This book presents topical research in the study of liver cirrhosis, including etiologic types of end stage chronic liver disease; hepatocellular carcinoma screening in the cirrhotic patient; hepatic myofibroblasts and their role in liver fibrogenesis; the role of trace elements in the pathogenesis of liver cirrhosis and cell-based therapy for liver cirrhosis.

Insulin resistance (IR) and metabolic syndrome are associated with the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD). It encompasses a spectrum of hepatic pathology, ranging from simple steatosis in its most benign form (fatty liver), going through nonalcoholic steatohepatitis (NASH) in its intermediate form, until cirrhosis and hepatocellular carcinoma, its most advanced forms. This book presents current research on the background of fatty acid oxidation; hepatic steatosis and its progression to NASH and cirrhosis; fibrosis and myofibroblastic cells differentiation; methods of diagnosis; clinical features and laboratory tests and, finally, rodent NAFLD and NASH models.

Hepatobiliary and pancreatic surgery is a relatively new specialty and the vast majority of patients present initially outside tertiary referral centres. Many conditions such as gallstones, acute and chronic pancreatitis, obstructive jaundice and malignancies of the liver, biliary tract and pancreas are still managed outside specialist centres or are not suitable for referral. Many general surgeons continue to manage these problems and in some parts of the world the geography and distances involved makes referral for specialist care difficult or impossible. The relative scarcity of specialist centres for the management of these difficult conditions also means that the majority of trainees do not get sufficient exposure prior their definitive appointment to equip them with the tools needed to confidently manage many of the problems they may face.
Operative Solutions in Hepatobiliary and Pancreatic Surgery combines clearly written, practical text with over 200 illustrations and numerous flow charts which take the reader through the management of all the commonly encountered hepatobiliary and pancreatic pathologies and procedures. All aspects of hepatobiliary and pancreatic surgery are discussed in a clear and consistent style, while the flow charts are designed to be modified by the reader to adapt them to local practice and the facilities and expertise available. This book is invaluable for the senior trainee or newly appointed specialist who requires clear, practical advice on how to manage the wide range of problems that present to surgeons outside specialist centres.

Liver disease is a rapidly growing speciality, and nurses and health care professionals need to have the relevant knowledge and skills to care for patients with liver problems in a safe and effective way. "Liver Diseases" is a comprehensive, evidence-based, practical guide to the nursing care and management of patients with liver disease.

"Liver Diseases" explores a range of liver conditions, including cirrhosis, portal hypertension, alcoholic liver disease, viral hepatitis, autoimmune hepatitis, Wilson's disease and acute liver failure. It looks at the anatomy & physiology of the liver, assessment of liver function and diagnostic studies, acute and chronic liver disease, pregnancy related liver disease, liver transplantation and infectious liver diseases. For each condition the epidemiology, complications and nursing management are provided, along with illustrative case studies and further reading. "Liver Diseases" is an invaluable tool for all nurses and health care professionals working with people with liver disease.
SPECIAL FEATURESThe first UK book on care of the liver from a nursing and healthcare perspectiveWritten by a well-respected and renowned author in the fieldCovers a wide spectrum of liver diseases, with relevant nursing management guidelinesWith case studies, further reading and illustrations throughout

This book discusses in detail new aspects of the metabolic basis of important chronic liver diseases. Entities such as non-alcoholic fatty liver disease (fatty liver and Non-Alcoholic SteatoHepatitis -- NASH), diabeties in chronic hepetitis C, hemochromatosis, Wilson's disease, Gaucher disease, porphyria, as well as liver cirrhosis and its metabolic consequences will be discussed in detail. These clinical conditions are highly prevalent and affect millions of patients in the USA and world-wide. For example, non-alcoholic fatty liver disease is the most common cause of elevated liver enzymes in the general population. This field has been practically transformed over the last few years, with many new insights gained, regarding both pathogenesis and effective novel treatments.

