This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990's. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.

In "The Skinnygirl Dish, " four-time "New York Times" bestselling author Bethenny Frankel builds on the foundation of healthy living from her bestseller, "Naturally Thin "to share her passion for healthful, natural foods.
In the "New York Times" bestseller "The Skinnygirl Dish," Bethenny Frankel adds additional healthy eating advice to the foundation she created with her hugely popular book, "Naturally Thin." In "The Skinnygirl Dish" she shows how to find your food voice, know when you are really hungry, and which filling and fiber-rich foods to reach for.
"The Skinnygirl Dish" serves up three weeks of tasty meals, snacks, and drinks to break the cycle of yo-yo dieting. Drawing on her now famous rules like "Your Diet is a Bank Account" and "Taste Everything, Eat Nothing," Bethenny caters to real lifestyles and shows how to maintain a healthy diet wherever you are: in a restaurant, on a plane, or with your family. With recipes and advice for holidays and special occasions and a guide to a healthful kitchen--all with Bethenny's fun, informative personality--here's another breakout hit from everyone's favorite fixologist.

First Published in 1978. Routledge is an imprint of Taylor & Francis, an informa company.

First Published in 2004. Routledge is an imprint of Taylor & Francis, an informa company.

The intent of the book is to provide readers with a summary of the obesity problem with specific focus on the metabolic health issues (ie, diabetes mellitus), obstructive sleep apnea, non-alcoholic fatty liver disease and the psychological effects of obesity. This will provide readers with an understanding of the commonly performed operations for obesity along with evidence-based outcomes, nutritional issues, and metabolic consequences.

This volume examines the biocultural dimensions of obesity from an anthropological perspective in an effort to broaden understanding of a growing public health concern. The United States of America currently has the highest rates of obesity among developed countries, with an alarming rise in prevalence in recent decades which promises to affect the nation for years to come. Bellisari helps students to grasp the complex nature of this obesity epidemic, demonstrating that it is the consequence of many interacting forces which range from individual genetic and physiological predispositions to national policies and American cultural beliefs and practices. As much a social problem as an individual one, the development of obesity is in fact encouraged by the pattern of high consumption and physical inactivity that is promoted by American economic, political, and ideological systems. With a range of up-to-date scientific and medical data, The Anthropology of Obesity in the United States provides students with a comprehensive picture of obesity, its multiple causes, and the need for society-wide action to address the issue.

Family Therapy Techniques briefly reviews the basic theories of marriage and family therapy. It then goes into treatment models designed to facilitate the tailoring of therapy to specific populations and the integration of techniques from what often seems like disparate theories. Based on the assumption that no single approach is the definitive approach for every situation, the book leads students through multiple perspectives. In teaching students to integrate and tailor techniques, this book asks them to take functional methods and approaches from a variety of theoretical approaches, without attempting to reiterate the theoretical issues and research covered in theories courses.

This book is unique in exploring the process of conducting short-term intensive group play therapy and the subsequent results. It focuses on play therapy with special populations of aggressive acting-out children, autistic children, chronically ill children, traumatized children, selective mute children, disassociative identity disorder adults with child alters, and the elderly. The book addresses such vital issues as: * How play therapy helps children * Confidentiality in working with children * How to work with parents * What the play therapist needs to know about medications for children The difficult dimension of diagnosis is clarified through specific descriptions of how the play therapist can use play behaviors to diagnose physical abuse, sexual abuse, and emotional maladjustment in children.

Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed.Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs - many based on incretin action - have been added to the therapeutic armoury.Following an introduction detailing the historical perspective and discovery of incretin therapies and clinical applications, the book looks at the release of incretins at a cellular level from entero-endocrine cells, and actions on the pancreas (alpha and beta cells) and brain. It then looks at changes in incretins seen in diabetes and following bariatric surgery. Finally, the side effects of incretin therapy are discussed. Importantly, each chapter contains a methodology section aimed at providing a practical guide to key techniques in the field of incretin biology and ranges from basic laboratory research to clinical practice.Incretin Biology - A Practical Guide offers a unique perspective within this field of research by bringing together scientists, physicians and bariatric surgeons. Thus, it is a comprehensive text that offers a broad overview of the subject.

