A Times Best Book of 2021 From the very first dog to glowing fish and designer pigs - the human history of remaking nature. Virus-free mosquitoes, resurrected dinosaurs, designer humans - such is the power of the science of tomorrow. But the idea that humans have only recently begun to tinker with the natural world is false. We've been meddling with nature since the last ice age, and we're getting a lot better at it. Drawing on decades of research, Beth Shapiro reveals the surprisingly long history of human intervention in evolution - for good and for ill - and looks ahead to the future, casting aside scaremongering myths about the dangers of interference. New biotechnologies can present us with the chance to improve our own lives, and increase the likelihood that we will continue to live in a rich and biologically diverse world.

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series. Chapter "Application of iPSC to Modelling of Respiratory Diseases" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Ethanol as an alternative fuel is receiving a lot of attention because it addresses concerns related to dwindling oil supplies, energy independence, and climate change. The majority of the ethanol in the US is produced from corn starch. With the US Department of Energy's target that 30% of the fuel in the US is produced from renewable resources by 2030, the anticipated demand for corn starch will quickly exceed the current production of corn. This, plus the concern that less grain will become available for food and feed purposes, necessitates the use of other feedstocks for the production of ethanol. For the very same reasons, there is increasing research activity and growing interest in many other biomass crops. Genetic Improvement of Bio-Energy Crops focuses on the production of ethanol from lignocellulosic biomass, which includes corn stover, biomass from dedicated annual and perennial energy crops, and trees as well as a number of important biomass crops. The biomass is typically pretreated through thermochemical processing to make it more amenable to hydrolysis with cellulolytic enzymes. The enzymatic hydrolysis yields monomeric sugars that can be fermented to ethanol by micro-organisms. While much emphasis has been placed on the optimization of thermo-chemical pretreatment processes, production of more efficient hydrolytic enzymes, and the development of robust microbial strains, relatively little effort has been dedicated to the improvement of the biomass itself.

While the WTO agreements do not regulate the use of biotechnology per se, their rules can have a profound impact on the use of the technology for both commercial and non-commercial purposes. This book seeks to identify the challenges to international trade regulation that arise from biotechnology. The contributions examine whether existing international obligations of WTO Members are appropriate to deal with the issues arising for the use of biotechnology and whether there is a need for new international legal instruments, including a potential WTO Agreement on Biotechnology. They combine various perspectives on and topics relating to genetic engineering and trade, including human rights and gender; intellectual property rights; traditional knowledge and access and benefit sharing; food security, trade and agricultural production and food safety; and medical research, cloning and international trade.

While there has been great progress in the development of plant breeding over the last decade, the selection of suitable plants for human consumption began over 13,000 years ago. Since the Neolithic era, the cultivation of plants has progressed in Asia Minor, Asia, Europe, and ancient America, each specific to the locally wild plants as well as the ecological and social conditions. A handy reference for knowing our past, understanding the present, and creating the future, this book provides a comprehensive treatment of the development of crop improvement methods over the centuries. It features an extensive historical treatment of development, including influential individuals in the field, plant cultivation in various regions, techniques used in the Old World, and cropping in ancient America. The advances of scientific plant breeding in the twentieth century is extensively explored, including efficient selection methods, hybrid breeding, induced polyploidy, mutation research, biotechnology, and genetic manipulation. Finally, this book presents information on approaches to the sustainability of breeding and to cope with climatic changes as well as the growing world population.

The oil palm is a remarkable crop, producing around 40% of the world's vegetable oil from around 6% of the land devoted to oil crops. Conventional breeding has clearly been the major focus of genetic improvement in this crop. A mix of improved agronomy and management, coupled with breeding selection have quadrupled the oil yield of the crop since breeding began in earnest in the 1920s. However, as for all perennial crops with long breeding cycles, oil palm faces immense challenges in the coming years with increased pressure from population growth, climate change and the need to develop environmentally sustainable oil palm plantations. In Oil Palm: Breeding, Genetics and Genomics, world leading organizations and individuals who have been at the forefront of developments in this crop, provide their insights and experiences of oil palm research, while examining the different challenges that face the future of the oil palm. The editors have all been involved in research and breeding of oil palm for many years and use their knowledge of the crop and their disciplinary expertise to provide context and to introduce the different research topics covered.

