This volume addresses the particular problems associated with several classes of biotechnology products, and at the same time demonstrates that the principles are the same as in the development of small new chemical entities. The first chapter addresses FDA regulatory expectations for biotech products. The next several chapters discuss general issues common to each class of biotech drug such as proteins, peptides, and nucleic acids. The balance of the chapters deal with specific biotech drugs that have successfully made it into clinical trials. The reviews are written by renowned experts in their fields.

This reference provides contemporary information on all aspects of Down syndrome, investigating health concerns by age group and by organ system. The text sets out to identify and correct problems before they interrupt developing skills. It includes preventive medical checklists with summaries of appropriate medical intervention; supplies background information about history, genetics and epidemiology; outlines clinical management strategies; establishes guidelines on how to inform parents of the diagnosis and conveys practical suggestions on the handling and care of the infant; and offers a detailed review of the medical literature. Appendices provide information including growth charts and financial checklists.

This sensitive book provides a much-needed compilation and description of OT programs for the care of individuals disabled by traumatic brain injury (TBI). Focusing on the disabled individual, the family, and the societal responses to the injured, this comprehensive book covers the spectrum of available services from intensive care to transitional and community living. Both theoretical approaches to the problems of brain injury as well as practical treatment techniques are explored in Occupational Therapy Approaches to Traumatic Brain Injury. The processes of assessment and intervention are vital to the recovery of brain-injured patients and this thorough book devotes two chapters specifically to assessment and several chapters on intervention and family involvement. This useful volume contains information about rehabilitation from coma to community, 'as well as numerous other approaches.The findings and treatment suggestions presented here are applicable to many helping professionals working with TBI patients. Health care practitioners working with brain injured persons and their families in both institutional and community contexts, physical therapists, physicians, nurses, and psychologists and social workers involved with assessment will find this an invaluable addition to their professional references.

Fung zeroes in on why insulin resistance has become so prevalent and offers specific outside-the-box solutions that have emerged as the key to maximizing health." --Jimmy Moore, author, Keto Clarity and Cholesterol Clarity Everything you believe about how to lose weight is wrong. Weight gain and obesity are driven by hormones--in everyone--and only by understanding the effects of insulin and insulin resistance can we achieve lasting weight loss. In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps, a set of lifelong habits that will improve your health and control your insulin levels, Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight--for good.

Based on the success of the best-selling "Comfort Food Diet Cookbook and the Comfort Food Diet Family Classics Collection," Taste of Home is excited to bring you the brand-new time-saving edition, "The Comfort Food Diet, New Quick and Easy Favorites "

Inside you'll find 380 mouthwatering recipes that will satisfy your cravings in a healthy way. You can induldge in hearty casseroles, creamy pastas, crunchy snacks -even rich tasting desserts--and still lose weight And you can cut back on the time you spend in the kitchen, since more than a third of the recipes are quick and easy to prepare.

The diet is simple. Inside you'll discover a 6-week meal plan that counts up the calories for you. Each day you'll find breakfast, lunch, and dinner menus that keep your weight-loss goals in focus. The plan even includes snacks and desserts. Each recipe features prep and cook times so you can make dishes that fit your family's schedule. The slow-cooker and 20-minute or less prep chapters will save you time in the kitchen while the 8-ingredients or less chapter will save you time at the store.

Also included are motivational "before and after" weight loss stories and tips from followers of the diet on how they get the most from the program, their weight-loss strategies and advice.

* Provides the reader with information and education, enabling the provision of support to reduce psychological distress and improve diabetes self-management. * A necessary guide to understanding mental health issues in those with diabetes. * Explores cultural differences in the experience of diabetes * Includes anonymous quotes from people with diabetes based on numerous independent studies concerning how people self-manage their condition to illustrate the patient's perspective of the issues highlighted in each chapter.

CLINICAL APPLICATION OF MECHANCIAL VENTILATION, FOURTH EDITION integrates fundamental concepts of respiratory physiology with the day-to-day duties of a respiratory care professional. Utilizing the wide degree of topics covered, including airway management, understanding ventilator waveforms, and addressing critical care issues, readers have the best resource available for understanding mechanical ventilation and its clinical application. Enhancing the learning experience are valuable illustrations of concepts and equipment, highlighted key points, and self-assesment questions in NRBC format with answers. Whether preparing for the national exam or double-checking a respiratory care calculation, this book provides the fundamental principles of repsiratory care with the clinical guidance necessary for mechanical ventilation.