The increasing global prevalence of obesity and nutrition-based non-communicable disease has many causes, including food availability; social norms as evidenced in local foodways; genetic predisposition; economic circumstance; cultural variation in norms surrounding body composition; and policies affecting production, distribution, and consumption of food locally and globally. The Applied Anthropology of Obesity: Prevention, Intervention, and Identity advances understanding of the many cultural factors underlying increased global obesity prevalence. This collection of chapters showcase the value of anthropology's holistic approach to human interaction by exploring how human identity associated with obesity/overweight is affected by cultural norms, policy decisions, and perceptions of cultural change. They also demonstrate best practices for the application of anthropological skillsets to develop culturally-appropriate nutritional behavior change across multiple levels of analysis, from local programming to policy decisions at local and national levels. In addition to soliciting explanatory models used by respondents in different cultures and situations, anthropologists find themselves on the front lines of public health and policy attempts at affecting behavioral change. As such, this applied-focused volume will be of utility to scholars and practitioners in applied and medical anthropology, as well as to scholars and professionals in public health and other disciplines. The volume's authors are professional and student anthropologists from both public health practice and academia. Chapters are geographically diverse, containing lessons learned from attempts to combat obesity by anthropologically focusing on culture, history, economy, and power relative to obesity causation, prevention, and intervention. The Applied Anthropology of Obesity: Prevention, Intervention, and Identity candidly provides rich information about social identity, obesity, and treatment.

A growing sense of urgency over obesity at the national and international level has led to a proliferation of medical and non-medical interventions into the daily lives of individuals and populations. This work focuses on the biopolitical use of lifestyle to govern individual choice and secure population health from the threat of obesity. The characterization of obesity as a threat to society caused by the cumulative effect of individual lifestyles has led to the politicization of daily choices, habits and practices as potential threats. This book critically examines these unquestioned assumptions about obesity and lifestyle, and their relation to wider debates surrounding neoliberal governmentality, biopolitical regulation of populations, discipline of bodies, and the possibility of community resistance. The rationale for this book follows Michel Foucault's approach of problematization, addressing the way lifestyle is problematized as a biopolitical domain in neoliberal societies. Mayes argues that in response to the threat of obesity, lifestyle has emerged as a network of disparate knowledges, relations and practices through which individuals are governed toward the security of the population's health. Although a central focus is government health campaigns, this volume demonstrates that the network of lifestyle emanates from a variety of overlapping domains and disciplines, including public health, clinical medicine, media, entertainment, school programs, advertising, sociology and ethics. This book offers a timely critique of the continued interventions into the lives of individuals and communities by government agencies, private industries, medical and non-medical experts in the name of health and population security and will be of interests to students and scholars of critical international relations theory, health and bioethics and governmentality studies.

Encouraging the development of a personal model of supervision built upon the integration of theory, research, and regard for the uniqueness of clinical settings, this new text will prepare readers for approved supervisor credential while advancing their ability to blend systemic theory with clinical practice in the context of personal and professional development.

