspectives on Childhood Obesity: Current Status, Consequences and Prevention, Second Edition examines the current childhood obesity epidemic, outlines the consequences of this crisis, and develops strategies to forestall and prevent it. This book provides a thorough investigation of the causes of childhood obesity and, more importantly, offers specific prevention strategies that can be used by medical and mental health professionals, policymakers, community organizers, and individuals. New chapters on BMI and cardiovascular disease, exercise, neurotransmitters, neurocognition, nutrigenomics and combined prevention strategies are included, making this a solid introduction on the childhood obesity crisis. Researchers, practitioners, and advanced students in public health, health policy, and health economics, as well those working in medicine, pharmacy, nutrition, school health, physiology, and neuroscience related to obesity will find this to be a comprehensive resource.

Advances and Techniques in Restoration Therapy focuses on the practical elements of the Restoration Therapy Model to help mental health professionals working with individuals, couples, and families, to restore broken identities and senses of safety, and to move toward action that is functional and healing. Richly illustrated with case examples from experienced clinicians, this volume brings new insights and a range of established and emerging therapeutic techniques to the framework and Restoration Therapy community. This is an innovative and much-needed step-by-step manual, which will provide marriage and family therapists and counselors with practical ways of applying key interventions to varied situations of pain, to help clients find functional, healing solutions with integrity.

Fung zeroes in on why insulin resistance has become so prevalent and offers specific outside-the-box solutions that have emerged as the key to maximizing health." --Jimmy Moore, author, Keto Clarity and Cholesterol Clarity Everything you believe about how to lose weight is wrong. Weight gain and obesity are driven by hormones--in everyone--and only by understanding the effects of insulin and insulin resistance can we achieve lasting weight loss. In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps, a set of lifelong habits that will improve your health and control your insulin levels, Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight--for good.

This book provides an up to date review on antimicrobials dosing in obese patients, including practice recommendations for clinical use. The book is written by a group of doctors and pharmacists working in infectious diseases practice and research. The introductory chapter outlines the important physiological changes in obesity including factors affecting the dosing of antimicrobials in obese patients. The introductory chapter is followed by ten chapters covering the major classes of antibiotics, antifungals, and antivirals. Each chapter briefly discusses the pharmacokinetics changes related to obesity and a summary of the relevant up-to-date literature. Specific dosing recommendations are provided for each class supplemented by real-life examples as clinical cases that are included as an appendix to the book. The book is a useful resource for clinicians, students and researchers needing up-to-date information on antimicrobial dosing in obese patients. Doctors, pharmacists, nurses working in hospital settings, and students of health courses (medical, pharmacy and nursing students) will find this book particularly useful.

THE COMPLETE PSYCHOTHERAPY TREATMENT PLANNER

Of Related interest

Arthur E. Jongsma, Jr. and L. Mark Peterson

This valuable guide provides a thorough introduction to treatment planning and contains all of the necessary elements for developing formal treatment plans. In an easy-reference, prewritten format, this book presents detailed problem definitions, treatment goals, objectives, therapeutic interventions, and DSM-IVTM diagnoses for over thirty common clinical problems. Practitioners in the field will find this book to be a great time-saver and an invaluable reference.

1995 (0-471-11738-2) 176 pp.

THERASCRIBETM FOR WINDOWS(r)

The Computerized Assistant to Psychotherapy Treatment Planning.

Arthur E. Jongsma, Jr., L. Mark Peterson, and Kenneth Jongsma.

This revolutionary computerized treatment planning software lets you create detailed, customized treatment plans easily and quickly. Designed for use in both inpatient and outpatient settings, its user-friendly format allows clinicians to easily access a wide variety of behavioral definitions, treatment goals and objectives, therapeutic interventions, and DSM-IV diagnoses from its huge database. Its well-organized reports are designed to meet the requirements of Medicare, HMOs, and other third-party payers, which makes this program an important tool for evaluating and treating mental illness.

1997 (0-471-18415-2) 4 3.5 disks

THE COMPLETE GUIDE TO MANAGED BEHAVIORAL HEALTHCARE

Edited by Chris E. Stout and Gerald A. Theis

Managed care has radically altered the mental health services landscape. This loose-leaf style reference manual, which is updated semiannually, offers in-depth analysis from leading experts of changes in practice management, quality and outcome issues, technology, and automation. It also addresses important legal, regulatory, fiscal, and contractual concerns. Packed with practical tools and useful sample forms, the Guide includes a comprehensive glossary of managed care terms and a complete list of managed care organizations.

1996 (0-471-12586-5) 324 pp.

THE MEASUREMENT & MANAGEMENT OF CLINICAL OUTCOMES IN MENTAL HEALTH

Once used almost exclusively by psychotherapy researchers, clinical outcomes testing is quickly becoming a standard component of mental health practice. JCAHO has mandated that outcomes must be included in mental health record keeping by the end of the decade, and the six largest managed care firms have announced plans to begin tracking clinical outcomes. While debates over the potential advantages and disadvantages of this move rage on, the fact remains that all clinicians in managed care systems will soon be compelled to incorporate outcomes assessment into their clinical routines.

The Measurement and Management of Clinical Outcomes in Mental Health prepares clinicians and administrators for this inevitability. Written by a team of experts with extensive experience in design and implementation, this timely book explores the rationale behind outcomes measurement and offers readers concrete advice and guidelines on conducting accurate and effective outcomes measurement.

In the first half of the book, the authors review the conceptual and practical aspects of outcomes management. Among the issues receiving special attention are: the psychometrics of outcomes; measuring patient satisfaction; implementation strategies; the role of consumer characteristics in outcomes management, especially in regard to needs-based planning; case-mix adjustment strategies; and barriers to implementation and strategies for overcoming them.

The second half of the book is devoted entirely to detailed case examples. Over the course of five chapters, the authors vividly illustrate their approaches to outcomes management in five different specialty areas--outpatient psychotherapy, acute psychiatric services, community services, child and adolescent services, and substance-abuse treatment services.

The first comprehensive guide to designing and implementing outcomes evaluation systems, The Measurement and Management of Clinical Outcomes in Mental Health is an important resource for all mental health practitioners as well as mental health and managed care administrators.