Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients.
The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.

The Physics of Conformal Radiotherapy: Advances in Technology provides a thorough overview of conformal radiotherapy and biological modeling, focusing on the underlying physics and methodology of three-dimensional techniques in radiation therapy. This carefully written, authoritative account evaluates three-dimensional treatment planning, optimization, photon multileaf collimation, proton therapy, transit dosimetry, intensity-modulation techniques, and biological modeling. It is an invaluable teaching guide and reference for all medical physicists and radiation oncologists/therapists that use conformal radiotherapy.

The volume Appetite Control provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify additional targets and agents for a pharmacological intervention. Thus, the mechanisms of appetite control as well as all agents interfering with its control are of considerable practical interest.

The authors of the volume are distinguished scientists who are leading experts in the field, and who have contributed important, original data to our understanding of the mechanisms of appetite control. They have quite different scientific backgrounds and, together, they represent all relevant disciplines. Thereby, the topics are presented from different points of view, not exclusively from that of pharmacology and neuroendocrinology. Thus, the volume addresses all scientists who are interested in the field of obesity research and the pathophysiology of appetite control."

This volume addresses the particular problems associated with several classes of biotechnology products, and at the same time demonstrates that the principles are the same as in the development of small new chemical entities. The first chapter addresses FDA regulatory expectations for biotech products. The next several chapters discuss general issues common to each class of biotech drug such as proteins, peptides, and nucleic acids. The balance of the chapters deal with specific biotech drugs that have successfully made it into clinical trials. The reviews are written by renowned experts in their fields.

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

This reference provides contemporary information on all aspects of Down syndrome, investigating health concerns by age group and by organ system. The text sets out to identify and correct problems before they interrupt developing skills. It includes preventive medical checklists with summaries of appropriate medical intervention; supplies background information about history, genetics and epidemiology; outlines clinical management strategies; establishes guidelines on how to inform parents of the diagnosis and conveys practical suggestions on the handling and care of the infant; and offers a detailed review of the medical literature. Appendices provide information including growth charts and financial checklists.

This sensitive book provides a much-needed compilation and description of OT programs for the care of individuals disabled by traumatic brain injury (TBI). Focusing on the disabled individual, the family, and the societal responses to the injured, this comprehensive book covers the spectrum of available services from intensive care to transitional and community living. Both theoretical approaches to the problems of brain injury as well as practical treatment techniques are explored in Occupational Therapy Approaches to Traumatic Brain Injury. The processes of assessment and intervention are vital to the recovery of brain-injured patients and this thorough book devotes two chapters specifically to assessment and several chapters on intervention and family involvement. This useful volume contains information about rehabilitation from coma to community, 'as well as numerous other approaches.The findings and treatment suggestions presented here are applicable to many helping professionals working with TBI patients. Health care practitioners working with brain injured persons and their families in both institutional and community contexts, physical therapists, physicians, nurses, and psychologists and social workers involved with assessment will find this an invaluable addition to their professional references.

This book provides a detailed summary of the therapeutic benefits of natural extracts from medicinal plants, mushrooms, algae, fungi and sponges and their role in the prevention and treatment of obesity and diabetes, offering readers a solid introduction to obesity and diabetes as well as current treatment models. In addition, it examines how genomics and multi-omics approaches have revolutionized our understanding of these diseases, and discusses the role of microbiome-host interactions, probiotics, prebiotics and the future of metabolic phenotyping. Focusing on the pharmacokinetics of anti-obesity and anti-diabetic phytochemicals, their bioavailability in the respective target tissues and their elimination times, the book also describes the nanoformulations of phytochemicals and herbal extracts. Lastly, it presents an overview of the advances in clinical studies on the use of herbal and mushroom extracts in obesity and diabetes management. Given its scope, this book is useful not only for researches in the field but also for students studying nutrition, food sciences, plant sciences or pharmacology, as well as for health professionals and practitioners.