Much more than an archive, these are the vivid, still pertinent voices and messages of the pioneers worldwide. The nineteen articles chosen by the editors of Applied Theatre Research represent key themes and elements from the early days of applied theatre that are still - and indeed now more than ever - relevant. They are all high-quality articles, some of which were highly influential in their own time. All of them still have plenty to say to today's applied theatre, both in their own terms and sometimes in terms of how their publication influenced the development at the time of this still-expanding field, or refracted it in ways that give us new insights with hindsight. They have been arranged in sections according to some of the key themes - and problematic issues - that were discovered, thought out and sometimes stumbled across by the pioneer writers in the collection. Each section is preceded by a critical editorial commentary on those themes, besides thorough introductions to all the articles and in some cases re-evaluations. The editors have added substantial additional new material to the collection and in doing so, bring their own applied theatre experience to bear on these themes, as they raise general questions that are wide-ranging, contemporary and urgent: from the vital and contested issues of power, partnerships and the giving of voice through theatre to applied theatre's proactive response to COVID-19, to the need to identify, take account of and address the needs of all stakeholders in any applied theatre project. The articles are grouped in six sections, covering areas such as diversity of geography, community contexts, forms of applied theatre and organizational factors that characterize applied theatre; the definition and nature of applied theatre; how the best intentioned projects could be compromised by any of the many opportunities for applied theatre to go wrong; opportunities for change it can offer and the incorporation of new media technologies, and ethnographic performance, two factors that have now become major preoccupations for our field, particularly in the years since the articles were written. The final section recognizes that applied theatre has been around not for 30 years, but for thousands, and in countless cultures. The editorial chapters have strong connections with the rest of the book, but are written with the editors' deep insights into the field, and are sharp in their focus and context. The book offers useful insights into the start of applied theatre and its development as an area of practice and research. The chapter collection is relevant and includes influential names in the field who have contributed significantly to the development of applied theatre over time. The primary market will be academics and advanced practitioners in applied theatre, drama education and theatre studies - including the expanding fields of drama therapy, theatre and health etc. It will also be useful for educators exploring creative pedagogy and drama in education strategies across the curriculum. It will be valuable introductory background reading for advanced undergraduate and post-graduate students in drama, theatre studies and theatre arts, performance studies and community theatre.

Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the polynuclear charged platinum BBR3464-are also fully considered. Timely and interdisciplinary, Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics specialists an illuminating survey of every aspect of platinum drugs from mechanisms of action to toxicology, tumor resistance, and new analogs.

Childhood obesity has become a central concern in many countries and a range of policies have been proposed or implemented to address it. This co-authored book is the first to focus on the complex set of ethical and policy issues that childhood obesity raises. Throughout the book, authors Kristin Voigt, Stuart G. Nicholls, and Garrath Williams emphasize that childhood obesity is a multi-faceted phenomenon, and just one of many issues that parents, schools and societies face. They argue that it is important to acknowledge the resulting complexities and not to think in terms "single-issue" policies. After first reviewing some of the factual uncertainties about childhood obesity, the authors explore central ethical questions. What priority should be given to preventing obesity? To what extent are parents responsible? How should we think about questions of stigma and inequality? In the second part of the book, the authors consider key policy issues, including the concept of the aobesogenic environment,a debates about taxation and marketing, and the role that schools can play in obesity prevention. The authors argue that political debate is needed to decide the importance given to childhood obesity and how to divide responsibilities for action. These debates have no simple answers. Nonetheless, the authors argue that there are reasons for hope. There are a wide range of opportunities for action. Many of these options also promise wider social benefits. "This book provides a welcome re-appraisal of commonly-held beliefs about child obesity and misconceptions about what needs to be done. The authors expose the futility of holding parents responsible for children's unhealthy behaviour, they challenge the assumption that education and family support will solve the problem, and they condemn the prejudice and stigma which surround the narrative of blame. The book shows convincingly how the causes of obesity - and the range of associated diseases - lie in the fabric of the modern market economy: in the food supply which shapes our diets, the social and physical environment which encourages sedentary behaviour, and in the media which promote ever greater consumption. Obesity is not the problem: it is the symptom of a more complex social and economic malaise encouraging poor health. The case for interventions by governments to promote health and wellbeing above crude economic growth is comprehensively proven." - Dr. Tim Lobstein, Director of Policy and Programmes, The International Association for the Study of Obesity and The International Obesity Task Force A well-researched, highly critical, but carefully balanced examination of everyday assumptions about childhood obesity and its prevention from an intensely moral perspective. Although the authors demonstrate that no intervention is without ethical complications or effective entirely on its own, they call for immediate actions to reduce the stigma of childhood obesity, support parents, and create food environments healthier for children, adults, and the environment.- Marion Nestle, Paulette Goddard Professor of Nutrition, Food Studies, and Public Health, NYU Steinhardt School of Culture, Education, and Human Development

Yoga Therapy: Theory and Practice is a vital guidebook for any clinician or scholar looking to integrate yoga into the medical and mental health fields. Chapters are written by expert yoga therapy practitioners and offer theoretical, historical, and practice-based instruction on cutting-edge topics such as application of yoga therapy to anger management and the intersection of yoga therapy and epigenetics; many chapters also include Q&A "self-inquiries." Readers will find that Yoga Therapy is the perfect guide for practitioners looking for new techniques as well as those hoping to begin from scratch with yoga therapy.