This specially curated collection features six reviews of current and key research on genetic modification of crops. The first chapter reviews key challenges facing banana production, primarily the risk of species decimation by diseases such as Fusarium wilt, and considers how genetic modification may be a solution to this. The second chapter discusses the development and establishment of 'Golden Rice' - a biofortified variety designed as a health intervention to help alleviate the problem of vitamin A deficiency. The third chapter details recent advances in the genetic modification of important agronomic traits of soybean crops, such as herbicide tolerance and insect resistance. The fourth chapter addresses progress in and prospects for transgenic interventions in the improvement of grain legumes, concentrating on chickpea, pigeonpea, cowpea and more. The fifth chapter reviews recent research efforts in the production of genetically modified (GM) oil palm plants and looks towards establishing stable lines of commercially viable GM varieties. The final chapter describes recent progress relating to transgenic modification of cassava and how future research can strengthen food security and commercialization of the crop.

This open access book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer look at genetically engineered oilseed rape, genetically engineered olive flies as well as plants and animals with so-called gene drives. The book mainly adresses researchers.

Although designed for undergraduates with an interest in molecular biology, biotechnology, and bioengineering, this book-Techniques in Genetic Engineering-IS NOT: a laboratory manual; nor is it a textbook on molecular biology or biochemistry. There is some basic information in the appendices about core concepts such as DNA, RNA, protein, genes, and genomes; however, in general it is assumed that the reader has a background on these key issues. Techniques in Genetic Engineering briefly introduces some common genetic engineering techniques and focuses on how to approach different real-life problems using a combination of these key issues. Although not an exhaustive review of these techniques, basic information includes core concepts such as DNA, RNA, protein, genes, and genomes. It is assumed that the reader has background on these key issues. The book provides sufficient background and future perspectives for the readers to develop their own experimental strategies and innovations. This easy-to-follow book presents not only the theoretical background of molecular techniques, but also provides case study examples, with some sample solutions. The book covers basic molecular cloning procedures; genetic modification of cells, including stem cells; as well as multicellular organisms, using problem-based case study examples.

Stem cell research has been a problematic endeavour. For the past twenty years it has attracted moral controversies in both the public and the professional sphere. The research involves not only laboratories, clinics and people, but ethics, industries, jurisprudence, and markets. Today it contributes to the development of new therapies and affects increasingly many social arenas. The matrix approach introduced in this book offers a new understanding of this science in its relation to society. The contributions are multidisciplinary and intersectional, illustrating how agency and influence between science and society go both ways. Conceptually, this volume presents a situated and reflexive approach for philosophy and sociology of the life sciences. The practices that are part of stem cell research are dispersed, and the concepts that tie them together are tenuous; there are persistent problems with the validation of findings, and the ontology of the stem cell is elusive. The array of applications shapes a growing bioeconomy that is dependent on patient donations of tissues and embryos, consumers, and industrial support. In this volume it is argued that this research now denotes not a specific field but a flexible web of intersecting practices, discourses, and agencies. To capture significant parts of this complex reality, this book presents recent findings from researchers, who have studied in-depth aspects of this matrix of stem cell research. This volume presents state-of-the-art examinations from senior and junior scholars in disciplines from humanities and laboratory research to various social sciences, highlighting particular normative and epistemological intersections. The book will appeal to scholars as well as wider audiences interested in developments in life science and society interactions. The novel matrix approach and the accessible case studies make this an excellent resource for science and society courses.

Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting, cell tracking, and determining therapeutic efficacy. The book first presents background information and insight on the major classes of stem and progenitor cells. It then describes the main imaging modalities and state-of-the-art techniques that are currently employed for stem cell tracking. In the final chapters, leading scholars offer clinical perspectives on existing and potential uses of stem cells as well as the impact of image-guided delivery and tracking in major organ systems. Through clear descriptions and color images, this volume illustrates how noninvasive imaging is used to track stem cells as they repair damaged tissue in the body. With contributions from some of the most prominent preclinical and clinical researchers in the field, the book helps readers to understand the evolving concepts of stem cell labeling and tracking as the field continues to move forward.

