With cutting-edge and clinically relevant information, MECHANICAL VENTILATION, 2nd Edition takes a practical, clinical approach to the principles and practice of mechanical ventilation. This informative resource explains mechanical ventilation decisions and procedures in real-world terms so information is easy to understand and apply. This thoroughly updated edition includes one new chapter, four completely updated chapters, and a wealth of new user-friendly features. Detailed, clinically focused coverage of the application of mechanical ventilation to the most common respiratory diseases, provides practical answers to real life problems. UNIQUE! Sections of chapters on Special Techniques and Future Therapies include information on the newest techniques for treating patients in respiratory distress. A separate appendix of case studies helps you apply what you've learned to realistic situations. Well-known and respected authors, Neil MacIntyre and Rich Branson, share their vast expertise and accurate, cutting-edge information. Chapter Objectives, Key Point Summaries, and Assessment Questions reinforce basic concepts from each chapter. New chapter on Unique Patient Populations highlights the mechanical ventilation issues of traumatic brain injury, neuromuscular disease, lung transplantation, burn injury, and perioperative patient populations. Expanded glossary includes relevant terminology and key terms to help you easily find unfamiliar terminology.

This issue of Physical Medicine and Rehabilitation Clinics, guest edited by Dr. Aloysia L. Schwabe, will cover a number of important topics related to Cerebral Palsy. This issue is one of four each year selected by our series Consulting Editor, Dr. Santos Martinez. Articles in this issue include but are not limited to: Comprehensive Care in CP, The Expanding Role of Genetics in CP, Musculoskeletal Imaging in CP, Updates in Medical Management of Hypertonia, Biomechanics and Lower Limb Bracing, Surgical tone Reduction In CP, Motion Analysis in Pre-operative Surgical Planning, Technological Advances in CP Rehabilitation, Adaptive Sports and Recreation, Transition, Adult Orthopedic Issues in CP, and CPRN.

This comprehensive resource covers a broad array of research strategies available to massage therapists to give them the tools they need to be knowledgeable readers of research literature, as well as active researchers. The primary focus of the book is on the quantitative aspect of research that encompasses the principal types of studies most extensively used in the various health care professions, specifically massage therapy. Extensive coverage is also given to the qualitative and integrative research categories that are progressively gaining recognition among researchers in various health science disciplines and professions. Accommodates the March 2003 mandate from the Commission on Massage Therapy Accreditation (COMTA) that massage therapy schools incorporate into their curricula provisions to ensure a research literate profession. Examples and techniques for interpreting research guide practitioners and students to be knowledgeable readers of massage therapy research, allowing application to practice. Relies heavily on concept maps, flowcharts, tables, and illustrations and excerpts of published studies to augment the book's narrative development of topics by providing pictorial displays and summaries of the material. Literature-based and hypothetical research examples/illustrations from several manual therapy professions employing therapeutic massage make the material pertinent to real-life settings An introductory section at the beginning of each chapter reviews the material covered in the previous chapter and how it relates to the new material. Chapter coverage spans the quantitative, qualitative, and integrative research categories and affiliated research strategies and methods are considered in detail. Review/summary tables give an overview of the narrative development of topics. Boxes provide the essential features of a given topic. Relies on multiple examples of possible research scenarios and illustrative excerpts from the published research literature. Content is cross-referenced for use with the Massage Therapy Foundation's Massage Therapy Research Curriculum Kit to provide both instructors and students in the 6-, 15-, and 24-hour options/levels an extensively-developed resource in one place. Each chapter includes recommended web sites and software application packages for further information.

Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians' offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.

Guest edited by Drs. Marjorie Eskay-Auerbach and Robert Rondinelli, this issue of Physical Medicine and Rehabilitation Clinics will discuss Medical Impairment and Disability Evaluation and Associated Medicolegal Issues. This issue is one of four selected each year by our series Consulting Editor, Dr. Santos Martinez of the Campbell Clinic. Topics in this issue include, but are not limited to: The Physician's Approach to Impairment Rating and Disability Benefits Determinations; Claimant-related Issues; Evaluating Return-to-work ability using Functional Capacity Evaluation; Evaluating Human Functioning Using CAT Methodology for Disability Determination within the SSA; Burden of treatment compliance; Measuring Quality of Life Loss in Litigation; Medical-Legal Causation Analysis; Actuarial Analysis and Life Expectancy Determination after Catastrophic Illness or Injury; Validity Assessment in Acquired Brain Injury Disability Evaluation; Medicolegal Expert Core Competencies & Professionalism; The Physician as Expert Witness; Rehabilitating the Injured Worker to Maximum Medical Improvement (MMI); The Independent Medical Examination (IME); and Life Care Planning, among other topics.