Recent years have witnessed an explosion of technological advances, which has transformed virtually every aspect of human existence. Prominent among these advances are assistive technologies, which have been employed to improve the quality of life for individuals with disabilities. In this volume, recent advances in technological applications for individuals with learning and behavioural disabilities are described and discussed, in a collection that includes reviews of research, and original research reports. Technologies in this area have provided a multiplicity of uses, from advances in tools for basic research to text and content-enhancements to promote learning and behaviour change in educational environments. Discussed in this volume are technologies for improving our understanding of eye movements in learning from text, as well as technological applications in reading and literacy development. These technologies are employed to promote learning within classrooms, and also to connect learners with mentors outside the classroom. Beyond text, the use of virtual reality has been employed to promote understanding of complex concepts in physics. In many cases, these technologies have been employed effectively with students with emotional or behavioural disorders. Also discussed are issues in technological applications, including considerations of the most effective and appropriate uses of technology, where research is or should be heading, and teachers' understandings of the uses of technology with students with learning and behavioral disabilities. Also included in this volume are discussions of issues in learning disabilities, including discussions of significant issues in discrepancy models, and strategic coherence of individuals with learning difficulties. Overall, the ten chapters in this volume aim to provide some of the most current thinking and applications in learning and behavioural disabilities.

Childhood obesity has reached epidemic proportions in the United States and continues to increase in prevalence in almost all countries in which it has been studied, including developed and developing countries around the globe. The causes of obesity are complex and multi-factorial. Childhood obesity becomes a life-long problem in most cases and is associated with long term chronic disease risk for a variety of diseases including type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, as well as psychosocial as issues and obesity seems to affect almost every organ system in the body. In recent years there has been tremendous progress in the understanding of this problem and in strategies for prevention and treatment in the pediatric years. Childhood Obesity: Causes, Consequences, and Intervention Approaches presents current reviews on the complex problem of obesity from the multi-level causes throughout early life before adulthood and the implications for this for long-term disease risk. It reviews numerous types of strategies that have been used to address this issue from conventional clinical management to global policy strategies attempting to modify the global landscape of food, nutrition, and physical activity. Each chapter is written by a global authority in his or her respective field with a focus on reviewing the current status and recent developments. The book features information on contributing factors to obesity, including developmental origins, social/family, birth cohort studies, influence of ethnicity, and global perspectives. It takes a life-course approach to the subject matter and includes exhaustive treatment of contributing factors to childhood obesity, such as assessment, environmental factors, nutrition and dietary factors, host factors, interventions and treatment, consequences, and further action for future prevention. This broad range of topics relevant to the rapidly changing field of childhood obesity is suitable for students, health care professionals, physicians, and researchers.

Dry needling is the ideal tool for a wide range of therapists involved in treating myofascial trigger points in adults. This book is written in a concise manner as a "quick to hand" reference guide regarding key issues around safe, effective and appropriate dry needling. It represents the ideal accompaniment to course notes and the perfect in-office tableside reference guide. The Concise Book of Dry Needling provides accurate and essential information for the identification and subsequent treatment of myofascial trigger points through the exclusive use of a fine, filiform needle. Skilled palpation skills supported by the ability to visualize and observe anatomical landmarks are essential to avoid neurovascular and other vital structures that could result in insult, injury, or additional pain. The book includes a description of the origin, etiology and pathophysiology of the myofascial trigger point, plus indications and contraindications for myofascial trigger point dry needling, supplemented by color anatomical images, referred pain patterns, and photographs to show correct needle application/insertion.

The first text of its kind, Communication for Kinesiology serves as a communication primer for undergraduate students in kinesiology and sport studies, preparing them for successful written and oral scholarly communication within the field.Assuming a contextual approach to communication, the text focuses on formal writing and presentations in scholarly and professional settings. The author provides a wealth of pedagogical features including chapter overviews outlining the topics to be discussed, brief recap lists at the end of each chapter, examples, definitions, tips, and techniques, as well as an end-of-text glossary. Structured with both instructors and students in mind, the modular chapters allow for fluid and flexible application and contain practical and theoretically grounded advice to encourage students to hone their writing and presentation skills by changing how they think about the process and engaging with the rules and conventions of the field. Written to address the needs of undergraduate kinesiology students in North America, Communication for Kinesiology is an invaluable introductory resource for the classroom and beyond.

