The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

Originally published in French, this updated and expanded English translation offers a definitive treatment on clays and effects on human health including the long history of clays used as pharmaceutical and therapeutic agents, the origins of clays, their structural properties and modes of action.

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

Almost one out of every three US children is overweight or obese, with minority youth at highest risk. There are limited efficacious pediatric obesity interventions available for clinicians, and successful weight loss trials for minority youth are rare. Even fewer interventions have been shown to significantly improve clinical health outcomes such as adiposity, blood pressure, and cholesterol level, and maintenance of behavior change over the long-term remains a challenge Translation I research in which "bench" findings are applied to the "bedside" is uncommon in the behavioral arena. Thus, advances in our understanding of fundamental human processes such as motivation, emotion, cognition, self-regulation, decision-making, stress, and social networks are not being optimally applied to our most pressing behavioral health problems. This issue of Pediatric Clinics will focus on promising behavioral treatments "in the pipeline" that have been translated from basic behavioral science and are the process of refinement and proof of concept testing.

Fung zeroes in on why insulin resistance has become so prevalent and offers specific outside-the-box solutions that have emerged as the key to maximizing health." --Jimmy Moore, author, Keto Clarity and Cholesterol Clarity Everything you believe about how to lose weight is wrong. Weight gain and obesity are driven by hormones--in everyone--and only by understanding the effects of insulin and insulin resistance can we achieve lasting weight loss. In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps, a set of lifelong habits that will improve your health and control your insulin levels, Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight--for good.

Childhood obesity has become a central concern in many countries and a range of policies have been proposed or implemented to address it. This co-authored book is the first to focus on the complex set of ethical and policy issues that childhood obesity raises. Throughout the book, authors Kristin Voigt, Stuart G. Nicholls, and Garrath Williams emphasize that childhood obesity is a multi-faceted phenomenon, and just one of many issues that parents, schools and societies face. They argue that it is important to acknowledge the resulting complexities and not to think in terms "single-issue" policies. After first reviewing some of the factual uncertainties about childhood obesity, the authors explore central ethical questions. What priority should be given to preventing obesity? To what extent are parents responsible? How should we think about questions of stigma and inequality? In the second part of the book, the authors consider key policy issues, including the concept of the aobesogenic environment,a debates about taxation and marketing, and the role that schools can play in obesity prevention. The authors argue that political debate is needed to decide the importance given to childhood obesity and how to divide responsibilities for action. These debates have no simple answers. Nonetheless, the authors argue that there are reasons for hope. There are a wide range of opportunities for action. Many of these options also promise wider social benefits. "This book provides a welcome re-appraisal of commonly-held beliefs about child obesity and misconceptions about what needs to be done. The authors expose the futility of holding parents responsible for children's unhealthy behaviour, they challenge the assumption that education and family support will solve the problem, and they condemn the prejudice and stigma which surround the narrative of blame. The book shows convincingly how the causes of obesity - and the range of associated diseases - lie in the fabric of the modern market economy: in the food supply which shapes our diets, the social and physical environment which encourages sedentary behaviour, and in the media which promote ever greater consumption. Obesity is not the problem: it is the symptom of a more complex social and economic malaise encouraging poor health. The case for interventions by governments to promote health and wellbeing above crude economic growth is comprehensively proven." - Dr. Tim Lobstein, Director of Policy and Programmes, The International Association for the Study of Obesity and The International Obesity Task Force A well-researched, highly critical, but carefully balanced examination of everyday assumptions about childhood obesity and its prevention from an intensely moral perspective. Although the authors demonstrate that no intervention is without ethical complications or effective entirely on its own, they call for immediate actions to reduce the stigma of childhood obesity, support parents, and create food environments healthier for children, adults, and the environment.- Marion Nestle, Paulette Goddard Professor of Nutrition, Food Studies, and Public Health, NYU Steinhardt School of Culture, Education, and Human Development

Medical treatment guidelines are written from a clinical perspective, to guide clinical care. The review criteria that will be included in this issue of Physical Medicine & Rehabilitation Clinics are evidence based and are developed by practicing physicians and advisors who work in physical medicine and rehabilitation. Health care providers are expected to be familiar with the guidelines and follow the recommendations. Good medical judgment is important in deciding how to use and interpret this information.

