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Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
This handbook contains a complication of Electron Paramagnetic Resonance (EPR) data of numerous semiquinones and related radicals. The handbook is intended as a general reference guide to the structural studies of the radicals obtained by redox processes from natural and synthetic quinones and quinols.
Luminescent Spectroscopy of Proteins is devoted to the method of intrinsic protein luminescence, one of the most popular experimental methods in modern biophysics and biochemistry. The book discusses general physical principles of the luminescence method; spectral properties of the main protein chromophores; and protein luminescence and its use for studies on structural, physico-chemical, and functional properties of proteins. Principles of luminescent spectroscopy are illustrated by real-life applications and problems. Luminescent Spectroscopy of Proteins will be an excellent reference for biophysicists, biochemists, analytical chemists, and other scientists interested in this topic.
This work focuses on the structural and functional description of the microtubule proteins. The objective of the authors is to establish a relationship between the structure of microtubule proteins and the functions in which these polymers are involved. This book covers topics which have been treated only in a preliminary manner in previous works, such as microtubule dynamics and microtubule poisons. Microtubules display a variety of cellular roles and are vital for the separation and correct distribution of chromosomes during cell division. They also play an important role in morphogenesis, intracellular transport, secretion, and motility. Microtubule Proteins is a concise, easy-to-read text which is particularly of interest to cell biologists, chemists, neurochemists, and graduate students interested in cell biology.
This comprehensive volume focuses on the ways in which synthetic peptides have been exploited in order to expand our understanding of the molecular mechanisms involved in protein phosphorylation. It recognizes that virtually all physiological processes are regulated by protein phosphorylation. It discusses the use of synthetic peptides in studying the catalytic mechanism and regulation of protein kinases. It also includes the chemical synthesis of phosphorylated peptides and preparation of specific antisera. This incredible work has lead to the development of a new generation of peptide inhibitors with potencies of greater magnitude than those previously known. Everyone involved with biochemistry and molecular biology will find this one-of-a-kind resource fascinating and filled with useful information.
NMR is a technique that can spoil you. It is true that it is not as sensitive as some of the spectroscopic methods, but the quality of the information and the incredible ease of sample preparation make it one of the tools that have opened new vistas in biological research. This volume is intended to show how those vistas can range from the molecule to the microbe to man himself. Further, it is what prompts the rather broad title.
This book has been written in part with the aim of providing a text which will be useful in teaching the biochemical applications of spectroscopy. This book will be of particular use to the biochemist or biologist who does not have a background in spectroscopy, but desires to find out what sort of information spectroscopy can provide. Attention was limited to those techniques most frequently used, and which at present have the widest applications.
The Logic of Biochemical Sequencing examines how to determine the primary structures of proteins and DNA and use them to stimulate the process of logical problem-solving. It concentrates on sequencing work and stresses the thought processes needed to make sense of what might otherwise be indecipherable data. The book also introduces "biocryptography," which serves as a basis for four short stories that use the results of sequence determinations to provide clues to higher order problems. Problems in the book range from elementary to difficult, and solutions to all problems are provided, many of them completely worked out. The book is an excellent supplementary text for students in a full-year biochemistry course, as well as for biochemists and molecular biologists.
During the past 20 years, marine chemical ecology has emerged as a respected field of study providing a better understanding of the role natural products play in organisms and their environments. Ample data in this book advocates the conservation of marine environments for future drug discovery efforts while sustaining their overall health. Marine chemical ecology has expanded to include research in the areas of predator-prey interactions, marine microbial chemical ecology, and seasonal and geographical distribution of marine natural products.
Bioethanol and Natural Resources: Substrates, Chemistry and Engineered Systems provides a comprehensive review of feedstocks, physiochemical and biological pretreatments, molecular substrates, cellulolytic and ligninolytic enzymes, and advanced technologies for producing bioethanol. Although this book provides a review of first-generation bioethanol feedstocks, chemistry, and processes, there is an emphasis on second-generation "cellulosic" ethanol production. With rapid advances in biofuels technologies and the continued global dependency on unsustainable extraction of fossil fuels, this text is timely. Although it is intended to be used as a supplemental text for advanced undergraduate or graduate level courses, the book is accessible to a non-academic audience. This book provides a unique opportunity to understand bioethanol production from the basic concepts and processes to the most cutting-edge technologies under development.
