With cutting-edge and clinically relevant information, MECHANICAL VENTILATION, 2nd Edition takes a practical, clinical approach to the principles and practice of mechanical ventilation. This informative resource explains mechanical ventilation decisions and procedures in real-world terms so information is easy to understand and apply. This thoroughly updated edition includes one new chapter, four completely updated chapters, and a wealth of new user-friendly features. Detailed, clinically focused coverage of the application of mechanical ventilation to the most common respiratory diseases, provides practical answers to real life problems. UNIQUE! Sections of chapters on Special Techniques and Future Therapies include information on the newest techniques for treating patients in respiratory distress. A separate appendix of case studies helps you apply what you've learned to realistic situations. Well-known and respected authors, Neil MacIntyre and Rich Branson, share their vast expertise and accurate, cutting-edge information. Chapter Objectives, Key Point Summaries, and Assessment Questions reinforce basic concepts from each chapter. New chapter on Unique Patient Populations highlights the mechanical ventilation issues of traumatic brain injury, neuromuscular disease, lung transplantation, burn injury, and perioperative patient populations. Expanded glossary includes relevant terminology and key terms to help you easily find unfamiliar terminology.

Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associations Provides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and clinicians Contains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials

Obesity continues to accelerate resulting in an unprecedented epidemic that shows no significant signs of slowing down any time soon. The World Health Organization reports that in 2016, nearly 2 billion adults were overweight and that worldwide obesity has nearly tripled since 1975. Obesity: Global Impact and Epidemiology is an important tool in proving a link to new knowledge, serving researchers and clinicians. The field of obesity is evolving very quickly and there is an abundance of scientific data that has emerged and is emerging constantly. Researchers and physicians need new updated information about the epidemiology and global impact of obesity that come from authors that have a wide perspective in the field. For health professionals and researchers, there is a need to understand how obesity begins. While a simple question, the answer is very complex.

This issue of Physical Medicine and Rehabilitation Clinics, guest edited by Dr. Aloysia L. Schwabe, will cover a number of important topics related to Cerebral Palsy. This issue is one of four each year selected by our series Consulting Editor, Dr. Santos Martinez. Articles in this issue include but are not limited to: Comprehensive Care in CP, The Expanding Role of Genetics in CP, Musculoskeletal Imaging in CP, Updates in Medical Management of Hypertonia, Biomechanics and Lower Limb Bracing, Surgical tone Reduction In CP, Motion Analysis in Pre-operative Surgical Planning, Technological Advances in CP Rehabilitation, Adaptive Sports and Recreation, Transition, Adult Orthopedic Issues in CP, and CPRN.

Guest edited by Drs. Marjorie Eskay-Auerbach and Robert Rondinelli, this issue of Physical Medicine and Rehabilitation Clinics will discuss Medical Impairment and Disability Evaluation and Associated Medicolegal Issues. This issue is one of four selected each year by our series Consulting Editor, Dr. Santos Martinez of the Campbell Clinic. Topics in this issue include, but are not limited to: The Physician's Approach to Impairment Rating and Disability Benefits Determinations; Claimant-related Issues; Evaluating Return-to-work ability using Functional Capacity Evaluation; Evaluating Human Functioning Using CAT Methodology for Disability Determination within the SSA; Burden of treatment compliance; Measuring Quality of Life Loss in Litigation; Medical-Legal Causation Analysis; Actuarial Analysis and Life Expectancy Determination after Catastrophic Illness or Injury; Validity Assessment in Acquired Brain Injury Disability Evaluation; Medicolegal Expert Core Competencies & Professionalism; The Physician as Expert Witness; Rehabilitating the Injured Worker to Maximum Medical Improvement (MMI); The Independent Medical Examination (IME); and Life Care Planning, among other topics.

The Science and Practice of Manual Therapy, previously entitled The Fundamentals of Manual Therapy, is an extensive examination of how manual therapy (MT) techniques work, and how to match the most suitable techniques to different conditions. Drawing on evidence-based research, it explores the physiological, neurological and psychophysiological responses of the human body to MT techniques. A highly practical book, which provides useful clinical strategies for the treatment of common conditions seen in manual therapy practice. This new edition has been completely rewritten, extensively updated and expanded, with addition of new research material, novel clinical approaches and demonstration of new techniques and assessments. The text aims to assist practitioner and students of manual therapy develop a deeper understanding of their patient's processes and how they may be affected by different MT techniques. It aims to help MT practitioners deliver a more effective and safer treatment and to be able to treat a broader range of conditions Comprehensive overview helps provide an understanding of how and why MT techniques work. Content is written in jargon-free, easy-to-read style, with most terms explained. Text is enhanced by over 120 diagrams, photographs and tables. Manual pain relief is extensively discussed throughout the book. Section 1 examines the direct effects of manual therapy on connective tissue and muscle physiology, examining how MT can help assist repair and adaptation processes in these tissues. Section 2 examines the effect of MT on the neuromuscular system, identifying conditions where neuromuscular dysfunctions can be treated by MT. Section 3 examines the psychological, emotional and behavioral impacts of MT, in addition to the psychophysiological affects of MT, including psychomotor, neuroendocrine, and autonomic responses. More than 1,000 references relevant to manual therapy are included, making this an essential source book for students and researchers of MT. Content is completely rewritten, extensively updated and expanded, adding new research material, novel clinical approaches, and demonstrations of new techniques and assessments. Pain coverage is expanded. More information is included on the responses of muscle to mechanical stimuli when applying MT techniques.