Food Allergy and Gluten-Free Weight Loss gives definitive answers to the question, "Why is it so hard to lose weight?" It is because we have missed or ignored the most important pieces in the puzzle of how our bodies determine whether to store or burn fat. Those puzzle pieces are hormones such as insulin, cortisol, leptin, and others. Individuals with food allergies or gluten intolerance face additional weight-loss challenges such as inflammation due to allergies or a diet too high in rice. This book explains how to put your body chemistry and hormones to work for you rather than against you, reduce inflammation which inhibits the action of your master weight control hormone, leptin, and flip your fat switch from "store" to "burn." It includes a flexible healthy eating plan that eliminates hunger, promotes the burning of fat, and reduces inflammation and tells how to customize the plan so it fits you, your allergies or intolerances, and your need for pleasure in what you eat. Information about cooking for special diets, 175 recipes, a list of sources for special foods, and extensive appendix and reference sections are also included.

As bariatric procedures become more commonplace, the safety and quality of bariatric surgery continues to rise. Risk factors remain inconsistent from hospital to hospital and procedure to procedure, however, highlighting the necessity for comprehensive education on the prevention and management of their resulting complications. In response to this need, Prevention and Management of Complications in Bariatric Surgery is the first book to compile the most up-to-date prevention and management strategies in this field. Edited by leading experts, it provides sound recommendations for collecting, monitoring, and analyzing outcomes, with an emphasis on quality and process improvement. Its scope is tremendously comprehensive, covering everything from common complications, such as leaks, bleeding, wound infections, and venous thromboembolism; to rare-but-deadly complications, such as Wernicke's encephalopathy and rhabdomyolsis as well as the emergency management of various life-threatening complications, including internal hernia, gastric nectrosis from banding, pulmonary embolus, and bleeding. Readers also learn about early-day, late-day, and intraoperative complications, for which the authors provide evidence-based recommendations for swift and accurate diagnosis, preventive strategies, and best practices in medical and surgical management. Comprehensive and accessible, this book is a valuable resource for bariatric surgeons and surgical trainees, physicians, and nurses who participate in the perioperative care of the bariatric patient.

This issue of Immunology and Allergy Clinics, devoted to Obesity and Asthma, is edited by Dr. Anurag Agrawal. Articles in this issue include: Clinical Implications of the Obese Asthma Phenotypes; Childhood Obesity and the Risk of Allergy; Metabolic Asthma: Is there a link between obesity, asthma, and diabetes?; Role of Weight Management in Obese-Asthma Control; Obesity and Airway Disease: A Bioenergetic Problem?; Nutrition, Obesity, and Asthma: Exploring Epigenetic Programming; Obesity and Asthma: The Role of Environmental Pollutants; Novel Therapeutic Strategies for Adult Obese Asthmatics; and From ADMA to Asthma.

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn s disease, diabetes, multiple sclerosis, critical limb ischemia and many others.

MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies "in vitro. "In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable "in vitro "expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress.

The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: Genetic approaches for personal oncologyTargeting epigenetic dysregulation and protein interaction networksVaccines and antibodies in cancer immunotherapyTumor heterogeneity and chemotherapy resistanceTumor associated macrophages in anticancer treatment

Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences

Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviewsseries, which features reviews published in "Cell Press" primary research and "Trends" reviews journals.
Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics
Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy
Features reviews on basic science advances translated into drug discovery and therapeutic approaches
Includes articles originally published in "Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine," and "Trends in Pharmacological Sciences""

First published in 1943, "Vitamins and Hormones" is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, "Vitamins and Hormones" continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on obesity.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans.
Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant potential as new anti-obesity drugs.

Chapters are written by leading experts.

