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Books > Science & Mathematics > Biology, life sciences > Biochemistry > General

Genomics Handbook: Volume II (Hardcover): Rosanna Mann Genomics Handbook: Volume II (Hardcover)
Rosanna Mann
R3,435 R3,105 Discovery Miles 31 050 Save R330 (10%) Ships in 10 - 15 working days
Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600 (Hardcover):... Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600 (Hardcover)
Maria Spies, Anna Malkova
R4,830 Discovery Miles 48 300 Ships in 12 - 19 working days

Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.

Affinity Chromatography (Hardcover): Nina Murphy Affinity Chromatography (Hardcover)
Nina Murphy
R3,406 R3,077 Discovery Miles 30 770 Save R329 (10%) Ships in 10 - 15 working days
Clinical Metabolomics - Methods and Protocols (Hardcover, 1st ed. 2018): Martin Giera Clinical Metabolomics - Methods and Protocols (Hardcover, 1st ed. 2018)
Martin Giera
R3,524 Discovery Miles 35 240 Ships in 10 - 15 working days

This detailed volume presents a comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. The methodologies explored here form the core of several very promising initiatives evolving around personalized health care and precision medicine, which can be seen as complimentary to the field of clinical chemistry and aid the aforementioned field with novel disease markers and diagnostic patterns. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Metabolomics: Methods and Protocols aims to serve as the basis for successful communication between scientists from several fields, including chemists, biologist, bioinformaticians, and clinicians, ultimately leading to effective study design and completion.

Engineering and Application of Pluripotent Stem Cells (Hardcover, 1st ed. 2018): Ulrich Martin, Robert Zweigerdt, Ina Gruh Engineering and Application of Pluripotent Stem Cells (Hardcover, 1st ed. 2018)
Ulrich Martin, Robert Zweigerdt, Ina Gruh
R9,030 Discovery Miles 90 300 Ships in 12 - 19 working days

This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening. This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

Thyroid Hormone, Volume 106 (Hardcover): Gerald Litwack Thyroid Hormone, Volume 106 (Hardcover)
Gerald Litwack
R4,813 Discovery Miles 48 130 Ships in 12 - 19 working days

Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics.

Alkaloids: Chemical and Biological Perspectives, Volume 11 (Hardcover): S. William Pelletier Alkaloids: Chemical and Biological Perspectives, Volume 11 (Hardcover)
S. William Pelletier
R5,779 Discovery Miles 57 790 Ships in 12 - 19 working days

Volume 11 of this series presents five timely reviews on current research on alkaloids. Chapter 1 by Paul L. Schiff, Jr. is a monumental survey of research that has been carried out over the past decade on the "Thalictrum" alkaloids. Forty-six new alkaloids are described from fifteen species of the genus "Thalictrum," as well as 116 alkaloids of known structure from thirty-six species and subspecies of the genus. The chapter includes discussions of isolation and structure elucidation, analysis, biosynthesis, cell culture, and pharmacology. Also featured are inclusive compilations of botanical sources, alkaloids by alkaloid types, and calculated molecular weights of the "Thalictrum" alkaloids.

Chapter 2 by Giovanni Appendino provides a fascinating treatment of Taxine, a collective name referring to a mixture of diterpenoid alkaloids from the yew tree (genus: "Taxus"). Taxine is responsible for the toxic properties of the yew tree that has been documented in historical and fictional literature, from Julius Caesar to Shakespeare, and from Agatha Christie to T.S. Eliot. The chapter treats the history, isolation techniques, structure elucidation, chemistry, and pharmacology of Taxine.

Chapter 3 by Mary D. Menachery surveys the alkaloids of South American Menispermaceae (moonseed family). Many different structural types are included in this family. The alkaloid-bearing plants are woody-vines, shrubs, or small trees. Several of these species possess potent curare activity. The chemistry as well as pharmacology of these alkaloids is summarized.

Chapter 4 by Russell J. Molyneux, Robert J. Nash, and Naoki Asano treats the chemistry and biological activity of the calystegines and related "nor"tropane alkaloids. These polyhydroxylated bicyclic alkaloids represent another class of compounds that inhibit glycosidases, producing profound effects in biological systems by disrupting the essential cellular function of glycoprotein processing.

Chapter 5, a related chapter by Robert J. Nash, Naoki Asano, and Alison A. Watson, reviews polyhydroxylated alkaloids that inhibit glycosidases. Topics covered include distribution, ecological significance and toxicity, isolation, synthesis, and biosynthesis.