Edited by Kenneth A. Jacobson and Michael F. Jarvis
The roles of extracellular purines and pyrimidines in cellular homeostasis and disease etiology have come to be understood gradually over the past 40 years. However, due to the recent cloning and expression of receptors for ATP and adenosine, novel compounds have been developed with unique therapeutic potential for the treatment of thrombosis, stroke, epilepsy, chronic pain, immunological disorders, and cancer. As a result, the study of adenosine- and ATP-mediated responses in cellular regulation is entering a phase of opportunity and development unmatched since the days of serotonin receptor research in the 1970s.
The only definitive book on the topic, Purinergic Approaches in Experimental Therapeutics covers all of the major therapeutic applications of purinergic receptors and reflects the very latest developments in this new area of therapeutic research. Twenty-eight chapters, authored by an international group of contributors who are the leading authorities in the field, provide details on molecular pharmacology; medicinal chemistry; and therapeutic implications, including cardiology, metabolism, immunology, neurology, and cancer.
Among the topics covered:
* Purinergic Neurotransmission and Neuromodulation: A Historical Perspective
* Adenosine Receptor Subtypes: New Insights from Cloning and Functional Studies
* Modulators of Adenosine Uptake, Release, and Inactivation
* Cardiac Electrophysiology of Adenosine: Antiarrhythmic and Proarrhythmic Actions
* Purinergic Modulation of Gastrointestinal Function
* The Role of Adenosine in Asthma
* ATP in Brain Function
* ATP in the Treatment of Cancer

For researchers in pharmacology, physiology, molecular biology, and medicinal chemistry, Purinergic Approaches in Experimental Therapeutics heralds an exciting new era in the understanding of purinergic neurotransmission and the development of novel therapeutic modalities.

This issue of Physical Medicine and Rehabiltiation Clinics, guest edited by Drs. Karen Barr and Ileana Michelle Howard, will cover several key aspects of Value-Added Electrodiagnostics. At the invitation of series Consulting Editor Dr. Santos Martinez, the editors put together a comprehensive issue discussing topics including: Targeting interventions for fall risk reduction; Detecting toxic myopathies as medication side effect; Predicting response from interventional spine procedures; Planning interventions to treat plexopathies; Minimizing risk of cancer therapeutics; Predicting Recovery from Peripheral Nerve Trauma; Detecting complications of metabolic syndrome and diabetes; Steering peripheral neuropathy work-up; Elucidating the cause of pelvic pain; and Guiding treatment for foot pain, among others.

While some individuals with asthma consider the condition only a minor nuisance, for others it significantly interferes with daily activities and may even be life-threatening. This book offers readers a broad introduction to this common respiratory issue. Asthma is a respiratory condition marked by spasms, swelling, and excess mucus production in the bronchial passages of the lungs. This triggers coughing, wheezing, chest tightness, and shortness of breath. While asthma can usually be managed with medications and avoidance of certain triggers, it's a serious-potentially deadly-chronic disease. What You Need to Know about Asthma is part of Greenwood's Inside Diseases and Disorders series. This series profiles a variety of physical and psychological conditions, distilling and consolidating vast collections of scientific knowledge into concise, readable volumes. A list of "top 10" essential questions begins each book, providing quick-access answers to readers' most pressing concerns. The text follows a standardized, easy-to-navigate structure, with each chapter exploring a particular facet of the topic. In addition to covering such basics as causes, signs and symptoms, diagnosis, and treatment options, books in this series delve into issues that are less commonly addressed but still critically important, such as effects on loved ones and caregivers. Case illustrations highlight key themes discussed in the book and are accompanied by insightful analyses and recommendations. Approaches the subject in a holistic manner, covering such often-overlooked areas as societal perceptions and impact on family and friends An Essential Questions section provides quick answers to the questions readers are most likely to have and serves as a springboard to explore the content of the book in more detail Case Illustrations provide relatable, real-world examples of concepts discussed in the text An annotated Directory of Resources points readers toward useful books, organizations, and websites, acting as a gateway to further study and research

An overview written for general readers of the history, prevention, treatment, causes, and consequences of obesity. What makes obesity a disease instead of just a matter of overeating? What are the genetic and environmental factors behind it? What new breakthroughs are being developing to combat it? This concise, information-rich volume looks at these and other important questions, clearing away misconceptions about this devastating condition. Obesity explains what scientists now know about the causes and consequences of being overweight, including the latest on the links between obesity and heart disease, diabetes, some cancers, asthma, and sleep difficulties. The book pays specific attention to the problem among obese young people, who more and more are being diagnosed with chronic illnesses that used to only be seen in adults. It also reports on promising efforts to battle obesity, from medical treatments to community awareness programs. The work is combines materials from history, epidemiology, behavioral science, surgery, pharmacology, economics, and policy Includes a glossary of key terms related to the study of obesity

Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists.

Learn not only how to recognize high-quality research, but how to improve your own research and apply it to patient care. Plus, find out how to start a journal club, write quality case reports and how to most effectively present your research to others. This book is ideal guide for students at both graduate and undergraduate levels who might be having difficulty with research concepts as well as for practiced clinicians interested in a fresh approach to clinical research. * A jargon-free guide to understanding and conducting research * Uses metaphors, visual images, and examples to simplify complex research concepts * Includes easy-to-do computer exercises to help you understand statistical concepts

Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biological process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.

Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for "in vivo" efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections.
Key Features
* Discusses ethical and safety aspects in an introductory background section
* Covers principles of animal care and current techniques appropriate for the use of animal models of infection
* Details a wide range of animals including rodents, rabbits, cats, and primates
* Provides hands-on descriptions of how to set up the model
* Discusses the major advantages and limitations of each model
* Ensures full coverage of bacterial, fungal, viral, and parasitic infections