Liver disease is a widespread and increasing problem throughout the world, however little is published on how different types and degrees of liver dysfunction affect the body's ability to handle medicines."Drugs and the Liver" is designed to assist practitioners in making pragmatic choices for their patients. It aims to: enable the practitioner to assess liver function using biochemical markers, other tests, signs, symptoms and disease knowledge; identify which pharmacokinetic and pharmacodynamic parameters of a drug are likely to be affected by different types of liver disease; and consider the impact of a drug's side effects on a patient with liver disease.This practical guide covers background information on liver function, the principles of drug use in liver disease and includes a section of worked examples of commonly asked questions. It will be invaluable to clinical pharmacists and anyone making medicine choices in patients with liver impairment.

This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.

Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action.

This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.

The latest information on living with and treating liver disorders

"The Liver Disorders and Hepatitis Sourcebook, Revised Edition," gives you frank assessments of the latest therapies and drugs. It also provides advice on how you can navigate the day-to-day challenges of living with a liver disorder, and diet and nutrition guidelines, including the truth about the effectiveness of herbal remedies and liver-cleansing diets.

This book presents state-of-the-art information summarizing the current understanding of a range of liver diseases, and reviews some key diagnostic and therapeutic advances. The book is a collection of selected clinical and scientific topics divided into two volumes, each divided into two sections. The first volume treats the cellular, biochemical and immunological mechanisms underlying liver diseases; the second focuses on clinical liver disease pathophysiology and related diagnostics and therapeutic insights. It is hoped that the target readers - hepatologists, clinicians, researchers and academicians - will be exposed to new ideas, and subjects beyond their own scientific disciplines. In addition, students and all those who wish to enlarge their knowledge of advances in the field of liver diseases will find this book a good source of information.

The Liver in Biology and Disease was conceived as a sequel in the series "Principles of Medical Biology," whose general aim continues to be the integration of human biology and molecular cell biology into modern molecular medicine. It is a volume molded by the Information Revolution which few will deny has forced the teaching faculties in our medical schools to curtail and prune the teaching load and focus on fundamentals and principles. With this intention in mind, a volume of this nature takes into account the close dependence of progress in the medical sciences on bioinformatics (gene and protein analysis) or more precisely, computational biology and of course, the Internet. In general, it follows the pattern of its predecessors.
*Chapters are illustrated with numerous figures and references are current
*Clear, concise and accurate text about a large number of liver diseases
*Describes the liver's histology, biochemistry, and pathology in molecular terms

Proceedings of the Third Baveno International Consensus Workshop on Definitions, Methodology and Therapeutic Strategies.

The participants attempted to develop consensus definitions of key events in portal hypertension and variceal bleeding, diagnostic and therapeutic issues, and the complications of therapies for portal hypertension, as well as producing updated guidelines. The lectures summarized the consensus reached in the earlier workshops, addressed two important new areas of research, and analyzed the quality of trials in portal hypertension and other fields of hepatology.

As a major transplantation center, the University of Pittsburgh has conducted more than 300 liver transplants. Because the problems faced by an institution contemplating the initiation of such an organ transplantation program are many, unique, and often unexpected, the university has been beseiged by requests from other physicians and hospitals for training and advice. This book represents much of the accumulated experience on hepatic transplantation to date.

The authors explore the history of man's thoughts about hepatic structure, function, and disorders, both chronologically and thematically. The first two chapters present the anatomy and physiology of the liver as explained through the ages. Subsequent chapters deal with hepatic function and disorders and therapies used to treat liver disease. The text is enhanced by chronological tables, extensive notes, and a bibliographic essay.