"Leonardo's Choice: Genetic Technologies and Animals" is an edited collection of twelve essays and one dialogue focusing on the profound affect the use of animals in biotechnology is having on both humans and other species. Communicating crucial understandings of the integrated nature of the human and non-human world, these essays, unlike the majority of discussions of biotechnology, take seriously the impact of these technologies on animals themselves. This collection's central questions revolve around the disassociation Western ideas of creative freedom have from the impacts those ideas and practices have on the non-human world.

"This transdisciplinary collection includes perspectives from the disciplines of philosophy, cultural theory, art and literary theory, history and theory of science, environmental studies, law, landscape architecture, history, and geography. Included authors span three continents and four countries."

"Included essays contribute significantly to a growing scholarship surrounding "the question of the animal" emanating from philosophical, cultural and activist discourses. Its authors are at the forefront of the growing number of theorists and practitioners across the disciplines concerned with the impact of new technologies on the more-than-human world."

DNA "fingerprinting," genetic engineering of food, genetic screening, gene therapy, the human genome project...there is no shortage of news these days about the genetic revolution. The purpose of this book is to take the interested reader behind the headlines to explore the fascinating world of molecular biology. Eschewing jargon, author Susan Aldridge gives an accessible account of the world of DNA and also explores its present and future applications. In the first part of the book, she explains what DNA is and how it functions within living organisms. In the second part, she explores genetic engineering and its applications to humans--such as gene therapy, genetic screening, and DNA fingerprinting. In the third, the author looks at the wider world of biotechnology and how genetic engineering can be applied to such problems as producing vegetarian cheese or cleaning up the environment. Finally, she explains how knowledge of the structure and function of genes sheds light on evolution and our place in the world. Aldridge has written with a light touch full of historical references; her achievement will make rewarding reading for anyone who reads popular accounts of the life sciences.

GENETIC THEORY AND ANALYSIS Understand and apply what drives change of characteristic genetic traits and heredity Genetics is the study of how traits are passed from parents to their offspring and how the variation in those traits affects the development and health of the organism. Investigating how these traits affect the organism involves a diverse set of approaches and tools, including genetic screens, DNA and RNA sequencing, mapping, and methods to understand the structure and function of proteins. Thus, there is a need for a textbook that provides a broad overview of these methods. Genetic Theory and Analysis meets this need by describing key approaches and methods in genetic analysis through a historical lens. Focusing on the five basic principles underlying the field—mutation, complementation, recombination, segregation, and regulation—it identifies the full suite of tests and methodologies available to the geneticist in an age of flourishing genetic and genomic research. This second edition of the text has been updated to reflect recent advances and increase accessibility to advanced undergraduate students. Genetic Theory and Analysis, 2nd edition readers will also find: Detailed treatment of subjects including mutagenesis, meiosis, complementation, suppression, and more Updated discussion of epistasis, mosaic analysis, RNAi, genome sequencing, and more Appendices discussing model organisms, genetic fine-structure analysis, and tetrad analysis Genetic Theory and Analysis is ideal for both graduate students and advanced undergraduates undertaking courses in genetics, genetic engineering, and computational biology.

The fast-growing sugarcane plant is a major source of sugar (sucrose) in tropical and sub-tropical regions. The high productivity of the plant also makes it a key target for use as an energy crop. The fiber of the plant is used to generate electricity and produce ethanol as a fuel. Sugarcane is a hybrid of two species, each of which is genetically complex. The high level of genetic complexity in sugarcane creates challenges in the application of both conventional and molecular breeding to the genetic improvement of sugarcane as a sugar and energy crop. This book describes technologies that support the continued use and improvement of sugarcane as source of food and energy. Recent technology developments indicate the potential to greatly increase our understanding of the sugarcane plant by application of emerging genomic technologies. This should result in an increased rate of improvement of sugarcane for human uses.

