Spanning every critical element of validation for any pharmaceutical, diagnostic, medical device or equipment, and biotech product, this Second Edition guides readers through each step in the correct execution of validating processes required for non-aseptic and aseptic pharmaceutical production. With 14 exclusive environmental performance evaluations, it features 64 new protocols on topics such as sterility assurance, media fill guidelines, and environmental control.

Over the last twenty years there has been tremendous growth in the research and development of sensors and sensor signal processing methods. Advances in materials and fabrication techniques have led to a departure from traditional sensor types and the development of novel sensing techniques and devices, many of which are now finding favor in industry. Novel Sensors and Sensing provides an introduction to modern sensor types and sensor signal processing methods, with emphasis placed on the underlying physics and the generic operating principles involved. It includes a review of the fundamentals of measurement and instrumentation and covers the principle types of modern sensor-resonator, semiconductor based, and optical fiber (including an overview of optical propagation and transmission.) The final chapter of the book is devoted to flow measurement, an area that has benefited greatly from the developments in novel sensing devices and techniques.

Methods in bioinspiration and biomimicking have been around for a long time. However, due to current advances in modern physical, biological sciences, and technologies, our understanding of the methods have evolved to a new level. This is due not only to the identification of mysterious and fascinating phenomena but also to the understandings of the correlation between the structural factors and the performance based on the latest theoretical, modeling, and experimental technologies. Bioinspiration: From Nano to Micro Scale provides readers with a broad view of the frontiers of research in the area of bioinspiration from the nano to macroscopic scales, particularly in the areas of biomineralization, antifreeze protein, and antifreeze effect. It also covers such methods as the lotus effect and superhydrophobicity, structural colors in animal kingdom and beyond, as well as behavior in ion channels. A number of international experts in related fields have contributed to this book, which offers a comprehensive and synergistic look into challenging issues such as theoretical modeling, advanced surface probing, and fabrication. The book also provides a link to the engineering of novel advanced materials playing an important role in advancing technologies in various fields.

This book presents a computer-aided approach to the design of mechatronic systems. Its subject is an integrated modeling and simulation in a visual computer environment. Since the first edition, the simulation software changed enormously, became more user-friendly and easier to use. Therefore, a second edition became necessary taking these improvements into account. The modeling is based on system top-down and bottom-up approach. The mathematical models are generated in a form of differential-algebraic equations and solved using numerical and symbolic algebra methods. The integrated approach developed is applied to mechanical, electrical and control systems, multibody dynamics, and continuous systems.

Tape measures, those useful sewing tools in imaginative cases, are now becoming a collecting passion. Presented here are over 700 tape measures in brass, wood, celluloid and porcelain figural shapes, dating back to the 1820s and up to the present. Over 500 color photographs show tape measures in hundreds of variations from animals and birds to people and their houses, and the captions describe their particular winding mechanisms. Each measure is also given a value range

"Semiconductor-On-Insulator Materials for NanoElectronics Applications is devoted to the fast evolving field of modern nanoelectronics, and more particularly to the physics and technology of nanoelectronic devices built on semiconductor-on-insulator (SemOI) systems. The book contains the achievements in this field from leading companies and universities in Europe, USA, Brazil and Russia. It is articulated around four main topics: 1. New semiconductor-on-insulator materials; 2. Physics of modern SemOI devices; 3. Advanced characterization of SemOI devices; 4. Sensors and MEMS on SOI. "Semiconductor-On-Insulator Materials for NanoElectonics Applications is useful not only to specialists in nano- and microelectronics but also to students and to the wider audience of readers who are interested in new directions in modern electronics and optoelectronics.

Challenged by stringent regulations, vigorous competition, and liability lawsuits, medical device manufactures must develop safe, reliable, and cost-effective products, and managing and reducing risk is a vital element of reaching that goal. These guidelines focus on Failure Modes and Effects Analysis (FMEA) and its application throughout the life cycle of a medical device. It outlines the major U.S. and E.U. standards and regulations and provides a detailed yet easy-to-read overview of risk management and risk analysis methodologies, common FMEA pitfalls, and FMECA-Failure Mode, Effects, and Criticality Analysis.