This book guides practitioners in the assessment of patients with a liver problem. The emphasis is on the role of macro- and microscopic pathology in elucidating pathogenesis as well as identifying confounding features of image findings that may lead to a more elaborate differential diagnosis. If appropriate, the role of light and electron microscopic examination, along with the role of specific stains and molecular techniques, is illustrated. In addition, the concept of each liver disease is summarized briefly and its up-to-data is provided, and unresolved problems in diagnosis, treatment, and pathogenesis are clearly described.The approach in this book is a practical one with a focus on the evaluation of illustrative cases, simultaneously demonstrating cross-sectional images (ultrasonography, computed tomography, magnetic resonance imaging, and angiography), pathological findings, and peritoneoscopic images. The diagnosis and therapy are summed up in helpful tables, and association of clinical manifestations with image analysis and pathological findings is shown to be important in differential diagnosis and treatment. With the authors comprising internationally renowned experts, this book will serve as a useful source of information for medical students, physicians, internists, hepatologists, gastroenterologists, radiologists, and pathologists worldwide.

Each volume in this richly illustrated series, published in association with the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytologic and histologic diagnosis of small tissue samples. Benign, pre-malignant and malignant entities are presented in a well-organized and standardized format, with high-resolution color photomicrographs, tables, and lists of key specific morphologic criteria. Example vignettes allow the reader to assimilate the diagnostic principles in a case-based format. This volume provides comprehensive coverage of both surgical pathology and cytopathology of focal liver lesions. Extensively illustrated throughout, it contains key cytologic and histologic features, practical points, radiologic and morphologic pictures, flow charts, and tabulated summaries for easy comprehensive overview and quick reference and provides a pragmatic algorithmic approach to cytohistologic diagnosis. With over 700 printed photomicrographs and a CD-ROM offering all images in a downloadable format, this is an important resource for all anatomic pathologists.

This book fills a void in the market for specialists who are working in areas without the support of gastroenterologists. Due to a lack of local expertise, treatment decisions in the field of gastroenterology frequently have to be made by non-gastroenterologists. The book addresses this problem by providing clear instructions on the diagnosis, medical management and on-going treatment of the most common disease patterns encountered in gastroenterology. Written by leading experts in their respective fields, it offers up-to-date evidence and insights into these conditions to enable adequate decision-making and safe management of these conditions.

This atlas is a problem-based practical book presenting clinical scenarios for children with liver disease. Each chapter demonstrates the clinical presentation, diagnostic pathway, therapy and outcome. Rich in illustrations of clinical pictures, tables and graphs of data, each chapter also contains pictures of radiology, histopathology and other important diagnostic information. This book outlines a multidisciplinary approach to diagnosis and management of pediatric liver disease and covers diseases encountered in South Asia, the Far East and the Middle East. This work will appeal to a wide readership, from trainees in hepatology and Paediatric Gastroenterology to General Paediatricians and Allied Health Professionals including Dieticians, Nurses, Transplant Co-Ordinators.

The Clinical Pocket Guide to Advanced Practice Palliative Nursing is a companion guide to Advanced Practice Palliative Nursing, the first text devoted to advanced practice nursing care of the seriously ill and dying. Each chapter of this pocket guide presents point-of-care guidance on palliative care issues for quick reference in daily practice. Edited by leaders in the field, this handbook provides consistency in the nursing process from assessment to management and evaluation of symptoms and various clinical situations. The Clinical Pocket Guide to Advanced Practice Palliative Nursing contains clinical pearls developed from the textbook and practical tools on pain and symptom assessment, functional status, and communication, making it an ideal resource for practicing APNs.

Radioembolization is a widely used treatment for non-resectable primary and secondary liver cancer. This handbook addresses the radiation biology, physics, nuclear medicine, and imaging for radioembolization using Yttrium-90 (90Y) microspheres, in addition to discussing aspects related to interventional radiology. The contents reflect on and off-label treatment indications, dose-response relationships, treatment-planning, therapy optimization, radiation safety, imaging follow-up and many other facets of this therapy necessary for both novice and advanced users alike.

Hepatitis means an inflammation of the liver, but it also refers to a group of viral infections that affect the liver. There are several types of viral hepatitis, but the most common are A, B, and C. Viral hepatitis is spread through contact with infected blood, bodily fluids, or feces, though it may also result from alcohol and drug use or from other diseases. Acute hepatitis refers to the initial infection and can be mild or severe; chronic hepatitis refers to a serious condition in which the infection lasts six months or longer. Currently, vaccines are available for the prevention of hepatitis A and B viruses. This second edition of Hepatitis delves into the history, causes, and current treatments for this disease, giving valuable information to student researchers.