Examining the layers of meaning encoded in software and the rhetoric surrounding it, this book offers a much-needed perspective on the intersections between software, morality, and politics. In software development culture, evangelism typically denotes a rhetorical practice that aims to convert software developers, as well as non-technical lay users, from one platform to another (e.g., from the operating system Microsoft Windows to Linux). This book argues that software evangelism, like its religious counterpart, must also be understood as constructing moral and political values that extend well beyond the boundaries of the development culture. Unlike previous studies that locate such values in the effects of code in-use or in certain types of code like free and open source (FOSS) software, Maher argues that all code is meaningful beyond its technical, executable functions. To facilitate this analysis, this study builds a theory of evangelism and illustrates this theory at work in the proprietary software industry and FOSS communities. As an example of political liberalism at work at the level of code, these evangelical rhetorics of software construct competing conceptions of what is good that fall within a shared belief in what is just. Maher illustrates how these beliefs in goodness and justice do not always execute in replicable ways, as the different ways of decoding software evangelisms in the contexts of Brazil and China reveal. Demonstrating how software evangelisms exert a transformative force on the world, one comparable in significance to code itself, this book highlights the importance of rhetoric in even the most seemingly a-rhetorical of technical endeavors and foregrounds the crucial need for rhetorical literacy in the digital age.
Biochemistry Explained employs an innovative approach which has proven highly successful in the author's own classes. The author establishes a thorough understanding of the foundations of and common linkages between molecular structures and reactions, so that eventual interpretation of complex biochemical pathways and reactions is easy. All of the major molecular structures and biochemical pathways are explained, and, for the most part, these center on mammalian biochemistry. The text is supported by biochemical nomenclature and questions to bear in mind while reading. Higher learning sections are also provided for advanced students. Written in an informal, conversational style, this textbook will serve as an invaluable resource for any student who is struggling with the standard texts and for postgraduate students who need to refresh their knowledge.
Completely revised and expanded to reflect the most recent innovations in HPLC from the past decade, this authoritative reference presents practical strategies for the evaluation and analysis of proteins, peptides, and polynucleotides and offers class-specific applications for the characterization and fractionation of biological macromolecules. Contains updated material on organic supports, size exclusion, ion exchange, hydrophobic interaction, and metal interaction chromatography With more than 2200 contemporary references-over 1000 more than the previous edition- HPLC of Biological Macromolecules, Second Edition is an essential source for biochemists and analytical biochemists, molecular and cell biologists, biophysicists, geneticists, chemical and biotechnological engineers, biochemical neuroendocrinologists, and upper-level undergraduate and graduate students in these disciplines.
Food Phytates takes a new look at phytates, including their potential health benefits. It includes the latest information on the beneficial heath effects of phytates, the influence of phytates in disease prevention, the potential use of phytate as an antioxidant in foods, and phytase expression in transgenic plants. In 14 chapters, leading researchers shed new light on phytates' potential ability to lower blood glucose, reduce cholesterol and triacylglycerols, and reduce the risks of cancer and heart disease.
Historically, the amino acid tryptophan has been considered to play a role in cancer development and the aging process. In recent times, this nutrient has been associated with eosinophila myalgia syndrome - a new human disease that attacks the muscular system. This detailed book examines the implications of the large measure of fresh information gained in recent years. Tryptophan: Biochemical and Health Implications presents an up-to-date, comprehensive view of how L-tryptophan acts and discusses its pivotal role in protein metabolism.
Contains new and expanded material on antioxidants in beverages and
herbal products, nitric oxide and selenium, and the effect of
vitamin C on cardiovascular disease and of lipoic acid on aging,
hyperglycemia, and insulin resistance!