Guidelines for Failure Modes and Effects Analysis for Medical Devices is written as a practical guide to achieving corporate consistency while dramatically cutting the time required for studies. It will help you prevent patient injuries, costly product recalls, and production department down-time.

Discover how the FMEA methodology can help your company achieve a more cost-effective manufacturing process by improving the quality and reliability of your products. This new FMEA manual from the experts at Dyadem is the ultimate resource for you and your colleagues to learn more about Failure Modes and Effects Analysis and then teach others at your facility. This comprehensive manual is sure to become a standard reference for engineering professionals.

Wireless Sensor Networks presents a comprehensive and tightly organized compilation of chapters that surveys many of the exciting research developments taking place in this field. Chapters are written by several of the leading researchers exclusively for this book. Authors address many of the key challenges faced in the design, analysis and deployment of wireless sensor networks. Included is coverage of low-cost sensor devices equipped with wireless interfaces, sensor network protocols for large scale sensor networks, data storage and compression techniques, security architectures and mechanisms, and many practical applications that relate to use in environmental, military, medical, industrial and home networks. The book is organized into six parts starting with basic concepts and energy efficient hardware design principles. The second part addresses networking protocols for sensor networks and describes medium access control, routing and transport protocols. In addition to networking, data management is an important challenge given the high volumes of data that are generated by sensor nodes. deals with security protocols and mechanisms for wireless sensor networks. Sensor network localization systems and network management techniques are covered in Part V. The final part focuses on target detection and habitat monitoring applications of sensor networks. This book is intended for researchers starting work in the field and for practitioners seeking a comprehensive overview of the various aspects of building a sensor network. It is also an invaluable reference resource for all wireless network professionals.

This book showcases the state of the art in the field of sensors and microsystems, revealing the impressive potential of novel methodologies and technologies. It covers a broad range of aspects, including: bio-, physical and chemical sensors; actuators; micro- and nano-structured materials; mechanisms of interaction and signal transduction; polymers and biomaterials; sensor electronics and instrumentation; analytical microsystems, recognition systems and signal analysis; and sensor networks, as well as manufacturing technologies, environmental, food and biomedical applications. The book gathers a selection of papers presented at the 19th AISEM National Conference on Sensors and Microsystems. Held in Lecce, Italy in February 2017, the event brought together researchers, end users, technology teams and policy makers.

Thin Film Magnetoresistive Sensors presents a comprehensive review of thin film magnetoresistive (MR) sensors, including the theory of MR effects as well as the design, fabrication, properties, and applications of MR sensors. With over 1,000 references, the book fully reviews the theory, development, and use of these sensors. It provides essential information about the performance of various kinds of sensors, including permalloy magnetoresistors, spin valve sensors, multilayer sensors, colossal effect sensors, spin dependent tunneling sensors, and magnetoimpedance sensors.
Divided into three independent parts, the book first concentrates on the most widely used sensors-anisotropic magnetoresistive sensors (AMR). The second part deals with giant magnetoresistive (GMR) sensors, including those still in development. In the third section, the book describes the applications of MR sensors, especially in data storage systems, industrial measurements, and nondestructive material testing systems.

This book gives an overview of nanostructures and nanomaterials applied in the fields of energy and organic electronics. It combines the knowledge from advanced deposition and processing methods of nanomaterials such as laser-based growth and nanopatterning and state-of-the-art characterization techniques with special emphasis on the optical, electrical, morphological, surface and mechanical properties. Furthermore it contains theoretical and experimental aspects for different types of nanomaterials such as nanoparticles, nanotubes and thin films for organic electronics applications. The international group of authors specifically chosen for their distinguished expertise belong to the academic and industrial world in order to provide a broader perspective. The authors take an interdisciplinary approach of physics, chemistry, engineering, materials science and nanotechnology. It appeals to researchers and graduate students.