Foreword by David Heymann, World Health Organization

Chapters include:

The Phases of Hepatitis

Symptoms of Hepatitis

Inflammation and Immune Response

Hepatitis A

Hepatitis B

Hepatitis C

"This attractive, compact handbook offers highly practical, to-the-point guidance to residents and students. The Handbook gives equal weight to both diagnosis and therapy, includes an easy-to-reference emergency section, and maintains a focus on practical disease management. The book's anatomically organized sections are supplemented by special sections on management of GI emergencies and the Top 10 GI Problems, including pertinent algorithms and practice guidelines from the American Gastroenterology Association. Useful appendices provide CT images of common GI problems, normal laboratory ranges, and links to useful websites"--Provided by publisher.

This comprehensive and critical review of current and established treatment modalities for malignant liver tumors is designed to help you sort through the proliferation of competitive approaches and choose the best treatment options for your patient. Dr. Clavien and his contributors consider all the options - radiological, surgical, pharmaceutical, and emerging/novel therapies - and help you find the best single or combined therapy. Building on the success of the previous edition, this extremely thorough revision: * features a new section on Guidelines for Liver Tumors, where you will find specific strategies for treating common liver malignancies; the guidelines were prepared by the Associate Editors and take into account national and international society guidelines * reflects actual practice by taking a multidisciplinary approach, with contributions from international experts who have extensive experience with this patient population * achieves comprehensive and balanced coverage by having each chapter reviewed by the Editor, Deputy Editor, two Associate Editors, and at least one external reviewer * includes 16 new chapters that cover liver anatomy, histologic changes in the liver, epidemiology and natural history of HCC, CCC and colorectal liver metastases, strategies of liver resection, and economic aspects as well as novel therapies * facilitates the kind of daily interaction among hepatologists, hepatic surgeons, medical oncologists, radiotherapists, and interventional radiologists that is essential when treating patients with complex liver malignancies In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.

Lau (The Chinese University of Hong Kong) collects work by experts from 15 countries to present the latest understanding of hepatocellular carcinoma. Coverage encompasses all topics in the field, from epidemiology and prevention through molecular biology, gross pathology, screening and atypical presentations, diagnosis, treatment and management, surgery, and palliative care. There is also a chapter on treatment with extracorporeal energy therapy, covering high-intensity focused ultrasound, conformal radiotherapy, stereotactic radiotherapy, and proton beam therapy. Controversial areas are discussed from different perspectives. The readership for the book includes liver surgeons, hepatologists, interventional and diagnostic radiologists, and basic researchers. General physicians and surgeons, pathologists, and instrument manufacturers will also find the book useful.

Hepatobiliary medicine has seen major recent scientific advances in viral hepatitis, haemochromatosis and autoimmune liver/disease helped by imaging advances in MRI and CT. This volume of some 200 cases by an internationally renowned author team, covers the whole spectrum of liver disease, focusing on the clinical photos, imaging, charts and graphs. The problem-oriented, randomized self-assessment format, lends itself to revision and continuing professional development. The book will appeal particularly to young doctors preparing for membership and board examinations.

Molecular and Cell Biology of the Liver features the latest research findings regarding liver structure and function. A unique feature of the book is the brief science reviews that are included in each chapter which provide essential background information to allow readers to better grasp the subject matter within a chapter. The book covers liver biology from the molecular level to groups of liver cells and explains how groups of hepatocytes interact in similar microenvironments. Other important cell types found in the liver are also examined. Illustrations ranging from electron micrographs to fully rendered drawings act as visual aids to help readers understand complex structural-functional interactions. Molecular and Cell Biology of the Liver will benefit hepatologists, gastroenterologists, cell biologists, anatomists, toxicologists, and other researchers interested in liver structure and function.