Provides information on methodologies and techniques concerning the biochemical laboratory, as well as improvements or advancements made on existing methodologies. Original methodologies for the purification of biological macromolecules and methodologies for metabolic pathways and enzyme kinetics are covered. The application of biochemical and biophysical methodologies for the structural and dynamic characterization of biological macromolecules is considered. The elaboration of automated systems for biochemical research and computer programs for the management and processing of experimental data are both reviewed. Development of instruments and equipment for biochemical research is also presented.
Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual cofactor 6-hydroxydopa quinine derived from a posttranslational modification of a tyrosine residue. It also covers the differences of between AOs from bacteria, plants, and mammals. Finally, the text examines the importance of this ubiquitous class of enzymes in physiology and in metabolism of biogenic amines.
For more than four decades, scientists and researchers have relied upon the Advances in Chromatography Series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Covering the state of the art in separation science, this volume continues to present timely, cutting-edge reviews on chromatography in the fields of bio-, analytical, organic, polymer, and pharmaceutical chemistry. Compiled by leading researchers from around the world, new chapters cover topics related to countercurrent chromatography and large-scale genotyping as well as cyclic voltammetry detection, a powerful tool for determining the electrochemical characteristics of organic compounds.
As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade's worth of advances in research techniques that are pertinent in understanding how lipid-mediated signal transduction ties to pathologic disorders. Part I describes methods used to identify activities of and assay the expression of different enzymes involved in lipid-mediated signaling. Part II highlights the use of mass spectrometry to ascertain the lipid content in various systems. Part III contains two chapters devoted to techniques used to determine the role of lipids in the activation of gene transcription. Part IV rounds out the book's solid coverage by focusing on methods used to assess fatty acid uptake and metabolism. Lipid-Mediating Signaling is an unrivaled reference for this rapidly expanding, yet resource-limited field, and it is a valuable resource for for cell biologists, biochemists, and pharmacologists, as well as for researchers studying signaling transduction.
Medicinal Chemistry of Anticancer Drugs, Third Edition provides an updated resource for students and researchers from the point-of-view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. The new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point-of-view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references, reviews and primary literature.
Phospholipids are no longer considered exclusively as the building blocks of biomembranes, but are now regarded to be exceptionally important to cellular signalling.Another conclusion resulting from studies over the past several years is that no single general scheme for the role of phospholipids during cell activation can be drawn as representative of all cells. This book presents a comprehensive view of the recent advances made in certain major research areas within the field of phospholipid metabolism in cellular signalling. Topics discussed within this volume include lipid composition of cellular membranes and their organization in biological systems, the dynamic aspects of phospholipid metabolism and its regulation by extracellular stimuli, and the role of newly discovered glycosyl-phosphatidylinositols in insulin action . The book also discusses two biologically active phospholipids: the sphingolipids, and ether-linked glycerophospholipids (the platelet activating factor). Phospholipid Metabolism in Cellular Signaling is an important research reference that should be considered required reading by all scientists and graduate students working on cell activation (e.g., growth factors, hormones, and oncogenes).
Ranging from elegantly simple to extremely complex, a wide variety of flavors and fragrances stimulate our senses. It is difficult to understand the myriad sensory interactions involved because of the sheer complexity of their chemical composition. The aim of this text is to describe the use of chemometric techniques for understanding these complex systems and to serve as a practical guide to the acquisition, organization and reduction of chemical and sensory data. It explains chemical, sensory and multivariate analysis tools and their application. Pertinent concepts are discussed in-depth and are sufficiently illustrated with enough original data in complementary tables and figures to provide the basis for the execution of complex studies. The book emphasizes techniques that have been proven to work rather than those that "should" work from a theoretical standpoint. The book focuses on the acquisition of quality data and the subsequent interpretation of data rather than numerical computations used in data analysis. Chemometrics: Chemical and Sensory Data is an excellent resource for students and newcomers to flavor and fragrance research, as well as for experienced workers and product development managers. |
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