Individuals with serious and persistent mental illnesses, including schizophrenia and affective disorders, often experience cognitive deficits that make it challenging to perform everyday tasks. For example, they may have difficulty paying attention, remembering and learning, thinking quickly, and solving problems, and this may interfere with functioning at work, school, and in social and living situations. Cognitive remediation is an evidence-based behavioral treatment for people who are experiencing cognitive impairments that interfere with role functioning. Cognitive Remediation for Psychological Disorders contains all the information therapists need to set up a cognitive remediation program that helps clients strengthen the cognitive skills necessary for everyday functioning. The program described is called Neuropsychological and Educational Approach to Remediation (NEAR), an evidence-based approach that utilizes carefully crafted instructional techniques which promote learning. The goals of NEAR are to provide a positive learning experience and to promote independent learning and optimal cognitive functioning in daily life. The second edition of this popular Therapist Guide provides step-by-step instructions on how to implement NEAR techniques with patients. Guidelines for setting up and running a successful cognitive remediation program are laid out in an easy-to-follow format. Therapists will learn how to choose appropriate cognitive exercises, recruit and work with clients, perform intakes, and create treatment plans. This Guide comes complete with all the tools necessary for facilitating treatment, including program evaluation forms and client handouts.

This detailed book presents a comprehensive collection of state-of-the-art protocols on muscular dystrophy therapeutics, covering therapeutics using antisense oligonucleotides, gene replacement, genome editing, small molecules, stem cells, and antibodies. Written by leaders in the field, the volume explores techniques that are currently in use and are starting an exciting therapeutic revolution in muscular dystrophy. As a part of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Muscular Dystrophy Therapeutics: Methods and Protocols serves as an ideal resource to inspire readers and provide tips, strategies, and advice to develop new therapeutic technologies for this group of diseases.

This book examines the technologies and processes for the development and commercial production of stem cells according to cGMP guidelines. The initial chapter of the book discusses the therapeutic potentials of stem cells for the treatment of various diseases, including degenerative disorders and genetic diseases. The book then reviews the recent developments in the cultivation of stem cells in bioreactors, including critical cultural parameters, possible bioreactor configuration and integrations of novel technologies in bioprocess developmental stages. The book also introduces microscopic, molecular, and cellular techniques for characterization of stem cells for regulatory approvals. Further, it describes optimal cell transporting conditions to maintain cell viability and properties. Further, it summarizes characterization strategies of clinical grade stem cells for stem cell therapy. This book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Recent years have witnessed an explosion of technological advances, which has transformed virtually every aspect of human existence. Prominent among these advances are assistive technologies, which have been employed to improve the quality of life for individuals with disabilities. In this volume, recent advances in technological applications for individuals with learning and behavioural disabilities are described and discussed, in a collection that includes reviews of research, and original research reports. Technologies in this area have provided a multiplicity of uses, from advances in tools for basic research to text and content-enhancements to promote learning and behaviour change in educational environments. Discussed in this volume are technologies for improving our understanding of eye movements in learning from text, as well as technological applications in reading and literacy development. These technologies are employed to promote learning within classrooms, and also to connect learners with mentors outside the classroom. Beyond text, the use of virtual reality has been employed to promote understanding of complex concepts in physics. In many cases, these technologies have been employed effectively with students with emotional or behavioural disorders. Also discussed are issues in technological applications, including considerations of the most effective and appropriate uses of technology, where research is or should be heading, and teachers' understandings of the uses of technology with students with learning and behavioral disabilities. Also included in this volume are discussions of issues in learning disabilities, including discussions of significant issues in discrepancy models, and strategic coherence of individuals with learning difficulties. Overall, the ten chapters in this volume aim to provide some of the most current thinking and applications in learning and behavioural disabilities.