This issue of Physical Medicine and Rehabiltiation Clinics, guest edited by Drs. Karen Barr and Ileana Michelle Howard, will cover several key aspects of Value-Added Electrodiagnostics. At the invitation of series Consulting Editor Dr. Santos Martinez, the editors put together a comprehensive issue discussing topics including: Targeting interventions for fall risk reduction; Detecting toxic myopathies as medication side effect; Predicting response from interventional spine procedures; Planning interventions to treat plexopathies; Minimizing risk of cancer therapeutics; Predicting Recovery from Peripheral Nerve Trauma; Detecting complications of metabolic syndrome and diabetes; Steering peripheral neuropathy work-up; Elucidating the cause of pelvic pain; and Guiding treatment for foot pain, among others.

An overview written for general readers of the history, prevention, treatment, causes, and consequences of obesity. What makes obesity a disease instead of just a matter of overeating? What are the genetic and environmental factors behind it? What new breakthroughs are being developing to combat it? This concise, information-rich volume looks at these and other important questions, clearing away misconceptions about this devastating condition. Obesity explains what scientists now know about the causes and consequences of being overweight, including the latest on the links between obesity and heart disease, diabetes, some cancers, asthma, and sleep difficulties. The book pays specific attention to the problem among obese young people, who more and more are being diagnosed with chronic illnesses that used to only be seen in adults. It also reports on promising efforts to battle obesity, from medical treatments to community awareness programs. The work is combines materials from history, epidemiology, behavioral science, surgery, pharmacology, economics, and policy Includes a glossary of key terms related to the study of obesity

This volume takes a fresh look at the problems of designing effective and humane service care delivery systems for the seriously mentally ill. The author addresses a number of major themes, including the differing definitions of mental illness and the differing treatment technologies that have logically developed from them, the varying theories regarding the structure and design of the service delivery system, and the policy dilemmas that lead to inconsistent and inequitable treatment. Demonstrating that there are wide areas of agreement among the disputing professionals. Chandler offers guidelines for finding these zones of agreement and achieving a consensus for realistically improving the system of care. The focus throughout is on the development of practical problem-solving strategies for professionals, advocates, patients, and their families. A particularly valuable feature is the inclusion of an in- depth case study that demonstrates the application of effective conflict resolution techniques in the mental health setting.

Following an introductory overview of the persistent problems of people with mental illnesses, Chandler analyzes the recurring themes and issues that have surrounded the mental health field since its earliest conception. She goes on to examine such issues as the failure of the deinstitutionalization policies for the seriously and persistently mentally ill and the changing roles and responsibilities of state and local governments, families, mental health providers, and welfare agencies. The remaining chapters explore the nature of advocacy in the mental health field. Chandler describes the framework and belief structures of prominent advocacy organizations, discusses the advocacy wars among the organizations and agencies whose goal it is to help the mentally ill, and delineates a negotiation strategy for meeting the needs of the mentally ill. Topics such as the rise of the National Alliance for the Mentally Ill, the growth of patient rights groups, and strategies for altering the definitions of mental illness receive extended treatment. In the final chapter, Chandler outlines the knowledge necessary to understand the complex issues surrounding the mentally ill and the skills necessary to work successfully in this field.

Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists.

Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells.

Learn not only how to recognize high-quality research, but how to improve your own research and apply it to patient care. Plus, find out how to start a journal club, write quality case reports and how to most effectively present your research to others. This book is ideal guide for students at both graduate and undergraduate levels who might be having difficulty with research concepts as well as for practiced clinicians interested in a fresh approach to clinical research. * A jargon-free guide to understanding and conducting research * Uses metaphors, visual images, and examples to simplify complex research concepts * Includes easy-to-do computer exercises to help you understand statistical concepts

Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biological process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.

Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy. The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability.

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. Caroline M. Apovian and Nawfal Istfan, is devoted to Obesity. Articles in this comprehensive issue include: Guidelines for Obesity Management; Obesity is a Disease; Pharmacotherapy for Obesity; Bariatric Surgery Mechanisms; Diabetes Treatment in the Patient with Obesity; Adipose Tissue: Inflammation and the Endocrine Organ; Behavioral Treatment of the Patient with Obesity; The Role of Macronutrient Content in the Diet for Weight Loss and Weight Maintenance; Substrate Oxidation and Brown Adipose Tissue; Brown and Beige Adipose Tissue: Therapy for Obesity?; Ethnic Differences in Diabetes Lipids HTN and Obesity; Genetics of Bariatric Surgery Outcomes; Leptin and Hormones: Energy Homeostatis; Bariatric Surgery Clinical Outcomes; Medical Devices for Obesity; Adolescent Bariatric Surgery; Psychological Aspects of Obesity; and Nutrient Timing.