Combining elements of biochemistry, molecular biology, and immunology, artificial DNA can be employed in a number of scientific disciplines. Some of the varied applications include site-specific mutagenesis, hybridization, amplification, protein engineering, anti-sense technology, DNA vaccines, protein vaccines, recombinant antibodies, screening for genetic and pathogenic diseases, development of materials with new biochemical and structural properties, and many more. Artificial DNA: Methods and Applications introduces the concept of artificial DNA that has been rationally designed and explains how it may be exploited in order to develop products that will achieve your intended purpose. The first part of the book covers methods of oligonucleotide synthesis and direct applications of synthetic DNA. The second part describes methods of gene assembly from synthetic oligonucleotides and applications of synthetic genes. The authors also discuss the different trends and future developments within each application area . With state-of-the art research, the contributing authors describe how to engineer proteins using rational and semi-rational design to exhibit the desired traits and detail the various amplification reactions and hybridization techniques for modeling evolution and for use in basic research. The only text devoted to this subject, Artificial DNA offers a comprehensive review that allows you to understand the strategy, design, and applications of synthetic oligonucleotides.

Very Short Introductions: Brilliant, Sharp, Inspiring In this exploration of the concept of the gene, Jonathan Slack looks at the discovery, nature, and role of genes in both evolution and development. By explaining the nature of genetic variation in the human population, how hereditary factors were identified as molecules of DNA, and how certain specific mutations can lead to disease, Slack highlights how DNA variants are used to trace human ancestry and migration, and can also be used by forensic scientists to identify individuals in crime. He also explores issues such as the role of genetic heritability and IQ as well as the changes that occur in the genes of populations during evolution. An ideal guide for anyone curious about what genes are and how genetics can be put to use, this Very Short Introduction demonstrates the ways in which the gene concept has been understood and used by molecular biologists, population biologists, and social scientists around the world. This second edition has been fully updated and contains new sections on the CRISPR method for targeted genetic modification, on DNA profiling, and developments in our understanding of human ancestry using ancient DNA. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

An increasing number of genetically modified organisms (GMOs) continues to be produced every day. In response to the concerns raised by the development of GMOs and their incorporation in foods and feed, guidelines and regulations to govern and control the use of GMOs and their products have been enacted. These regulations necessitated the design of methods to detect and analyse the presence of GMOs or their products in agriculture produce, food and feed production chains. Design of techniques and instruments that would detect, identify, and quantify GM ingredients in food and feed will help inspection authorities to relay reliable information to consumers who might be concerned about the presence of GM ingredients. Information generated by detection of GMOs in food and feed would be helpful for setting regulations that govern the use of GM components as well as for labeling purposes. Qualitative detection methods of GM-DNA sequences in foods and feeds have evolved fast during the past few years. There is continuous need for the development of more advanced multi-detection systems and for periodic updates of the databases related to these systems. Testing and Analysis of GMO-containing Foods and Feed presents updates and comprehensive views on the various methods and techniques in use today for the detection, identification and quantification of GMOs in foods and feed. The eleven book chapters cover recent developments on sample preparation techniques, immunoassays methods and the PCR technique used in GMO analysis, the use of biosensors in relation to GMO analysis, the application of nucleic acid microarrays for the detection of GMOs, validation and standardization methods for GMO testing, in addition to the type of reference material and reference methods used in GMO testing and analysis. Some of the ISO standards designed for identifying and detecting the presence of GM material in foods are also presented in the book.

A vision of the future where the latest Silicon Valley tech meets cutting-edge genetics. Decoding the World is a buddy adventure about the quest to live meaningfully in a world with such uncertainty. It starts with Po Bronson coming to IndieBio. Arvind Gupta created IndieBio as a laboratory for early biotech startups trying to solve major world problems. Glaciers melting. Dying bees. Infertility. Cancer. Ocean plastic. Pandemics. As they travel around the world, finding scientists to join their cause, the authors bring their first-hand experience to the great mysteries that haunt our future. Natural resource depletion. Job-taking robots. China's global influence. Decoding the World is the kind of book you get when you give two guys $40 million, a world full of messy big problems, a genetics laboratory to play in, and a set of Borges' collected works. After looking through their lens, you'll never see the world the same.

First published in 1982 . This report examines the application of classical and molecular genetic technologies to micro-organisms, plants, and animals. This book is one of the first comprehensive documents on emerging genetic technologies and their implications for society. The authors discuss the opportunities and problems involved, describe current techniques, and attempt to project some of the economic, environmental, and institutional impacts of those techniques. The issues they raise go beyond those of technology, utility, and economic feasibility. As we gain the ability to manipulate life, we must face basic questions of just what life means and how far we can reasonably-and safely-allow ourselves to go.