Chemical Glycobiology: Monitoring Glycans and Their Interactions, Volume 598 (Hardcover): Barbara Imperiali Chemical Glycobiology: Monitoring Glycans and Their Interactions, Volume 598 (Hardcover)
Barbara Imperiali
R4,586 Discovery Miles 45 860 Ships in 12 - 19 working days

Chemical Glycobiology, Part B, Volume 598, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume is the second release on chemical glycobiology.

Regulation of Primary Metabolic Pathways in Plants (Hardcover): Nicholas J. Kruger, Steven A. Hill, George R. Ratcliffe Regulation of Primary Metabolic Pathways in Plants (Hardcover)
Nicholas J. Kruger, Steven A. Hill, George R. Ratcliffe
R2,601 Discovery Miles 26 010 Ships in 12 - 19 working days

This book provides a timely review of progress in the area of primary plant metabolism, and in particular highlights the extent to which molecular techniques now influence the investigation and understanding of plant metabolism. The emphasis of the book is centred on processes related to the dominant pathways of carbohydrate production and utilisation, and is arranged to reflect the current focus of researchers on three broadly overlapping areas of investigation. -- The molecular architecture of selected enzymes of primary metabolism;
-- The integration of metabolism between organelles, cells, tissues and organs;
-- The manipulation of major pathways of carbohydrate metabolism.

Each of the contributors is an internationally recognised researcher who presents a cogent summary of recent advances in the field. The volume will be of particular value to undergraduates, graduates and advanced researchers in plant biology, biotechnology and biochemistry, as well as researchers in related areas of plant physiology, crop production and horticulture who need to keep abreast of current developments in the understanding of the fundamental aspects of plant carbohydrate metabolism.

Genomics Handbook: Volume I (Hardcover): Rosanna Mann Genomics Handbook: Volume I (Hardcover)
Rosanna Mann
R3,434 R3,104 Discovery Miles 31 040 Save R330 (10%) Ships in 10 - 15 working days
The Evolution of Molecular Biology - The Search for the Secrets of Life (Paperback): Kensal Van Holde, Jordanka Zlatanova The Evolution of Molecular Biology - The Search for the Secrets of Life (Paperback)
Kensal Van Holde, Jordanka Zlatanova
R1,554 R1,471 Discovery Miles 14 710 Save R83 (5%) Ships in 12 - 19 working days

The Evolution of Molecular Biology: The Search for the Secrets of Life provides the historical knowledge behind techniques founded in molecular biology, also presenting an appreciation of how, and by whom, these discoveries were made. It deals with the evolution of intellectual concepts in the context of active research in an approachable language that accommodates readers from a variety of backgrounds. Each chapter contains a prologue and epilogue to create continuity and provide a complete framework of molecular biology. This foundational work also functions as a historical and conceptual supplement to many related courses in biochemistry, biology, chemistry, genetics and history of science. In addition, the book demonstrates how the roots of discovery and advances-and an individual's own research-have grown out of the history of the field, presenting a more complete understanding and context for scientific discovery.

Prebiotic Chemistry and Chemical Evolution of Nucleic Acids (Hardcover, 1st ed. 2018): Cesar Menor-Salvan Prebiotic Chemistry and Chemical Evolution of Nucleic Acids (Hardcover, 1st ed. 2018)
Cesar Menor-Salvan
R4,383 Discovery Miles 43 830 Ships in 10 - 15 working days

The origin of life is one of the biggest unsolved scientific questions. This book deals with the formation and first steps of the chemical evolution of nucleic acids, including the chemical roots behind the origin of their components from the simplest sources in a geochemical context. Chemical evolution encompasses the chemical processes and interactions conducive to self-assembly and supramolecular organization, leading to an increase of complexity and the emergence of life. The book starts with a personal account of the pioneering work of Stanley Miller and Jeffrey Bada on the Chemistry of Origins of Life and how the development of organic chemistry beginning in the 19th century led to the emergence of the field of prebiotic chemistry, situated at the frontier between organic, geo- and biochemistry. It then continues reviewing in tutorial manner current central topics regarding the organization of nucleic acids: the origin of nucleobases and nucleosides, their phosphorylation and polymerization and ultimately, their self-assembly and supramolecular organization at the inception of life.

Aptamers in Biotechnology (Hardcover, 1st ed. 2020): Katharina Urmann, Johanna-Gabriela Walter Aptamers in Biotechnology (Hardcover, 1st ed. 2020)
Katharina Urmann, Johanna-Gabriela Walter
R10,413 Discovery Miles 104 130 Ships in 12 - 19 working days

This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology.