Edited by Kenneth A. Jacobson and Michael F. Jarvis
The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expression of receptors for ATP and adenosine, novel compounds have been developed with unique therapeutic potential for the treatment of thrombosis, stroke, epilepsy, chronic pain, immunological disorders, and cancer. As a result, the study of adenosine- and ATP-mediated responses in cellular regulation is entering a phase of opportunity and development unmatched since the days of serotonin receptor research in the 1970s.
The only definitive book on the topic, Purinergic Approaches in Experimental Therapeutics covers all of the major therapeutic applications of purinergic receptors and reflects the very latest developments in this new area of therapeutic research. Twenty-eight chapters, authored by an international group of contributors who are the leading authorities in the field, provide details on molecular pharmacology; medicinal chemistry; and therapeutic implications, including cardiology, metabolism, immunology, neurology, and cancer.
Among the topics covered:
* Purinergic Neurotransmission and Neuromodulation: A Historical Perspective
* Adenosine Receptor Subtypes: New Insights from Cloning and Functional Studies
* Modulators of Adenosine Uptake, Release, and Inactivation
* Cardiac Electrophysiology of Adenosine: Antiarrhythmic and Proarrhythmic Actions
* Purinergic Modulation of Gastrointestinal Function
* The Role of Adenosine in Asthma
* ATP in Brain Function
* ATP in the Treatment of Cancer

For researchers in pharmacology, physiology, molecular biology, and medicinal chemistry, Purinergic Approaches in Experimental Therapeutics heralds an exciting new era in the understanding of purinergic neurotransmission and the development of novel therapeutic modalities.

Nutrition in the Prevention and Treatment of Disease has been proving itself in the classroom for nearly 10 years and is praised as being accessible, applicable and a valuable textbook. It focuses specifically on the relationship between disease and nutrition, an area of ever increasing interest and concern as health care costs and availability continue to be an issue worldwide. Now reaching beyond just the individual healthcare concern, the potential for nutritional interventions to improve health status is also of heightened interest to public health professionals who are faced with an aging, obese, at-risk-of-diabetes population who may or may not have access to insurance. This textbook is the foundation of understanding how nutrition can be used to improve health status.

New to this edition:

100% overall new material. 26 new authors or co-authors and all chapters have been completed updated

4 completely new chapters: "

Surgery for Severe Obesity

Snacking and Energy Balance in Humans

Phytochemicals in the Prevention and Treatment of Obesity and Its Related Cancers

Bioavailability and Metabolism of Bioactive Compounds from Foods "

New section on "Dietary Bioactive Compounds for Health" explores bioactive components present in edible plants of particular interest for the prevention of disease

New to the obesity section is a chapter on the management of patients who have undergone surgical treatment for obesity
Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences librariesIntegration of food issues with nutrition provides a unique perspective to disease prevention/controlMaterial in the book is up-to-date with current researchIndividual sections of the book can be used for mini-courses or in-depth studyDiversity of material makes this text useful for nutritional scientists and also for upper division nutrition course work

Neurological Rehabilitation is the latest volume in the definitive Handbook of Clinical Neurology series. It is the first time that this increasing important subject has been included in the series and this reflects the growing interest and quality of scientific data on topics around neural recovery and the practical applications of new research. The volume will appeal to clinicians from both neurological and rehabilitation backgrounds and contains topics of interest to all members of the multidisciplinary clinical team as well as the neuroscience community. The volume is divided into five key sections. The first is a summary of current research on neural repair, recovery and plasticity. The authors have kept the topics readable for a non-scientific audience and focused on the aspects of basic neuroscience that should be most relevant to clinical practice. The next section covers the basic principles of neurorehabilitation, including excellent chapters on learning and skill acquisition, outcome measurement and functional neuroimaging. The key clinical section comes next and includes updates and reviews on the management of the main neurological disabling physical problems, such as spasticity, pain, sexual functioning and dysphagia. Cognitive, emotional and behavioural problems are just as important and are covered in the next section, with excellent chapters, for example, on memory and management of executive dysfunction. The final part draws the sections on symptom management together by discussing the individual diseases that are most commonly seen in neurorehabilitation and providing an overview of the management of the disability associated with those disorders. The volume is a definitive review of current neurorehabilitation practice and will be valuable to a wide range of clinicians and scientists working in this rapidly developing field.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient's blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.

As technology becomes an increasingly vital aspect of modern social interaction, the field of disability informatics and web accessibility has made significant progress in consolidating theoretical approaches and exploring new application domains for those with motor and cognitive disabilities. Disability Informatics and Web Accessibility for Motor Limitations explores the principles, methods, and advanced technological solutions in the use of assistive technologies to enable users with motor limitations. This book is essential for academia, industry, and various professionals in fields such as web application designers, rehabilitation scientists, ergonomists, and teachers in inclusive and special education. This publication is integrated with its pair book Assistive Technologies and Computer Access for Motor Disabilities.