As bariatric procedures become more commonplace, the safety and quality of bariatric surgery continues to rise. Risk factors remain inconsistent from hospital to hospital and procedure to procedure, however, highlighting the necessity for comprehensive education on the prevention and management of their resulting complications. In response to this need, Prevention and Management of Complications in Bariatric Surgery is the first book to compile the most up-to-date prevention and management strategies in this field. Edited by leading experts, it provides sound recommendations for collecting, monitoring, and analyzing outcomes, with an emphasis on quality and process improvement. Its scope is tremendously comprehensive, covering everything from common complications, such as leaks, bleeding, wound infections, and venous thromboembolism; to rare-but-deadly complications, such as Wernicke's encephalopathy and rhabdomyolsis as well as the emergency management of various life-threatening complications, including internal hernia, gastric nectrosis from banding, pulmonary embolus, and bleeding. Readers also learn about early-day, late-day, and intraoperative complications, for which the authors provide evidence-based recommendations for swift and accurate diagnosis, preventive strategies, and best practices in medical and surgical management. Comprehensive and accessible, this book is a valuable resource for bariatric surgeons and surgical trainees, physicians, and nurses who participate in the perioperative care of the bariatric patient.

Nowadays a plethora of treatment technologies is available to the consumer, each employing a variety of concepts of the body, self, sickness and healing. This volume explores the options, strategies and consequences that are both relevant and necessary for patients and practitioners who are manoeuvring this medical plurality. Although wideranging in scope and covering areas as diverse as India, Ecuador, Ghana and Norway, central to all contributions is the observation that technologies of healing are founded on socially learned and to some extent fluid experiences of body and self.

This title includes a number of Open Access chapters. The research contained in this valuable compendium offers a much-needed perspective on one of the most dangerous health crises our world faces today: obesity. Obesity has become an epidemic, a fact frequently discussed in the media, with many references to both childhood and adult obesity. These discussions, however, overlook an important demographic: the adolescent who is obese or overweight. The authors offer critical insights into the forces and factors that result in the numerous metabolic and psychological consequences of adolescent obesity. The book delves into the prevalence, causes and correlates, and implications and consequences of adolescent obesity, and goes on to present considerations for future action. The research covers many of the causes of adolescent obesity, including increased consumption of high carbohydrate snacks; eating too much, too fast, and too frequently; eating high-fat, cheap, convenient, and readily assessable foods; increased sedentary activities, such as TV watching and video games, accompanied by decreased physical activity; parents' and schools' lack of nutrition vigilance; and the commercial incentives to sell calorie-dense foods aggressively and relentlessly. Edited by an eminent doctor and professor, The Complexity of Adolescent Obesity is an easily accessible and well-organized volume that offers vital research context for policymakers, educators, medical providers, and families.

Originally published in 1991, this book covers a comprehensive range of the applications of hypnotic techniques in therapy for psychological disorders, and medical conditions where such techniques are a valuable adjunct. In the years before publication psychologists, medical doctors, dentists and allied professional workers had come to make increasing use of hypnosis in their work, and there was a considerable amount of relevant research literature available in journals. Such literature is reviewed, and served as a practical guide for professionals at the time. The book begins by explaining what is meant by hypnosis today, and traces its historical background. Some fundamental questions such as individual differences in susceptibility to hypnosis are discussed in relation to therapy. Separate chapters are devoted to the key topics of behaviour therapy, different forms of psychotherapy, psychosomatic medicine, the treatment of pain, and applications in medical and surgical procedures. The modern status of hypnotic techniques in obstetrics and in dentistry is reviewed, and a separate chapter on the use of hypnosis with children will be of special interest to educational and clinical psychologists. A final chapter reviews the use of hypnosis by various professions and para-medical disciplines, and discusses the possible abuses that may arise both through unqualified people seeking to practise "hypnotherapy", and by professionals acting outside their proper range of competence.