Advances in Protein Purification (Hardcover): Caroline Gardner Advances in Protein Purification (Hardcover)
Caroline Gardner
R2,499 R2,279 Discovery Miles 22 790 Save R220 (9%) Ships in 10 - 15 working days
CRISPR in Animals and Animal Models, Volume 152 (Hardcover): Raul Torres-Ruiz, Sandra Rodriguez-Perales CRISPR in Animals and Animal Models, Volume 152 (Hardcover)
Raul Torres-Ruiz, Sandra Rodriguez-Perales
R3,944 Discovery Miles 39 440 Ships in 12 - 19 working days

CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges.

Fe-S Cluster Enzymes Part B, Volume 599 (Hardcover): Sheila S. David Fe-S Cluster Enzymes Part B, Volume 599 (Hardcover)
Sheila S. David
R4,828 Discovery Miles 48 280 Ships in 12 - 19 working days

Methods in Enzymology, Volume 599 is the second of two volumes focused on Fe-S cluster enzymes. Topics of interest in this new release include steps towards understanding mitochondrial Fe/S cluster biogenesis, iron sulfur clusters in zinc finger proteins, electrochemistry of Iron-sulfur enzymes, NRVS for Fe in biology and its experiment and basic interpretation, methods for studying iron regulatory protein 1, an important protein in human iron metabolism, the characterization of glutaredoxin Fe-S cluster binding interactions using circular dichroism spectroscopy, fluorescent reporters to track Fe-S cluster assembly and transfer reactions, methods for studying the Fe-S cluster containing base excision repair glycosylase MUTYH, and more.

Calmodulin and Signal Transduction (Hardcover): Linda J Van Eldik, D.Martin Watterson Calmodulin and Signal Transduction (Hardcover)
Linda J Van Eldik, D.Martin Watterson
R6,320 R4,329 Discovery Miles 43 290 Save R1,991 (32%) Ships in 12 - 19 working days

This book focuses on emerging themes in the molecular mechanisms of calcium signal transduction through calmodulin-regulated pathways. It provides the reader with selected examples and experimental precedents that underlie current models of cell regulation through calmodulin-regulated pathways and their linkage with other regulatory pathways.
Highlights:
* Molecular mechanisms of calcium signal transduction through calmodulin-regulated enzymes
* Selected case studies and precedents related to molecular mechanisms
* Protein-protein recognition between calmodulin and the enzymes it regulates
* Cross-talk and interdigitation with other signal transduction pathways

Concepts and Applications of Biochemistry (Hardcover): Oliver Stone Concepts and Applications of Biochemistry (Hardcover)
Oliver Stone
R3,522 R3,184 Discovery Miles 31 840 Save R338 (10%) Ships in 10 - 15 working days
Biotransformations in Organic Chemistry - A Textbook (Hardcover, 7th ed. 2018): Kurt Faber Biotransformations in Organic Chemistry - A Textbook (Hardcover, 7th ed. 2018)
Kurt Faber
R4,469 Discovery Miles 44 690 Ships in 12 - 19 working days

This well-established textbook on biocatalysis provides a basis for undergraduate and graduate courses in modern organic chemistry, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts-principles of stereoselective transformations, enzyme properties and kinetics-the different types of reactions are explained according to the 'reaction principle', such as hydrolysis, reduction, oxidation, C-C bond formation, etc. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques, artificial enzymes and the design of cascade-reactions are treated in a separate section. A final chapter deals with the basic rules for the safe and practical handling of biocatalysts. The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry. Over the last two decades, this methodology has become an indispensable tool for asymmetric synthesis, not only at the academic level, but also on an industrial scale. In this 7th edition new topics have been introduced which include alcohol and amine oxidases, amine dehydrogenases, imine reductases, haloalkane dehalogenases, ATP-independent phosphorylation, Michael-additions and cascade reactions. This new edition also emphasizes the use of enzymes in industrial biotransformations with practical examples.

Overflow Metabolism - From Yeast to Marathon Runners (Paperback): Alexei Vazquez Overflow Metabolism - From Yeast to Marathon Runners (Paperback)
Alexei Vazquez
R2,168 R2,054 Discovery Miles 20 540 Save R114 (5%) Ships in 12 - 19 working days

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage.