This book covers all major aspects of cutting-edge research in the field of neuromorphic hardware engineering involving emerging nanoscale devices. Special emphasis is given to leading works in hybrid low-power CMOS-Nanodevice design. The book offers readers a bidirectional (top-down and bottom-up) perspective on designing efficient bio-inspired hardware. At the nanodevice level, it focuses on various flavors of emerging resistive memory (RRAM) technology. At the algorithm level, it addresses optimized implementations of supervised and stochastic learning paradigms such as: spike-time-dependent plasticity (STDP), long-term potentiation (LTP), long-term depression (LTD), extreme learning machines (ELM) and early adoptions of restricted Boltzmann machines (RBM) to name a few. The contributions discuss system-level power/energy/parasitic trade-offs, and complex real-world applications. The book is suited for both advanced researchers and students interested in the field.

This comprehensive guide offers authoritative answers on flow measurement from dozens of leading experts. Fully illustrated with diagrams, tables, and formulas, Flow Measurement covers virtually every type of flow meter in use today, including those for heat exchangers and gaseous fuels, and laminar, magnetic and mass flow meters. Valuable information on applications and selection criteria.

After the tremendous reception their first book received, Stuart Schneider and George Fischler went to work on this, their second volume. To their delight, despite their comprehensive study of fountain pens and pencils, there were hundreds that had not been included in Fountain Pens and Pencils: The Golden Age of Writing Instruments. This completely new collection will fill you with delight, as well. The colors, designs, and general creativity of the pens illustrated make it easy to understand why this is one of the fastest growing areas of collecting. As the authors say, "The hobby of pen collecting has mushroomed beyond expectations. We are witness to a hobby with incredible appeal throughout the world". While the first book illustrated over 1000 pens mostly made by companies like Scheaffer, Waterman, and Parker, whose reputation for high quality was known to collectors of writing instruments, there were many small pen companies that exhibited quality workmanship and individuality. While the familiar companies are included, this book will introduce more pens and pen makers, many of which will be unfamiliar to pen collectors. A value guide is included, which offers the pen collector or trader a reference to determine comparative values of pens. We hope you enjoy this new volume, and find it a useful, valued tool in your collecting life.

This study examines findings from a 4-year-long ethnography of communication among a research university's community of scientists and engineers working in nanoscience and nanotechnology. It includes analysis of 20 in-depth interviews with scientists and engineers from 18 different disciplines self-identified as working in nanoscale science and engineering. Using multiple methods of inquiry, including fieldwork, interviews, and textual analysis, elements of a shared speech code are presented, each of which indicate culturally distinctive understandings of psychology, sociology and rhetoric. In particular, the interview data addresses questions such as "What kind of person is a scientist?" "What is the role of science in society?" and "What is the role of communication in science?" This book will appeal to readers interested in science and society, scientific communication, and ethnography of communication.

This book presents the design and manufacturing of microsystems as well as necessary key technologies developed within the Collaborative Research Center 516. The research efforts of this collaboration are focused on active micro systems which are based on the electromagnetic actuator principle. The travel of the investigated actuator systems is on the order of several millimeters. The total construction size of the actuator is on the range of several centimeters whereas essential structures being several micrometers. The methods and the production technologies that are investigated on the basis of various research models incorporate the fundamental process chains of microsystems.

The Incredible Ball Point Pen tells the story of the ball point pen's painful development, its cacophonous launching, the public hysteria accompanying its debut, and its outrageous and scandalous promotion. It recounts the fabulous riches which followed, the public's rapid and total disillusionment with the product, the collapse of the market, scientific breakthroughs in the 1950s, the industry's resurrection, myriad improvements occurring from 1950 to 1959, and the modern period from 1960 on. This is the most exhaustive work available on early ball point brands, manufacturers, and models. It includes over 400 photos of pens, copies of original ads, patents, documentation, and a comprehensive spotter and price guide. All who appreciate the ball point pen as a collectible and investment and who wish to further their knowledge about this fascinating topic will certainly want this book.