Diets don't work. People can't keep the weight off. Many invest billions of dollars into the weight-loss industry, but are not getting the pay-back in pounds that people are able to keep off. The programs don't work and never have, because they only focus on taking the weight off for now. They set many up for failure with rigid, restrictive and unrealistic weight loss programs that offer a quick fix, but let's face it, they aren't sustainable. Enter Kris J. Simpson and his All Inclusive approach to keeping the weight off. All Inclusive Diet is about finding the balance and keeping the weight off. If you have taken weight off in the past only to put it back on again, All Inclusive Diet will teach you how to keep it off forever.

Stimulant drugs are widely used in the treatment of ADHD in children and adults. Hundreds of studies over the past 60 years have demonstrated their effectiveness in improving attention span, increasing impulse control, and reducing hyperactivity and restlessness. Despite widespread interest in these compounds, however, their mechanisms of action in the central nervous system have remained poorly understood. Recent advances in the basic and clinical neurosciences now afford the possibility of elucidating these mechanisms. The current volume is the first to bring this expanding knowledge to bear on the central question of why and how stimulants exert their therapeutic effects. The result is a careful, comprehensive, and insightful integration of material by well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research. Part I presents a comprehensive description of the clinical features of ADHD and the clinical repsonse to stimulants. Part II details the cortical and subcortical neuroanatomy and functional neurophysiology of dopamine and norepinephrine systems with respect to the regulation of attention, arousal, activity, and impulse control on the basis of animal studies. Part III is devoted to clinical research, including recent studies of neuroimaging, genetics, pharmacodynamic and pharmacokinetic properties of stimulants, effects on cognitive functions, neurophysiological effects in humans with and without ADHD and in non-human primates, and comparison of stimulants and non-stimulants in the treatment of ADHD. Part IV is a masterful synthesis that presents alternative models of stimulant drug action and generates key hypotheses for continued research. The volume will be of keen interest to researchers and clinicians in psychiatry, psychology, and neurology, neuroscientists studying stimulants, and those persuing development of new drugs to treat ADHD.

The perennial bestseller that you MUST READ in order to fully understand the interplay between electric energy and living organisms

The Body Electric tells the fascinating story of our bioelectric selves. Robert O. Becker, a pioneer in the field of regeneration and its relationship to electrical currents in living things, challenges the established mechanistic understanding of the body. He found clues to the healing process in the long-discarded theory that electricity is vital to life. But as exciting as Becker's discoveries are, pointing to the day when human limbs, spinal cords, and organs may be regenerated after they have been damaged, equally fascinating is the story of Becker's struggle to do such original work.

The Body Electric explores new pathways in our understanding of evolution, acupuncture, psychic phenomena, and healing.

Why is music so important to most of us? How does music help us both in our everyday lives, and in the more specialist context of music therapy? This book suggests a new way of approaching these topical questions, drawing from Ansdell's long experience as a music therapist, and from the latest thinking on music in everyday life. Vibrant and moving examples from music therapy situations are twinned with the stories of 'ordinary' people who describe how music helps them within their everyday lives. Together this complementary material leads Ansdell to present a new interdisciplinary framework showing how musical experiences can help all of us build and negotiate identities, make intimate non-verbal relationships, belong together in community, and find moments of transcendence and meaning. How Music Helps is not just a book about music therapy. It has the more ambitious aim to promote (from a music therapist's perspective) a better understanding of 'music and change' in our personal and social life. Ansdell's theoretical synthesis links the tradition of Nordoff-Robbins music therapy and its recent developments in Community Music Therapy to contemporary music sociology and music studies. This book will be relevant to practitioners, academics, and researchers looking for a broad-based theoretical perspective to guide further study and policy in music, well-being, and health.

This title includes a number of Open Access chapters. The book provides a comprehensive perspective on the subject of obesity epidemiology, pathophysiology, and management of obesity. The chapters provide a better understanding of obesity and obesity-related diseases and offer an integrative framework for individualized dietary and exercise programs, behavior modification, pharmaceutical approaches, surgery, and population interventions to reduce the growing epidemic of obesity.