Sweet Biochemistry - Remembering Structures, Cycles, and Pathways by Mnemonics (Paperback): Asha Kumari Sweet Biochemistry - Remembering Structures, Cycles, and Pathways by Mnemonics (Paperback)
Asha Kumari
R2,139 Discovery Miles 21 390 Ships in 12 - 19 working days

Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics makes biochemistry lively, interesting and memorable. by connecting objects, images and stories. Dr. Kumari has converted cycles and difficult pathways into very simple formula, very short stories and images which will help readers see familiar things in complicated cycles and better visualize biochemistry.

Lipidomics - Methods and Protocols (Hardcover, 1st ed. 2017): Sanjoy Bhattacharya Lipidomics - Methods and Protocols (Hardcover, 1st ed. 2017)
Sanjoy Bhattacharya
R4,743 Discovery Miles 47 430 Ships in 12 - 19 working days

This volume explores lipidomics through protocols that focus on areas of utility, techniques, and bioinformatics advancements. The protocols in this book cover topics such as isolation of specific membranes and specialized fractionation of subcellular compartments, and computational and functional analysis of lipid metabolizing enzymes. Each protocol also discusses methods of dealing with fractionated organelles-cells to whole organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Lipidomics: Methods and Protocols is a useful and valuable resource for biochemists, molecular biologists, and neuroscientists interested in neurology, ophthalmology and vision sciences, as well as mass spectrometrists with interest in disease discovery.

Frontiers in Pharmacology of Neurotransmitters (Hardcover, 1st ed. 2020): Puneet Kumar, Pran Kishore Deb Frontiers in Pharmacology of Neurotransmitters (Hardcover, 1st ed. 2020)
Puneet Kumar, Pran Kishore Deb
R7,041 Discovery Miles 70 410 Ships in 12 - 19 working days

Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

Achieving the Sustainable Development Goals Through Sustainable Food Systems (Hardcover, 1st ed. 2019): Riccardo Valentini,... Achieving the Sustainable Development Goals Through Sustainable Food Systems (Hardcover, 1st ed. 2019)
Riccardo Valentini, John L. Sievenpiper, Marta Antonelli, Katarzyna Dembska
R4,373 Discovery Miles 43 730 Ships in 10 - 15 working days

This publication offers a systemic analysis of sustainability in the food system, taking as its framework the Sustainable Development Goals of the 2030 Agenda of the United Nations. Targeted chapters from experts in the field cover main challenges in the food system and propose methods for achieving long term sustainability. Authors focus on how sustainability can be achieved along the whole food chain and in different contexts. Timely issues such as food security, climate change and migration and sustainable agriculture are discussed in depth. The volume is unique in its multidisciplinary and multi-stakeholder approach. Chapter authors come from a variety of backgrounds, and authors include academic professors, members of CSO and other international organizations, and policy makers. This plurality allows for a nuanced analysis of sustainability goals and practices from a variety of perspectives, making the book useful to a wide range of readers working in different areas related to sustainability and food production. The book is targeted towards the academic community and practitioners in the policy, international cooperation, nutrition, geography, and social sciences fields. Professors teaching in nutrition, food technology, food sociology, geography, global economics, food systems, agriculture and agronomy, and political science and international cooperation may find this to be a useful supplemental text in their courses.

Structure-Activity Relationships for Development of Neurokinin-3 Receptor Antagonists - Reducing Environmental Impact... Structure-Activity Relationships for Development of Neurokinin-3 Receptor Antagonists - Reducing Environmental Impact (Hardcover, 1st ed. 2020)
Koki Yamamoto
R2,873 Discovery Miles 28 730 Ships in 10 - 15 working days

This book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact. Pharmaceuticals are used to cure diseases and to alleviate symptoms in humans and animals. However, the stable, bioactive substances excreted by patients have unfavorable effects on non-target species. To overcome these disadvantages of these highly stable, potent substances, drug design to turn off bioactivity after release into the environment is needed. The book describes the development of eco-friendly NK3R antagonists by introducing a labile functional moiety and substituting a scaffold. This resulted in a novel NK3R antagonist that oxidized into its inactive form when exposed to air. Further, the book presents an efficient and easily achievable synthetic method of creating triazolopiperazine scaffolds, as well as a structure-activity relationship study involving scaffold hopping for decomposable motifs, which led to a novel photodegradable NK3R antagonist. Demonstrating that it is possible to develop compounds that convert into their inactive forms under environmental conditions, this book is useful for anyone interested in therapeutic agents with reduced environmental impact.

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