* Provides the reader with information and education, enabling the provision of support to reduce psychological distress and improve diabetes self-management. * A necessary guide to understanding mental health issues in those with diabetes. * Explores cultural differences in the experience of diabetes * Includes anonymous quotes from people with diabetes based on numerous independent studies concerning how people self-manage their condition to illustrate the patient's perspective of the issues highlighted in each chapter.

Nutrition in the Prevention and Treatment of Abdominal Obesity, Second Edition focuses on the important role that exercise, dietary changes and foods play in promoting and reducing visceral fat. Nutritionists, dieticians and healthcare providers seeking to address the abdominal obesity epidemic will find this book to be a valuable resource in their long-term goal of preventing chronic diseases, especially heart, vascular and diabetic diseases. Chapters define a range of dietary approaches to reduce risk for the associated chronic diseases. In addition, discussions of the importance of dietary approaches to reduce abdominal obesity, along with clinical approaches, are discussed, including costs and risks.

Childhood obesity has reached epidemic proportions in the United States and continues to increase in prevalence in almost all countries in which it has been studied, including developed and developing countries around the globe. The causes of obesity are complex and multi-factorial. Childhood obesity becomes a life-long problem in most cases and is associated with long term chronic disease risk for a variety of diseases including type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, as well as psychosocial as issues and obesity seems to affect almost every organ system in the body. In recent years there has been tremendous progress in the understanding of this problem and in strategies for prevention and treatment in the pediatric years. Childhood Obesity: Causes, Consequences, and Intervention Approaches presents current reviews on the complex problem of obesity from the multi-level causes throughout early life before adulthood and the implications for this for long-term disease risk. It reviews numerous types of strategies that have been used to address this issue from conventional clinical management to global policy strategies attempting to modify the global landscape of food, nutrition, and physical activity. Each chapter is written by a global authority in his or her respective field with a focus on reviewing the current status and recent developments. The book features information on contributing factors to obesity, including developmental origins, social/family, birth cohort studies, influence of ethnicity, and global perspectives. It takes a life-course approach to the subject matter and includes exhaustive treatment of contributing factors to childhood obesity, such as assessment, environmental factors, nutrition and dietary factors, host factors, interventions and treatment, consequences, and further action for future prevention. This broad range of topics relevant to the rapidly changing field of childhood obesity is suitable for students, health care professionals, physicians, and researchers.

Obesity is a continuing issue around the world and in many contexts. The growing number of obese people is an increasing concern for those in the medical profession, and obesity can pose specific challenges in relation to fertility and pregnancy. Patients who are obese require specific considerations and knowledge. Bringing together experts from a variety of specialties to examine the issues and challenges of obesity, this book discusses how obesity affects fertility, reproduction, and pregnancy. Beginning with an exploration of the epidemiology of obesity, further chapters focus on specific issues related to obesity and both male and female reproduction, the complications of obesity during pregnancy and labour, and the long term effects of obesity. This is the most comprehensive resource to examine the topic of obesity and reproductive issues, making it invaluable for medical students, professionals, and researchers in public policy and medicine.
Comprehensive examination of fertility issues arising from male and female obesityClinical knowledge and expertise given to the subjectsIn-depth examination through 47 chapters of a growing, but often overlooked, issue in fertility and pregnancy

By the 500,000-copy bestselling author of The Obesity Code. Recipes to revolutionalise the way you cook, eat, and live. In The Obesity Code, Dr Jason Fung introduced the idea that obesity is caused by our hormones, specifically insulin, and offered practical, easy-to-follow advice on how to lose weight for good. Now, The Obesity Code Cookbook makes it easier than ever to follow his methods. Over 90 mouth-watering recipes - from slow-roasted pork shoulder to chia pudding and almond cake - showcase healthy fats, nutrient-dense foods, and low or no carbs, with diet plans to help balance your nutrition and energy requirements with your long-term health objectives. The Obesity Code Cookbook is an indispensable tool for home cooks looking to lower insulin, lose weight, or simply lead a healthy, longer life.

Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians' offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.