Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

America's emerging "fat war" threatens to pit a shrinking population of trim Americans against an expanding population of heavy Americans in raging policy debates over "fat taxes" and "fat bans." These "fat policies" would be designed to constrain what people eat and drink - and theoretically crimp the growth in Americans' waistlines and in the country's healthcare costs.

Richard McKenzie's "HEAVY The Surprising Reasons America Is the Land of the Free-And the Home of the Fat"offers new insight into the economic causes and consequences of America's dramatic weight gain over the past half century. It also uncovers the follies of seeking to remedy the country's weight problems with government intrusions into people's excess eating, arguing that controlling people's eating habits is fundamentally different from controlling people's smoking habits.

McKenzie controversially links America's weight gain to a variety of causes: the growth in world trade freedom, the downfall of communism, the spread of free-market economics, the rise of women's liberation, the long-term fall in real minimum wage, and the rise of competitive markets on a global scale.

In no small way - no, in a very BIG way - America is the "home of the fat" "because "it has been for so long the "land of the free." Americans' economic, if not political, freedoms, however, will come under siege as well-meaning groups of "anti-fat warriors" seek to impose their dietary, health, and healthcare values on everyone else.

"HEAVY " details the unheralded consequences of the country's weight gain, which include greater fuel consumption and emissions of greenhouse gases, reduced fuel efficiency of cars and planes, growth in health insurance costs and fewer insured Americans, reductions in the wages of heavy people, and required reinforcementof rescue equipment and hospital operating tables.

McKenzie advocates a strong free-market solution to how America's weight problems should and should not be solved. For Americans to retain their cherished economic freedoms of choice, heavy people must be held fully responsible for their weight-related costs and not be allowed to shift blame for their weight to their genes or environment. Allowing heavy Americans to shift responsibility for their weight gain can only exacerbate the country's weight problems."

Over the past two decades considerable progress has been made in developing specialist psychosocial treatments for borderline personality disorder (BPD), yet the majority of people with BPD receive treatment within generalist mental health services, rather than specialist treatment centres. This is a book for general mental health professionals who treat people with borderline personality disorder (BPD). It offers practical guidance on how to help people with BPD with advice based on research evidence. After a discussion of the symptoms of BPD, the authors review all the generalist treatment interventions that have resulted in good outcomes in randomised controlled trials, when compared with specialist treatments, and summarise the effective components of these interventions. The treatment strategies are organised into a structured approach called Structured Clinical Management (SCM), which can be delivered by general mental health professionals without extensive additional training. The heart of the book outlines the principles underpinning SCM and offers a step-by-step guide to the clinical intervention. Practitioners can learn the interventions easily and develop more confidence in treating people with BPD. In addition, a chapter is devoted to how to help families - an issue commonly neglected when treating patients with BPD. Finally the authors discuss the top 10 strategies for delivering treatment and outline how the general mental health clinician can deliver these strategies competently.

Prognosis is a core concept in psychiatry. This book is concerned with prediction of neuroleptic treatment outcome in schizophrenia from a conceptual and methodological point of view. Various aspects of the topic, such as definition and measurement of response, dimensions of treatment outcome, neuropsychological, neuropsychopharmacological and neurobiochemical predictors as well as the clinical application of neuroimaging methods and neurogenetics are treated by experts in the field. One aim of the book is to summarize the present state of the art in prediction research and thereby to provide a useful compendium. Moreover guidelines for future research strategies are formulated.

When all you need is a basic understanding of the anatomy of the muscular system, supplemented by current evidence and research, Cram Sessions on Functional Anatomy: Applications and Problem Solving for Real-Life Situations is what you will look to for quick, at-your-fingertips facts. Cram Sessions on Functional Anatomy by Drs. Benjamin, Bechtel, and Conroy is a concise and illustrated quick reference that takes over 60 years of combined clinical experience to provide an understanding of the muscular system and its relation to the fascial and ligamentous systems in the human body, providing benefits for improved patient care and streamlined exercise prescription. What is in your Cram Session? * Translation of basic anatomy through both clinical expertise and research evidence * A unique understanding of the muscular system and its role in health and disease * A section on "clinical pearls" for each muscle or group - helping make practical use of the anatomical data, and improving the diagnosis and treatment of common patient problems * Over 100 photographs and line art depicting each muscle or group of muscles Cram Sessions on Functional Anatomy: Applications and Problem Solving for Real-Life Situations is a practical, easy-to-read handbook for all students and clinicians involved in physical therapy, athletic training, occupational therapy, and other rehabilitation professions.

This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.

Thinking in Circles about Obesity: Applying Systems Thinking to Weight Management

Tarek K.A. Hamid, Operational and Information Sciences, Naval Postgraduate School, Monterey, California

Low-carb low-fat high-protein high-fiber Americans are food-savvy, label-conscious, calorie-aware and still gaining weight in spite of all their good intentions. Worse still, today s children run the risk of a shorter life expectancy than their parents.

Thinking in Circles About Obesity brings a healthy portion of critical thinking, spiced with on-target humor and lively graphics, to the obesity debate. Systems scholar Tarek Hamid proposes that a major shift in perspective is needed to address the problem. This book unites systems (non-linear) thinking and information technology to provide powerful insights and practical strategies for managing our bodies, as well as our health. Applying these creative, business-tested techniques to personal health lets readers approach weight problems like CEOs not bean-counters and connect the elusive links between the biological, environmental, social, and psychological factors that contribute to overweight and obesity, yo-yo dieting and willpower issues. The author s clear insights dispel dieters unrealistic expectations and illuminate dead-end behaviors to tap into a deeper understanding of how the body works, why it works that way, and how to improve the bottom line. For optimum results, he includes innovative tools for:

• Understanding why diets almost always fall short of our expectations.
• Assessing weight gain, loss, and goals with greater accuracy.
• Abandoning one-size-fits-all solutions in lieu of personal solutions that do fit.
• Replacing outmoded linear thinking with feedback systems thinking.
• Getting the most health benefits from information technology.
• Making behavior and physiology work in sync instead of in opposition.

Given the current level of the weight crisis, the ideas in Thinking in Circles About Obesity have much to offer the clinical or health psychologist, the primary care physician, the public health professional the parent and the lay reader. For those struggling with overweight, this book charts a new path in health decision-making, to see beyond calorie charts, Body Mass Indexes, and silver bullets."

People with Down syndrome are increasingly encouraged to participate in community activities, and effective patterns of movement need to be established during early childhood to aid their social integration and acceptance. This book considers the full life cycle of a person with Down syndrome and outlines practices and activities that will foster constructive patterns of movement from infancy through childhood and adolescence to later adulthood.;By providing a background for understanding the movement of persons with Down syndrome, detrimental patterns of movement can be avoided. Incompetent motor behaviour can hinder the person's ability to succeed with employment, self care, and recreational activities. Obesity, awkward gait, clumsiness, and the lack of fine motor skills are likely to impede social acceptance and personal satsifaction. If such maladaptive attributes are to be avoided, effective patterns of movement need to be established during early childhood.;Written for professionals working in the field of developmental disabilities, including physiotherapists, occupational therapists, physical and special education teachers, and nurses, this book is also suitable for students for courses in movement and disability.