Validation of computer systems is the process that assures the formal assessment and report of quality and performance measures for all the life-cycle stages of software and system development, its implementation, qualification and acceptance, operation, modification, requalification, maintenance and retirement (PICS CSV PI 011-3). It is a process that demonstrates the compliance of computer systems functional and non-functional requirements, data integrity, regulated company procedures and safety requirements, industry standards, and applicable regulatory authority's requirements. Compliance is a state of being in adherence to application-related standards or conventions or regulations in laws and similar prescriptions. This book, which is relevant to the pharmaceutical and medical devices regulated operations, provides practical information to assist in the computer validation to production systems, while highlighting and efficiently integrating worldwide regulation into the subject. A practical approach is presented to increase efficiency and to ensure that the validation of computer systems is correctly achieved.

ATILA Finite Element Method (FEM) software facilitates the modelling and analysis of applications using piezoelectric, magnetostrictor and shape memory materials. It allows entire designs to be constructed, refined and optimized before production begins. Through a range of instructive case studies, Applications of ATILA FEM software to smart materials provides an indispensable guide to the use of this software in the design of effective products.
Part one provides an introduction to ATILA FEM software, beginning with an overview of the software code. New capabilities and loss integration are discussed, before part two goes on to present case studies of finite element modelling using ATILA. The use of ATILA in finite element analysis, piezoelectric polarization, time domain analysis of piezoelectric devices and the design of ultrasonic motors is considered, before piezo-composite and photonic crystal applications are reviewed. The behaviour of piezoelectric single crystals for sonar and thermal analysis in piezoelectric and magnetostrictive materials is also discussed, before a final reflection on the use of ATILA in modelling the damping of piezoelectric structures and the behaviour of single crystal devices.
With its distinguished editors and international team of expert contributors, Applications of ATILA FEM software to smart materials is a key reference work for all those involved in the research, design, development and application of smart materials, including electrical and mechanical engineers, academics and scientists working in piezoelectrics, magenetostrictors and shape memory materials.
Provides an indispensable guide to the use of ATILA FEM software in the design of effective productsDiscusses new capabilities and loss integration of the software code, before presenting case studies of finite element modelling using ATILADiscusses the behaviour of piezoelectric single crystals for sonar and thermal analysis in piezoelectric and magnetostrictive materials, before a reflection on the use of ATILA in modelling the damping of piezoelectric structures

This book provides an in-depth introduction to the sol to gel transition in inorganic and hybrid organic-inorganic systems, one of the most important chemical-physical transitions and the basis of the sol-gel process. Familiarity with the fundamental chemistry and physics of this transition is essential for students in chemistry and materials science through academic and industry researchers working on sol-gel-related applications. The book features a didactic approach, using simple and clear language to explain the sol to gel transition and the accompanying processes. The text is also suitable for use in short courses and workshops for graduate students as well as professionals.This fully revised and updated new edition contains a wealth of new content. In particular, it includes a detailed discussion of the chemistry of transition metal alkoxides and organosilanes, and an extended discussion of the sol to gel transition models.

This book presents the proceedings of SympoSIMM 2019, the 2nd edition of the Symposium on Intelligent Manufacturing and Mechatronics. Focusing on "Strengthening Innovations Towards Industry 4.0", the book presents studies on the details of Industry 4.0's current trends. Divided into five parts covering various areas of manufacturing engineering and mechatronics stream, namely, artificial intelligence, instrumentation and controls, intelligent manufacturing, modelling and simulation, and robotics., the book is a valuable resource for readers wishing to embrace the new era of Industry 4.0.