Photonanotechnology for Therapeutics and Imaging surveys major concepts and recent advances in the use of photonanotechnology with nanomaterials reported in various interdisciplinary fields, including chemistry, materials science, biomedical engineering and biomedicine. This book discusses the impact of this technology on the advancement of therapeutic modalities and imaging methods in cancers, infectious diseases and other serious diseases. Photonanotechnology studies the design principle, application and development of photoactive nanomaterials. It applies light-controlled strategies for the development of nanotherapeutics, imaging agents and diagnostic nanodevices.

This book brings the animal into the scholarly discussion of animal-assisted therapy and other interventions. Challenging the current reliance on outcome studies, the author offers a new way of thinking empirically about animal-assisted interventions-analysis of human-animal interaction as a critical component. Through empirical demonstrations from laboratory and applied settings, the book encourages practitioners and scholars to undergo a deeper examination of the basic interactions that occur between clients or patients and therapy animals. Dr. Fournier provides new ideas on measurement, experimentation, and interpretation of human-animal interaction, aimed at identifying the role of the animal in interventions for human health and well-being.

What State Do You Live In explains the events that take place in your body if you lose control over your weight. Tens of millions of adult Americanssuffer from weight related chronic disease states including pre-diabetes, high blood pressure, abnormal blood cholesterol, the metabolic syndrome, andtype II diabetes. If you are overweight and suffer from high blood glucose, you're suffering from insulin resistance and need to read this story.

What State Do You Live In begins with you in the normal state, when insulin is in complete control over blood glucose and blood fat levels. Itprogresses into the insulin resistant state which describes in detail the events that stem from weight related insulin resistance including elevatedtriglycerides, high blood pressure, unhealthy cholesterol, the metabolic syndrome, and type II diabetes.

What State Do You live In is different from other books. It provides you with realistic expectations. It does not suggest pills, supplements, or anyother form of synthetic nutrition as a means to reverse faulty nutrition. It does offer you more than a single solution to begin reversing the insulinresistant state, including the lower carbohydrate approach to improve high blood glucose.

What State Do You Live In provides you with five different levels of food strategies to put you back in control of your blood glucose. Don't ignorehigh blood glucose, if left untreated, the consequences are life threatening.

Nutrition in the Prevention and Treatment of Abdominal Obesity, Second Edition focuses on the important role that exercise, dietary changes and foods play in promoting and reducing visceral fat. Nutritionists, dieticians and healthcare providers seeking to address the abdominal obesity epidemic will find this book to be a valuable resource in their long-term goal of preventing chronic diseases, especially heart, vascular and diabetic diseases. Chapters define a range of dietary approaches to reduce risk for the associated chronic diseases. In addition, discussions of the importance of dietary approaches to reduce abdominal obesity, along with clinical approaches, are discussed, including costs and risks.

Noncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) - what they are, their burden, their determinants and how they can be prevented and controlled. Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world's biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action. Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology

Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, "Medicinal Chemistry of Nucleic Acids" presents a thorough overview of nucleic acid chemistry--a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids--such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs--to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes:

In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry

A close look at a large range of current topics on nucleic acid chemistry and biology

Essential information on the use of nucleic acid drugs to treat diseases like cancer

A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area

Thorough in its approach and promising in its message, "Medicinal Chemistry of Nucleic Acids" probes the new domains of pharmaceutical research--and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

This is a timely and informative updated edition for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, this updated title is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current treatment issues and strategies for both adults and children. While several of the chapters are no longer relevant from the first edition, other topics have emerged as interesting and current. This edition will keep the two-section format of Physiology and Pathophysiology and Clinical Management, but it increases the first section to 10 chapters and reduces the second section to 12 chapters. The plan is to keep this edition in the range of about 350 to 400, maximum, printed pages. The volume is again divided into two parts. Part 1 covers new discoveries in the physiological control of body weight, as well as the pathophysiology of obesity. Expert authors discuss pathways that control food intake, energy expenditure and peripheral nutrient metabolism, including a look at the emerging evidence of the role of adipose tissue as an endocrine organ. Part 2 covers all the key issues central to clinical management, including recent developments in the epidemiology of obesity, assessment of the obese patient, behavioral strategies in weight management, dietary modification as a weight management strategy, physical activity as a weight management strategy, weight loss drugs, surgical approaches to obesity and other important clinical topics. An essential, practical text that sorts, synthesizes and interprets the latest information on obesity-related topics, this second edition will be an essential resource for clinical endocrinologists and other health care providers across a broad spectrum of specialties.