High quality optical components for consumer products made of glass and plastic are mostly fabricated by replication. This highly developed production technology requires several consecutive, well-matched processing steps called a "process chain" covering all steps from mold design, advanced machining and coating of molds, up to the actual replication and final precision measurement of the quality of the optical components. Current market demands for leading edge optical applications require high precision and cost effective parts in large volumes. For meeting these demands it is necessary to develop high quality process chains and moreover, to crosslink all demands and interdependencies within these process chains. The Transregional Collaborative Research Center "Process chains for the replication of complex optical elements" at Bremen, Aachen and Stillwater worked extensively and thoroughly in this field from 2001 to 2012. This volume will present the latest scientific results for the complete process chain giving a profound insight into present-day high-tech production.

The intersection of nanostructuredmaterials with photonics and electronics shows greatpotential for clinical diagnostics, sensors, ultrafast telecommunication devices, and a new generation of compact and fast computers. Nanophotonics draws upon cross-disciplinary expertise from physics, materials science, chemistry, electrical engineering, biology, and medicine to create novel technologies to meet a variety of challenges. This is the first book to focus onnovel materials and techniques relevant to the burgeoning areaofnanoscale photonics and optoelectronics, including novel-hybrid materials with multifunctional capabilities andrecent advancements in the understanding of optical interactions in nanoscale materials and quantum-confined objects. Leading experts provide a fundamental understanding of photonics and the related science and technology of plasmonics, polaritons, quantum dots for nanophotonics, nanoscale field emitters, near-field optics, nanophotonic architecture, and nanobiophotonic materials. "

This proceedings book gathers contributions presented at the 2nd International Conference of Mechatronics and Cyber-MixMechatronics/ICOMECYME, organized by the National Institute of R&D in Mechatronics and Measurement Technique in Bucharest, Romania, on September 6th-7th, 2018. Further, it reflect the expansion of the field of Mechatronics, which has yielded newer trans-disciplinary fields including Adaptronics, Integronics, and Cyber-Mix-Mechatronics. These are also the topics addressed by the respective book chapters. The conference has a rich scientific tradition and attracts specialists from all over the world - including North America, South America, and Asia. ICOMECYME is focused on presenting research results and is mainly directed at academics and advanced students, but also offers a venue for interacting with R&D experts. These proceedings will especially benefit entrepreneurs who want to invest in research and who are open for collaborations.

This is a textbook for graduate and final-year-undergraduate computer-science and electrical-engineering students interested in the hardware and software aspects of embedded and cyberphysical systems design. It is comprehensive and self-contained, covering everything from the basics to case-study implementation. Emphasis is placed on the physical nature of the problem domain and of the devices used. The reader is assumed to be familiar on a theoretical level with mathematical tools like ordinary differential equation and Fourier transforms. In this book these tools will be put to practical use. Engineering Embedded Systems begins by addressing basic material on signals and systems, before introducing to electronics. Treatment of digital electronics accentuating synchronous circuits and including high-speed effects proceeds to micro-controllers, digital signal processors and programmable logic. Peripheral units and decentralized networks are given due weight. The properties of analog circuits and devices like filters and data converters are covered to the extent desirable by a systems architect. The handling of individual elements concludes with power supplies including regulators and converters. The final section of the text is composed of four case studies: * electric-drive control, permanent magnet synchronous motors in particular; * lock-in amplification with measurement circuits for weight and torque, and moisture; * design of a simple continuous wave radar that can be operated to measure speed and distance; and * design of a Fourier transform infrared spectrometer for process applications. End-of-chapter exercises will assist the student to assimilate the tutorial material and these are supplemented by a downloadable solutions manual for instructors. The "pen-and-paper" problems are further augmented with laboratory activities. In addition to its student market, Engineering Embedded Systems will assist industrial practitioners working in systems architecture and the design of electronic measurement systems to keep up to date with developments in embedded systems through self study.